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Current opinion in orthopaedics最新文献

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Bone regeneration in limb lengthening 肢体延长术中的骨再生
Pub Date : 2006-12-01 DOI: 10.1097/01.BCO.0000247360.29009.56
Janet Walker, Simone Battibugli
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引用次数: 0
Percutaneous bone grafting of benign bone tumors 良性骨肿瘤的经皮植骨术
Pub Date : 2006-12-01 DOI: 10.1097/01.BCO.0000247368.49201.8F
B. Rougraff
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引用次数: 1
Interferon therapy for giant cell tumor of bone 干扰素治疗骨巨细胞瘤
Pub Date : 2006-12-01 DOI: 10.1097/BCO.0B013E328010913B
A. Yasko
Purpose of reviewInhibition of key regulators of angiogenesis has gained momentum as a promising approach for the treatment of vascular tumors. Antitumor activity of interferons has been observed in childhood hemangiomas, hematologic malignancies and giant cell lesions of the mandible. The response
抑制血管生成的关键调节因子已成为治疗血管肿瘤的一种有前景的方法。干扰素的抗肿瘤活性已被观察到在儿童血管瘤,血液恶性肿瘤和下颌骨巨细胞病变。响应
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引用次数: 12
Hyperthermic isolated limb perfusion: evolving concepts in the treatment of extremity soft tissue sarcomas 离体肢体热灌注:肢体软组织肉瘤治疗概念的演变
Pub Date : 2006-12-01 DOI: 10.1097/01.BCO.0000247367.49201.6B
James M. Lewis, Geremy L. Sanders, D. Reintgen, G. Letson
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引用次数: 2
Expandable prostheses for reconstruction after tumor resection in young patients 可扩展假体在年轻肿瘤切除术后重建中的应用
Pub Date : 2006-12-01 DOI: 10.1097/01.BCO.0000247369.26330.C5
R. Heck, M. Neel
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引用次数: 2
Endoprosthetic reconstruction following bone sarcoma resection 骨肉瘤切除术后假体内重建
Pub Date : 2006-12-01 DOI: 10.1097/01.BCO.0000247370.33954.B5
R. Jesus-Garcia
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引用次数: 1
Cell–cell and cell–matrix interactions during development and pathogenesis 细胞-细胞和细胞-基质在发育和发病过程中的相互作用
Pub Date : 2006-10-01 DOI: 10.1097/01.BCO.0000244027.27597.B1
T. Kirsch
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引用次数: 3
Immune-cell–cartilage interactions in arthritis 关节炎中免疫细胞-软骨的相互作用
Pub Date : 2006-10-01 DOI: 10.1097/01.BCO.0000244032.02047.92
Y. Xiang, Tomohiro Kato
Arthritis is demonstrated in association with autoimmunity to cartilage tissue. This review discusses interaction between autoantigens from cartilage tissue and the immune cells in specific responses to these molecules in arthritis. The autoantigens from cartilage tissue play different roles in the pathogenesis of arthritis dependent on their different sources. Fibroblastic synovial cells and chondrocytes can also present antigens to antigen-specific T cells as well as synovial macrophages, dendritic cells and B cells. CD4+ T cells play crucial roles in rheumatoid arthritis whereas CD8+ T cells play dominant roles in seronegative spondylarthropathies. The Th1/Th2 and Th-/T-regulatory cell imbalance is associated with initiation and maintenance of the diseases. Recent research has revealed that B cells contribute to cartilage destruction by means of specific antigen presentation, adjustment of T-cell activity, proinflammatory-cytokine secretion and autoantibody production. The interaction between cartilage and immune cells plays pivotal roles in arthritis. Autoantigens from cartilage tissue, antigen-presenting cells, T cells and B cells are major players in cartilage destruction. Recovery of the balance of Th1/Th2 and Th-/T-regulatory cells as well as depletion of B cells may be new topics of therapy for arthritis.
关节炎被证实与软骨组织自身免疫有关。本文综述了软骨组织自身抗原与免疫细胞在关节炎中对这些分子的特异性反应中的相互作用。软骨组织自身抗原来源不同,在关节炎发病过程中发挥的作用也不同。成纤维滑膜细胞和软骨细胞也可以向抗原特异性T细胞以及滑膜巨噬细胞、树突状细胞和B细胞呈递抗原。CD4+ T细胞在类风湿关节炎中起关键作用,而CD8+ T细胞在血清阴性颈椎病中起主导作用。Th1/Th2和Th-/ t调节细胞失衡与疾病的发生和维持有关。最近的研究表明,B细胞通过特异性抗原的呈递、t细胞活性的调节、促炎细胞因子的分泌和自身抗体的产生,参与软骨破坏。软骨和免疫细胞之间的相互作用在关节炎中起着关键作用。软骨组织的自身抗原、抗原呈递细胞、T细胞和B细胞是软骨破坏的主要参与者。恢复Th1/Th2和Th-/ t调节细胞的平衡以及B细胞的消耗可能是关节炎治疗的新课题。
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引用次数: 0
Crystal/cell interactions in osteoarthritis 骨关节炎中的晶体/细胞相互作用
Pub Date : 2006-10-01 DOI: 10.1097/01.BCO.0000244033.09671.38
H. Cheung
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引用次数: 3
Breaking with the past: preventing secondary fractures 与过去决裂:预防继发性骨折
Pub Date : 2006-10-01 DOI: 10.1097/01.BCO.0000244034.09671.F6
L. Tosi
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引用次数: 0
期刊
Current opinion in orthopaedics
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