The Naples prognostic score (NPS) is a novel multidimensional inflammatory and nutritional assessment system in cancer patients. However, its significance in patients with chronic kidney disease (CKD) after percutaneous coronary intervention (PCI) remains unclear. The study has a single-center, retrospective design and included 631 patients with CKD who underwent index PCI between 2019 and 2022. All participants were divided into 2 groups according to the NPS (Low-risk group: n = 209; High-risk group: n = 422) and followed up until November 2022. The primary endpoint was Major Adverse Cardiac Events (MACE). NPS predicted MACE events better than other scores, besides, high-risk NPS with severe renal dysfunction (RD) group (MODEL 2) had superior MACE diagnostic efficiency than NPS high-risk group lonely. (NPS: AUC: 0.605, P < .001; MODEL 2: AUC: 0.624, P < .001, respectively). Kaplan-Meier survival analysis of two groups showed that high-risk group had higher incidence of MACE (P < .001). Meanwhile, high-risk group had higher MACE events [adjusted Hazard Ratio (aHR) 2.013, 95% CI 1.294, 3.132; P = .002]. NPS is an independent prognostic factor for CKD patients undergoing index PCI before operation whose predictive value for survival prognosis is better than other nutritional and inflammatory indicators. Compared with low NPS, patients with high NPS have a relatively poor prognosis.
{"title":"Predictive Value of the Naples Prognostic Score for Cardiovascular Outcomes in Patients With Chronic Kidney Disease Receiving Percutaneous Coronary Intervention.","authors":"Xue Zhang, Jing-Kun Zhang, Xue Wu, Xing Liu, Tong Liu, Kang-Yin Chen","doi":"10.1177/00033197241285970","DOIUrl":"https://doi.org/10.1177/00033197241285970","url":null,"abstract":"<p><p>The Naples prognostic score (NPS) is a novel multidimensional inflammatory and nutritional assessment system in cancer patients. However, its significance in patients with chronic kidney disease (CKD) after percutaneous coronary intervention (PCI) remains unclear. The study has a single-center, retrospective design and included 631 patients with CKD who underwent index PCI between 2019 and 2022. All participants were divided into 2 groups according to the NPS (Low-risk group: <i>n</i> = 209; High-risk group: <i>n</i> = 422) and followed up until November 2022. The primary endpoint was Major Adverse Cardiac Events (MACE). NPS predicted MACE events better than other scores, besides, high-risk NPS with severe renal dysfunction (RD) group (MODEL 2) had superior MACE diagnostic efficiency than NPS high-risk group lonely. (NPS: AUC: 0.605, <i>P</i> < .001; MODEL 2: AUC: 0.624, <i>P</i> < .001, respectively). Kaplan-Meier survival analysis of two groups showed that high-risk group had higher incidence of MACE (<i>P</i> < .001). Meanwhile, high-risk group had higher MACE events [adjusted Hazard Ratio (aHR) 2.013, 95% CI 1.294, 3.132; <i>P</i> = .002]. NPS is an independent prognostic factor for CKD patients undergoing index PCI before operation whose predictive value for survival prognosis is better than other nutritional and inflammatory indicators. Compared with low NPS, patients with high NPS have a relatively poor prognosis.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197241285970"},"PeriodicalIF":2.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1177/00033197241273433
Nicholas Weight,Saadiq Moledina,Claire A Lawson,Harriette G C Van Spall,Harindra C Wijeysundera,Muhammad Rashid,Evangelos Kontopantelis,Mamas A Mamas
Patients with lower socioeconomic status (SES) have poorer outcomes following acute myocardial infarction (AMI) than patients with higher SES; however, how sex modifies socioeconomic differences is unclear. Using the United Kingdom (UK) Myocardial Ischaemia National Audit Project (MINAP) registry, alongside Office of National Statistics (ONS) mortality data, we analyzed 736,420 AMI patients between 2005 and 2018, stratified by Index of Multiple Deprivation (IMD) score Quintiles (most affluent [Q1] to most deprived [Q5]). There was no significant difference in probability of in-hospital mortality in our adjusted model according to sex. The probability of 30-day mortality in our adjusted model was similar between men and women throughout Quintiles, ((Q5; Men 7.6%; 95% CI 7.3-7.8% (P < .001), Women; 7.0%; 95% CI 6.8-7.3%, P < .001)) ((Q1; Men 7.1%; 95% CI 6.8-7.4%, P < .001, Women; 6.9%; 95% CI 6.6-7.1%, P < .001)). The probability of one-year mortality in our adjusted model was higher in men throughout all Quintiles (Q1; Men 15.0%; 95% CI 14.8-15.6%), P < .001, Women; 14.5%; 95% CI 14.2-14.9%, P < .001) (Q5; Men 16.9%; 95% CI 16.5-17.3%, P < .001, Women; 15.5%; 95% CI 15.1-15.9 by %, P < .001). Overall, female sex did not significantly influence the effect of deprivation on AMI processes of care and outcomes.
与社会经济地位较高的患者相比,社会经济地位较低的患者在急性心肌梗死(AMI)后的预后较差;然而,性别如何改变社会经济差异尚不清楚。我们利用英国心肌缺血国家审计项目(MINAP)登记册和英国国家统计局(ONS)的死亡率数据,对2005年至2018年间的736420名急性心肌梗死患者进行了分析,并按多重贫困指数(IMD)五分法(最富裕[Q1]至最贫困[Q5])进行了分层。在我们的调整模型中,院内死亡概率与性别无明显差异。在我们的调整模型中,男性和女性在整个五分位数中的30天死亡率概率相似((Q5;男性7.6%;95% CI 7.3-7.8% (P < .001),女性7.0%;95% CI 6.8-7.3%, P < .001))((Q1;男性7.1%;95% CI 6.8-7.4%, P < .001,女性6.9%;95% CI 6.6-7.1%, P < .001))。在我们的调整模型中,男性在所有五分位数中的一年期死亡率均较高(Q1;男性 15.0%;95% CI 14.8-15.6%,P < .001,女性 14.5%;95% CI 14.2-14.9%,P < .001)(Q5;男性 16.9%;95% CI 16.5-17.3%,P < .001,女性 15.5%;95% CI 15.1-15.9%,P < .001)。总体而言,女性性别对贫困对急性心肌梗死护理过程和结果的影响没有明显影响。
{"title":"The Intersection of Socioeconomic Differences and Sex in the Management and Outcomes of Acute Myocardial Infarction: A Nationwide Cohort Study.","authors":"Nicholas Weight,Saadiq Moledina,Claire A Lawson,Harriette G C Van Spall,Harindra C Wijeysundera,Muhammad Rashid,Evangelos Kontopantelis,Mamas A Mamas","doi":"10.1177/00033197241273433","DOIUrl":"https://doi.org/10.1177/00033197241273433","url":null,"abstract":"Patients with lower socioeconomic status (SES) have poorer outcomes following acute myocardial infarction (AMI) than patients with higher SES; however, how sex modifies socioeconomic differences is unclear. Using the United Kingdom (UK) Myocardial Ischaemia National Audit Project (MINAP) registry, alongside Office of National Statistics (ONS) mortality data, we analyzed 736,420 AMI patients between 2005 and 2018, stratified by Index of Multiple Deprivation (IMD) score Quintiles (most affluent [Q1] to most deprived [Q5]). There was no significant difference in probability of in-hospital mortality in our adjusted model according to sex. The probability of 30-day mortality in our adjusted model was similar between men and women throughout Quintiles, ((Q5; Men 7.6%; 95% CI 7.3-7.8% (P < .001), Women; 7.0%; 95% CI 6.8-7.3%, P < .001)) ((Q1; Men 7.1%; 95% CI 6.8-7.4%, P < .001, Women; 6.9%; 95% CI 6.6-7.1%, P < .001)). The probability of one-year mortality in our adjusted model was higher in men throughout all Quintiles (Q1; Men 15.0%; 95% CI 14.8-15.6%), P < .001, Women; 14.5%; 95% CI 14.2-14.9%, P < .001) (Q5; Men 16.9%; 95% CI 16.5-17.3%, P < .001, Women; 15.5%; 95% CI 15.1-15.9 by %, P < .001). Overall, female sex did not significantly influence the effect of deprivation on AMI processes of care and outcomes.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":"100 1","pages":"33197241273433"},"PeriodicalIF":2.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-15DOI: 10.1177/00033197241284958
{"title":"Corrigendum to \"Clinical Characteristics and Management of Peripancreatic Arterial Aneurysms: A 20-Year Experience\".","authors":"","doi":"10.1177/00033197241284958","DOIUrl":"https://doi.org/10.1177/00033197241284958","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197241284958"},"PeriodicalIF":2.6,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-14DOI: 10.1177/00033197241285277
De-Gang Mo
{"title":"Letter: Insights and Limitations of CRP-Albumin Ratio as a Biomarker for Carotid In-Stent Restenosis","authors":"De-Gang Mo","doi":"10.1177/00033197241285277","DOIUrl":"https://doi.org/10.1177/00033197241285277","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":"3 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-14DOI: 10.1177/00033197241284378
Senol Arslan, Halil İbrahim Doru, Nazım Onur Can, Furkan Akpınar, Sidar Şiyar Aydın
Although there are many scoring systems for acute coronary syndromes, there is no suitable score for early risk stratification during initial medical contact with non-ST-elevation myocardial infarction (NSTEMI) patients. The present study compared the Rapid Emergency Medicine Score (REMS), an easy-to-use scoring system in emergency departments, with the Global Registry of Acute Coronary Events (GRACE) score used for in-hospital mortality risk stratification of NSTEMI patients. The results were: (i) the REMS score outperformed the GRACE score in predicting the in-hospital mortality; (ii) in estimating in-hospital mortality, the sensitivity of the GRACE score was 88%, the specificity was 65%, while the sensitivity of the REMS score was 100% and the specificity was 76%; (iii) the AUC (Area Under Curve) value of the REMS score (AUC 0.89) was superior to the GRACE score (AUC 0.79) in the data obtained from Receiver operating characteristic (ROC) descriptive analysis, but not statistically significant ( P > .05). We suggest that the REMS score can be used to predict in-hospital mortality in patients with NSTEMI.
{"title":"Comparison of Global Registry of Acute Coronary Events and Rapid Emergency Medicine Scores in In-Hospital Mortality of Patients Admitted to the Emergency Service and Diagnosed with Non-ST-Segment Elevation Myocardial Infarction","authors":"Senol Arslan, Halil İbrahim Doru, Nazım Onur Can, Furkan Akpınar, Sidar Şiyar Aydın","doi":"10.1177/00033197241284378","DOIUrl":"https://doi.org/10.1177/00033197241284378","url":null,"abstract":"Although there are many scoring systems for acute coronary syndromes, there is no suitable score for early risk stratification during initial medical contact with non-ST-elevation myocardial infarction (NSTEMI) patients. The present study compared the Rapid Emergency Medicine Score (REMS), an easy-to-use scoring system in emergency departments, with the Global Registry of Acute Coronary Events (GRACE) score used for in-hospital mortality risk stratification of NSTEMI patients. The results were: (i) the REMS score outperformed the GRACE score in predicting the in-hospital mortality; (ii) in estimating in-hospital mortality, the sensitivity of the GRACE score was 88%, the specificity was 65%, while the sensitivity of the REMS score was 100% and the specificity was 76%; (iii) the AUC (Area Under Curve) value of the REMS score (AUC 0.89) was superior to the GRACE score (AUC 0.79) in the data obtained from Receiver operating characteristic (ROC) descriptive analysis, but not statistically significant ( P > .05). We suggest that the REMS score can be used to predict in-hospital mortality in patients with NSTEMI.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":"18 1","pages":"33197241284378"},"PeriodicalIF":2.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdominal aortic aneurysm (AAA) is a chronic vascular disease that commonly affects elderly individuals but has recently increased in younger populations. As the aneurysm grows, it can cause compression symptoms such as abdominal pain, rupture, and bleeding, which are absent in the early stages. Once an AAA ruptures and causes bleeding, the mortality rate is alarmingly high. Currently, the pathogenesis for AAA is unknown, and therapeutic options are limited, necessitating improvement in treatment efficacy. An essential research method for studying the processes and potential treatment of AAA is establishing animal models using mice. The present study provides a detailed overview of the widely used AAA mouse animal models and their construction strategies, advantages, disadvantages, scope of applications, and prospects.
{"title":"Establishment of Mouse Models of Abdominal Aortic Aneurysm","authors":"Yongpan Cui, Chengpeng Tan, Wuming Zhang, Peng Jiang, Jianfeng Sun, Fei Mei","doi":"10.1177/00033197241284848","DOIUrl":"https://doi.org/10.1177/00033197241284848","url":null,"abstract":"Abdominal aortic aneurysm (AAA) is a chronic vascular disease that commonly affects elderly individuals but has recently increased in younger populations. As the aneurysm grows, it can cause compression symptoms such as abdominal pain, rupture, and bleeding, which are absent in the early stages. Once an AAA ruptures and causes bleeding, the mortality rate is alarmingly high. Currently, the pathogenesis for AAA is unknown, and therapeutic options are limited, necessitating improvement in treatment efficacy. An essential research method for studying the processes and potential treatment of AAA is establishing animal models using mice. The present study provides a detailed overview of the widely used AAA mouse animal models and their construction strategies, advantages, disadvantages, scope of applications, and prospects.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-11DOI: 10.1177/00033197241280527
Dan Yang,Kexin Li,Qiujuan Zhang,Tian Yu,Ling Liu,You Wang,Shuyuan Kang,Shumiao Song,Baofeng Xu,Rui Liu
We investigated the effect of sex and age on the association between serum creatinine/cystatin C (CCR) ratio and carotid plaque in patients with type 2 diabetes mellitus (T2DM). The carotid plaque group and the non-plaque group were divided according to cervical vascular ultrasound; the general and biochemical data of the two groups were compared according to CCR, gender, and age. Binary logistic regression was used to analyze the factors influencing carotid plaque. A total of 1429 patients with T2DM were included in this study. On multivariate analysis, CCR was an independent predictor of carotid plaque with an adjusted odds ratio (OR) of 1.681 [1.250-2.260]. The risk of carotid plaque in men with T2DM increased significantly (P < .05) with decreasing levels of CCR. In addition, an association between CCR and carotid plaque was found in individuals with T2DM <65 years of age (P < .05). CCR is strongly associated with the risk of carotid plaques in persons with T2DM and are an independent risk factor for carotid plaques in men and people aged <65 years with T2DM.
{"title":"Sex and Age Influence the Relationship Between Serum Creatinine/Cystatin C and Carotid Plaque in Patients With Type 2 Diabetes Mellitus.","authors":"Dan Yang,Kexin Li,Qiujuan Zhang,Tian Yu,Ling Liu,You Wang,Shuyuan Kang,Shumiao Song,Baofeng Xu,Rui Liu","doi":"10.1177/00033197241280527","DOIUrl":"https://doi.org/10.1177/00033197241280527","url":null,"abstract":"We investigated the effect of sex and age on the association between serum creatinine/cystatin C (CCR) ratio and carotid plaque in patients with type 2 diabetes mellitus (T2DM). The carotid plaque group and the non-plaque group were divided according to cervical vascular ultrasound; the general and biochemical data of the two groups were compared according to CCR, gender, and age. Binary logistic regression was used to analyze the factors influencing carotid plaque. A total of 1429 patients with T2DM were included in this study. On multivariate analysis, CCR was an independent predictor of carotid plaque with an adjusted odds ratio (OR) of 1.681 [1.250-2.260]. The risk of carotid plaque in men with T2DM increased significantly (P < .05) with decreasing levels of CCR. In addition, an association between CCR and carotid plaque was found in individuals with T2DM <65 years of age (P < .05). CCR is strongly associated with the risk of carotid plaques in persons with T2DM and are an independent risk factor for carotid plaques in men and people aged <65 years with T2DM.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":"6 1","pages":"33197241280527"},"PeriodicalIF":2.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-06DOI: 10.1177/00033197241280703
Yusuf Ziya Şener, Alexandr Ceasovschih
{"title":"Letter: The Role of Medical Treatment on Outcomes After Endovascular Revascularization of Infrainguinal Peripheral Artery Disease.","authors":"Yusuf Ziya Şener, Alexandr Ceasovschih","doi":"10.1177/00033197241280703","DOIUrl":"https://doi.org/10.1177/00033197241280703","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197241280703"},"PeriodicalIF":2.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-02-22DOI: 10.1177/00033197241235757
Xiaocong Liu, Yanan Zhang, Yan Li, Cuiping Lv
{"title":"Letter: Adropin as a Novel Biomarker of Endothelial Dysfunction in Patients With Preeclampsia.","authors":"Xiaocong Liu, Yanan Zhang, Yan Li, Cuiping Lv","doi":"10.1177/00033197241235757","DOIUrl":"10.1177/00033197241235757","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"800-801"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139929718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Endothelial dysfunction (ED) plays a prominent role in the pathogenesis of preeclampsia (PE). There is a need for non-invasive methods to assess endothelial function in preeclamptic patients. In the present study, adropin, autotaxin (ATX), and lysophosphatidic acid (LPA) were evaluated as indicators of ED. Patients diagnosed with PE and healthy pregnant women (n = 42 for each group) were compared. After measuring flow-mediated dilation (FMD), the participants were stratified as ED (+) or ED (-) based on a cut-off value of 6.5%. The PE patients were divided as early/late onset PE and severe/mild PE. Adropin, ATX, and LPA levels were measured, and their relevance to ED was evaluated. Student t, Mann-Whitney U, or ANOVA tests were used for statistics, as appropriate. Adropin levels were diminished in the ED (+) group, whereas ATX and LPA levels were increased. The decrease in adropin levels was more pronounced in severe PE, showing a positive correlation with the FMD. In the logistic regression model, adropin was the only parameter that was an independent variable for the FMD test (P < .001). Adropin measurements in serum may be of value for disease follow-up in patients with PE.
内皮功能障碍(ED)在子痫前期(PE)的发病机制中起着重要作用。目前需要一种非侵入性方法来评估子痫前期患者的内皮功能。在本研究中,阿托品、自体表皮生长因子(ATX)和溶血磷脂酸(LPA)被作为 ED 的指标进行评估。对确诊为 PE 的患者和健康孕妇(每组 42 人)进行了比较。在测量血流介导的扩张(FMD)后,根据 6.5% 的临界值将参与者分为 ED(+)和 ED(-)两组。PE 患者分为早发/晚发 PE 和重度/轻度 PE。测量了Adropin、ATX和LPA水平,并评估了它们与ED的相关性。根据情况采用学生 t 检验、曼-惠特尼 U 检验或方差分析进行统计。ED(+)组的促肾上腺皮质激素水平降低,而ATX和LPA水平升高。在重度 PE 中,促肾上腺皮质激素水平的下降更为明显,与 FMD 呈正相关。在逻辑回归模型中,阿托品是 FMD 测试的唯一自变量参数(P < .001)。血清中阿托品的测量值可能对 PE 患者的疾病随访有价值。
{"title":"The Evaluation of Adropin and Autotaxin as Potential Markers of Endothelial Dysfunction in Preeclampsia.","authors":"Ece Karaca, Celal Caner Ercan, Celal Akdemir, Tugba Sarac Sivrikoz, Artur Salmaslioglu, Fatma Ferda Verit, Figen Gurdol, Beyhan Omer","doi":"10.1177/00033197231183228","DOIUrl":"10.1177/00033197231183228","url":null,"abstract":"<p><p>Endothelial dysfunction (ED) plays a prominent role in the pathogenesis of preeclampsia (PE). There is a need for non-invasive methods to assess endothelial function in preeclamptic patients. In the present study, adropin, autotaxin (ATX), and lysophosphatidic acid (LPA) were evaluated as indicators of ED. Patients diagnosed with PE and healthy pregnant women (n = 42 for each group) were compared. After measuring flow-mediated dilation (FMD), the participants were stratified as ED (+) or ED (-) based on a cut-off value of 6.5%. The PE patients were divided as early/late onset PE and severe/mild PE. Adropin, ATX, and LPA levels were measured, and their relevance to ED was evaluated. Student t, Mann-Whitney U, or ANOVA tests were used for statistics, as appropriate. Adropin levels were diminished in the ED (+) group, whereas ATX and LPA levels were increased. The decrease in adropin levels was more pronounced in severe PE, showing a positive correlation with the FMD. In the logistic regression model, adropin was the only parameter that was an independent variable for the FMD test (P < .001). Adropin measurements in serum may be of value for disease follow-up in patients with PE.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"779-785"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10011770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}