Pub Date : 2019-07-01DOI: 10.1023/B:CHUM.0000009353.57404.05
G. Pal
{"title":"Instructions for Authors","authors":"G. Pal","doi":"10.1023/B:CHUM.0000009353.57404.05","DOIUrl":"https://doi.org/10.1023/B:CHUM.0000009353.57404.05","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"38 1","pages":"107-113"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/B:CHUM.0000009353.57404.05","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46259631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-01Epub Date: 2016-01-01DOI: 10.1177/0271678X16641127
Frank Richter, Annett Eitner, Johannes Leuchtweis, Reinhard Bauer, Alfred Lehmenkühler, Hans-Georg Schaible
During brain damage and ischemia, the cytokine interleukin-1ß is rapidly upregulated due to activation of inflammasomes. We studied whether interleukin-1ß influences cortical spreading depolarization, and whether lipopolysaccharide, often used for microglial stimulation, influences cortical spreading depolarizations. In anaesthetized rats, cortical spreading depolarizations were elicited by microinjection of KCl. Interleukin-1ß, the IL-1 receptor 1 antagonist, the GABAA receptor blocker bicuculline, and lipopolysaccharide were administered either alone or combined (interleukin-1ß + IL-1 receptor 1 antagonist; interleukin-1ß + bicuculline; lipopolysaccharide + IL-1 receptor 1 antagonist) into a local cortical treatment area. Using microelectrodes, cortical spreading depolarizations were recorded in a non-treatment and in the treatment area. Plasma extravasation in cortical grey matter was assessed with Evans blue. Local application of interleukin-1ß reduced cortical spreading depolarization amplitudes in the treatment area, but not at a high dose. This reduction was prevented by IL-1 receptor 1 antagonist and by bicuculline. However, interleukin-1ß induced pronounced plasma extravasation independently on cortical spreading depolarizations. Application of lipopolysaccharide reduced cortical spreading depolarization amplitudes but prolonged their duration; EEG activity was still present. These effects were also blocked by IL-1 receptor 1 antagonist. Interleukin-1ß evokes changes of neuronal activity and of vascular functions. Thus, although the reduction of cortical spreading depolarization amplitudes at lower doses of interleukin-1ß may reduce deleterious effects of cortical spreading depolarizations, the sum of interleukin-1ß effects on excitability and on the vasculature rather promote brain damaging mechanisms.
{"title":"Effects of interleukin-1ß on cortical spreading depolarization and cerebral vasculature.","authors":"Frank Richter, Annett Eitner, Johannes Leuchtweis, Reinhard Bauer, Alfred Lehmenkühler, Hans-Georg Schaible","doi":"10.1177/0271678X16641127","DOIUrl":"10.1177/0271678X16641127","url":null,"abstract":"<p><p>During brain damage and ischemia, the cytokine interleukin-1ß is rapidly upregulated due to activation of inflammasomes. We studied whether interleukin-1ß influences cortical spreading depolarization, and whether lipopolysaccharide, often used for microglial stimulation, influences cortical spreading depolarizations. In anaesthetized rats, cortical spreading depolarizations were elicited by microinjection of KCl. Interleukin-1ß, the IL-1 receptor 1 antagonist, the GABA<sub>A</sub> receptor blocker bicuculline, and lipopolysaccharide were administered either alone or combined (interleukin-1ß + IL-1 receptor 1 antagonist; interleukin-1ß + bicuculline; lipopolysaccharide + IL-1 receptor 1 antagonist) into a local cortical treatment area. Using microelectrodes, cortical spreading depolarizations were recorded in a non-treatment and in the treatment area. Plasma extravasation in cortical grey matter was assessed with Evans blue. Local application of interleukin-1ß reduced cortical spreading depolarization amplitudes in the treatment area, but not at a high dose. This reduction was prevented by IL-1 receptor 1 antagonist and by bicuculline. However, interleukin-1ß induced pronounced plasma extravasation independently on cortical spreading depolarizations. Application of lipopolysaccharide reduced cortical spreading depolarization amplitudes but prolonged their duration; EEG activity was still present. These effects were also blocked by IL-1 receptor 1 antagonist. Interleukin-1ß evokes changes of neuronal activity and of vascular functions. Thus, although the reduction of cortical spreading depolarization amplitudes at lower doses of interleukin-1ß may reduce deleterious effects of cortical spreading depolarizations, the sum of interleukin-1ß effects on excitability and on the vasculature rather promote brain damaging mechanisms.</p>","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"6 1","pages":"1791-1802"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73887511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent publications","authors":"Ziyanah Ladak, Sarah Taylor, Emilie Whitman","doi":"10.1007/BF02402635","DOIUrl":"https://doi.org/10.1007/BF02402635","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"6 1","pages":"160"},"PeriodicalIF":0.0,"publicationDate":"2016-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02402635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52265720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-12-01Epub Date: 2015-11-17DOI: 10.1016/j.tem.2015.10.003
Steven B Heymsfield, Houchun Harry Hu, Wei Shen, Owen Carmichael
Non-Communicable diseases (NCDs), including obesity, are emerging as the major health concern of the 21st century. Excess adiposity and related NCD metabolic disturbances have stimulated development of new lipid compartment measurement technologies to help us to understand cellular energy exchange, to refine phenotypes, and to develop predictive markers of adverse clinical outcomes. Recent advances now allow quantification of multiple intracellular lipid and adipose tissue compartments that can be evaluated across the human lifespan. With magnetic resonance methods leading the way, newer approaches will give molecular structural and metabolic information beyond the laboratory in real-world settings. The union between these new technologies and the growing NCD population is creating an exciting interface in advancing our understanding of chronic disease mechanisms.
{"title":"Emerging Technologies and their Applications in Lipid Compartment Measurement.","authors":"Steven B Heymsfield, Houchun Harry Hu, Wei Shen, Owen Carmichael","doi":"10.1016/j.tem.2015.10.003","DOIUrl":"10.1016/j.tem.2015.10.003","url":null,"abstract":"<p><p>Non-Communicable diseases (NCDs), including obesity, are emerging as the major health concern of the 21st century. Excess adiposity and related NCD metabolic disturbances have stimulated development of new lipid compartment measurement technologies to help us to understand cellular energy exchange, to refine phenotypes, and to develop predictive markers of adverse clinical outcomes. Recent advances now allow quantification of multiple intracellular lipid and adipose tissue compartments that can be evaluated across the human lifespan. With magnetic resonance methods leading the way, newer approaches will give molecular structural and metabolic information beyond the laboratory in real-world settings. The union between these new technologies and the growing NCD population is creating an exciting interface in advancing our understanding of chronic disease mechanisms. </p>","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"35 1","pages":"688-698"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80106742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Gilkes, Daniel Jandréus, Elani Owen, D. Runde
{"title":"Recent publications","authors":"Sarah Gilkes, Daniel Jandréus, Elani Owen, D. Runde","doi":"10.1007/BF02402497","DOIUrl":"https://doi.org/10.1007/BF02402497","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"2 1","pages":"222"},"PeriodicalIF":0.0,"publicationDate":"2015-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02402497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52264636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editor's note","authors":"Arien Mack, J. Béja","doi":"10.1007/BF02400127","DOIUrl":"https://doi.org/10.1007/BF02400127","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"20 1","pages":"323-324"},"PeriodicalIF":0.0,"publicationDate":"2014-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02400127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52214149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-11-01DOI: 10.1007/S10579-004-2323-6
Fawaz S. Al-Anzi
{"title":"Stochastic Models for Automatic Diacritics Generation of Arabic Names","authors":"Fawaz S. Al-Anzi","doi":"10.1007/S10579-004-2323-6","DOIUrl":"https://doi.org/10.1007/S10579-004-2323-6","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"14 1","pages":"469-481"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S10579-004-2323-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52068958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-11-01DOI: 10.1007/s10579-004-1917-3
B. Hammo, S. Abuleil, S. Lytinen, M. Evens
{"title":"Experimenting with a Question Answering System for the Arabic Language","authors":"B. Hammo, S. Abuleil, S. Lytinen, M. Evens","doi":"10.1007/s10579-004-1917-3","DOIUrl":"https://doi.org/10.1007/s10579-004-1917-3","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"38 1","pages":"397-415"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10579-004-1917-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52068903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-11-01DOI: 10.1007/s10579-004-1948-9
Krister Lindén
{"title":"Evaluation of Linguistic Features for Word Sense Disambiguation with Self-Organized Document Maps","authors":"Krister Lindén","doi":"10.1007/s10579-004-1948-9","DOIUrl":"https://doi.org/10.1007/s10579-004-1948-9","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"38 1","pages":"417-435"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10579-004-1948-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52068942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-11-01DOI: 10.1007/s10579-004-1926-2
E. Morin, C. Jacquemin
{"title":"Automatic Acquisition and Expansion of Hypernym Links","authors":"E. Morin, C. Jacquemin","doi":"10.1007/s10579-004-1926-2","DOIUrl":"https://doi.org/10.1007/s10579-004-1926-2","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"38 1","pages":"363-396"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10579-004-1926-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52068930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号