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Epidemiologic basis for the practice of travel medicine 旅行医学实践的流行病学基础
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.56
Robert Steffen MD , Hans O. Lobel MD, MPH

The major health risks for travelers to developing countries include injuries, malaria, hepatitis A, hepatitis B, rabies, AIDS and travelers’ diarrhea. Most illnesses can be avoided by use of preventive measures including use of seatbelts in cars, hygienic measures and use of effective immunization and chemoprophylaxis. Practitioners of travel medicine need to know the health risks that confront travelers in order to advise which preventive measures should be used. Most available data apply to travelers visiting developing countries.

前往发展中国家的旅行者面临的主要健康风险包括受伤、疟疾、甲型肝炎、乙型肝炎、狂犬病、艾滋病和旅行者腹泻。大多数疾病可以通过采取预防措施来避免,包括在汽车中使用安全带、采取卫生措施以及使用有效的免疫和化学预防。旅行医学从业人员需要了解旅行者面临的健康风险,以便建议应采取哪些预防措施。大多数可用数据适用于访问发展中国家的旅行者。
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引用次数: 41
Carbon monoxide hazard in sub-Antarctic exploration 亚南极探险中的一氧化碳危害
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.4
Rowland M.F. Gill MRCGP AFOM

During a sub-Antarctic expedition, petrol stoves were used for cooking inside tents and snow-holes (snow caves). The carbon monoxide hazard from the use of petrol stoves was assessed by measuring atmospheric levels with direct-reading indicator tubes (Draeger tubes). Levels up to 300 ppm were recorded, higher than previous field experiments have shown. The levels recorded were unlikely to have affected the exercise capacity of expedition members or to have had other serious effects. Direct-reading tubes were a simple and effective means of measurement. One episode of acute serious hazard occurred and is described, but the atmospheric carbon monoxide level was not recorded. It is concluded that the most important hazard from carbon monoxide under mountaineering and exploration conditions is that of acute fatal poisoning.

在亚南极探险期间,人们在帐篷和雪洞(雪洞)内使用燃油灶做饭。使用燃油炉产生的一氧化碳危害是通过使用直读指示管(Draeger管)测量大气水平来评估的。记录到的浓度高达百万分之300,高于以前的实地实验结果。所记录的水平不太可能影响探险队成员的运动能力或产生其他严重影响。直读管是一种简单有效的测量手段。发生了一次急性严重危害,并进行了描述,但没有记录大气中的一氧化碳水平。在登山和探险条件下,一氧化碳最主要的危害是急性致死中毒。
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引用次数: 3
A comparative study of pulmonary hemodynamics in six lowlanders at an altitude of 15 400 ft in China 中国海拔15400英尺的6个低地居民肺血流动力学的比较研究
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.1
Chengyu Miao , Liangrui Yang , Jingyi Yang

Six immigrants were studied with cardiac catheterization at Tuotuohe village of Qinghai, China (15400 ft above sea level, barometric pressure 470 torr) to study the pulmonary hemodynamic changes.

在青海省托托河村(海拔15400 ft,气压470 torr)对6名移民进行心导管插管,研究其肺血流动力学变化。
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引用次数: 3
Carbonic anhydrase inhibition in the immediate therapy of acute mountain sickness 碳酸酐酶抑制在急性高山病即时治疗中的应用
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.49
Alexander D. Wright FRCP, Michael H. Winterborn FRCP, Peter J. Forster MRCP, John P. Delamere FRCP, Ginette L. Harrison MRCOG, Arthur R. Bradwell FRCP, The Birmingham Medical Research Expeditionary Society, University of Birmingham

The objective was to assess the effectiveness of acetazolamide and the relative speed of response to acetazolamide and methazolamide on blood gases and symptoms of acute mountain sickness (AMS). Thirty-seven subjects suffering from AMS were given 1–1.5 g acetazolamide or 400–500 mg methazolamide in randomized, double-blind trials during three expeditions to high altitude (3200–5486 m). Both drugs improved PaO2 by 7.7–8.0 mmHg, with a more rapid response at 3 h following methazolamide. Symptom scores improved over 24 h following both drugs, but headaches were induced in 28% of subjects. It was concluded that treatment with acetazolamide and methazolamide improves arterial oxygenation and symptoms of AMS. The differences in time of response between the two drugs were not proven to be clinically important.

目的是评估乙酰唑胺的有效性以及乙酰唑胺和甲基唑胺对血气和急性高原反应(AMS)症状的相对反应速度。37例AMS患者在3次高海拔(3200 ~ 5486 m)的随机双盲试验中,分别给予1 ~ 1.5 g乙酰唑胺或400 ~ 500 mg甲唑胺,两种药物均能改善PaO2水平,改善幅度为77.8 ~ 8.0 mmHg,且甲唑胺治疗后3 h的反应速度更快。两种药物服用后24小时症状评分均有所改善,但28%的受试者出现头痛症状。结论乙酰唑胺和甲唑胺治疗可改善AMS的动脉氧合和症状。两种药物在反应时间上的差异在临床上并不重要。
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引用次数: 12
Serious Physalia (Portuguese man o’war) stings: implications for scuba divers 严重的Physalia(葡萄牙人o 'war)蜇伤:对潜水者的启示
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.71
Joseph W. Burnett MD , Peter J. Fenner MRCGP, DRCOG, FACTM , Franco Kokelj MA , John A. Williamson Bsc, FANZCA, DipDHM, FACTM

The objective of this study was to describe a serious jellyfish envenomation in a scuba diver by an Atlantic Physalia physalis, to review the related literature and to recommend safe diving practices that may reduce the risk of serious jellyfish envenomation in divers. A healthy scuba diving instructor wearing a full wetsuit and gloves but no hood ascended from a night dive and surfaced directly under a large Atlantic Physalia jellyfish. He suffered multiple severe stings to the unprotected areas of his face and neck. He developed acute subjective respiratory distress with hyperventilation, muscle pain and spasms, and impaired consciousness en route to hospital, more than 10 min following envenomation. He recovered quickly in hospital with oxygen, aminophylline and intravenous fluid administration. Delayed recovery of the envenomated skin took several weeks and serology was positive for Physalia venom antibodies. Full protective clothing (e.g. a full, long sleeved wetsuit, plus gloves and hood when appropriate) should be worn by scuba divers on all dives. Ascent routines in diving should include looking directly upwards at the surface with one wetsuited arm outstretched towards the surface throughout the ascent. Removal of tentacles should not be attempted by the diver until he or she has exited from the water.

本研究的目的是描述一名潜水者被大西洋水母严重中毒的情况,回顾相关文献,并推荐安全的潜水方法,以减少潜水员严重水母中毒的风险。一位健康的水肺潜水教练穿着全套潜水服,戴着手套,但没有戴风帽,从夜间潜水中爬上来,直接在一只巨大的大西洋水母下面浮出水面。他的脸和脖子上未受保护的地方被多次严重蜇伤。中毒后10多分钟,患者在送往医院的途中出现急性主观呼吸窘迫,伴有换气过度、肌肉疼痛和痉挛,意识受损。他在医院接受吸氧、氨茶碱和静脉输液治疗后迅速康复。中毒皮肤的延迟恢复需要几个星期,血清学检测Physalia毒液抗体阳性。潜水者在潜水时应穿戴全套防护服(如全套长袖潜水服,以及手套和帽)。在整个上升过程中,穿着潜水衣的一只手臂向水面伸出,眼睛直视水面。在潜水员离开水之前,不应该试图去除触须。
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引用次数: 12
Nutritional intake and carbohydrate supplementation at high altitude 高海拔地区的营养摄入和碳水化合物补充
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.20
John S.A. Edwards PhD, E. Wayne Askew PhD, Nancy King PhD, Charles S. Fulco PhD

A high carbohydrate (CHO) diet has previously been shown to lessen the severity of the symptoms of Acute Mountain Sickness (AMS). The aims of this study were to ascertain whether selected military field rations provided adequate nutritional support, and assess the effectiveness of a high CHO food supplement in reducing the severity of the symptoms of AMS at high altitude. An experimental group (n = 32) received field rations plus a CHO food supplement and a control group (n = 35) only received field rations. Food intakes for 15 consecutive days were recorded using a visual estimation technique and 24-h dietary log. Food acceptability was assessed with a 9-point hedonic scale. Daily urine samples and body weights were obtained from all subjects and a 24-h urine sample obtained from a subsample of the combined groups (n = 30) for the first and last two days of the study.

Results show that energy intake decreased for the first three days at altitude, improved on day four and leveled out thereafter. Mean daily energy intakes were 2265 kcal for the supplemented group and 2140 kcal for the control group; body weight losses were 1.71 kg and 1.68 kg. Mean CHO intake was 271 and 244 g per day; 48 and 46% of energy intake. Ration acceptability was generally good and did not decline over time.

It was concluded that rations used at sea level could also be satisfactorily used at altitude, but given an ad libitum dietary regimen and a CHO food supplement, CHO intake was not automatically increased. Supplementation via a beverage component, rather than a food supplement, may therefore be more effective in increasing CHO intake.

高碳水化合物(CHO)饮食先前已被证明可以减轻急性高原病(AMS)症状的严重程度。本研究的目的是确定选定的军事野战口粮是否提供足够的营养支持,并评估高CHO食物补充剂在减轻高海拔AMS症状严重程度方面的有效性。试验组(n = 32)给予野战口粮加CHO食品添加剂,对照组(n = 35)只给予野战口粮。采用目测法和24小时饮食日志记录连续15天的食物摄入量。食物可接受性用9分的享乐量表进行评估。收集了所有受试者的每日尿液样本和体重,并在研究的第一天和最后两天从联合组(n = 30)的子样本中获取了24小时尿液样本。结果表明,在高海拔地区,前三天的能量摄入下降,第四天有所改善,之后趋于平稳。补充组的平均每日能量摄入量为2265千卡,对照组为2140千卡;体重分别减少1.71公斤和1.68公斤。CHO的平均摄入量分别为271克和244克/天;48%和46%的能量摄入配给的可接受性总体上是好的,并没有随着时间的推移而下降。综上所述,在海平面上使用的口粮在高原上也能令人满意地使用,但在随意饮食和补充CHO的情况下,CHO的摄入量不会自动增加。因此,通过饮料成分的补充,而不是通过食物补充,可能更有效地增加CHO的摄入量。
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引用次数: 15
On trips where there is a danger of hypothermia, should the trip physician carry a hypothermia thermometer which reads below the standard 94°F of most thermometers? 在有体温过低危险的旅行中,旅行医生是否应该携带一个读数低于大多数温度计的标准94°F的体温过低温度计?
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.115
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引用次数: 0
Alcohol ingestion and temperature regulation during cold exposure 低温暴露时酒精摄入与体温调节
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.88
Beau J. Freund, Catherine O’brien, Andrew J. Young

Outdoor or wilderness activities are sometimes combined with the ingestion of alcoholic beverages. Despite the feeling of warmth induced by alcohol ingestion, it is widely believed that alcohol actually causes a decrease in body core temperature and increases the risk of hypothermia during cold exposure. However, the literature on the effects of alcohol ingestion on thermoregulation is conflicting. This review summarizes the scientific findings concerning this topic and identifies a number of confounding factors that may explain the conflicting observations. These factors include quantity of alcohol ingested, severity of the cold stress, nutritional state of the individual, composition of the drink, body composition of the individual and alcohol tolerance of the individual. When these factors are considered, it appears that (1) alcohol acts as a poikilothermic agent, causing a reduction in body core temperature during cold exposure, with the magnitude of reduction related to blood alcohol concentration, (2) the severity of cold and the individual's body composition modify the thermoregulatory effects of alcohol, and (3) hypoglycemia greatly exacerbates the reduction in body temperature caused by alcohol ingestion. Furthermore, the primary mechanism by which alcohol ingestion exacerbates the fall in body core temperature during cold exposure appears to be via an impairment of shivering thermogenesis resulting from alcohol-induced hypoglycemia, rather than by increasing heat dissipation via vasodilation as commonly believed.

户外或野外活动有时与饮用酒精饮料结合在一起。尽管饮酒会让人感到温暖,但人们普遍认为,酒精实际上会降低身体核心温度,增加在寒冷环境中体温过低的风险。然而,关于酒精摄入对体温调节的影响的文献是相互矛盾的。这篇综述总结了有关这一主题的科学发现,并确定了一些可能解释相互矛盾的观察结果的混淆因素。这些因素包括摄入的酒精量、冷应激的严重程度、个人的营养状况、饮料的成分、个人的身体成分和个人的酒精耐受性。考虑到这些因素,似乎:(1)酒精作为一种变热剂,在寒冷暴露时引起体温下降,其下降幅度与血液酒精浓度有关;(2)寒冷的严重程度和个体的身体成分改变了酒精的体温调节作用;(3)低血糖大大加剧了酒精摄入引起的体温下降。此外,在寒冷环境中,酒精摄入加剧身体核心温度下降的主要机制似乎是通过酒精诱导的低血糖导致的寒颤产热损伤,而不是通常认为的通过血管舒张增加热量散失。
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引用次数: 17
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.99
210 min (group 3) rapid venom immunotherapy (RVIT) protocol using honey bee or yellow jacket venom at cumulative doses of 527.6 I-tg, 226.6 I-tg and 101.1I-tg, respectively. The four day protocol involved four times as many injections as the 210 min protocol and twice as many injections as the 6 h protocol. Desensitization was conducted in a hospital providing full emergency resuscitation facilities. In group 1, 1 X 100 I-tg boosters were given on days 7, 10, 15 and 45; and in groups 2 and 3, 2 X 50 I-tg boosters were given on day 15 and 1 X 100 I-tg on day 45. The patients in the three groups were comparable in clinical characteristics and immunological reactivity determined by skin tests. All patients had large local reactions. Systemic reactions occurred in 28.2% of patients in group 1, 28.6% in group 2 and 6.9% in group 3. The mean total cumulative venom dose for occurrence of systemic reactions was 123.75 (± 24.2) in group 1, 183.27 (± 28.5) in group 2 and 36.43 (± 9.3) in group 3. Honey bee venom led to more systemic reactions than did yellow jacket venom. The rate of systemic reactions decreased when the cumulative venom dose was reduced during RVIT. The median dose was 137.6 !!g in group 1, 226.6 I-tg in group 2 and 21.1 !!g in group 3. No systemic reactions were observed after the booster injections. The results of this study suggest that short RVIT protocols with low cumulative doses carry a lesser risk of systemic reaction and that a 210 min venom immunotherapy protocol is safe. Since October 1986, we have been using the 210 min protocol routinely in our Department of Chest Diseases. Immediate systemic reactions have been mild and have responded readily to properly supervised treatment. Although no late reactions have been observed so far, we advise patients to stay in the hospital for the night following rapid venom immunotherapy.
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引用次数: 0
Eastern massasauga rattlesnake envenomations in an urban wilderness 城市荒野中的东部马萨索加响尾蛇
Pub Date : 1994-02-01 DOI: 10.1580/0953-9859-5.1.77
Kimberly Sing MD , Timothy Erickson MD , Steven Aks DO , Heidi Rothenberg MD , Jack Lipscomb RPh

The eastern massasauga rattlesnake (Sistrurus catenatus), one of the few members of the Crotalidae family indigenous to the Great Lakes region, is considered to be more reclusive and docile than other types of rattlesnake. We report three cases of eastern massasauga rattlesnake envenomation within the Chicagoland area which required therapy with Crotalidae antivenin. Although bites are relatively uncommon, provoked snakes can inflict significant morbidity.

东部马萨索加响尾蛇(Sistrurus catenatus)是五大湖地区本土响尾蛇科为数不多的成员之一,被认为比其他类型的响尾蛇更隐居和温顺。我们报告了芝加哥地区东部马萨索加响尾蛇中毒的三例,需要用响尾蛇科抗蛇毒血清治疗。虽然咬伤相对不常见,但被激怒的蛇会造成严重的发病率。
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引用次数: 4
期刊
Journal of wilderness medicine
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