Pub Date : 2020-06-01DOI: 10.23736/s0393-3660.19.04171-8
C. Correia, José G. Freitas, A. Martins, Jorge Oliveira
{"title":"Primary adrenal failure and central nervous system lesions: a rare case report of primary adrenal lymphoma","authors":"C. Correia, José G. Freitas, A. Martins, Jorge Oliveira","doi":"10.23736/s0393-3660.19.04171-8","DOIUrl":"https://doi.org/10.23736/s0393-3660.19.04171-8","url":null,"abstract":"","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74627950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.23736/s0393-3660.19.04072-5
Kelsi J. Wood, W. Berg, N. Salcedo, M. Walsh, Kelsey L. Biller
{"title":"The effects of closed and open kinetic chain exercise on strength and onset timing of hip musculature and dynamic knee valgus in women","authors":"Kelsi J. Wood, W. Berg, N. Salcedo, M. Walsh, Kelsey L. Biller","doi":"10.23736/s0393-3660.19.04072-5","DOIUrl":"https://doi.org/10.23736/s0393-3660.19.04072-5","url":null,"abstract":"","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73505363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.23736/s0393-3660.19.04153-6
Kenji Taninobu, M. Miura, S. Shirai, Masaomi Hayashi, M. Ishibashi, H. Takiguchi, S. Ito, Mariko Yano, T. Kawaguchi, Takashi Morinaga, Akihiro Isotani, S. Kakumoto, K. Seo, Y. Arai, G. Sakaguchi, K. Ando
{"title":"Transcatheter aortic valve implantation for patients with low left ventricular ejection fraction under prophylactic use of veno-arterial extracorporeal membrane oxygenation","authors":"Kenji Taninobu, M. Miura, S. Shirai, Masaomi Hayashi, M. Ishibashi, H. Takiguchi, S. Ito, Mariko Yano, T. Kawaguchi, Takashi Morinaga, Akihiro Isotani, S. Kakumoto, K. Seo, Y. Arai, G. Sakaguchi, K. Ando","doi":"10.23736/s0393-3660.19.04153-6","DOIUrl":"https://doi.org/10.23736/s0393-3660.19.04153-6","url":null,"abstract":"","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73577267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.23736/s0393-3660.19.04197-4
Inês Albuquerque, Inês Nogueira, Iolanda Vieira, V. Chaves, Inês Ferreira, P. Rodrigues, Manuela Dias, Jorge Almeida
{"title":"Paraneoplastic microangiopathic anemia with thrombocytopenia","authors":"Inês Albuquerque, Inês Nogueira, Iolanda Vieira, V. Chaves, Inês Ferreira, P. Rodrigues, Manuela Dias, Jorge Almeida","doi":"10.23736/s0393-3660.19.04197-4","DOIUrl":"https://doi.org/10.23736/s0393-3660.19.04197-4","url":null,"abstract":"","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89219537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.23736/s0393-3660.19.04132-9
A. Yordanov, I. Iliev, Latchezar S. Tanchev, P. Vasileva, S. Strashilov, Denis H. Farhat
{"title":"Unconventional myomectomy for large nascent myoma","authors":"A. Yordanov, I. Iliev, Latchezar S. Tanchev, P. Vasileva, S. Strashilov, Denis H. Farhat","doi":"10.23736/s0393-3660.19.04132-9","DOIUrl":"https://doi.org/10.23736/s0393-3660.19.04132-9","url":null,"abstract":"","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91485823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.23736/s0393-3660.19.04061-0
P. Tsaklis
{"title":"A method for modification of aerobic training intensity for special and general populations","authors":"P. Tsaklis","doi":"10.23736/s0393-3660.19.04061-0","DOIUrl":"https://doi.org/10.23736/s0393-3660.19.04061-0","url":null,"abstract":"","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79744680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-01DOI: 10.23736/S0393-3660.19.04036-1
J. Mizuno, M. Otsuji, Y. Fukuoka, Yasuhiro Tanaka, M. Ohishi, Y. Hata, T. Yokoyama, Hideko Arita, K. Hanaoka
{"title":"Hybrid logistic function characterization of left ventricular pressure-time curve in left heart catheterization","authors":"J. Mizuno, M. Otsuji, Y. Fukuoka, Yasuhiro Tanaka, M. Ohishi, Y. Hata, T. Yokoyama, Hideko Arita, K. Hanaoka","doi":"10.23736/S0393-3660.19.04036-1","DOIUrl":"https://doi.org/10.23736/S0393-3660.19.04036-1","url":null,"abstract":"","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77827181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-01DOI: 10.23736/s0393-3660.19.04030-0
V. Pizzimenti, D. Formica, J. Sultana, Simona Lucchesi, A. Aiello, Valentina Ientile, G. Trifirò
BACKGROUND: In Italy, pharmaceutical market access depends on European Medicines Agency (EMA), Italian national drug agency (AIFA) and regional regulatory procedures (Sicilian Drug Formulary Committee). The regulatory and economic outcomes of the Sicilian Regional Drug Formulary Committee have not yet been described. The objective of this study was to quantify: 1) the number of drugs approved regionally; 2) the drug review time by European, national and regional competent authorities; 3) regional healthcare expenditure associated with the approved drugs. METHODS: All drugs approved by the Sicilian Drug Formulary Committee between 1st January 2013 to 1st April 2016 were identified. For these drugs, the median (with interquartile range, IQR) approval time taken by the European, national and regional competent authorities were estimated for all drugs and innovative drugs separately. Finally, the economic impact of regional regulatory decisions was estimated one year after drug approval. RESULTS: In total 117 drugs were approved. Median (IQR) time between EMA and AIFA approval was 1.17 years (0.93-1.66), while between AIFA and the Sicilian regional approval this was 0.35 years (0.27-0.94). The time elapsed for innovative drugs was 0.91 years (IQR: 0.66-1.75) between EMA and AIFA and 0.13 years (IQR: 0.02-0.25) between AIFA and Sicilian regional approval. Regional drug approvals were associated with a yearly cost of 525,489,586. CONCLUSIONS: The approval of 117 drugs over 3 years was associated with a 525 million pharmaceutical expenditure yearly. The total median time for pharmaceutical market access in Sicily was 1.52 years, and 1.04 years for innovative drugs.
{"title":"Access of medicines to the market: three years' experience of Sicily's regional drug formulary","authors":"V. Pizzimenti, D. Formica, J. Sultana, Simona Lucchesi, A. Aiello, Valentina Ientile, G. Trifirò","doi":"10.23736/s0393-3660.19.04030-0","DOIUrl":"https://doi.org/10.23736/s0393-3660.19.04030-0","url":null,"abstract":"BACKGROUND: In Italy, pharmaceutical market access depends on European Medicines Agency (EMA), Italian national drug agency (AIFA) and regional regulatory procedures (Sicilian Drug Formulary Committee). The regulatory and economic outcomes of the Sicilian Regional Drug Formulary Committee have not yet been described. The objective of this study was to quantify: 1) the number of drugs approved regionally; 2) the drug review time by European, national and regional competent authorities; 3) regional healthcare expenditure associated with the approved drugs. METHODS: All drugs approved by the Sicilian Drug Formulary Committee between 1st January 2013 to 1st April 2016 were identified. For these drugs, the median (with interquartile range, IQR) approval time taken by the European, national and regional competent authorities were estimated for all drugs and innovative drugs separately. Finally, the economic impact of regional regulatory decisions was estimated one year after drug approval. RESULTS: In total 117 drugs were approved. Median (IQR) time between EMA and AIFA approval was 1.17 years (0.93-1.66), while between AIFA and the Sicilian regional approval this was 0.35 years (0.27-0.94). The time elapsed for innovative drugs was 0.91 years (IQR: 0.66-1.75) between EMA and AIFA and 0.13 years (IQR: 0.02-0.25) between AIFA and Sicilian regional approval. Regional drug approvals were associated with a yearly cost of 525,489,586. CONCLUSIONS: The approval of 117 drugs over 3 years was associated with a 525 million pharmaceutical expenditure yearly. The total median time for pharmaceutical market access in Sicily was 1.52 years, and 1.04 years for innovative drugs.","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74361978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.23736/s0393-3660.19.04045-2
I. Zelenkova, Sergey Zotkin, P. Korneev, Sergey V. Koprov, D. Almiashev, A. Grushin, O. Glazachev
{"title":"Individual variation in hypoxic tolerance across athletes of different level and sport specialisations","authors":"I. Zelenkova, Sergey Zotkin, P. Korneev, Sergey V. Koprov, D. Almiashev, A. Grushin, O. Glazachev","doi":"10.23736/s0393-3660.19.04045-2","DOIUrl":"https://doi.org/10.23736/s0393-3660.19.04045-2","url":null,"abstract":"","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84934616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.23736/s0393-3660.19.04213-x
V. Chaves, G. Rosa, F. M. Nogueira, S. Tavares, Inês Ferreira, Verónica Guiomar, A. Ferreira, E. Ferreira
{"title":"A rare case of familial cerebral cavernous angioma presenting with seizure","authors":"V. Chaves, G. Rosa, F. M. Nogueira, S. Tavares, Inês Ferreira, Verónica Guiomar, A. Ferreira, E. Ferreira","doi":"10.23736/s0393-3660.19.04213-x","DOIUrl":"https://doi.org/10.23736/s0393-3660.19.04213-x","url":null,"abstract":"","PeriodicalId":8358,"journal":{"name":"Archivio per le scienze mediche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77965703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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