Flora S DE, A Camoirano, D Serra, C Basso, P Zanacchi, C Bennicelli
THE EFFECTS OF DICUMAROL, A SPECIFIC INHIBITOR OF DT-DIAPHORASE, WERE INVESTIGATED IN THE AMES REVERSION TEST BY ASSAYING SEVERAL MUTAGENS OF DIFFERENT CHEMICAL CLASSES IN THE PRESENCE OF A VARIETY OF METABOLIC SYSTEMS. DICUMAROL PARTIALLY PREVENTED THE METABOLIC LOSS OF MUTAGENICITY OF FIVE HEXAVALENT CHROMIUM COMPOUNDS AND, VERY EFFICIENTLY, INHIBITED THE METABOLISM OF 4-NITROQUINOLINE-N-OXIDE. THESE FINDINGS RAISE THE HYPOTHESIS THAT DT-DIAPHORASE (A) MAY PLAY SOME ROLE ALSO IN THE METABOLISM OF INORGANIC COMPOUNDS AND (B) MAY BE INVOLVED NOT ONLY IN THE DETOXIFICATION BUT ALSO IN THE METABOLIC ACTIVATION OF CARCINOGENS.
在Ames逆转试验中，通过分析几种不同化学类别的诱变剂在多种代谢系统中的作用，研究了双豆醇(一种特定的dt-diaphorase抑制剂)的作用。双双酚能部分阻止5种六价铬化合物致突变性的代谢损失，并能非常有效地抑制4-硝基喹啉- n -氧化物的代谢。这些发现提出了一种假设，即dt-diaphorase (a)可能在无机化合物的代谢中也起一定作用，(b)可能不仅参与解毒，还参与致癌物质的代谢激活。
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