首页 > 最新文献

Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)最新文献

英文 中文
SECONDARY SCIENCE TEACHERS' DEVELOPMENT OF PEDAGOGICAL CONTENT KNOWLEDGE AS RESULT OF INTEGRATING NANOSCIENCE CONTENT IN THEIR CURRICULUM 纳米科学内容融入中学科学教师教学内容知识的发展
Pub Date : 2013-06-26 DOI: 10.1142/S0219607712500073
Emily Wischow, L. Bryan, G. Bodner
Nanoscale science is a rapidly-developing, multidisciplinary field of science and research that combines engineering, chemistry, physics, biology, and information technology pushes and the boundary between the science and the technology required to conduct it. Nanoscale science involves investigating and working with matter on the scale of 1–100 microns and has broad societal implications for new technologies. It is estimated that the worldwide workforce necessary to support the field of nanoscale science and nanotechnology will be close to 2 million by 2015 (National Nanotechnology Initiative, 2005). With such rapid developments in nanoscale science and technology, it is becoming more incumbent upon K-12 science teachers to provide the learning experiences necessary for students to understand the principles that govern behavior at the nanoscale and develop the skills needed to apply these concepts to improve everyday life. While onlya limited amount of nanoscale curricular materials are available for K-12 and undergraduate education many important unanswered questions exist, including: How do science teachers learn to teach nanoscale science?
纳米科学是一个快速发展的、多学科的科学和研究领域,它结合了工程学、化学、物理学、生物学和信息技术,推动了科学与实施它所需的技术之间的界限。纳米科学涉及对1-100微米尺度的物质进行调查和研究,对新技术具有广泛的社会意义。据估计,到2015年,支持纳米科学和纳米技术领域所需的全球劳动力将接近200万(国家纳米技术倡议,2005年)。随着纳米科学技术的快速发展,K-12科学教师越来越有责任为学生提供必要的学习经验,让他们理解纳米尺度下支配行为的原理,并培养应用这些概念改善日常生活所需的技能。虽然只有有限数量的纳米级课程材料可用于K-12和本科教育,但仍存在许多重要的未解问题,包括:科学教师如何学习教授纳米级科学?
{"title":"SECONDARY SCIENCE TEACHERS' DEVELOPMENT OF PEDAGOGICAL CONTENT KNOWLEDGE AS RESULT OF INTEGRATING NANOSCIENCE CONTENT IN THEIR CURRICULUM","authors":"Emily Wischow, L. Bryan, G. Bodner","doi":"10.1142/S0219607712500073","DOIUrl":"https://doi.org/10.1142/S0219607712500073","url":null,"abstract":"Nanoscale science is a rapidly-developing, multidisciplinary field of science and research that combines engineering, chemistry, physics, biology, and information technology pushes and the boundary between the science and the technology required to conduct it. Nanoscale science involves investigating and working with matter on the scale of 1–100 microns and has broad societal implications for new technologies. It is estimated that the worldwide workforce necessary to support the field of nanoscale science and nanotechnology will be close to 2 million by 2015 (National Nanotechnology Initiative, 2005). With such rapid developments in nanoscale science and technology, it is becoming more incumbent upon K-12 science teachers to provide the learning experiences necessary for students to understand the principles that govern behavior at the nanoscale and develop the skills needed to apply these concepts to improve everyday life. While onlya limited amount of nanoscale curricular materials are available for K-12 and undergraduate education many important unanswered questions exist, including: How do science teachers learn to teach nanoscale science?","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"106 1","pages":"187-209"},"PeriodicalIF":0.0,"publicationDate":"2013-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87951934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Barriers and Benefits to Learning in Natural Environments: Towards a Reconceptualisation of the Possibilities for Change 在自然环境中学习的障碍和益处:对改变可能性的重新概念化
Pub Date : 2013-06-26 DOI: 10.1142/S0219607712300056
J. Dillon
Policies designed to increase public engagement with biodiversity advocate increased education across a range of educational contexts. Evidence of the benefits of learning in natural environments (LINE) continues to be amassed. LINE affords direct benefits as diverse as educational, health and psychological and indirect benefits ranging from social to financial. Research into the value of LINE has failed to address the full range of benefits. Instead, there has been a narrow focus on easily measurable outcomes and a desire to seek answers to simplistic questions such as "does LINE raise standards more than learning in the classroom?" An attempt is made to outline the full range of benefits which are available to all school students. The outcomes include: benefits to individual participants (knowledge and understanding; skills; attitudes and behaviours; health and well-being; self-efficacy and self-worth); benefits to teachers, schools and the wider community, and benefits to the natural environment sector. Several barriers exist to the effective delivery of LINE. These barriers can be grouped into those that challenge the natural environment sector and those that challenge schools. The challenges facing the sector include a lack of a coordinated effective approach to working with schools at a local level. The challenges facing schools include those frequently mentioned such as the risk of accidents, cost and curriculum pressures. However, another set of challenges exists, at local, institutional and personal levels. These challenges include teachers' confidence, self-efficacy and their access to training in using natural environments close to the school and further afield.
旨在提高公众对生物多样性参与的政策提倡在一系列教育背景下加强教育。在自然环境中学习(LINE)的好处的证据不断积累。LINE提供教育、健康和心理等多种直接效益,以及从社会到经济的间接效益。对LINE价值的研究未能解决它的全部益处。相反,人们一直狭隘地关注容易衡量的结果,并渴望寻找简单问题的答案,比如“LINE是否比课堂学习更能提高标准?”我们试图概述所有学生都能享受到的各种福利。结果包括:个体参与者的利益(知识和理解;技能;态度和行为;健康和福祉;自我效能感和自我价值感);对教师、学校和更广泛的社区有利,对自然环境部门有利。有效提供LINE存在几个障碍。这些障碍可分为对自然环境部门的挑战和对学校的挑战。该部门面临的挑战包括缺乏与地方一级学校合作的协调有效的方法。学校面临的挑战包括那些经常被提及的,比如事故风险、成本和课程压力。然而,在地方、机构和个人各级存在着另一组挑战。这些挑战包括教师的信心、自我效能以及他们在利用学校附近和更远的自然环境方面获得培训的机会。
{"title":"Barriers and Benefits to Learning in Natural Environments: Towards a Reconceptualisation of the Possibilities for Change","authors":"J. Dillon","doi":"10.1142/S0219607712300056","DOIUrl":"https://doi.org/10.1142/S0219607712300056","url":null,"abstract":"Policies designed to increase public engagement with biodiversity advocate increased education across a range of educational contexts. Evidence of the benefits of learning in natural environments (LINE) continues to be amassed. LINE affords direct benefits as diverse as educational, health and psychological and indirect benefits ranging from social to financial. Research into the value of LINE has failed to address the full range of benefits. Instead, there has been a narrow focus on easily measurable outcomes and a desire to seek answers to simplistic questions such as \"does LINE raise standards more than learning in the classroom?\" An attempt is made to outline the full range of benefits which are available to all school students. The outcomes include: benefits to individual participants (knowledge and understanding; skills; attitudes and behaviours; health and well-being; self-efficacy and self-worth); benefits to teachers, schools and the wider community, and benefits to the natural environment sector. Several barriers exist to the effective delivery of LINE. These barriers can be grouped into those that challenge the natural environment sector and those that challenge schools. The challenges facing the sector include a lack of a coordinated effective approach to working with schools at a local level. The challenges facing schools include those frequently mentioned such as the risk of accidents, cost and curriculum pressures. However, another set of challenges exists, at local, institutional and personal levels. These challenges include teachers' confidence, self-efficacy and their access to training in using natural environments close to the school and further afield.","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"3 1","pages":"153-166"},"PeriodicalIF":0.0,"publicationDate":"2013-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75268674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
MEDICINAL RADIOPHARMACEUTICAL CHEMISTRY OF METAL RADIOPHARMACEUTICALS 金属放射性药物的医用放射性药物化学
Pub Date : 2012-07-26 DOI: 10.1142/S0219607712300044
M. M. Saw
Metal complexes have been used as medicinal compounds. Metals have advantageous features over organic compounds. Significant applications of metal complexes are in the field of nuclear medicine. Radiopharmaceuticals are drugs containing radioisotopes used for diagnostic and therapeutic purposes. The generalized targeting strategy for molecular imaging probe consists of three essential parts: (i) reporter unit or payload, (ii) carrier, and (iii) targeting system. Medicinal radiopharmaceutical chemistry pays special consideration to radioisotopes, as a reporter unit for diagnostic application or as a payload for therapeutic application. Targeting is achieved by a few approaches but the most common is the bifunctional chelator approach. While designing a radiopharmaceutical, a range of issues needs to be considered including properties of metal radioisotopes, bifunctional chelators, linkers, and targeting molecules. Designing radiopharmaceuticals requires consideration of two key words: "compounds of biological interest" and "fit for intended use." The ultimate goal is the development of new diagnostic methods and treatment. Diagnostic metal radiopharmaceuticals are used for SPECT and PET applications. Technetium chemistry constitutes a major portion of SPECT and gallium chemistry constitutes a major portion of PET. Therapeutic radiopharmaceuticals can be constructed by using alpha-, beta minus-, or Auger electron-emitting radiometals. Special uses of medicinal radiopharmaceuticals include internal radiation therapy, brachytherapy, immunoPET, radioimmunotherapy, and peptide receptor radionuclide imaging and therapy.
金属配合物已被用作药用化合物。金属具有比有机化合物更有利的特性。金属配合物的重要应用是在核医学领域。放射性药物是用于诊断和治疗目的的含有放射性同位素的药物。分子成像探针的广义靶向策略包括三个基本部分:(i)报告单元或有效载荷,(ii)载体,(iii)靶向系统。医用放射性药物化学特别考虑放射性同位素,作为诊断应用的报告单位或作为治疗应用的有效载荷。靶向是通过几种方法实现的,但最常见的是双功能螯合剂方法。在设计放射性药物时,需要考虑一系列问题,包括金属放射性同位素的性质、双功能螯合剂、连接剂和靶向分子。设计放射性药物需要考虑两个关键词:“具有生物学意义的化合物”和“适合预期用途”。最终目标是开发新的诊断方法和治疗方法。诊断金属放射性药物用于SPECT和PET应用。锝化学是SPECT的主要组成部分,镓化学是PET的主要组成部分。治疗性放射性药物可以通过使用-,-或俄歇电子发射放射性金属来构建。医用放射性药物的特殊用途包括内部放射治疗、近距离放射治疗、免疫pet、放射免疫治疗和肽受体放射性核素成像和治疗。
{"title":"MEDICINAL RADIOPHARMACEUTICAL CHEMISTRY OF METAL RADIOPHARMACEUTICALS","authors":"M. M. Saw","doi":"10.1142/S0219607712300044","DOIUrl":"https://doi.org/10.1142/S0219607712300044","url":null,"abstract":"Metal complexes have been used as medicinal compounds. Metals have advantageous features over organic compounds. Significant applications of metal complexes are in the field of nuclear medicine. Radiopharmaceuticals are drugs containing radioisotopes used for diagnostic and therapeutic purposes. The generalized targeting strategy for molecular imaging probe consists of three essential parts: (i) reporter unit or payload, (ii) carrier, and (iii) targeting system. Medicinal radiopharmaceutical chemistry pays special consideration to radioisotopes, as a reporter unit for diagnostic application or as a payload for therapeutic application. Targeting is achieved by a few approaches but the most common is the bifunctional chelator approach. While designing a radiopharmaceutical, a range of issues needs to be considered including properties of metal radioisotopes, bifunctional chelators, linkers, and targeting molecules. Designing radiopharmaceuticals requires consideration of two key words: \"compounds of biological interest\" and \"fit for intended use.\" The ultimate goal is the development of new diagnostic methods and treatment. Diagnostic metal radiopharmaceuticals are used for SPECT and PET applications. Technetium chemistry constitutes a major portion of SPECT and gallium chemistry constitutes a major portion of PET. Therapeutic radiopharmaceuticals can be constructed by using alpha-, beta minus-, or Auger electron-emitting radiometals. Special uses of medicinal radiopharmaceuticals include internal radiation therapy, brachytherapy, immunoPET, radioimmunotherapy, and peptide receptor radionuclide imaging and therapy.","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"31 1","pages":"11-81"},"PeriodicalIF":0.0,"publicationDate":"2012-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82586404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
DEVELOPMENT OF PLATINUM(IV) COMPLEXES AS ANTICANCER PRODRUGS: THE STORY SO FAR 铂(iv)配合物作为抗癌前药的发展:迄今为止的故事
Pub Date : 2012-07-26 DOI: 10.1142/S0219607712300020
Daniel Yuan Qiang Wong, W. Ang
The serendipitous discovery of the antitumor properties of cisplatin by Barnett Rosenberg some forty years ago brought about a paradigm shift in the field of medicinal chemistry and challenged conventional thinking regarding the role of potentially toxic heavy metals in drugs. Platinum(II)-based anticancer drugs have since become some of the most effective and widely-used drugs in a clinician's arsenal and have saved countless lives. However, they are limited by high toxicity, severe side-effects and the incidence of drug resistance. In recent years, attention has shifted to stable platinum(IV) complexes as anticancer prodrugs. By exploiting the unique chemical and structural attributes of their scaffolds, these platinum(IV) prodrugs offer new strategies of targeting and killing cancer cells. This review summarizes the development of anticancer platinum(IV) prodrugs to date and some of the exciting strategies that utilise the platinum(IV) construct as targeted chemotherapeutic agents against cancer.
大约四十年前,Barnett Rosenberg偶然发现了顺铂的抗肿瘤特性,这给药物化学领域带来了范式转变,并挑战了关于药物中潜在有毒重金属作用的传统思维。基于铂(II)的抗癌药物已经成为临床医生武器库中最有效和最广泛使用的药物之一,并挽救了无数人的生命。然而,它们受到高毒性、严重副作用和耐药发生率的限制。近年来,人们的注意力已经转移到稳定的铂(IV)配合物作为抗癌前药。通过利用其支架的独特化学和结构属性,这些铂(IV)前药提供了靶向和杀死癌细胞的新策略。本文综述了迄今为止抗癌铂(IV)前体药物的发展,以及利用铂(IV)结构作为靶向化疗药物的一些令人兴奋的策略。
{"title":"DEVELOPMENT OF PLATINUM(IV) COMPLEXES AS ANTICANCER PRODRUGS: THE STORY SO FAR","authors":"Daniel Yuan Qiang Wong, W. Ang","doi":"10.1142/S0219607712300020","DOIUrl":"https://doi.org/10.1142/S0219607712300020","url":null,"abstract":"The serendipitous discovery of the antitumor properties of cisplatin by Barnett Rosenberg some forty years ago brought about a paradigm shift in the field of medicinal chemistry and challenged conventional thinking regarding the role of potentially toxic heavy metals in drugs. Platinum(II)-based anticancer drugs have since become some of the most effective and widely-used drugs in a clinician's arsenal and have saved countless lives. However, they are limited by high toxicity, severe side-effects and the incidence of drug resistance. In recent years, attention has shifted to stable platinum(IV) complexes as anticancer prodrugs. By exploiting the unique chemical and structural attributes of their scaffolds, these platinum(IV) prodrugs offer new strategies of targeting and killing cancer cells. This review summarizes the development of anticancer platinum(IV) prodrugs to date and some of the exciting strategies that utilise the platinum(IV) construct as targeted chemotherapeutic agents against cancer.","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"47 1","pages":"121-134"},"PeriodicalIF":0.0,"publicationDate":"2012-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82532727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
GADOLINIUM(Gd)-BASED AND ION OXIDE NANOPARTICLE CONTRAST AGENTS FOR PRE-CLINICAL AND CLINICAL MAGNETIC RESONANCE IMAGING (MRI) RESEARCH 钆基和氧化离子纳米颗粒造影剂用于临床前和临床磁共振成像(MRI)研究
Pub Date : 2012-07-26 DOI: 10.1142/S0219607712500048
T. Ng
It is known that one strength of MRI is its excellent soft tissue discrimination. It naturally provides sufficient contrast between the structural differences of normal and pathological tissues, their spatial extent and progression. However, to further extend its applications and enhance even more contrast for clinical studies, various Gadolinium (Gd)-based contrast agents have been developed for different organs (brain strokes, cancer, cardio-MRI, etc). These Gd-based contrast agents are paramagnetic compounds that have strong T1-effect for enhancing the contrast between tissue types. Gd-contrast can also enhance magnetic resonance angiography (CE-MRA) for studying stenosis and for measuring perfusion, vascular susceptibility, interstitial space, etc. Another class of contrast agents makes use of ferrite iron oxide nanoparticles (including Superparamagnetic Ion Oxide (SPIO) and Ultrasmall Superparamagnetic Iron Oxide (USPIO)). These nanoparticles have superior magnetic susceptibility effect and produce a drop in signal, namely in -weighted images, useful for the determination of lymph nodes metastases, angiogenesis and arteriosclerosis plaques.
众所周知,MRI的一个优势是其出色的软组织识别能力。它自然地提供了正常和病理组织的结构差异、空间范围和进展之间的充分对比。然而,为了进一步扩大其应用范围并增强临床研究的造影剂,各种钆(Gd)基造影剂已被开发用于不同的器官(脑中风,癌症,心脏mri等)。这些基于gd的造影剂是顺磁性化合物,具有很强的t1效应,可以增强组织类型之间的对比。Gd-contrast还可以增强磁共振血管造影(CE-MRA),用于研究狭窄,测量灌注、血管易感性、间质间隙等。另一类造影剂使用的是铁氧体氧化铁纳米颗粒(包括超顺磁离子氧化物(SPIO)和超小超顺磁氧化铁(USPIO))。这些纳米颗粒具有优越的磁化率效应,并产生信号下降,即加权图像,可用于确定淋巴结转移,血管生成和动脉硬化斑块。
{"title":"GADOLINIUM(Gd)-BASED AND ION OXIDE NANOPARTICLE CONTRAST AGENTS FOR PRE-CLINICAL AND CLINICAL MAGNETIC RESONANCE IMAGING (MRI) RESEARCH","authors":"T. Ng","doi":"10.1142/S0219607712500048","DOIUrl":"https://doi.org/10.1142/S0219607712500048","url":null,"abstract":"It is known that one strength of MRI is its excellent soft tissue discrimination. It naturally provides sufficient contrast between the structural differences of normal and pathological tissues, their spatial extent and progression. However, to further extend its applications and enhance even more contrast for clinical studies, various Gadolinium (Gd)-based contrast agents have been developed for different organs (brain strokes, cancer, cardio-MRI, etc). These Gd-based contrast agents are paramagnetic compounds that have strong T1-effect for enhancing the contrast between tissue types. Gd-contrast can also enhance magnetic resonance angiography (CE-MRA) for studying stenosis and for measuring perfusion, vascular susceptibility, interstitial space, etc. Another class of contrast agents makes use of ferrite iron oxide nanoparticles (including Superparamagnetic Ion Oxide (SPIO) and Ultrasmall Superparamagnetic Iron Oxide (USPIO)). These nanoparticles have superior magnetic susceptibility effect and produce a drop in signal, namely in -weighted images, useful for the determination of lymph nodes metastases, angiogenesis and arteriosclerosis plaques.","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"190 1","pages":"103-119"},"PeriodicalIF":0.0,"publicationDate":"2012-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74450673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Application of Technetium and Rhenium in Nuclear Medicine 锝、铼在核医学中的应用
Pub Date : 2012-07-26 DOI: 10.1142/S0219607712300019
R. Alberto
Technetium and Rhenium are the two lower elements in the manganese triad. Whereas rhenium is known as an important part of high resistance alloys, technetium is mostly known as a cumbersome product of nuclear fission. It is less known that its metastable isotope 99mTc is of utmost importance in nuclear medicine diagnosis. The technical application of elemental rhenium is currently complemented by investigations of its isotope 188Re, which could play a central role in the future for internal, targeted radiotherapy. This article will briefly describe the basic principles behind diagnostic methods with radionuclides for molecular imaging, review the 99mTc-based radiopharmaceuticals currently in clinical routine and focus on the chemical challenges and current developments towards improved, radiolabeled compounds for diagnosis and therapy in nuclear medicine.
锝和铼是锰三联体中较低的两个元素。铼被认为是高电阻合金的重要组成部分,而锝通常被认为是核裂变的一种笨重的产物。鲜为人知的是,它的亚稳同位素99mTc在核医学诊断中具有极其重要的意义。元素铼的技术应用目前由其同位素188Re的研究补充,这可能在未来的内部靶向放疗中发挥核心作用。本文将简要介绍放射性核素分子成像诊断方法的基本原理,综述目前临床常规使用的基于99mtc的放射性药物,并重点介绍核医学诊断和治疗中改进的放射性标记化合物的化学挑战和最新进展。
{"title":"Application of Technetium and Rhenium in Nuclear Medicine","authors":"R. Alberto","doi":"10.1142/S0219607712300019","DOIUrl":"https://doi.org/10.1142/S0219607712300019","url":null,"abstract":"Technetium and Rhenium are the two lower elements in the manganese triad. Whereas rhenium is known as an important part of high resistance alloys, technetium is mostly known as a cumbersome product of nuclear fission. It is less known that its metastable isotope 99mTc is of utmost importance in nuclear medicine diagnosis. The technical application of elemental rhenium is currently complemented by investigations of its isotope 188Re, which could play a central role in the future for internal, targeted radiotherapy. This article will briefly describe the basic principles behind diagnostic methods with radionuclides for molecular imaging, review the 99mTc-based radiopharmaceuticals currently in clinical routine and focus on the chemical challenges and current developments towards improved, radiolabeled compounds for diagnosis and therapy in nuclear medicine.","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"20 1","pages":"83-101"},"PeriodicalIF":0.0,"publicationDate":"2012-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84428244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
NANOFABRICATION BY COVALENT MOLECULAR ASSEMBLY: A PATHWAY TO ROBUST STRUCTURES 共价分子组装的纳米制造:通往坚固结构的途径
Pub Date : 2011-11-20 DOI: 10.1142/S0219607711000717
S. Punireddy, Sundaramurthy Jayaraman, R. Gupta, S. Yeong, F. Zhang, Z. Jia, M. Srinivasan
A wide range of new materials for many applications can be formed by controlling the composition and order of constituents at the molecular level. For systems thus engineered, ensuring chemical, thermal and mechanical robustness is a major challenge. Consequently, polyimides and other imide-containing materials are attractive as matrices for functional materials. We investigate the construction of functional nanostructures in organic/polymeric matrices with clearly demonstrated chemical, thermal and mechanical stability. Surface functionalization, layer-by-layer (LBL) assembly in various media (including supercritical), incorporation of functional moieties, molecular orientation, and interfacial reactions are areas of interest. We demonstrate the robustness of ultrathin film structures containing polyimides and oligoimides formed by LBL molecular assembly with inter-layer covalent links. Covalent bonding between the layers provides strength, while utilizing a supercritical medium for the processing, results in the deployment of a solvent-free environment and avoids problems related to residual solvent, thereby improving film quality when compared to conventional films.
通过在分子水平上控制成分的组成和顺序,可以形成广泛的新材料,用于许多应用。对于这样设计的系统,确保化学、热和机械的稳健性是主要的挑战。因此,聚酰亚胺和其他含亚酰亚胺的材料作为功能材料的基质是有吸引力的。我们研究了在有机/聚合物基质中构建具有明确化学、热和机械稳定性的功能纳米结构。表面功能化,在各种介质(包括超临界)中逐层组装(LBL),功能部分的结合,分子取向和界面反应是感兴趣的领域。我们证明了由层间共价键的LBL分子组装形成的含有聚酰亚胺和低聚亚胺的超薄膜结构的稳健性。层之间的共价键提供了强度,同时利用超临界介质进行加工,导致无溶剂环境的部署,避免了与残留溶剂相关的问题,从而提高了与传统薄膜相比的薄膜质量。
{"title":"NANOFABRICATION BY COVALENT MOLECULAR ASSEMBLY: A PATHWAY TO ROBUST STRUCTURES","authors":"S. Punireddy, Sundaramurthy Jayaraman, R. Gupta, S. Yeong, F. Zhang, Z. Jia, M. Srinivasan","doi":"10.1142/S0219607711000717","DOIUrl":"https://doi.org/10.1142/S0219607711000717","url":null,"abstract":"A wide range of new materials for many applications can be formed by controlling the composition and order of constituents at the molecular level. For systems thus engineered, ensuring chemical, thermal and mechanical robustness is a major challenge. Consequently, polyimides and other imide-containing materials are attractive as matrices for functional materials. We investigate the construction of functional nanostructures in organic/polymeric matrices with clearly demonstrated chemical, thermal and mechanical stability. Surface functionalization, layer-by-layer (LBL) assembly in various media (including supercritical), incorporation of functional moieties, molecular orientation, and interfacial reactions are areas of interest. We demonstrate the robustness of ultrathin film structures containing polyimides and oligoimides formed by LBL molecular assembly with inter-layer covalent links. Covalent bonding between the layers provides strength, while utilizing a supercritical medium for the processing, results in the deployment of a solvent-free environment and avoids problems related to residual solvent, thereby improving film quality when compared to conventional films.","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"12 1","pages":"31-42"},"PeriodicalIF":0.0,"publicationDate":"2011-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81129185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
KEY MATERIALS CHALLENGES FOR ELECTROCHEMICAL ENERGY STORAGE SYSTEMS 电化学储能系统的关键材料挑战
Pub Date : 2011-11-20 DOI: 10.1142/S0219607711000729
S. Adams
Batteries are in most people's mind devices to power small-scale mobile applications ranging from children's toys, cell phones and cameras to tablet computers and laptops, but we hardly think about the considerably wider range of electrochemical energy storage (EES) down to microbatteries that deliver milliwatts for smart-card devices or up via 10 30 kWh batteries powering electric drive vehicles to utility-scale stationary EES system that need to store tens to hundreds of MWh to locally balance demand in the power grid with energy supply from renewable sources. Currently it is the two latter applications, electromobility in battery electric vehicles (BEV) or plug-in hybrid electric vehicles (PHEV) and load leveling of power grids based on renewable sources, that appear to pose the key challenges to materials scientists and drive advancement of electrochemical energy storage technology. Due to their high energy density, rechargeable lithium ion batteries (LIBs) based on layered electrode materials [LiCoO2 as cathode (positive electrode), graphite as anode (negative electrode)] and organic liquid or polymeric gel electrolytes are the present-day choice as EES for small-scale portable appliances. LIBs possess high working voltage ( 3.6V) and thereby high energy-density compared to earlier rechargeable battery technologies such as Ni-Cd, NiMH and lead acid batteries. Global production (mostly in Asia) grows by 30% per year so that LIBs steadily increase their share of the also expanding battery market, that is estimated to reach 86 billion US$ in 2016. Road transportation constitutes a signi cant portion of energy consumption in Singapore as in most industrialized countries, 5 and the fast rise of vehicle population in developing countries is one of the main drivers of petroleum price increases. Provided that energy storage systems are technically and economically viable, high e±ciency electric vehicles (EV) have a number of advantages over current internal combustion engine cars:
在大多数人的心目中,电池是为小型移动应用供电的设备,从儿童玩具、手机和相机到平板电脑和笔记本电脑,但我们几乎没有想到电化学储能(EES)的更广泛范围,小到为智能卡设备提供毫瓦的微电池,大到10个30千瓦时的电池为电动驱动车辆供电,大到需要存储数十到数百兆瓦时的电力的公用事业规模的固定EES系统,以局部平衡电网与可再生能源供应的需求。目前,电池电动汽车(BEV)或插电式混合动力汽车(PHEV)中的电动交通和基于可再生能源的电网负载均衡这两种应用似乎对材料科学家构成了关键挑战,并推动了电化学储能技术的进步。由于其高能量密度,基于层状电极材料的可充电锂离子电池(lib) [LiCoO2作为阴极(正极),石墨作为阳极(负极)]和有机液体或聚合物凝胶电解质是目前小型便携式电器的EES的选择。与早期的可充电电池技术(如镍镉电池、镍氢电池和铅酸电池)相比,lib具有高工作电压(3.6V),因此具有高能量密度。全球产量(主要在亚洲)以每年30%的速度增长,因此锂电池在不断扩大的电池市场中的份额稳步增加,预计2016年将达到860亿美元。与大多数工业化国家一样,道路运输占新加坡能源消耗的很大一部分,而发展中国家车辆数量的迅速增加是石油价格上涨的主要驱动因素之一。只要储能系统在技术上和经济上可行,高效电动汽车(EV)与目前的内燃机汽车相比具有许多优势:
{"title":"KEY MATERIALS CHALLENGES FOR ELECTROCHEMICAL ENERGY STORAGE SYSTEMS","authors":"S. Adams","doi":"10.1142/S0219607711000729","DOIUrl":"https://doi.org/10.1142/S0219607711000729","url":null,"abstract":"Batteries are in most people's mind devices to power small-scale mobile applications ranging from children's toys, cell phones and cameras to tablet computers and laptops, but we hardly think about the considerably wider range of electrochemical energy storage (EES) down to microbatteries that deliver milliwatts for smart-card devices or up via 10 30 kWh batteries powering electric drive vehicles to utility-scale stationary EES system that need to store tens to hundreds of MWh to locally balance demand in the power grid with energy supply from renewable sources. Currently it is the two latter applications, electromobility in battery electric vehicles (BEV) or plug-in hybrid electric vehicles (PHEV) and load leveling of power grids based on renewable sources, that appear to pose the key challenges to materials scientists and drive advancement of electrochemical energy storage technology. Due to their high energy density, rechargeable lithium ion batteries (LIBs) based on layered electrode materials [LiCoO2 as cathode (positive electrode), graphite as anode (negative electrode)] and organic liquid or polymeric gel electrolytes are the present-day choice as EES for small-scale portable appliances. LIBs possess high working voltage ( 3.6V) and thereby high energy-density compared to earlier rechargeable battery technologies such as Ni-Cd, NiMH and lead acid batteries. Global production (mostly in Asia) grows by 30% per year so that LIBs steadily increase their share of the also expanding battery market, that is estimated to reach 86 billion US$ in 2016. Road transportation constitutes a signi cant portion of energy consumption in Singapore as in most industrialized countries, 5 and the fast rise of vehicle population in developing countries is one of the main drivers of petroleum price increases. Provided that energy storage systems are technically and economically viable, high e±ciency electric vehicles (EV) have a number of advantages over current internal combustion engine cars:","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"101 1","pages":"11-24"},"PeriodicalIF":0.0,"publicationDate":"2011-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75455476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
OPTICAL METAMATERIALS AND SUPER-RESOLUTION IMAGING 光学超材料和超分辨率成像
Pub Date : 2011-11-20 DOI: 10.1142/S0219607711000699
E. Leong, Hong Liu, Y. Liu, J. Teng
Metamaterials are specially designed periodic structures (a ) that give rise to extraordinary optical properties that no natural materials can possess. It can have extremely large refractive index or a negative refractive index over a frequency band. The refractive index, n, determines how light travels in a medium and is related to the permittivity, ", and permeability, , by the relation n 1⁄4 ð" Þ1=2. It was ̄rst pointed out by Veselago that if " < 0 and < 0, then n becomes negative. Nevertheless, there are no natural materials that possess negative permeability, though metals possess negative permittivity at subplasma frequency. However it was Pendry's suggestion that negative refraction would make a perfect lens that drawn worldwide interests in this ̄eld. 5 Besides subwavelength di®raction limited imaging, metamaterials have also found applications in areas such as wideband directive antennas, band-stop ̄lters, radar absorbers, broadband phase shifters, cloaking and far̄eld optical microscopy. These can be achieved by engineering the propagation of light in the structure. This list of potential applications is non-exhaustive asmore concentrated e®orts are currently ongoing all over the world to design new structures and improve on old ones. The beauty of using metamaterial structures in devices is that the design can be made much smaller with improved performances, or at least comparable performances with conventionally established techniques. Ernest Abbe (184
超材料是一种特殊设计的周期性结构(a),它能产生任何天然材料都无法拥有的非凡光学特性。它可以有极大的折射率或负折射率在一个频带。折射率n决定了光在介质中的传播方式,并与介电常数和磁导率有关,关系为n 1⁄4 ð Þ1=2。首先由Veselago指出,如果< 0且< 0,则n为负。然而,没有天然材料具有负磁导率,尽管金属在亚等离子体频率具有负介电常数。然而,彭德里的建议是负折射可以制造出完美的透镜,这引起了全世界对这一领域的兴趣。除了亚波长反应受限成像,超材料还在宽带定向天线、带阻器、雷达吸收器、宽带移相器、隐形和远场光学显微镜等领域得到了应用。这些可以通过设计光在结构中的传播来实现。这个潜在应用的列表并非详尽无遗,因为目前世界各地正在进行更集中的研究,以设计新结构并改进旧结构。在设备中使用超材料结构的美妙之处在于,设计可以做得更小,性能更好,或者至少可以与传统技术相媲美。欧内斯特·阿贝(184岁
{"title":"OPTICAL METAMATERIALS AND SUPER-RESOLUTION IMAGING","authors":"E. Leong, Hong Liu, Y. Liu, J. Teng","doi":"10.1142/S0219607711000699","DOIUrl":"https://doi.org/10.1142/S0219607711000699","url":null,"abstract":"Metamaterials are specially designed periodic structures (a ) that give rise to extraordinary optical properties that no natural materials can possess. It can have extremely large refractive index or a negative refractive index over a frequency band. The refractive index, n, determines how light travels in a medium and is related to the permittivity, \", and permeability, , by the relation n 1⁄4 ð\" Þ1=2. It was ̄rst pointed out by Veselago that if \" < 0 and < 0, then n becomes negative. Nevertheless, there are no natural materials that possess negative permeability, though metals possess negative permittivity at subplasma frequency. However it was Pendry's suggestion that negative refraction would make a perfect lens that drawn worldwide interests in this ̄eld. 5 Besides subwavelength di®raction limited imaging, metamaterials have also found applications in areas such as wideband directive antennas, band-stop ̄lters, radar absorbers, broadband phase shifters, cloaking and far̄eld optical microscopy. These can be achieved by engineering the propagation of light in the structure. This list of potential applications is non-exhaustive asmore concentrated e®orts are currently ongoing all over the world to design new structures and improve on old ones. The beauty of using metamaterial structures in devices is that the design can be made much smaller with improved performances, or at least comparable performances with conventionally established techniques. Ernest Abbe (184","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"6 1","pages":"43-63"},"PeriodicalIF":0.0,"publicationDate":"2011-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83718769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NANOSCIENCE AND NANOTECHNOLOGY FOR MEMORY AND DATA STORAGE 用于内存和数据存储的纳米科学和纳米技术
Pub Date : 2011-11-20 DOI: 10.1142/S0219607711000705
T. Tahmasebi, S. Piramanayagam
Data storage is one area of technology where nanotechnology has been used even before the term nanotechnology became very popular. The magnetic recording media — the disk that stores information in hard disk drives — used nanotechnology in the late 1990s, in the form of grains which are 15 nm or less in diameter (the grains in current technology are about 8 nm in diameter). The reading sensors of hard disk also make use of thin nanostructures in several dimensions to read information from the recording media. This paper introduces the technology behind the magnetic random access memory and related topics, which form the core of the symposium L of ICMAT 2011, which is titled "Memory, Nanomagnetics, Materials and Devices".
数据存储是在纳米技术这个术语变得非常流行之前就已经使用纳米技术的一个技术领域。磁性记录介质——在硬盘驱动器中存储信息的磁盘——在20世纪90年代末使用了纳米技术,以直径为15纳米或更小的颗粒的形式(目前技术中的颗粒直径约为8纳米)。硬盘读取传感器也利用多层纳米结构从记录介质中读取信息。本文介绍了磁性随机存取存储器背后的技术和相关主题,这些主题构成了2011年ICMAT研讨会L的核心,题为“存储器,纳米磁学,材料和器件”。
{"title":"NANOSCIENCE AND NANOTECHNOLOGY FOR MEMORY AND DATA STORAGE","authors":"T. Tahmasebi, S. Piramanayagam","doi":"10.1142/S0219607711000705","DOIUrl":"https://doi.org/10.1142/S0219607711000705","url":null,"abstract":"Data storage is one area of technology where nanotechnology has been used even before the term nanotechnology became very popular. The magnetic recording media — the disk that stores information in hard disk drives — used nanotechnology in the late 1990s, in the form of grains which are 15 nm or less in diameter (the grains in current technology are about 8 nm in diameter). The reading sensors of hard disk also make use of thin nanostructures in several dimensions to read information from the recording media. This paper introduces the technology behind the magnetic random access memory and related topics, which form the core of the symposium L of ICMAT 2011, which is titled \"Memory, Nanomagnetics, Materials and Devices\".","PeriodicalId":80753,"journal":{"name":"Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)","volume":"10 1","pages":"25-30"},"PeriodicalIF":0.0,"publicationDate":"2011-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76396296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Bulletin - Cosmos Club. Cosmos Club (Washington, D.C.)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1