Pub Date : 2024-04-02DOI: 10.46439/toxicology.6.026
T. Addissouky, Ibrahim El Tantawy El Sayed, Majeed M. A. Ali, Yuliang Wang
{"title":"Towards personalized care: Unraveling the genomic and molecular basis of sepsisinduced respiratory complications","authors":"T. Addissouky, Ibrahim El Tantawy El Sayed, Majeed M. A. Ali, Yuliang Wang","doi":"10.46439/toxicology.6.026","DOIUrl":"https://doi.org/10.46439/toxicology.6.026","url":null,"abstract":"","PeriodicalId":8227,"journal":{"name":"Archives of clinical toxicology","volume":"30 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-23DOI: 10.46439/toxicology.5.022
K. Mensah
{"title":"Conceptualizing the use of the clinical index of liver fibrosis, FIB-4 index, in in vivo preclinical toxicological studies","authors":"K. Mensah","doi":"10.46439/toxicology.5.022","DOIUrl":"https://doi.org/10.46439/toxicology.5.022","url":null,"abstract":"","PeriodicalId":8227,"journal":{"name":"Archives of clinical toxicology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73301825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-09DOI: 10.46439/toxicology.5.020
L. Rashan, T. Efferth, Muhammed Bishir, M. Essa, Saravanabau Chidambaram, M. Qoronfleh
Frankincense oil is widely used across the globe for various therapeutic implications. However, the potential toxicity profile of Frankincense oil has not been well explored. The present study is a debut attempt to study the organ-specific (cardiac, hepatic, and neuromuscular) toxicity profile of Frankincense essential oil from Boswellia sacra using the zebrafish embryo model. The results revealed a “no observed effect concentration” (NOEC) dose of Frankincense oil of 300 µg/ml. Signs of cardiac toxicity were not observed if the zebrafish embryos were incubated with Frankincense oil (100 µg/ml). In addition, signs of genotoxicity were also not observed at the same concentration. Similarly, neuromuscular toxicity evaluated by the locomotor activity in the presence of light and hepatic toxicity measured by liver size, yolk retention, and steatosis were not found. Despite the absence of toxic effects of Frankincense oil on zebrafish embryo survival, it should be further investigated to assess if the prolonged administration of Frankincense oil in higher vertebrates might induce potential toxic effects.
{"title":"Acute, genetic, and target organ toxicity profiling of Frankincense essential oil from Boswellia sacra in zebrafish (Danio rerio)","authors":"L. Rashan, T. Efferth, Muhammed Bishir, M. Essa, Saravanabau Chidambaram, M. Qoronfleh","doi":"10.46439/toxicology.5.020","DOIUrl":"https://doi.org/10.46439/toxicology.5.020","url":null,"abstract":"Frankincense oil is widely used across the globe for various therapeutic implications. However, the potential toxicity profile of Frankincense oil has not been well explored. The present study is a debut attempt to study the organ-specific (cardiac, hepatic, and neuromuscular) toxicity profile of Frankincense essential oil from Boswellia sacra using the zebrafish embryo model. The results revealed a “no observed effect concentration” (NOEC) dose of Frankincense oil of 300 µg/ml. Signs of cardiac toxicity were not observed if the zebrafish embryos were incubated with Frankincense oil (100 µg/ml). In addition, signs of genotoxicity were also not observed at the same concentration. Similarly, neuromuscular toxicity evaluated by the locomotor activity in the presence of light and hepatic toxicity measured by liver size, yolk retention, and steatosis were not found. Despite the absence of toxic effects of Frankincense oil on zebrafish embryo survival, it should be further investigated to assess if the prolonged administration of Frankincense oil in higher vertebrates might induce potential toxic effects.","PeriodicalId":8227,"journal":{"name":"Archives of clinical toxicology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74050003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-09DOI: 10.46439/toxicology.5.021
D. Saravanan, S. Rafi, Monisha Mohan
Cancer is one of the major public health problems globally which arises due to uncontrolled cellular proliferation. Tumor necrosis factor alpha is a member of the TNF/TNFR cytokine superfamily. Currently, the venom from various sources have been widely used in the treatment of cancer. The bioactive present in bee venom has been reported to have potential antimicrobial, anti-inflammatory, and anticancer activity which has drawn the attention to identify the novel inhibitor against TNF-α. Bee venom has been reported to target ovarian, breast, prostate and malignant hepatocellular carcinoma. TNF-α is involved in the maintenance and homeostasis of the immune system, inflammation, and host defense. The oncogenic protein TNF-α plays a critical role in the development of various cancers including renal, lung, liver, prostate, bladder, and breast cancer. TNF-α enhances cancer cell growth, proliferation, invasion, and metastasis, as well as tumor angiogenesis. Due to the high prevalence and mortality, TNF-α associated cancers have remained a significant health problem globally. TNF acts biologically by activating certain signaling pathways such as nuclear factor κB (NF-κB) and c-Jun N-terminal kinase (JNK). Various toxins are being studied as alternatives for cancer treatments, and bee venom and its active components are drawing attention as potential anticancer agents. The present study identifies novel anticancer peptides that target the oncoprotein against life-threatening cancer. Docking calculations indicate that anticancer peptides, namely Melittin, Phospholipase A2, Tertiapin, and Hyaluronidase bind TNF-α respectively with the lowest binding affinity. Interestingly, Mast cell degranulating (MCD) and Apamin have the highest binding affinity with TNF-α in comparison with the above four peptides. The two lead compounds namely MCD and Apamin have the highest docking score -1253.4 and -1067.8 respectively. The present study reveals that the bee venom peptides namely MCD and Apamin interact with TNF-α associated cancer for targeted therapy of cancer. These predicted anticancer peptides are valuable candidates for in vitro or in vivo peptide therapeutic drug studies against the TNF-α associated cancers.
癌症是全球主要的公共卫生问题之一，是由于不受控制的细胞增殖而引起的。肿瘤坏死因子α是TNF/TNFR细胞因子超家族的一员。目前，各种来源的蛇毒已被广泛用于治疗癌症。据报道，蜂毒中存在的生物活性具有潜在的抗菌、抗炎和抗癌活性，这引起了人们对鉴定抗TNF-α的新型抑制剂的关注。蜂毒已被报道用于卵巢癌、乳腺癌、前列腺癌和恶性肝细胞癌。TNF-α参与免疫系统、炎症和宿主防御的维持和稳态。致癌蛋白TNF-α在各种癌症的发展中起着关键作用，包括肾癌、肺癌、肝癌、前列腺癌、膀胱癌和乳腺癌。TNF-α促进癌细胞生长、增殖、侵袭和转移，以及肿瘤血管生成。由于高患病率和死亡率，TNF-α相关癌症一直是全球的一个重大健康问题。TNF通过激活核因子κB (NF-κB)和c-Jun n -末端激酶(JNK)等信号通路发挥生物学作用。人们正在研究各种毒素作为癌症治疗的替代品，蜂毒及其有效成分作为潜在的抗癌剂正受到关注。目前的研究发现了新的抗癌肽，靶向癌蛋白对抗危及生命的癌症。对接计算表明，抗癌肽Melittin、Phospholipase A2、Tertiapin和Hyaluronidase分别以最低的结合亲和力与TNF-α结合。有趣的是，与上述四种肽相比，肥大细胞脱颗粒(MCD)和Apamin与TNF-α的结合亲和力最高。两个先导化合物MCD和Apamin的对接分数最高，分别为-1253.4和-1067.8。目前的研究表明，蜂毒肽MCD和Apamin与TNF-α相关的癌症相互作用，以靶向治疗癌症。这些预测的抗癌肽是体外或体内针对TNF-α相关癌症的肽治疗药物研究的有价值的候选者。
{"title":"Identification of novel Bioactivities from Bee venom to target TNF-α for cancer therapy","authors":"D. Saravanan, S. Rafi, Monisha Mohan","doi":"10.46439/toxicology.5.021","DOIUrl":"https://doi.org/10.46439/toxicology.5.021","url":null,"abstract":"Cancer is one of the major public health problems globally which arises due to uncontrolled cellular proliferation. Tumor necrosis factor alpha is a member of the TNF/TNFR cytokine superfamily. Currently, the venom from various sources have been widely used in the treatment of cancer. The bioactive present in bee venom has been reported to have potential antimicrobial, anti-inflammatory, and anticancer activity which has drawn the attention to identify the novel inhibitor against TNF-α. Bee venom has been reported to target ovarian, breast, prostate and malignant hepatocellular carcinoma. TNF-α is involved in the maintenance and homeostasis of the immune system, inflammation, and host defense. The oncogenic protein TNF-α plays a critical role in the development of various cancers including renal, lung, liver, prostate, bladder, and breast cancer. TNF-α enhances cancer cell growth, proliferation, invasion, and metastasis, as well as tumor angiogenesis. Due to the high prevalence and mortality, TNF-α associated cancers have remained a significant health problem globally. TNF acts biologically by activating certain signaling pathways such as nuclear factor κB (NF-κB) and c-Jun N-terminal kinase (JNK). Various toxins are being studied as alternatives for cancer treatments, and bee venom and its active components are drawing attention as potential anticancer agents. The present study identifies novel anticancer peptides that target the oncoprotein against life-threatening cancer. Docking calculations indicate that anticancer peptides, namely Melittin, Phospholipase A2, Tertiapin, and Hyaluronidase bind TNF-α respectively with the lowest binding affinity. Interestingly, Mast cell degranulating (MCD) and Apamin have the highest binding affinity with TNF-α in comparison with the above four peptides. The two lead compounds namely MCD and Apamin have the highest docking score -1253.4 and -1067.8 respectively. The present study reveals that the bee venom peptides namely MCD and Apamin interact with TNF-α associated cancer for targeted therapy of cancer. These predicted anticancer peptides are valuable candidates for in vitro or in vivo peptide therapeutic drug studies against the TNF-α associated cancers.","PeriodicalId":8227,"journal":{"name":"Archives of clinical toxicology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87583932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-21DOI: 10.46439/toxicology.5.019
{"title":"Response of Himalayan psychrotolerant Pseudomonas sp. (GBPI_Hb5) with caffeine in soil","authors":"","doi":"10.46439/toxicology.5.019","DOIUrl":"https://doi.org/10.46439/toxicology.5.019","url":null,"abstract":"","PeriodicalId":8227,"journal":{"name":"Archives of clinical toxicology","volume":"155 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83200178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.46439/toxicology.4.016
{"title":"Hydroxychloroquine and COVID-19: Usefulness and side effects","authors":"","doi":"10.46439/toxicology.4.016","DOIUrl":"https://doi.org/10.46439/toxicology.4.016","url":null,"abstract":"","PeriodicalId":8227,"journal":{"name":"Archives of clinical toxicology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73861762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.46439/toxicology.4.015
{"title":"Reengineering Mexiletine by chemical synthesis to decrease toxicity and improve pharmacological properties with patient-derived iPSC cardiomyocytes.","authors":"","doi":"10.46439/toxicology.4.015","DOIUrl":"https://doi.org/10.46439/toxicology.4.015","url":null,"abstract":"","PeriodicalId":8227,"journal":{"name":"Archives of clinical toxicology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80658565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.46439/toxicology.3.012
{"title":"Degradation of methylene blue dye in the presence of visible light using nanocomposite based on reduced graphene oxide decorated with silver nanowires","authors":"","doi":"10.46439/toxicology.3.012","DOIUrl":"https://doi.org/10.46439/toxicology.3.012","url":null,"abstract":"","PeriodicalId":8227,"journal":{"name":"Archives of clinical toxicology","volume":"54 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91399549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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