首页 > 最新文献

Archives of Cardiovascular Diseases Supplements最新文献

英文 中文
Characteristics and outcomes of neonatal balloon atrial septostomy for transposition of the great vessels: ORA – TGV study 新生儿球囊心房间隔造口术用于大血管移位的特点和结果:ORA-TGV研究
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.acvdsp.2023.07.012
H. Lucron , S.G. Malekzadeh-Milani , T. Perouse De Montclos , A.E. Baruteau , C. Ovaert , Z. Jalal , L. Bonnemains , C. Karsenty , O. Domanski , H. Bouvaist , P. Maragnes , A. Charbonneau , J.M. Jellimann , S. Hascoët , D. Bonnet

Introduction

Balloon atrial septostomy (BAS) improves oxygenation in neonates with Transposition of the Great Vessels (TGV). New non-EC marked BAS catheters have obtained temporary approval in France.

Objective

We aim to investigate outcomes of neonatal BAS in the current area.

Methods

An on-going multi-center French prospective observational registry was set up in September 2022 including all neonates undergoing BAS for TGV.

Results/Expected results

To date, 60 neonates (93.5% of term-babies, weight: 3.1 [2.8–3.4] Kg, prenatal diagnosis: 88.5%, isolated form of TGV: 68.9%) underwent 62 BAS (50% on general anaesthesia) in 14 participating centres. The procedure was performed over night or during weekend in 39.3% of cases. BAS was performed most often the day of birth (65.6%), in the catheter lab (59%) using an umbilical venous route (67.2%). The latter required conversion to a femoral route in 22.0% of patients. BAS was guided by ultrasounds and fluoroscopy in 90.2% and 55.7% of cases, respectively. Two to 4 BAS manoeuvre were required in 82.0% of cases. In 14.8% of patients, the use of a second type of BAS catheter was required. Z5 and Z6 catheters were used in 45.6% and 54.4% of cases, respectively. Overall, BAS was successfully achieved in 93.5% of cases. BAS failures included 3 crossing failures (n = 3) and a failure of enlargement of the atrial septum with a low-volume Z5 catheter (n = 1). One transient complete atrio-ventricular block was also reported.

Conclusion/Perspectives

To date, BAS success rate seems lower than expected. The continuation of this study and its expected European extension will likely contribute to clarify these points in a context of world shortage in dedicated low profile/high volume catheters.

气囊房间隔造口术(BAS)改善新生儿大血管转位(TGV)的氧合。新的非ec标记的BAS导管在法国获得临时批准。目的了解本地区新生儿BAS的预后。方法于2022年9月在法国建立了一个正在进行的多中心前瞻性观察登记,包括所有因TGV接受BAS治疗的新生儿。结果/预期结果迄今为止,在14个参与中心,60名新生儿(93.5%的足月婴儿,体重:3.1 [2.8-3.4]Kg,产前诊断:88.5%,TGV分离形式:68.9%)接受了62例BAS(50%为全身麻醉)。39.3%的病例在夜间或周末进行手术。BAS最常在出生当天(65.6%),在导管实验室(59%)使用脐静脉路径(67.2%)进行。后者在22.0%的患者中需要转换到股路。超声和透视引导下BAS分别占90.2%和55.7%。82.0%的病例需要2 ~ 4次BAS操作。14.8%的患者需要使用第二种类型的BAS导管。使用Z5和Z6导管的比例分别为45.6%和54.4%。总体而言,93.5%的病例成功实现了BAS。BAS失败包括3例交叉失败(n = 3)和使用小容量Z5导管扩大房间隔失败(n = 1)。还报道了1例短暂性完全性房室传导阻滞。结论/观点迄今为止,BAS的成功率似乎低于预期。这项研究的继续进行及其预期在欧洲的推广可能有助于在全球专用低姿态/大容量导尿管短缺的背景下澄清这些问题。
{"title":"Characteristics and outcomes of neonatal balloon atrial septostomy for transposition of the great vessels: ORA – TGV study","authors":"H. Lucron ,&nbsp;S.G. Malekzadeh-Milani ,&nbsp;T. Perouse De Montclos ,&nbsp;A.E. Baruteau ,&nbsp;C. Ovaert ,&nbsp;Z. Jalal ,&nbsp;L. Bonnemains ,&nbsp;C. Karsenty ,&nbsp;O. Domanski ,&nbsp;H. Bouvaist ,&nbsp;P. Maragnes ,&nbsp;A. Charbonneau ,&nbsp;J.M. Jellimann ,&nbsp;S. Hascoët ,&nbsp;D. Bonnet","doi":"10.1016/j.acvdsp.2023.07.012","DOIUrl":"10.1016/j.acvdsp.2023.07.012","url":null,"abstract":"<div><h3>Introduction</h3><p>Balloon atrial septostomy (BAS) improves oxygenation in neonates with Transposition of the Great Vessels (TGV). New non-EC marked BAS catheters have obtained temporary approval in France.</p></div><div><h3>Objective</h3><p>We aim to investigate outcomes of neonatal BAS in the current area.</p></div><div><h3>Methods</h3><p>An on-going multi-center French prospective observational registry was set up in September 2022 including all neonates undergoing BAS for TGV.</p></div><div><h3>Results/Expected results</h3><p><span><span><span>To date, 60 neonates (93.5% of term-babies, weight: 3.1 [2.8–3.4] Kg, prenatal diagnosis: 88.5%, isolated form of TGV: 68.9%) underwent 62 BAS (50% on general anaesthesia) in 14 participating centres. The procedure was performed over night or during weekend in 39.3% of cases. BAS was performed most often the day of </span>birth (65.6%), in the catheter lab (59%) using an umbilical venous route (67.2%). The latter required conversion to a femoral route in 22.0% of patients. BAS was guided by ultrasounds and </span>fluoroscopy in 90.2% and 55.7% of cases, respectively. Two to 4 BAS manoeuvre were required in 82.0% of cases. In 14.8% of patients, the use of a second type of BAS catheter was required. Z5 and Z6 catheters were used in 45.6% and 54.4% of cases, respectively. Overall, BAS was successfully achieved in 93.5% of cases. BAS failures included 3 crossing failures (n</span> <!-->=<!--> <span>3) and a failure of enlargement of the atrial septum with a low-volume Z5 catheter (n</span> <!-->=<!--> <!-->1). One transient complete atrio-ventricular block was also reported.</p></div><div><h3>Conclusion/Perspectives</h3><p>To date, BAS success rate seems lower than expected. The continuation of this study and its expected European extension will likely contribute to clarify these points in a context of world shortage in dedicated low profile/high volume catheters.</p></div>","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Pages 278-279"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47172259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of simulation-based communication training for cardio pediatricians in announcing congenital heart disease diagnosis in children: A randomized controlled trial (SIMUL - CHD) 基于模拟的沟通训练对心血管儿科医生宣布儿童先天性心脏病诊断的有效性:一项随机对照试验
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.acvdsp.2023.07.041
P. Padovani , Q. Hauet , B. Lefort , M. Letellier , M. Bergé , P. Amedro , A.E. Baruteau

Introduction

Appropriate communication between physicians and parents is key when announcing a diagnosis of critical congenital heart disease (CHD) in the perinatal period. However, young physicians often struggle with anxiety and self-confidence, hindering their ability to communicate adequately. Simulation-based learning has demonstrated efficacy in improving medical training, but its application in communication training is limited.

Objective

The aim of this study is to evaluate whether simulation-based training can improve the communication skills of paediatric cardiology fellows in announcing a diagnosis of critical CHD. The study will be implemented in collaboration with the associations of children's parents with CHD.

Methods

A randomized controlled trial will be conducted to compare the effect of simulation-based training versus theoretical training alone. The simulation group will receive both theoretical and practical training, while the control group will only receive theoretical training. The primary endpoint is to evaluate the effect of simulation-based training on the announcement of CHD diagnosis paediatric cardiologists in training. The primary endpoint will be measured by the difference in proficiency score (BBN Skills) for announcing the diagnosis, video judged by a panel of experts, and blinded to group assignment. The study will also assess self-assessment scores of anxiety and self-confidence before making the announcement.

Results/Expected results

It is expected to show an improvement in communication skills among the simulation group, regardless of the level of young doctors, as well as likely showing a decrease in anxiety and an increase in confidence scores in the simulation group.

Conclusion/Perspectives

This nationwide study could provide a uniform curriculum for training, written in collaboration with patients’ associations involving expert parents that may be further integrated into the national graduate program. It could then easily be applied to other clinical situations, for example, when announcing poor surgical outcomes, a treatment limitation, etc.

在宣布围产期危重型先天性心脏病(CHD)的诊断时,医生和家长之间适当的沟通是关键。然而,年轻的医生经常与焦虑和自信作斗争,阻碍了他们充分沟通的能力。基于模拟的学习在改善医学培训方面已经证明了有效性,但在沟通培训中的应用还很有限。目的本研究的目的是评估基于模拟的培训是否可以提高儿科心脏科医师在宣布危重冠心病诊断时的沟通技巧。该研究将与患有冠心病的儿童家长协会合作实施。方法进行随机对照试验,比较模拟训练与单纯理论训练的效果。模拟组将接受理论和实践培训,对照组只接受理论培训。主要目的是评估基于模拟的培训对儿科心脏病专家在培训中宣布冠心病诊断的影响。主要终点将通过宣布诊断的熟练程度评分(BBN Skills)的差异来衡量,由专家小组评判的视频,并对小组分配不知情。该研究还将在宣布这一消息之前评估焦虑和自信的自我评估分数。结果/预期结果无论年轻医生的水平如何,预计模拟组的沟通技巧都会有所改善,并且模拟组的焦虑程度可能会有所下降,信心得分会有所提高。结论/观点这项全国性的研究可以提供一个统一的培训课程,与涉及专家家长的患者协会合作编写,可能进一步纳入国家研究生计划。然后,它可以很容易地应用于其他临床情况,例如,当宣布手术结果不佳,治疗限制等。
{"title":"Effectiveness of simulation-based communication training for cardio pediatricians in announcing congenital heart disease diagnosis in children: A randomized controlled trial (SIMUL - CHD)","authors":"P. Padovani ,&nbsp;Q. Hauet ,&nbsp;B. Lefort ,&nbsp;M. Letellier ,&nbsp;M. Bergé ,&nbsp;P. Amedro ,&nbsp;A.E. Baruteau","doi":"10.1016/j.acvdsp.2023.07.041","DOIUrl":"10.1016/j.acvdsp.2023.07.041","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Appropriate communication between physicians and parents is key when announcing a diagnosis of critical congenital heart disease (CHD) in the </span>perinatal period. However, young physicians often struggle with anxiety and self-confidence, hindering their ability to communicate adequately. Simulation-based learning has demonstrated efficacy in improving medical training, but its application in communication training is limited.</p></div><div><h3>Objective</h3><p>The aim of this study is to evaluate whether simulation-based training can improve the communication skills of paediatric cardiology fellows in announcing a diagnosis of critical CHD. The study will be implemented in collaboration with the associations of children's parents with CHD.</p></div><div><h3>Methods</h3><p>A randomized controlled trial<span> will be conducted to compare the effect of simulation-based training versus theoretical training alone. The simulation group will receive both theoretical and practical training, while the control group will only receive theoretical training. The primary endpoint is to evaluate the effect of simulation-based training on the announcement of CHD diagnosis paediatric cardiologists in training. The primary endpoint will be measured by the difference in proficiency score (BBN Skills) for announcing the diagnosis, video judged by a panel of experts, and blinded to group assignment. The study will also assess self-assessment scores of anxiety and self-confidence before making the announcement.</span></p></div><div><h3>Results/Expected results</h3><p>It is expected to show an improvement in communication skills among the simulation group, regardless of the level of young doctors, as well as likely showing a decrease in anxiety and an increase in confidence scores in the simulation group.</p></div><div><h3>Conclusion/Perspectives</h3><p>This nationwide study could provide a uniform curriculum for training, written in collaboration with patients’ associations involving expert parents that may be further integrated into the national graduate program. It could then easily be applied to other clinical situations, for example, when announcing poor surgical outcomes, a treatment limitation, etc.</p></div>","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Page 292"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49402380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of immune response after cardiac surgery with cardiopulmonary bypass in young infants 婴幼儿体外循环心脏手术后免疫反应的特点
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.acvdsp.2023.07.039
E. André, C. Bridonneau, C. Jacqueline, M. Davieau, V. Gourain, A. Roquilly, A. Chenouard

Introduction

Cardiac surgeries with cardiopulmonary bypass (CPB) cause a complex systemic immuno-inflammatory response, which can lead to postoperative morbidity, particularly in young children. A better understanding of mechanisms involved is needed to improve the outcome. In a whole blood transcriptome study, we have recently identified 2,175 differentially expressed genes after CPB, mainly associated with the immune response. A group of 24 co-expressed immune-related genes correlated with postoperative complications was also identified.

Objective

To validate the transcriptomic analysis data by flow cytometry.

Methods

Peripheral blood mononuclear cells (PBMC) have been isolated from whole blood (4 ml EDTA tube) before and immediately after CPB in children less than 3 months of age after obtaining parental consent. The extensive phenotype of myeloid and lymphoid cells and their ability to secrete cytokines after in vitro stimulation were assessed using flow cytometry. Surface expression of proteins encoded by 5 of 24 co-expressed immune-related genes (VSIG4, LILRB4, LTF, MSR1 and PGLYRP1) were also investigated.

Results/Expected results

Among 6 patients included (Table 1), we noted important phenotypic changes of immune cells after CPB. The expression of HLA-DR, CD11b, CD86 in CD14 + cells (monocytes) and CD3 + lymphocytes function (PD1, ICOS) are decreased on their surfaces after CPB (Fig. 1). After lipopolysaccharide (LPS) in vitro stimulation, monocytes display an altered ability to produce IL1β after CPB (Median Fluorescence Intensity MFI : 2620 1610 - 3975 vs 3786 3200 - 7538, p = 0.03). Finally, as suggested by transcriptomic analysis, monocytic expression of some immune-related proteins (MSR1 and VSIG4) is modified by CPB.

Conclusion/Perspectives

We reported an immediate immune dysfunction after CPB, concerning myeloid and lymphoid cells. The involvement of MSR1 and VSIG4 genes, previously unknown in the CPB-related inflammation, need to be further explored to improve post-operative outcome.

体外循环心脏手术(CPB)引起复杂的全身免疫炎症反应,这可能导致术后发病率,特别是在幼儿中。为了改善结果,需要更好地了解所涉及的机制。在一项全血转录组研究中,我们最近发现了2175个CPB后差异表达基因,主要与免疫反应相关。还发现了一组24个与术后并发症相关的共表达免疫相关基因。目的用流式细胞术验证转录组学分析数据。方法经家长同意,从3月龄以下患儿全血(4 ml EDTA管)中分离外周血单个核细胞(PBMC)。骨髓细胞和淋巴细胞在体外刺激后的广泛表型及其分泌细胞因子的能力被流式细胞术评估。我们还研究了24个共表达免疫相关基因(VSIG4、LILRB4、LTF、MSR1和PGLYRP1)中5个基因编码蛋白的表面表达。结果/预期结果在纳入的6例患者中(表1),我们注意到CPB后免疫细胞的重要表型变化。CPB后,CD14 +细胞(单核细胞)和CD3 +淋巴细胞(PD1, ICOS)表面HLA-DR, CD11b, CD86的表达减少(图1)。体外脂多糖(LPS)刺激后,CPB后单核细胞显示出产生il - 1β的能力改变(中位荧光强度MFI: 2620 1610 - 3975 vs 3786 3200 - 7538, p = 0.03)。最后,转录组学分析表明,CPB修饰了一些免疫相关蛋白(MSR1和VSIG4)的单核细胞表达。结论/观点我们报道了CPB后立即出现的免疫功能障碍,涉及骨髓和淋巴细胞。在cpb相关炎症中,先前未知的MSR1和VSIG4基因的参与,需要进一步探索以改善术后预后。
{"title":"Characterization of immune response after cardiac surgery with cardiopulmonary bypass in young infants","authors":"E. André,&nbsp;C. Bridonneau,&nbsp;C. Jacqueline,&nbsp;M. Davieau,&nbsp;V. Gourain,&nbsp;A. Roquilly,&nbsp;A. Chenouard","doi":"10.1016/j.acvdsp.2023.07.039","DOIUrl":"10.1016/j.acvdsp.2023.07.039","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Cardiac surgeries with cardiopulmonary bypass<span> (CPB) cause a complex systemic immuno-inflammatory response, which can lead to postoperative morbidity, particularly in young children. A better understanding of mechanisms involved is needed to improve the outcome. In a whole blood transcriptome study, we have recently identified 2,175 differentially expressed genes after CPB, mainly associated with the immune response. A group of 24 co-expressed immune-related genes correlated with </span></span>postoperative complications was also identified.</p></div><div><h3>Objective</h3><p>To validate the transcriptomic analysis data by flow cytometry.</p></div><div><h3>Methods</h3><p><span>Peripheral blood mononuclear cells (PBMC) have been isolated from whole blood (4 ml </span>EDTA<span> tube) before and immediately after CPB in children less than 3 months of age after obtaining parental consent. The extensive phenotype of myeloid and lymphoid cells and their ability to secrete cytokines after in vitro stimulation were assessed using flow cytometry. Surface expression of proteins encoded by 5 of 24 co-expressed immune-related genes (VSIG4, LILRB4, LTF, MSR1 and PGLYRP1) were also investigated.</span></p></div><div><h3>Results/Expected results</h3><p>Among 6 patients included (<span>Table 1</span><span>), we noted important phenotypic changes of immune cells after CPB. The expression of HLA-DR, CD11b, CD86 in CD14</span> <!-->+<!--> <!-->cells (monocytes) and CD3<!--> <!-->+<!--> <span>lymphocytes function (PD1, ICOS) are decreased on their surfaces after CPB (</span><span>Fig. 1</span><span>). After lipopolysaccharide<span> (LPS) in vitro stimulation, monocytes display an altered ability to produce IL1β after CPB (Median Fluorescence Intensity MFI : 2620 1610 - 3975 vs 3786 3200 - 7538, </span></span><em>p</em> <!-->=<!--> <!-->0.03). Finally, as suggested by transcriptomic analysis, monocytic expression of some immune-related proteins (MSR1 and VSIG4) is modified by CPB.</p></div><div><h3>Conclusion/Perspectives</h3><p>We reported an immediate immune dysfunction after CPB, concerning myeloid and lymphoid cells. The involvement of MSR1 and VSIG4 genes, previously unknown in the CPB-related inflammation, need to be further explored to improve post-operative outcome.</p></div>","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Page 291"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49466324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The French Coccinelle study: Risk of lympho-hematopoietic malignancies after medical ionizing radiation exposure from cardiac catheterization during childhood 法国Coccinelle研究:儿童期心导管插入术电离辐射暴露后淋巴造血系统恶性肿瘤的风险
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.acvdsp.2023.07.016
E. Rage , S. Hascoët , C. Dauphin , S. Di Filippo , S. Douchin , F. Godart , P. Guérin , P. Helms , C. Karsenty , B. Lefort , P. Mauran , C. Ovaert , J.F. Piéchaud , J.B. Thambo , D. Bonnet

Introduction

Cardiac catheterization (CC) has largely improved the diagnosis and treatment of congenital heart disease in children over the last decades, but it leads to exposure to low doses of X-rays. Children have a greater radiation sensitivity, however, little is known about the long-term radiation associated cancer risks.

Objective

This study aims to assess the risk of lympho-hematopoietic malignancies among children diagnosed and/or treated with CC.

Methods

The COCCINELLE cohort includes children from 15 French paediatric cardiology departments who underwent a first CC between 2000–2013, before 16 years old. The cohort was linked with national registries to identify cancer cases and collect information on predisposing factors to cancer (PF). Individual cumulative doses to active bone marrow (ABM) were calculated with the PCXMC software, based on detailed dosimetric information retrieved from reports of 1,139 CC procedures. Standardised incidence ratios (SIRs) and relative risks (RR) of haematological malignancies associated with the 2-year lagged ABM dose were calculated.

Results/Expected results

The cohort included 17,104 children, followed 6.5 years on average. 22,227 CC procedures were collected, with a mean individual ABM cumulative dose of 3.0 mGy. 38 lympho-hematopoietic malignancies were counted (23 lymphoma and 15 leukemia). A significant excess of cancer incidence was observed (SIR = 3.8 [95% confidence interval 2.9; 4.9]), which wasn’t anymore observed after excluding patients with PF (SIR = 1.3 [0.6; 2.7]). The ABM dose wasn’t significantly associated with the risk of lympho-hematopoietic malignancies (RR/mGy = 1.00 [0.88; 1.10]) or lymphoma (RR/mGy = 1.03 [0.90; 1.14]) after adjustment for attained age, gender and PF.

Conclusion/Perspectives

No significant increase of cancer incidence was observed after excluding patients with PF and no dose-response relationship was observed between the risk of lympho-hematopoietic malignancies or lymphoma and cumulative ABM dose arising from CC procedure. The extension of the COCCINELLE study and the European Harmonic project will help to better assess health effects of CC exposure during childhood.

导读:在过去的几十年里,心导管(CC)在很大程度上改善了儿童先天性心脏病的诊断和治疗,但它会导致暴露在低剂量的x射线下。儿童对辐射更敏感,然而,人们对长期辐射相关的癌症风险知之甚少。本研究旨在评估诊断和/或接受CC治疗的儿童淋巴-造血系统恶性肿瘤的风险。方法COCCINELLE队列包括来自法国15个儿科心脏病科的儿童,他们在2000-2013年期间接受了第一次CC,年龄在16岁之前。该队列与国家登记处相关联,以确定癌症病例并收集有关癌症易感因素(PF)的信息。根据从1139例CC手术报告中检索到的详细剂量学信息,用PCXMC软件计算活性骨髓的个体累积剂量(ABM)。计算血液学恶性肿瘤的标准化发病率(SIRs)和相对危险度(RR)与滞后2年ABM剂量相关。结果/预期结果该队列包括17104名儿童,平均随访6.5年。收集了22,227例CC手术,平均个体ABM累积剂量为3.0 mGy。淋巴-造血系统恶性肿瘤38例(淋巴瘤23例,白血病15例)。癌症发病率显著增加(SIR = 3.8[95%可信区间2.9;4.9]),排除PF患者后不再观察到(SIR = 1.3 [0.6;2.7])。ABM剂量与淋巴-造血系统恶性肿瘤风险无显著相关性(RR/mGy = 1.00 [0.88;1.10])或淋巴瘤(RR/mGy = 1.03 [0.90;[14]在排除PF患者后,未观察到癌症发病率的显著增加,淋巴-造血恶性肿瘤或淋巴瘤的风险与CC手术引起的累积ABM剂量之间未观察到剂量-反应关系。延长COCCINELLE研究和欧洲和声项目将有助于更好地评估儿童时期接触CC对健康的影响。
{"title":"The French Coccinelle study: Risk of lympho-hematopoietic malignancies after medical ionizing radiation exposure from cardiac catheterization during childhood","authors":"E. Rage ,&nbsp;S. Hascoët ,&nbsp;C. Dauphin ,&nbsp;S. Di Filippo ,&nbsp;S. Douchin ,&nbsp;F. Godart ,&nbsp;P. Guérin ,&nbsp;P. Helms ,&nbsp;C. Karsenty ,&nbsp;B. Lefort ,&nbsp;P. Mauran ,&nbsp;C. Ovaert ,&nbsp;J.F. Piéchaud ,&nbsp;J.B. Thambo ,&nbsp;D. Bonnet","doi":"10.1016/j.acvdsp.2023.07.016","DOIUrl":"10.1016/j.acvdsp.2023.07.016","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Cardiac catheterization<span><span> (CC) has largely improved the diagnosis and treatment of </span>congenital heart disease in children over the last decades, but it leads to exposure to low doses of X-rays. Children have a greater </span></span>radiation sensitivity, however, little is known about the long-term radiation associated cancer risks.</p></div><div><h3>Objective</h3><p>This study aims to assess the risk of lympho-hematopoietic malignancies among children diagnosed and/or treated with CC.</p></div><div><h3>Methods</h3><p><span>The COCCINELLE cohort includes children from 15 French paediatric cardiology<span> departments who underwent a first CC between 2000–2013, before 16 years old. The cohort was linked with national registries to identify cancer cases and collect information on predisposing factors to cancer (PF). Individual cumulative doses to active bone marrow (ABM) were calculated with the PCXMC software, based on detailed dosimetric information retrieved from reports of 1,139 CC procedures. Standardised incidence ratios (SIRs) and relative risks (RR) of </span></span>haematological malignancies associated with the 2-year lagged ABM dose were calculated.</p></div><div><h3>Results/Expected results</h3><p>The cohort included 17,104 children, followed 6.5 years on average. 22,227 CC procedures were collected, with a mean individual ABM cumulative dose of 3.0 mGy. 38 lympho-hematopoietic malignancies were counted (23 lymphoma and 15 leukemia). A significant excess of cancer incidence was observed (SIR<!--> <!-->=<!--> <!-->3.8 [95% confidence interval 2.9; 4.9]), which wasn’t anymore observed after excluding patients with PF (SIR<!--> <!-->=<!--> <!-->1.3 [0.6; 2.7]). The ABM dose wasn’t significantly associated with the risk of lympho-hematopoietic malignancies (RR/mGy<!--> <!-->=<!--> <!-->1.00 [0.88; 1.10]) or lymphoma (RR/mGy<!--> <!-->=<!--> <!-->1.03 [0.90; 1.14]) after adjustment for attained age, gender and PF.</p></div><div><h3>Conclusion/Perspectives</h3><p>No significant increase of cancer incidence was observed after excluding patients with PF and no dose-response relationship was observed between the risk of lympho-hematopoietic malignancies or lymphoma and cumulative ABM dose arising from CC procedure. The extension of the COCCINELLE study and the European Harmonic project will help to better assess health effects of CC exposure during childhood.</p></div>","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Pages 280-281"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48512640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of cancer screening coverage in adults with congenital heart disease 成人先天性心脏病癌症筛查覆盖率评价
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.acvdsp.2023.07.030
M. Albertini , P. David , S. Hascoet , M. Ladouceur , L. Guirgis , E. Fournier , I. Van Aerschot , J. Radojevic , V. Waldmann , L. Iserin , S. Cohen

Introduction

The risk of cancer in adults with congenital heart disease (ACHD) is 23% higher than in the general population.

Objective

The objective of our study was to assess cancer screening coverage in ACHD.

Methods

This was a prospective, observational, bicentric study of ACHD patients. Data were collected through a self-questionnaire proposed to all consecutive patients over 25 years from September 2022 to March 2023. Information on cervical, breast and colorectal cancer screening was collected and compared with screening data provided by Santé Publique France.

Results/Expected results

A total of 263 patients were included. The mean age was 44 years (range, 25–78), 122 (46%) patients were male, and 99 (38%) patients had a complex CHD. Eleven (4%) patients had a history of cancer. The screening participation rate for breast cancer was higher in ACHD patients (72%) compared to the general population from Ile de France region (39%, P < 0.001) and from the whole French population (51%, P = 0.002). For colorectal and cervical cancers, the screening participation rate were 36% and 65%, compared to 31% and 51% in Île de France region and 34% and 59% in the whole French population, respectively with no statistically significant difference (Figure 1).

Conclusion/Perspectives

Cancer screening coverage in ACHD patients was greater than non-congenital patients for breast cancer, but comparable for colorectal and cervical cancers. The screening participation rate remained however lower than European objectives for all cancers. Our data call for specific actions to better screen this aging population at high risk for cancer.

成人先天性心脏病(ACHD)患者患癌症的风险比一般人群高23%。本研究的目的是评估ACHD的癌症筛查覆盖率。方法:这是一项前瞻性、观察性、双中心的ACHD患者研究。从2022年9月至2023年3月,通过对所有连续25年的患者进行自我问卷调查收集数据。收集了有关宫颈癌、乳腺癌和结直肠癌筛查的信息,并对法国圣公共机构提供的筛查数据进行了比较。结果/预期结果共纳入263例患者。平均年龄44岁(25-78岁),男性122例(46%),合并冠心病99例(38%)。11例(4%)患者有癌症病史。ACHD患者的乳腺癌筛查参与率(72%)高于法兰西岛地区的一般人群(39%,P <0.001)和整个法国人口(51%,P = 0.002)。结直肠癌和宫颈癌的筛查参与率分别为36%和65%,而Île de France地区的筛查参与率分别为31%和51%,整个法国人口的筛查参与率分别为34%和59%,差异无统计学意义(图1)。结论/观点ACHD患者的乳腺癌筛查覆盖率高于非先天性患者,但结直肠癌和宫颈癌的筛查覆盖率相当。然而,所有癌症的筛查参与率仍然低于欧洲的目标。我们的数据要求采取具体行动,更好地筛查癌症高风险的老年人群。
{"title":"Evaluation of cancer screening coverage in adults with congenital heart disease","authors":"M. Albertini ,&nbsp;P. David ,&nbsp;S. Hascoet ,&nbsp;M. Ladouceur ,&nbsp;L. Guirgis ,&nbsp;E. Fournier ,&nbsp;I. Van Aerschot ,&nbsp;J. Radojevic ,&nbsp;V. Waldmann ,&nbsp;L. Iserin ,&nbsp;S. Cohen","doi":"10.1016/j.acvdsp.2023.07.030","DOIUrl":"10.1016/j.acvdsp.2023.07.030","url":null,"abstract":"<div><h3>Introduction</h3><p>The risk of cancer in adults with congenital heart disease (ACHD) is 23% higher than in the general population.</p></div><div><h3>Objective</h3><p>The objective of our study was to assess cancer screening coverage in ACHD.</p></div><div><h3>Methods</h3><p>This was a prospective, observational, bicentric study of ACHD patients. Data were collected through a self-questionnaire proposed to all consecutive patients over 25 years from September 2022 to March 2023. Information on cervical, breast and colorectal cancer screening was collected and compared with screening data provided by Santé Publique France.</p></div><div><h3>Results/Expected results</h3><p>A total of 263 patients were included. The mean age was 44 years (range, 25–78), 122 (46%) patients were male, and 99 (38%) patients had a complex CHD. Eleven (4%) patients had a history of cancer. The screening participation rate for breast cancer was higher in ACHD patients (72%) compared to the general population from Ile de France region (39%, <em>P</em> <!-->&lt;<!--> <!-->0.001) and from the whole French population (51%, <em>P</em> <!-->=<!--> <!-->0.002). For colorectal and cervical cancers, the screening participation rate were 36% and 65%, compared to 31% and 51% in Île de France region and 34% and 59% in the whole French population, respectively with no statistically significant difference (<span>Figure 1</span>).</p></div><div><h3>Conclusion/Perspectives</h3><p>Cancer screening coverage in ACHD patients was greater than non-congenital patients for breast cancer, but comparable for colorectal and cervical cancers. The screening participation rate remained however lower than European objectives for all cancers. Our data call for specific actions to better screen this aging population at high risk for cancer.</p></div>","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Page 287"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43432610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical or transcatheter pulmonary valve replacement, how to choose ? 外科或经导管肺动脉瓣置换术,如何选择?
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.acvdsp.2023.07.018
P. Normandin , A. Houeijeh , J.B. Baudelet , O. Domanskii , A. Delarue , S. Bichali , F. Juthier , F. Godart

Introduction

Pulmonary valve replacement (PVR) is indicated for right ventricle outflow tract (RVOT) dysfunction. The choice between the transcatheter PVR (TPVR) and the surgical PVR (SPVR) is debated.

Objective

We aimed to compare the TPVR to the SPVR, considered previously as the gold standard, to determine the best choice for each patient.

Methods

A retrospective observational study was conducted in Lille University hospital. All patients who had PVR between January 2012 and May 2021 were included. The primary outcome was the incidence of valve failure defined as the occurrence of death, endocarditis or the need for secondary intervention.

Results

In total, 273 patients were included (100 patients with TPVR (36.6%) and 173 with SPVR (63.4%)). Age at the intervention was 25.1 ± 14.8 years for TPVR and 34.9 ± 15.7 years for SPVR. The outlet malformation was the main pathology (65% of TPVR and 61.3% of SPVR) followed by the Ross intervention (18% of TPVR and 11.6% of SPVR). The mean duration of the follow-up was 3.6 ± 2,8 years for TPVR and 3.9 ± 0,9 years for SPVR. Valve diameters were higher in the SPVR group (9% < 20 mm – 44% 20–22 mm and 47% > 22 mm for TPVR; and 3.6% < 22 mm and 96,4% > 22 mm for SPVR) and post-intervention transvalvular gradient was higher in the TPVR group.

The primary outcome was not significantly different in TPVR than in SPVR (16.33% vs. 8.7% respectively, P = 0.846), and the freedom from primary outcome at 9 years of follow up was 57% in TPVR and 84% in SPVR (Figure 1), after adjusting for predefined confounders (age at the intervention, size of the valve, and disease).

The risks factors for primary outcome were number of previous surgeries (P = 0.0190) and small size of the valve (threshold < 22 mm, hazard ratio 0.27, P = 0.0363).

Conclusion/Perspectives

The choice between TPVR and SPVR should be individualized based on each patient, their risk factors and the size of their right ventricle outflow tract. A larger size of the valve (> 22 mm if possible) may be preferable mainly in patients with several previous surgeries.

肺动脉瓣置换术(PVR)适用于右心室流出道功能障碍。经导管PVR (TPVR)和手术PVR (SPVR)的选择是有争议的。目的比较TPVR和SPVR(之前被认为是金标准),以确定每位患者的最佳选择。方法在美国里尔大学附属医院进行回顾性观察研究。所有在2012年1月至2021年5月期间患有PVR的患者均被纳入研究。主要结局是瓣膜衰竭的发生率,定义为死亡、心内膜炎或需要二次干预。结果共纳入273例患者,其中TPVR 100例(36.6%),SPVR 173例(63.4%)。干预时TPVR的年龄为25.1±14.8岁,SPVR的年龄为34.9±15.7岁。出口畸形是主要病理(65%的TPVR和61.3%的SPVR),其次是Ross干预(18%的TPVR和11.6%的SPVR)。TPVR的平均随访时间为3.6±2.8年,SPVR的平均随访时间为3.9±0.9年。SPVR组的瓣膜直径更高(9% <20毫米- 44% 20 - 22毫米和47% >TPVR 22mm;3.6% <22mm和96,4% >SPVR组为22 mm,干预后TPVR组的跨瓣梯度更高。TPVR和SPVR的主要结局无显著差异(分别为16.33%和8.7%,P = 0.846),在调整了预定混杂因素(干预时的年龄、瓣膜大小和疾病)后,TPVR和SPVR在9年随访时的主要结局自由度分别为57%和84%(图1)。影响主要结局的危险因素是既往手术次数(P = 0.0190)和瓣膜尺寸小(阈值<22 mm,风险比0.27,P = 0.0363)。结论/观点TPVR和SPVR的选择应根据每个患者、其危险因素和右心室流出道的大小进行个体化。较大尺寸的阀门(>22毫米(如果可能的话)可能主要适用于有过多次手术的患者。
{"title":"Surgical or transcatheter pulmonary valve replacement, how to choose ?","authors":"P. Normandin ,&nbsp;A. Houeijeh ,&nbsp;J.B. Baudelet ,&nbsp;O. Domanskii ,&nbsp;A. Delarue ,&nbsp;S. Bichali ,&nbsp;F. Juthier ,&nbsp;F. Godart","doi":"10.1016/j.acvdsp.2023.07.018","DOIUrl":"10.1016/j.acvdsp.2023.07.018","url":null,"abstract":"<div><h3>Introduction</h3><p>Pulmonary valve replacement<span> (PVR) is indicated for right ventricle outflow tract (RVOT) dysfunction. The choice between the transcatheter PVR (TPVR) and the surgical PVR (SPVR) is debated.</span></p></div><div><h3>Objective</h3><p>We aimed to compare the TPVR to the SPVR, considered previously as the gold standard, to determine the best choice for each patient.</p></div><div><h3>Methods</h3><p>A retrospective observational study was conducted in Lille University hospital. All patients who had PVR between January 2012 and May 2021 were included. The primary outcome was the incidence of valve failure defined as the occurrence of death, endocarditis or the need for secondary intervention.</p></div><div><h3>Results</h3><p>In total, 273 patients were included (100 patients with TPVR (36.6%) and 173 with SPVR (63.4%)). Age at the intervention was 25.1<!--> <!-->±<!--> <!-->14.8 years for TPVR and 34.9<!--> <!-->±<!--> <span>15.7 years for SPVR. The outlet malformation was the main pathology (65% of TPVR and 61.3% of SPVR) followed by the Ross intervention (18% of TPVR and 11.6% of SPVR). The mean duration of the follow-up was 3.6</span> <!-->±<!--> <!-->2,8 years for TPVR and 3.9<!--> <!-->±<!--> <!-->0,9 years for SPVR. Valve diameters were higher in the SPVR group (9%<!--> <!-->&lt;<!--> <!-->20<!--> <!-->mm – 44% 20–22<!--> <!-->mm and 47%<!--> <!-->&gt;<!--> <!-->22<!--> <!-->mm for TPVR; and 3.6%<!--> <!-->&lt;<!--> <!-->22<!--> <!-->mm and 96,4%<!--> <!-->&gt;<!--> <!-->22<!--> <!-->mm for SPVR) and post-intervention transvalvular gradient was higher in the TPVR group.</p><p>The primary outcome was not significantly different in TPVR than in SPVR (16.33% vs. 8.7% respectively, <em>P</em> <!-->=<!--> <!-->0.846), and the freedom from primary outcome at 9 years of follow up was 57% in TPVR and 84% in SPVR (<span>Figure 1</span>), after adjusting for predefined confounders (age at the intervention, size of the valve, and disease).</p><p>The risks factors for primary outcome were number of previous surgeries (<em>P</em> <!-->=<!--> <!-->0.0190) and small size of the valve (threshold<!--> <!-->&lt;<!--> <!-->22<!--> <!-->mm, hazard ratio 0.27, <em>P</em> <!-->=<!--> <!-->0.0363).</p></div><div><h3>Conclusion/Perspectives</h3><p>The choice between TPVR and SPVR should be individualized based on each patient, their risk factors and the size of their right ventricle outflow tract. A larger size of the valve (&gt;<!--> <!-->22<!--> <span>mm if possible) may be preferable mainly in patients with several previous surgeries.</span></p></div>","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Pages 281-282"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41430005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No coronary artery in the aorta: Severe congenital malformation under-diagnosed 主动脉无冠状动脉:诊断不足的严重先天性畸形
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.acvdsp.2023.07.032
J. Karila, L. Houyel

Introduction

Absence of connection of both coronary arteries to the aorta is an extremely rare congenital malformation. Most cases reported are anatomic variants of anomalous left coronary artery to pulmonary artery.

Objective

We describe here four cases of patients born without any coronary artery connecting connected to the aorta (Figure 1).

Results/Expected results

Case 1: a male infant was diagnosed with aortic coarctation and perimembranous ventricular septal defect (VSD). Left ventricular dysfunction appeared four months after coarctation repair and pulmonary artery banding. Heart catheterization showed no coronary artery in the aorta and a single coronary artery connected to the right pulmonary artery.

Case 2: a female neonate born with multiples VSD and aortic coarctation died during coarctation repair. At autopsy, there were no epicardial coronary arteries except a short segment in the posterior atrioventricular sulcus. Two small dimples were seen in aortic root. No proximal coronary artery connected to the aorta or the pulmonary arteries. Several intramyocardial arterial vessels of different sizes were detected, without any communication with the ventricles.

Case 3: a male neonate was born with pulmonary atresia with intact ventricular septum. Cardiac angiography revealed multiple coronary-ventricular fistulae and no coronary arteries from the aorta. Autopsy confirmed 1) absence of epicardial coronary arteries except a very short segment of left anterior descending and small fistulous apical segments 2) two large coronary-ventricular fistulas. There were no coronary ostia within the aorta or the pulmonary tree.

Case 4: a coronarography revealed a single coronary artery originating from the left ventricle just below the aortic valve in a 64-year old with syncope at exercise. Surgical reimplantation was performed with success.

Conclusion/Perspectives

Those exceptional coronary malformations have a poor prognosis and are often diagnosed at autopsy. Total absence of epicardial coronary arteries, described only once in the literature, leads us to reconsider current knowledge of human coronary artery development.

双冠状动脉与主动脉缺乏连接是一种极为罕见的先天性畸形。大多数病例报告为左冠状动脉到肺动脉异常的解剖变异。结果/预期结果病例1:一名男婴被诊断为主动脉缩窄和膜周室间隔缺损(VSD)。左心室功能障碍出现在缩窄修复和肺动脉绑扎术后4个月。心导管检查显示主动脉内无冠状动脉,仅有一根冠状动脉与右肺动脉相连。病例2:一名女性新生儿患有多发室间隔缺损和主动脉缩窄,在主动脉缩窄修复期间死亡。尸检时,除房室后沟一小段外,未见心外膜冠状动脉。主动脉根部可见两个小酒窝。没有近端冠状动脉与主动脉或肺动脉相连。心内动脉血管大小不一,与心室没有任何联系。病例3:一男新生儿先天性肺闭锁伴室间隔完整。心脏血管造影显示多个冠状室瘘,主动脉未见冠状动脉。尸检证实:1)心外膜冠状动脉缺失,除了左前降段很短和小的根尖段瘘管外;2)两个大的冠状室瘘。主动脉及肺动脉内未见冠状动脉开口。病例4:64岁运动时晕厥,冠状造影显示单冠状动脉起源于左心室主动脉瓣下方。手术再植成功。结论/观点那些特殊的冠状动脉畸形预后较差,通常在尸检时才被诊断出来。心外膜冠状动脉的完全缺失,在文献中只描述过一次,这使我们重新考虑目前对人类冠状动脉发育的认识。
{"title":"No coronary artery in the aorta: Severe congenital malformation under-diagnosed","authors":"J. Karila,&nbsp;L. Houyel","doi":"10.1016/j.acvdsp.2023.07.032","DOIUrl":"10.1016/j.acvdsp.2023.07.032","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Absence of connection of both coronary arteries<span> to the aorta is an extremely rare congenital malformation. Most cases reported are anatomic variants of anomalous </span></span>left coronary artery to pulmonary artery.</p></div><div><h3>Objective</h3><p>We describe here four cases of patients born without any coronary artery connecting connected to the aorta (<span>Figure 1</span>).</p></div><div><h3>Results/Expected results</h3><p><span><span>Case 1: a male infant was diagnosed with aortic coarctation and perimembranous </span>ventricular septal defect<span><span> (VSD). Left ventricular dysfunction appeared four months after coarctation repair and </span>pulmonary artery banding<span>. Heart catheterization showed no coronary artery in the aorta and a single coronary artery connected to the </span></span></span>right pulmonary artery.</p><p><span>Case 2: a female neonate born with multiples VSD and aortic coarctation died during coarctation repair. At autopsy, there were no </span>epicardial coronary arteries<span> except a short segment in the posterior atrioventricular sulcus. Two small dimples were seen in aortic root. No proximal coronary artery connected to the aorta or the pulmonary arteries. Several intramyocardial arterial vessels of different sizes were detected, without any communication with the ventricles.</span></p><p><span><span>Case 3: a male neonate was born with pulmonary atresia<span> with intact ventricular septum. Cardiac </span></span>angiography revealed multiple coronary-ventricular </span>fistulae and no coronary arteries from the aorta. Autopsy confirmed 1) absence of epicardial coronary arteries except a very short segment of left anterior descending and small fistulous apical segments 2) two large coronary-ventricular fistulas. There were no coronary ostia within the aorta or the pulmonary tree.</p><p>Case 4: a coronarography<span><span> revealed a single coronary artery originating from the left ventricle just below the </span>aortic valve<span> in a 64-year old with syncope at exercise. Surgical reimplantation was performed with success.</span></span></p></div><div><h3>Conclusion/Perspectives</h3><p>Those exceptional coronary malformations have a poor prognosis and are often diagnosed at autopsy. Total absence of epicardial coronary arteries, described only once in the literature, leads us to reconsider current knowledge of human coronary artery development.</p></div>","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Page 288"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42220318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ours redaction 我们的修订
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/S1878-6480(23)00277-X
{"title":"Ours redaction","authors":"","doi":"10.1016/S1878-6480(23)00277-X","DOIUrl":"https://doi.org/10.1016/S1878-6480(23)00277-X","url":null,"abstract":"","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Page i"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49752197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early spontaneous closure of large arterial ducts in two term neonates with ebstein anomaly after failed attempts of transcatheter closure 两例经导管闭合失败的ebstein异常足月新生儿大动脉导管早期自发闭合
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.acvdsp.2023.07.045
R. Haddad, D. Bonnet, S. Malekzadeh-Milani

Introduction

The unique features of neonatal Ebstein's anomaly (EA) are the presence of pulmonary atresia, arterial duct (AD) patency, and the variability of pulmonary vascular resistance. Promoting early ductal closure after ruling out or relieving anatomic pulmonary obstruction might improve neonatal survival. Transcatheter ductal closure is an interesting option but can be challenging in tiny neonates with large tortuous AD due to the limited available sizes of low-profile approved devices.

Objective

We report on 2 consecutive term newborns with EA and large AD in whom mechanical AD stimulus during failed attempts of transcatheter closure led after 2 days to definitive closure.

Methods

Two consecutive term neonates with EA were approached from the femoral vein for an attempted ductal closure. An 8 mm-AVPII was implanted in the AD (pulmonary end: 6.3 mm, length 8.9 mm) of the first 9-day-old patient (3 kg) and was removed before release for important leak and device instability. Delivery of 10 mm AVPII was laborious and procedure was aborted after important bleeding. A MVP-9Q was implanted in the AD (pulmonary end: 7.6 mm, length 16.1 mm) of the second 14-day-old patient (2.8 kg) and was removed before release after immediate migration to the pulmonary artery trunk. The procedure was aborted in the absence of a larger low-profile occlusion device in the armamentarium.

Results/Expected results

Patients were sent back to the ICU for surveillance and a re-discussion of the management strategy. Follow-up ultrasound showed a spontaneous and progressive diminution in the AD size until complete closure two days postoperative with good follow-up outcomes.

Conclusion/Perspectives

Transcatheter closure should be attempted in similar cases requiring early ductal closure. Surgical ligation can be postponed a couple of days after failed interventions when clinically possible. Further studies seem interesting to evaluate whether mechanical stimulation of the ductal wall can be a useful alternative to initiate spontaneous ductal closure in pre-term and term neonates.

新生儿Ebstein异常(EA)的独特特征是存在肺闭锁、动脉导管(AD)通畅和肺血管阻力的变异性。在排除或缓解解剖性肺梗阻后促进导管早期闭合可能提高新生儿的存活率。经导管导管闭合是一个有趣的选择,但由于低规格批准装置的可用尺寸有限,对于患有大面积弯曲AD的新生儿来说可能具有挑战性。目的我们报告了连续2例患有EA和大面积AD的足月新生儿,在经导管封堵失败的过程中,机械性AD刺激导致2天后最终封堵。方法从股静脉接近两名连续足月的EA新生儿,尝试闭合导管。在第一名9天大的患者(3公斤)的AD(肺端:6.3毫米,长度8.9毫米)中植入一个8毫米的AVPII,并在释放前取出,以应对重要的渗漏和装置不稳定。10毫米AVPII的分娩非常费力,并且在重要出血后中止了手术。将MVP-9Q植入第二名14天大的患者(2.8 kg)的AD(肺端:7.6 mm,长度16.1 mm)中,并在立即转移到肺动脉干后在释放前取出。由于医疗器械中没有更大的低剖面闭塞装置,手术中止。结果/预期结果患者被送回ICU进行监测并重新讨论管理策略。随访超声显示AD大小自发和渐进性缩小,直到术后两天完全闭合,随访结果良好。结论/透视在需要早期导管闭合的类似病例中,应尝试经导管闭合。在临床可能的情况下,手术结扎可以在干预失败后推迟几天。进一步的研究似乎很有意思,以评估导管壁的机械刺激是否可以成为足月前和足月新生儿自发导管闭合的有用替代方案。
{"title":"Early spontaneous closure of large arterial ducts in two term neonates with ebstein anomaly after failed attempts of transcatheter closure","authors":"R. Haddad,&nbsp;D. Bonnet,&nbsp;S. Malekzadeh-Milani","doi":"10.1016/j.acvdsp.2023.07.045","DOIUrl":"https://doi.org/10.1016/j.acvdsp.2023.07.045","url":null,"abstract":"<div><h3>Introduction</h3><p>The unique features of neonatal Ebstein's anomaly<span> (EA) are the presence of pulmonary atresia<span>, arterial duct (AD) patency, and the variability of pulmonary vascular resistance<span>. Promoting early ductal closure after ruling out or relieving anatomic pulmonary obstruction might improve neonatal survival. Transcatheter ductal closure is an interesting option but can be challenging in tiny neonates with large tortuous AD due to the limited available sizes of low-profile approved devices.</span></span></span></p></div><div><h3>Objective</h3><p>We report on 2 consecutive term newborns with EA and large AD in whom mechanical AD stimulus during failed attempts of transcatheter closure led after 2 days to definitive closure.</p></div><div><h3>Methods</h3><p><span>Two consecutive term neonates with EA were approached from the femoral vein for an attempted ductal closure. An 8</span> <!-->mm-AVPII was implanted in the AD (pulmonary end: 6.3<!--> <!-->mm, length 8.9<!--> <!-->mm) of the first 9-day-old patient (3<!--> <!-->kg) and was removed before release for important leak and device instability. Delivery of 10<!--> <!-->mm AVPII was laborious and procedure was aborted after important bleeding. A MVP-9Q was implanted in the AD (pulmonary end: 7.6<!--> <!-->mm, length 16.1<!--> <!-->mm) of the second 14-day-old patient (2.8<!--> <!-->kg) and was removed before release after immediate migration to the pulmonary artery trunk. The procedure was aborted in the absence of a larger low-profile occlusion device in the armamentarium.</p></div><div><h3>Results/Expected results</h3><p>Patients were sent back to the ICU for surveillance and a re-discussion of the management strategy. Follow-up ultrasound showed a spontaneous and progressive diminution in the AD size until complete closure two days postoperative with good follow-up outcomes.</p></div><div><h3>Conclusion/Perspectives</h3><p>Transcatheter closure should be attempted in similar cases requiring early ductal closure. Surgical ligation can be postponed a couple of days after failed interventions when clinically possible. Further studies seem interesting to evaluate whether mechanical stimulation of the ductal wall can be a useful alternative to initiate spontaneous ductal closure in pre-term and term neonates.</p></div>","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Pages 293-294"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49752461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sinus venosus atrial septal defect in adults: Surgical repair using partial thoracoscopic approach 成人静脉窦房间隔缺损:部分胸腔镜入路手术修复
IF 18 Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.acvdsp.2023.07.019
L. Le Gloan , A. Mugniot , F. Wautot , P. Guérin

Introduction

The decision regarding optimal treatment for atrial septal defect (ASD) in adults should be given by a multidisciplinary ACHD team; the best treatment in the presence of right ventricular overload is timely closure, irrespective of age. So far, despite new percutaneous approach for sinus venosus ASD closure, surgery remains gold standard, performed via a median sternotomy on cardiopulmonary bypass.

Methods

Minimally invasive cardiac surgery offers the possibility to repair ASD with a video-assisted approach through a right mini thoracotomy. We report the use of a partial thoracoscopic, combining a small anterior thoracotomy to thoracoscopy in 3 adults of 20, 42 and 46 years old, 1 woman and 2 men.

Results/Expected results

Our female patient was offered a periaareolar incision. All 3 patients had a sinus venosus ASD with right ventricular enlargement. They had no pulmonary hypertension and all had one isolated right superior pulmonary vein connected to the superior vena cava. None had a persistent left superior vena cava draining to the coronary sinus and none had significant tricuspid regurgitation. All ASD were successfully repaired with a two-patch technique, by means of 2 ports positioned on the right chest wall to allow the insertion of surgical instruments and a small thoracotomy. Mean time of cardiopulmonary bypass was 188 minutes, mean time of aortic cross-clamp was 122 minutes and mean time of operation was 242 minutes. Post-operative mechanical ventilation duration averaged 309 minutes and the mean duration of ICU stay was less than 24 hours for all. No death, residual shunt, moderate tricuspid regurgitation or lung atelectasis was found at 2 months.

Conclusion/Perspectives

This partial thoracoscopic approach appears as a feasible and safe approach for surgical closure of sinus venosus ASD in adults. Furthermore, it seems to allow less pain and better cosmetic outcome, particularly in women, using a periareolar incision.

成人房间隔缺损(ASD)的最佳治疗方案应由一个多学科的ACHD团队给出;右室负荷过重的最佳治疗方法是及时关闭,无论年龄大小。到目前为止,尽管有新的经皮静脉窦ASD闭合方法,手术仍然是金标准,在体外循环中通过正中胸骨切开术进行。方法微创心脏手术通过视频辅助右小开胸入路修复ASD提供了可能。我们报告了3例20岁、42岁和46岁的成人,1女2男,使用部分胸腔镜,结合小前开胸和胸腔镜。结果/预期结果我们为女性患者提供了一个网膜周围切口。3例患者均为静脉窦性ASD伴右心室增大。他们没有肺动脉高压,并且都有一条孤立的右上肺静脉与上腔静脉相连。无持续性左上腔静脉引流至冠状窦,无明显三尖瓣反流。所有ASD均通过双补片技术成功修复,通过在右胸壁上放置2个端口以允许手术器械插入和小开胸。体外循环平均时间188分钟,主动脉交叉夹持平均时间122分钟,手术平均时间242分钟。术后机械通气时间平均309分钟,ICU住院时间均小于24小时。2个月时未发现死亡、残余分流、中度三尖瓣反流或肺不张。结论/观点:部分胸腔镜入路是治疗成人静脉窦ASD的一种可行且安全的方法。此外,它似乎允许更少的疼痛和更好的美容效果,特别是在女性中,使用乳晕周围切口。
{"title":"Sinus venosus atrial septal defect in adults: Surgical repair using partial thoracoscopic approach","authors":"L. Le Gloan ,&nbsp;A. Mugniot ,&nbsp;F. Wautot ,&nbsp;P. Guérin","doi":"10.1016/j.acvdsp.2023.07.019","DOIUrl":"10.1016/j.acvdsp.2023.07.019","url":null,"abstract":"<div><h3>Introduction</h3><p><span><span>The decision regarding optimal treatment for </span>atrial septal defect<span> (ASD) in adults should be given by a multidisciplinary ACHD team; the best treatment in the presence of right ventricular overload is timely closure, irrespective of age. So far, despite new percutaneous approach for </span></span>sinus venosus<span> ASD closure, surgery remains gold standard, performed via a median sternotomy<span> on cardiopulmonary bypass.</span></span></p></div><div><h3>Methods</h3><p><span><span>Minimally invasive cardiac surgery offers the possibility to repair ASD with a video-assisted approach through a right mini </span>thoracotomy. We report the use of a partial thoracoscopic, combining a small anterior thoracotomy to </span>thoracoscopy in 3 adults of 20, 42 and 46 years old, 1 woman and 2 men.</p></div><div><h3>Results/Expected results</h3><p><span><span>Our female patient was offered a periaareolar incision<span><span>. All 3 patients had a sinus venosus ASD with right ventricular enlargement. They had no pulmonary hypertension and all had one isolated right superior pulmonary vein<span> connected to the superior vena cava. None had a </span></span>persistent left superior vena cava draining to the </span></span>coronary sinus<span> and none had significant tricuspid regurgitation. All ASD were successfully repaired with a two-patch technique, by means of 2 ports positioned on the right chest wall to allow the insertion of surgical instruments and a small thoracotomy. Mean time of cardiopulmonary bypass was 188</span></span> <!-->minutes, mean time of aortic cross-clamp was 122<!--> <!-->minutes and mean time of operation was 242<!--> <span>minutes. Post-operative mechanical ventilation duration averaged 309</span> <!-->minutes and the mean duration of ICU stay was less than 24<!--> <span>hours for all. No death, residual shunt, moderate tricuspid regurgitation or lung atelectasis was found at 2 months.</span></p></div><div><h3>Conclusion/Perspectives</h3><p>This partial thoracoscopic approach appears as a feasible and safe approach for surgical closure of sinus venosus ASD in adults. Furthermore, it seems to allow less pain and better cosmetic outcome, particularly in women, using a periareolar incision.</p></div>","PeriodicalId":8140,"journal":{"name":"Archives of Cardiovascular Diseases Supplements","volume":"15 4","pages":"Page 282"},"PeriodicalIF":18.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46437762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Archives of Cardiovascular Diseases Supplements
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1