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Office-Based Steroid Injections for Idiopathic Subglottic Stenosis: Patient-Reported Outcomes, Effect on Stenosis, and Side Effects 基于办公室的类固醇注射治疗特发性声门下狭窄:患者报告的结果、对狭窄的影响和副作用
Pub Date : 2019-11-20 DOI: 10.1177/0003489419889066
M. R. Hoffman, D. Francis, Johnny P. Mai, S. Dailey
Objective: Office-based steroid injection has shown promise for idiopathic subglottic stenosis (iSGS). It is important to understand safety and patient-lived experience. We report patient experience related to airway restriction, voice, and side effects. Methods: Sixteen patients (51 ± 14 years) with mild-moderate (20-50%) stenosis undergoing office-based transnasal steroid injections were included; fourteen had prior operations. Patients typically underwent three injections, 1 month apart, followed by transnasal tracheoscopy 1 month later to evaluate outcome; number of injections can vary based on disease severity and response. Outcomes were Dyspnea Index (DI), Modified Medical Research Council (MMRC) dyspnea scale, voice handicap index-10 (VHI-10), and degree of stenosis (estimated from procedural video). At each visit, patients were queried about post-injection airway restriction and side effects. Paired t-tests compared values at baseline versus follow-up tracheoscopy. Results: DI decreased (t = 3.938, P = 0.0013), as did MMRC (t = 2.179, P = 0.0457). There was no change in VHI-10 (t = 1.354; P = 0.1957) scores. Airway stenosis decreased (t = 4.331; P = 0.0006); this was not correlated with change in DI (r = 0.267, P = 0.318). Side effects included airway restriction lasting <48 hours (n = 5), cough (n = 3), and nasal pain (n = 2). Conclusion: Steroid injections improved upper airway symptoms. Side effects were mild and transient. Improvement in DI did not correlate with percent stenosis.
目的:以办公室为基础的类固醇注射治疗特发性声门下狭窄(iSGS)有希望。了解安全性和患者生活体验是很重要的。我们报告与气道限制,声音和副作用相关的患者经验。方法:纳入16例(51±14岁)轻中度(20-50%)狭窄患者,接受办公室经鼻类固醇注射;其中14人之前做过手术。患者通常接受三次注射,间隔1个月,1个月后进行经鼻气管镜检查以评估结果;注射次数可根据疾病的严重程度和反应而变化。结果为呼吸困难指数(DI)、改良医学研究委员会(MMRC)呼吸困难量表、语音障碍指数-10 (VHI-10)和狭窄程度(根据手术录像估计)。在每次访问时,询问患者注射后气道限制和副作用。配对t检验比较了基线值与随访气管镜检查值。结果:DI降低(t = 3.938, P = 0.0013), MMRC降低(t = 2.179, P = 0.0457)。VHI-10无变化(t = 1.354;P = 0.1957)分数。气道狭窄减少(t = 4.331;p = 0.0006);这与DI变化无关(r = 0.267, P = 0.318)。副作用包括持续<48小时的气道受限(n = 5)、咳嗽(n = 3)和鼻痛(n = 2)。结论:类固醇注射可改善上呼吸道症状。副作用轻微且短暂。DI的改善与狭窄百分比无关。
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引用次数: 23
Identifying Disadvantaged Groups for Cochlear Implantation: Demographics from a Large Cochlear Implant Program 识别人工耳蜗植入的弱势群体:来自大型人工耳蜗植入项目的人口统计数据
Pub Date : 2019-11-18 DOI: 10.1177/0003489419888232
Anthony M. Tolisano, Natalie Schauwecker, Bethany Baumgart, Johanna Whitson, J. Kutz, B. Isaacson, Jacob B. Hunter
Objective: To identify demographic predictors of patients undergoing cochlear implantation evaluation and surgery. Methods: Consecutive adult patients between 2009 and 2018 who underwent cochlear implantation evaluation at a university cochlear implantation program were retrospectively identified to determine (1) cochlear implantation qualification rate and (2) pursuit of surgery rate with respect to age, gender, race, primary spoken language, marital status, insurance type, and distance to the cochlear implantation center. Results: A total of 823 cochlear implantation evaluations were analyzed. Overall, 76.3% of patients qualified for cochlear implantation and 61.5% of these patients pursued surgery. Age was the only independent predictor for cochlear implantation qualification, such that, for each year younger, the odds of qualifying for cochlear implantation increased by 2.5% (OR 0.98; 95% CI: 0.96-0.99). Age, race, marital status, and insurance type were each independent predictors of the decision to pursue surgery. The odds of pursuing surgery increased by 2.8% for each year younger (OR 1.03; 95% CI: 1.01-1.05). Compared to White patients, non-Whites were half as likely to pursue surgery (OR 0.47; 95% CI: 0.25-0.88). Single (OR 0.49; 95% CI: 0.26-0.94) and widowed patients (OR 0.46; 95% CI: 0.23-0.95) were about half as likely to pursue surgery as compared to married patients. Patients with military insurance were 13 times more likely to pursue surgery as compared to patients with Medicare (OR 13.0; 95% CI: 1.67-101.4). Conclusion: Younger age is an independent predictor for a higher cochlear implantation qualification rate, suggesting the possibility for delayed candidacy referral. Rate of surgical pursuit in qualified cochlear implantation candidates is lower for racial minorities, single and widowed patients, and older patients.
目的:探讨人工耳蜗植入评估及手术患者的人口学预测因素。方法:回顾性分析2009年至2018年在某高校人工耳蜗植入项目接受人工耳蜗植入评估的连续成年患者,根据年龄、性别、种族、主要语言、婚姻状况、保险类型、与人工耳蜗植入中心的距离等因素,确定(1)人工耳蜗植入合格率和(2)手术追求率。结果:对823例人工耳蜗植入评价进行分析。总体而言,76.3%的患者符合人工耳蜗植入条件,其中61.5%的患者接受手术。年龄是人工耳蜗植入合格的唯一独立预测因素,因此,年龄越小,人工耳蜗植入合格的几率增加2.5% (OR 0.98;95% ci: 0.96-0.99)。年龄、种族、婚姻状况和保险类型都是决定进行手术的独立预测因素。年龄越小,接受手术的几率增加2.8% (OR 1.03;95% ci: 1.01-1.05)。与白人患者相比,非白人患者接受手术的可能性是白人患者的一半(OR 0.47;95% ci: 0.25-0.88)。单个(OR 0.49;95% CI: 0.26-0.94)和丧偶患者(OR 0.46;95% CI: 0.23-0.95),与已婚患者相比,接受手术的可能性约为前者的一半。与医疗保险患者相比,有军事保险的患者接受手术的可能性高13倍(OR 13.0;95% ci: 1.67-101.4)。结论:年龄较小是人工耳蜗植入合格率较高的独立预测因素,提示延迟候选转诊的可能性。少数民族、单身和丧偶患者以及老年患者中,合格的人工耳蜗植入候选人的手术追求率较低。
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引用次数: 30
The Nerve to Thyrohyoid Muscle as a Novel Donor Nerve for Laryngeal Reinnervation 甲状腺舌骨肌神经作为喉神经再支配的新供神经
Pub Date : 2019-11-18 DOI: 10.1177/0003489419888956
M. E. Graham, Marshall E. Smith
Objectives: Recurrent laryngeal nerve (RLN) injury may be a consequence of surgical procedures of the skull base, neck, and chest, with adverse consequences to function and quality of life. Laryngeal reinnervation offers a potentially stable improvement in vocal fold position and tone. The classic donor nerve is the ansa cervicalis, but is not always available due to damage or sacrifice during previous neck surgeries. Our objective was to introduce the nerve to the thyrohyoid (TH) muscle as an alternate donor nerve for reinnervation, which has not previously been described. Methods: Case series of two patients using the TH nerve for laryngeal reinnervation after RLN injury, with description of surgical harvest. Results: Follow-up results are available for 10 months (one patient) and 3 years (one patient) demonstrating both subjective and objective improvement in function. GRBAS scores were reduced. Maximal phonation time was improved. Patient rating of voice was stable or improved postoperatively. One patient described significant preoperative dyspnea which was significantly improved postoperatively, from a score of 24 to 10 out of 40 on the dyspnea handicap index. VHI was improved in one patient, but scores elevated in the other, despite a change from “moderately severe impairment” to “normal voice” subjectively. Neither patient experienced significant complications from the procedure. Conclusion: Laryngeal reinnervation procedures provide good outcomes in pediatric patients. When ansa cervicalis is not available as a donor nerve, the nerve to TH provides a reasonable alternative.
目的:喉返神经(RLN)损伤可能是颅底、颈部和胸部手术的结果,对功能和生活质量有不良影响。喉神经移植对声带位置和音色的改善具有潜在的稳定性。经典的供体神经是颈袢神经,但由于先前颈部手术的损伤或牺牲,并不总是可用的。我们的目的是将该神经引入甲状腺舌骨肌,作为替代供体神经进行再神经支配,这在以前没有被描述过。方法:选取2例RLN损伤后应用TH神经进行喉神经再支配的病例,并对手术收获情况进行描述。结果:随访10个月(1例)和3年(1例),主客观功能均有改善。GRBAS评分降低。最大发声时间得到改善。术后患者声音评分稳定或改善。一名患者描述了术前明显的呼吸困难,术后明显改善,呼吸困难障碍指数从24分到10分(满分40分)。一名患者的VHI得到了改善,但另一名患者的评分却有所上升,尽管主观上从“中度严重损害”变为“正常声音”。两名患者均未出现明显的手术并发症。结论:小儿喉神经移植治疗效果良好。当颈ansa不能作为供体神经时,通向TH的神经提供了一个合理的选择。
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引用次数: 7
Validity and Reliability of the Reflux Sign Assessment 反流体征评估的有效性和可靠性
Pub Date : 2019-11-15 DOI: 10.1177/0003489419888947
J. Lechien, A. Rodriguez Ruiz, D. Dequanter, F. Bobin, F. Mouawad, V. Muls, K. Huet, B. Harmegnies, Sarah Remacle, C. Finck, S. Saussez
Objective: To develop and validate the Reflux Sign Assessment (RSA), a clinical instrument evaluating the physical findings of laryngopharyngeal reflux (LPR). Methods: A total of 106 patients completed a 3-month treatment based on the association of diet, pantoprazole, alginate, or magaldrate with the LPR characteristics (acid, nonacid, mixed). Forty-two asymptomatic individuals completed the study (control group). The RSA results and reflux finding score (RFS) were documented for the LPR patients at baseline and after treatment. Intrarater reliability was assessed through a test-retest blinded evaluation of signs (7-day intervals). Interrater reliability was assessed by comparing the RSA evaluations of three blinded otolaryngologists through Kendall’s W. Responsiveness to change was evaluated through a comparison of the baseline and 3-month posttreatment findings. The RSA cutoffs for determining the presence and absence of LPR were examined by receiver operating characteristic (ROC) analysis. Results: A total of 102 LPR patients completed the study (68 females). The mean age was 53 years. The mean RSA at baseline was 25.95 ± 9.58; it significantly improved to 18.96 ± 7.58 after 3 months of therapy (P < .001). RSA exhibited good intra- (r = 0.813) and interrater (Kendall’s W = 0.663) reliabilities (N = 56). There was no significant association between the RSA, gastrointestinal endoscopy findings, and the types of reflux (acid, nonacid, or mixed) according to impedance-pH monitoring. An RSA >14 may be suggestive of LPR. Conclusion: The RSA is a complete clinical instrument evaluating both laryngeal and extralaryngeal findings associated with LPR. The RSA demonstrated high intra- and interrater reliabilities and responsiveness to change.
目的:研制并验证喉咽反流体征评估(RSA)——一种评估喉咽反流(LPR)体征的临床仪器。方法:106例患者根据饮食、泮托拉唑、海藻酸盐或magaldrate与LPR特征(酸、非酸、混合)的关联,完成了为期3个月的治疗。42名无症状个体完成了研究(对照组)。记录LPR患者基线和治疗后的RSA结果和反流发现评分(RFS)。通过对体征进行盲法评估(间隔7天)来评估事后信度。通过比较三位盲法耳鼻喉科医生的RSA评估,通过比较基线和治疗后3个月的结果,对变化的反应性进行评估。通过受试者工作特征(ROC)分析,确定LPR存在与否的RSA截止点。结果:共102例LPR患者完成研究(女性68例)。平均年龄为53岁。基线时平均RSA为25.95±9.58;治疗3个月后明显改善至18.96±7.58 (p14可能提示LPR)。结论:RSA是一种完整的临床仪器,可以评估与LPR相关的喉部和咽外表现。RSA显示了较高的内部和内部可靠性和对变化的响应能力。
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引用次数: 64
Utility of Audiometry in the Evaluation of Patients Presenting with Dysphonia 听力测量在评估语音障碍患者中的应用
Pub Date : 2019-11-15 DOI: 10.1177/0003489419889373
Justin Ross, William L. Valentino, A. Calder, David Bigly, S. Othman, B. McKinnon, R. Sataloff
Objectives: Hearing loss has been implicated in dysphonia secondary to voice misuse, although the data supporting this claim are scant. Determining the prevalence of hearing loss in patients with dysphonia and correlating it with self-perception of vocal handicap may help clarify the value of audiometry in evaluation of patients with dysphonia. Methods: This is a retrospective chart review of all new voice patients (n = 405) presenting with dysphonia to the primary investigator between 2015 and 2018. Each new patient routinely undergoes audiometric and voice objective analyses. Main outcomes measured include prevalence, severity of hearing loss, and voice handicap index-10 (VHI-10). Results: Of the 405 subjects reviewed, mean age was 49.0 years (SD = 17.4). 60.7% of subjects were female and 39.3% male. Patients with hearing loss defined as >25 dB in worse ear with pure tone average (PTA) thresholds at 0.5, 1, 2, and 3 kHz (PTA-S) accounted for 18% of the total cohort. The prevalence of previously undiagnosed hearing loss in this cohort was 13.1% (53 of 405 subjects). Of these subjects, 62.3% (33 subjects) reported no perception of hearing loss while 37.7% (20 subjects) suspected they had some hearing loss, yet never sought evaluation. Only increased PTA-S, speech discrimination, Reflux Symptom Index, and female gender demonstrated a significant relationship with VHI-10 when analyzed with multivariate linear regression analysis. Conclusions: The prevalence of hearing loss in patients presenting with dysphonia in this cohort is similar to normative population data. This study has also demonstrated that the majority of these patients did not perceive any hearing loss. The reasons behind this may be a result of or associated with the patients’ dysphonia. Furthermore, clinicians should consider performing audiometric evaluation in patients with abnormal VHI-10 scores in the appropriate clinical context.
目的:听力损失与继发于语音滥用的发声障碍有关,尽管支持这一说法的数据很少。确定发声障碍患者中听力损失的患病率,并将其与声带障碍的自我感知相关联,可能有助于阐明听力学在评价发声障碍患者中的价值。方法:对2015年至2018年期间向主要研究者报告的所有新发发声障碍患者(n = 405)进行回顾性图表回顾。每位新患者例行接受听力学和声音客观分析。测量的主要结果包括患病率、听力损失的严重程度和语音障碍指数-10 (VHI-10)。结果:405名受试者的平均年龄为49.0岁(SD = 17.4)。60.7%为女性,39.3%为男性。听力损失定义为较差耳>25 dB,纯音平均(PTA)阈值为0.5、1、2和3 kHz (PTA- s)的患者占总队列的18%。该队列中先前未确诊的听力损失患病率为13.1%(405名受试者中的53名)。在这些受试者中,62.3%(33人)报告没有感觉听力损失,37.7%(20人)怀疑他们有听力损失,但从未寻求评估。多因素线性回归分析显示,只有PTA-S、言语歧视、反流症状指数和女性性别升高与VHI-10有显著关系。结论:该队列中出现发音障碍的患者中听力损失的发生率与标准人群数据相似。这项研究还表明,大多数患者没有感觉到任何听力损失。这背后的原因可能是由于或与患者的语音障碍有关。此外,临床医生应考虑在适当的临床环境下对VHI-10评分异常的患者进行听力学评估。
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引用次数: 3
Pediatric Thyroidectomy: NSQIP-P Analysis of Adverse Perioperative Outcomes 儿童甲状腺切除术:NSQIP-P分析围手术期不良预后
Pub Date : 2019-11-15 DOI: 10.1177/0003489419889069
V. Patel, A. Khaku, M. Carr
Background: This study identifies risk factors and 30-day adverse outcomes of pediatric patients undergoing thyroidectomy. Methods: Retrospective analysis utilizing the American College of Surgeons National Surgical Quality Improvement–Pediatric Database (2015-2016). Study population includes pediatric patients (≤18 years) who underwent hemithyroidectomy (HT), total thyroidectomy (TT), and total thyroidectomy with central neck dissection (TT+ND). Results: A total of 720 cases were identified; mean age at time of surgery was 14.1 years, with a female-to-male ratio of 3.4:1. Following hospital discharge, there were 10 related readmissions, with 1 patient requiring reoperation for neck hematoma evacuation. Regression analysis revealed anesthesia time had a significant impact on total length of stay (P = .0020). Conclusion: Contemporary pediatric thyroidectomy has a low incidence of 30-day general surgical postoperative complications. Future research efforts are necessary once thyroidectomy specific variables are incorporated into ACS-NSQIP-P, which will provide further insights into managing this unique patient population.
背景:本研究确定了接受甲状腺切除术的儿科患者的危险因素和30天不良结局。方法:利用美国外科医师学会全国外科质量改进-儿科数据库(2015-2016)进行回顾性分析。研究人群包括接受甲状腺切除术(HT)、甲状腺全切除术(TT)和甲状腺全切除术合并中央颈部清扫术(TT+ND)的儿童患者(≤18岁)。结果:共发现病例720例;手术时平均年龄14.1岁,男女比例为3.4:1。出院后,有10例患者再次入院,其中1例患者因颈部血肿清除需要再次手术。回归分析显示麻醉时间对总住院时间有显著影响(P = 0.0020)。结论:当代小儿甲状腺切除术术后30天普通手术并发症发生率低。一旦将甲状腺切除术特异性变量纳入ACS-NSQIP-P,未来的研究工作是必要的,这将为管理这一独特的患者群体提供进一步的见解。
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引用次数: 11
Standard Setting of Competency in Mastoidectomy for the Cross-Institutional Mastoidectomy Assessment Tool 跨机构乳突切除术评估工具乳突切除术能力标准设定
Pub Date : 2019-11-15 DOI: 10.1177/0003489419889376
T. Kerwin, G. Wiet, Bradley Hittle, D. Stredney, P. De Boeck, A. Moberly, S. Andersen
Objective: Competency-based surgical training involves progressive autonomy given to the trainee. This requires systematic and evidence-based assessment with well-defined standards of proficiency. The objective of this study is to develop standards for the cross-institutional mastoidectomy assessment tool to inform decisions regarding whether a resident demonstrates sufficient skill to perform a mastoidectomy with or without supervision. Methods: A panel of fellowship-trained content experts in mastoidectomy was surveyed in relation to the 16 items of the assessment tool to determine the skills needed for supervised and unsupervised surgery. We examined the consensus score to investigate the degree of agreement among respondents for each survey item as well as additional analyses to determine whether the reported skill level required for each survey item was significantly different for the supervised versus unsupervised level. Results: Ten panelists representing different US training programs responded. There was considerable consensus on cut-off scores for each item and trainee level between panelists, with moderate (0.62) to very high (0.95) consensus scores depending on assessment item. Further analyses demonstrated that the difference between supervised and unsupervised skill levels was significantly meaningful for all items. Finally, minimum-passing scores for each item was established. Conclusion: We defined performance standards for the cross-institutional mastoidectomy assessment tool using the Angoff method. These cut-off scores that can be used to determine when trainees can progress from performance under supervision to performance without supervision. This can be used to guide training in a competency-based training curriculum.
目的:以能力为基础的外科训练包括给予受训者渐进的自主权。这需要系统的、以证据为基础的评估,以及明确定义的熟练程度标准。本研究的目的是制定跨机构乳突切除术评估工具的标准,以决定住院医生是否有足够的技能在有或没有监督的情况下进行乳突切除术。方法:对一组接受过奖学金培训的乳突切除术内容专家进行调查,以确定有监督和无监督手术所需的技能。我们检查了共识分数,以调查受访者对每个调查项目的同意程度,并进行了额外的分析,以确定每个调查项目所需的报告技能水平在监督水平与无监督水平之间是否存在显着差异。结果:10位代表美国不同培训项目的小组成员做出了回应。小组成员对每个项目和学员水平的分界点得分有相当大的共识,根据评估项目的不同,有中等(0.62)到非常高(0.95)的共识得分。进一步的分析表明,监督和非监督技能水平之间的差异对所有项目都有显著意义。最后,建立各题的最低及格分数。结论:我们使用Angoff方法定义了跨机构乳突切除术评估工具的性能标准。这些截止分数可以用来确定受训者何时可以从监督下的表现进步到没有监督的表现。这可用于指导以能力为基础的培训课程中的培训。
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引用次数: 2
Presentation and Management of Killian Jamieson Diverticulum: A Comprehensive Literature Review 基利安·贾米森憩室的表现与治疗:综合文献综述
Pub Date : 2019-11-09 DOI: 10.1177/0003489419887403
Narmien Haddad, Pratima Agarwal, Jessica R. Levi, J. Tracy, L. Tracy
Objective: To examine the clinical presentation, diagnostic evaluation, and management of Killian–Jamieson diverticula (KJD) through literature review. Methods: A comprehensive literature review was conducted through December 2018 using keywords Killian–Jamieson diverticula/diverticulum. Data extracted included clinical presentation, imaging characteristics, surgical management, and postoperative care. Sources: PubMed and Google Scholar. Results: Sixty-eight cases of KJD in 59 reports (29M:39F; median 58 years old) were identified for review. The most common presentation was dysphagia (n = 39), suspected thyroid nodule (n = 24) and globus (n = 14). The majority of KJD (n = 51) occur on the left, with rare reports of right side (n = 11) and bilateral (n = 5) presentation. Thirty-two cases describe surgical management: 22 utilizing a transcervical approach, with (n = 13) or without (n = 9) cricopharyngeal myotomy; and 10 reported endoscopic surgery. Diverticula managed transcervically averaged 3.8 cm in size in comparison to average 2.8 cm in the endoscopic group. Time to diet initiation after transcervical surgery averaged 4 days versus 2 days after endoscopic surgery. Complications were reported in 2/68 cases; both were diverticula recurrence after endoscopic surgery. Conclusion: Killian–Jamieson diverticula is a rare diagnosis that should be considered in the evaluation of dysphagia, globus, and also suspected thyroid nodule. When patient symptoms warrant intervention, a transcervical approach, with or without cricopharyngeal myotomy, is most commonly utilized. In recent years, an endoscopic approach has been presented as an alternative for smaller diverticula. Further understanding of the optimal treatment and postoperative management for KJD requires larger cohorts. Level of Evidence: 4
目的:通过文献复习,探讨Killian-Jamieson憩室(KJD)的临床表现、诊断评价及治疗方法。方法:以Killian-Jamieson憩室/憩室为关键词,对截至2018年12月的相关文献进行综述。提取的资料包括临床表现、影像学特征、手术处理和术后护理。来源:PubMed和Google Scholar。结果:59例报告68例KJD (29M:39F;中位年龄为58岁)。最常见的表现是吞咽困难(n = 39),疑似甲状腺结节(n = 24)和球形(n = 14)。大多数KJD (n = 51)发生在左侧,罕见的右侧(n = 11)和双侧(n = 5)出现。32例描述了手术治疗:22例采用经颈入路,(n = 13)或不(n = 9)环咽肌切开术;10例报告内窥镜手术。经颈处理的憩室的平均大小为3.8 cm,而内镜组的平均大小为2.8 cm。经颈椎手术后开始饮食的时间平均为4天,而内镜手术后平均为2天。2/68例出现并发症;两例均为内窥镜术后憩室复发。结论:Killian-Jamieson憩室是一种罕见的诊断,在评估吞咽困难、肾小球和疑似甲状腺结节时应予以考虑。当患者症状需要干预时,最常采用经颈入路,伴或不伴环咽肌切开术。近年来,内镜入路已被提出作为小憩室的一种替代方法。进一步了解KJD的最佳治疗和术后管理需要更大的队列。证据等级:4
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引用次数: 23
Quality and Readability of Online Information on In-Office Vocal Fold Injections 办公室内声带注射在线信息的质量和可读性
Pub Date : 2019-11-08 DOI: 10.1177/0003489419887406
Grace S. Yi, A. Hu
Objectives: Vocal fold injection augmentations are increasingly being performed in the office setting on awake patients, as opposed to the operating room. These procedures thus require patient cooperation and education. As the Internet is a widely-used resource for patients, our aim was to assess the quality and readability of online resources on in-office awake vocal fold injections. Methods: An online Google search using the terms “office vocal fold injection medialization” and “awake vocal fold injection” was conducted. The first 50 English-language websites were categorized into professional- and patient-targeted, and major and minor sources. They were analyzed using the Flesch Reading Ease Score (FRES), Flesch-Kincaid Grade Level (FKGL) test, and DISCERN quality score. Results: Fifty websites were evaluated, and the overall DISCERN score was 2.60 ± 1.01, the mean FRES was 32.16 ± 19.10, and the mean FKGL was 13.76 ± 4.12. Between the 25 professional-targeted and 25 patient-targeted websites, professional-targeted sites had significantly higher DISCERN (P < .05) and FKGL (P < .05) scores, and lower FRES (P < .05) scores. Between the 30 major and 20 minor websites, major websites had significantly lower FRES (P < .05) and higher FKGL (P < .05) scores, and there was a trend toward significance for higher DISCERN scores (P = .052). Conclusions: Our study shows that half of the top Google results for our topic were not written for patient education, but rather for health care professionals. The reading level of this information exceeds the recommended grade level for patient education materials, and may be less comprehensible than intended. While patient-targeted materials are easier to read than professional-targeted sites, they are of lower quality. The quality of the available online information on this topic is suboptimal for both patients and health care providers. This research highlights the need for more appropriate patient education materials given low health literacy rates.
目的:与手术室相比,声带注射增强术越来越多地在清醒的病人身上进行。因此,这些程序需要耐心的合作和教育。由于互联网是患者广泛使用的资源,我们的目的是评估在线资源在办公室清醒声带注射的质量和可读性。方法:在网上谷歌检索“办公室声带注射介质化”和“清醒声带注射”。首批50个英文网站被分为专业和患者目标、主要和次要来源。采用Flesch Reading Ease Score (FRES)、Flesch- kincaid Grade Level (FKGL) test和DISCERN quality Score进行分析。结果:共评估50个网站,总分为2.60±1.01分,平均FRES为32.16±19.10分,平均FKGL为13.76±4.12分。在25个专业网站和25个患者网站中,专业网站的DISCERN评分(P < 0.05)和FKGL评分(P < 0.05)显著高于专业网站,FRES评分显著低于专业网站(P < 0.05)。在30个主要网站和20个次要网站中,主要网站的FRES得分显著低于其他网站(P < 0.05), FKGL得分显著高于其他网站(P < 0.05),而DISCERN得分有显著高于其他网站的趋势(P = 0.052)。结论:我们的研究表明,我们主题的谷歌结果中有一半不是为患者教育而写的,而是为卫生保健专业人员而写的。这些信息的阅读水平超过了患者教育材料的推荐年级水平,可能比预期的更难以理解。虽然针对患者的材料比针对专业人士的网站更容易阅读,但它们的质量较低。对于患者和医疗保健提供者而言,关于该主题的可用在线信息的质量都不是最佳的。这项研究强调,鉴于卫生识字率低,需要更适当的患者教育材料。
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引用次数: 11
Five-year Survival Data on the Role of Endoscopic Endonasal Nasopharyngectomy in Advanced Recurrent rT3 and rT4 Nasopharyngeal Carcinoma 内镜鼻内咽切除术治疗晚期复发rT3和rT4鼻咽癌的5年生存数据
Pub Date : 2019-11-08 DOI: 10.1177/0003489419887410
E. Wong, Y. Liew, S. Loong, N. Prepageran
Aim: Endoscopic endonasal nasopharyngectomy (EEN) for recurrent nasopharyngeal carcinoma (rNPC) is being increasingly used due to the added high magnification, reduced morbidities associated with open procedures and good survival outcomes. Most studies looked at usage of EEN in patients with lower recurrent staging (rT1 and rT2) although more and more surgeons are studying the outcome of EEN in advanced rNPC (rT3 and rT4). The aims of this study were to report the long-term 5-year survival outcome of EEN performed in patients with advanced rNPC, and to determine any prognostic factors for patients’ survival. Methods: All patients who underwent EEN for advanced rNPC between January 2003 and December 2015 inclusive were analyzed. All surgeries were performed in University Malaya Medical Centre in Kuala Lumpur and Queen Elizabeth Hospital in Sabah. We reported the 5-year overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS) and any related complications and significant prognostic factors. Results: Twelve patients with rNPC (2 rT3 and 10 rT4) were followed-up over a mean duration of 44.8 months (range, 40-440 weeks). The 5-year OS was 50.0% (mean 44.75 months), DFS was 25.0% (mean 35.25 months) and the DSS was 58.3% (mean 43.33 months). No severe operative complications were encountered and no independent prognostic factors for survival outcome were identified. Conclusion: This is the first report in English that exclusively described the long-term 5-year survival data in patients with both rT3 and rT4 recurrent NPC after EEN. The data suggest that EEN is a feasible treatment to improve survival with minimal morbidities in patients with rT3 and rT4 recurrent NPC. However, more studies with larger patient size is recommended.
目的:内镜鼻内咽切除术(EEN)治疗复发性鼻咽癌(rNPC)越来越多地使用,因为它增加了高放大倍率,与开放手术相关的发病率降低了,生存率也很好。尽管越来越多的外科医生正在研究EEN在晚期rNPC (rT3和rT4)中的疗效,但大多数研究关注的是低复发分期(rT1和rT2)患者使用EEN的情况。本研究的目的是报告晚期rNPC患者行EEN的长期5年生存结果,并确定患者生存的任何预后因素。方法:分析2003年1月至2015年12月期间所有晚期rNPC患者行EEN治疗。所有手术均在吉隆坡的马来亚大学医疗中心和沙巴的伊丽莎白女王医院进行。我们报告了5年总生存期(OS)、无病生存期(DFS)和疾病特异性生存期(DSS)以及任何相关并发症和重要预后因素。结果:12例rNPC患者(2例rT3和10例rT4)平均随访时间44.8个月(范围40-440周)。5年OS 50.0%(平均44.75个月),DFS 25.0%(平均35.25个月),DSS 58.3%(平均43.33个月)。没有发生严重的手术并发症,也没有确定影响生存结果的独立预后因素。结论:这是第一个专门描述rT3和rT4复发性鼻咽癌EEN后5年长期生存数据的英文报告。数据表明,对于rT3和rT4复发性鼻咽癌患者,EEN是一种可行的治疗方法,可以以最小的发病率提高生存率。然而,更多的研究更大的患者规模是推荐的。
{"title":"Five-year Survival Data on the Role of Endoscopic Endonasal Nasopharyngectomy in Advanced Recurrent rT3 and rT4 Nasopharyngeal Carcinoma","authors":"E. Wong, Y. Liew, S. Loong, N. Prepageran","doi":"10.1177/0003489419887410","DOIUrl":"https://doi.org/10.1177/0003489419887410","url":null,"abstract":"Aim: Endoscopic endonasal nasopharyngectomy (EEN) for recurrent nasopharyngeal carcinoma (rNPC) is being increasingly used due to the added high magnification, reduced morbidities associated with open procedures and good survival outcomes. Most studies looked at usage of EEN in patients with lower recurrent staging (rT1 and rT2) although more and more surgeons are studying the outcome of EEN in advanced rNPC (rT3 and rT4). The aims of this study were to report the long-term 5-year survival outcome of EEN performed in patients with advanced rNPC, and to determine any prognostic factors for patients’ survival. Methods: All patients who underwent EEN for advanced rNPC between January 2003 and December 2015 inclusive were analyzed. All surgeries were performed in University Malaya Medical Centre in Kuala Lumpur and Queen Elizabeth Hospital in Sabah. We reported the 5-year overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS) and any related complications and significant prognostic factors. Results: Twelve patients with rNPC (2 rT3 and 10 rT4) were followed-up over a mean duration of 44.8 months (range, 40-440 weeks). The 5-year OS was 50.0% (mean 44.75 months), DFS was 25.0% (mean 35.25 months) and the DSS was 58.3% (mean 43.33 months). No severe operative complications were encountered and no independent prognostic factors for survival outcome were identified. Conclusion: This is the first report in English that exclusively described the long-term 5-year survival data in patients with both rT3 and rT4 recurrent NPC after EEN. The data suggest that EEN is a feasible treatment to improve survival with minimal morbidities in patients with rT3 and rT4 recurrent NPC. However, more studies with larger patient size is recommended.","PeriodicalId":8361,"journal":{"name":"Annals of Otology, Rhinology & Laryngology","volume":"28 1","pages":"287 - 293"},"PeriodicalIF":0.0,"publicationDate":"2019-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85017441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
期刊
Annals of Otology, Rhinology & Laryngology
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