Pub Date : 2024-04-22DOI: 10.1080/07853890.2024.2338244
Sandra Hertz, J. Anderson, H. L. Nielsen, Claire Schachtschneider, Kathryn E. McCauley, Mustafa Özçam, Lone Larsen, Susan V. Lynch, H. Nielsen
Abstract Introduction A large proportion of patients with inflammatory bowel disease (IBD) experience IBD-related inflammatory conditions outside of the gastrointestinal tract, termed extraintestinal manifestations (EIMs) which further decreases quality of life and, in extreme cases, can be life threatening. The pathogenesis of EIMs remains unknown, and although gut microbiota alterations are a well-known characteristic of patients with IBD, its relationship with EIMs remains sparsely investigated. This study aimed to compare the gut microbiota of patients with IBD with and without EIMs. Methods A total of 131 Danish patients with IBD were included in the study, of whom 86 had a history of EIMs (IBD-EIM) and 45 did not (IBD-C). Stool samples underwent 16S rRNA sequencing. Amplicon sequence variants (ASVs) were mapped to the Silva database. Diversity indices and distance matrices were compared between IBD-EIM and IBD-C. Differentially abundant ASVs were identified using a custom multiple model statistical analysis approach, and modules of co-associated bacteria were identified using sparse correlations for compositional data (SparCC) and related to patient EIM status. Results Patients with IBD and EIMs exhibited increased disease activity, body mass index, increased fecal calprotectin levels and circulating monocytes and neutrophils. Microbiologically, IBD-EIM exhibited lower fecal microbial diversity than IBD-C (Mann–Whitney’s test, p = .01) and distinct fecal microbiota composition (permutational multivariate analysis of variance; weighted UniFrac, R2 = 0.018, p = .01). A total of 26 ASVs exhibited differential relative abundances between IBD-EIM and IBD-C, including decreased Agathobacter and Blautia and increased Eggerthella lenta in the IBD-EIM group. SparCC analysis identified 27 bacterial co-association modules, three of which were negatively related to EIM (logistic regression, p < .05) and included important health-associated bacteria, such as Agathobacter and Faecalibacterium. Conclusions The fecal microbiota in IBD patients with EIMs is distinct from that in IBD patients without EIM and could be important for EIM pathogenesis.
{"title":"Fecal microbiota is associated with extraintestinal manifestations in inflammatory bowel disease","authors":"Sandra Hertz, J. Anderson, H. L. Nielsen, Claire Schachtschneider, Kathryn E. McCauley, Mustafa Özçam, Lone Larsen, Susan V. Lynch, H. Nielsen","doi":"10.1080/07853890.2024.2338244","DOIUrl":"https://doi.org/10.1080/07853890.2024.2338244","url":null,"abstract":"Abstract Introduction A large proportion of patients with inflammatory bowel disease (IBD) experience IBD-related inflammatory conditions outside of the gastrointestinal tract, termed extraintestinal manifestations (EIMs) which further decreases quality of life and, in extreme cases, can be life threatening. The pathogenesis of EIMs remains unknown, and although gut microbiota alterations are a well-known characteristic of patients with IBD, its relationship with EIMs remains sparsely investigated. This study aimed to compare the gut microbiota of patients with IBD with and without EIMs. Methods A total of 131 Danish patients with IBD were included in the study, of whom 86 had a history of EIMs (IBD-EIM) and 45 did not (IBD-C). Stool samples underwent 16S rRNA sequencing. Amplicon sequence variants (ASVs) were mapped to the Silva database. Diversity indices and distance matrices were compared between IBD-EIM and IBD-C. Differentially abundant ASVs were identified using a custom multiple model statistical analysis approach, and modules of co-associated bacteria were identified using sparse correlations for compositional data (SparCC) and related to patient EIM status. Results Patients with IBD and EIMs exhibited increased disease activity, body mass index, increased fecal calprotectin levels and circulating monocytes and neutrophils. Microbiologically, IBD-EIM exhibited lower fecal microbial diversity than IBD-C (Mann–Whitney’s test, p = .01) and distinct fecal microbiota composition (permutational multivariate analysis of variance; weighted UniFrac, R2 = 0.018, p = .01). A total of 26 ASVs exhibited differential relative abundances between IBD-EIM and IBD-C, including decreased Agathobacter and Blautia and increased Eggerthella lenta in the IBD-EIM group. SparCC analysis identified 27 bacterial co-association modules, three of which were negatively related to EIM (logistic regression, p < .05) and included important health-associated bacteria, such as Agathobacter and Faecalibacterium. Conclusions The fecal microbiota in IBD patients with EIMs is distinct from that in IBD patients without EIM and could be important for EIM pathogenesis.","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140672392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.1080/07853890.2024.2337735
Kevin C. Tseng, Le Wang, Chunkai Hsieh, Alice M. Wong
Robot-assisted upper-limb rehabilitation has been studied for many years, with many randomised controlled trials (RCTs) investigating the effects of robotic-assisted training on affected limbs. The...
{"title":"Portable robots for upper-limb rehabilitation after stroke: a systematic review and meta-analysis","authors":"Kevin C. Tseng, Le Wang, Chunkai Hsieh, Alice M. Wong","doi":"10.1080/07853890.2024.2337735","DOIUrl":"https://doi.org/10.1080/07853890.2024.2337735","url":null,"abstract":"Robot-assisted upper-limb rehabilitation has been studied for many years, with many randomised controlled trials (RCTs) investigating the effects of robotic-assisted training on affected limbs. The...","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140625536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.1080/07853890.2024.2331054
Erlend Sunde, Anette Harris, Olav Kjellevold Olsen, Ståle Pallesen
Cognitive function, including moral decision-making abilities, can be impaired by sleep loss. Blue-enriched light interventions have been shown to ameliorate cognitive impairment during night work....
{"title":"Moral decision-making at night and the impact of night work with blue-enriched white light or warm white light: a counterbalanced crossover study","authors":"Erlend Sunde, Anette Harris, Olav Kjellevold Olsen, Ståle Pallesen","doi":"10.1080/07853890.2024.2331054","DOIUrl":"https://doi.org/10.1080/07853890.2024.2331054","url":null,"abstract":"Cognitive function, including moral decision-making abilities, can be impaired by sleep loss. Blue-enriched light interventions have been shown to ameliorate cognitive impairment during night work....","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140625287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-13DOI: 10.1080/07853890.2024.2337724
Francisco Ayala, Francisco Javier Robles-Palazón, Desirée Blázquez-Rincón, Alejandro López-Valenciano, José Antonio López-López, Mark De Ste Croix
The objectives of this network meta-analysis were: (a) to estimate and compare the pooled effects of some injury prevention programs (IPPs) whose exercise-based components were categorized using a ...
{"title":"A systematic review and network meta-analysis on the effectiveness of exercise-based interventions for reducing the injury incidence in youth team-sport players. Part 2: an analysis by movement patterns","authors":"Francisco Ayala, Francisco Javier Robles-Palazón, Desirée Blázquez-Rincón, Alejandro López-Valenciano, José Antonio López-López, Mark De Ste Croix","doi":"10.1080/07853890.2024.2337724","DOIUrl":"https://doi.org/10.1080/07853890.2024.2337724","url":null,"abstract":"The objectives of this network meta-analysis were: (a) to estimate and compare the pooled effects of some injury prevention programs (IPPs) whose exercise-based components were categorized using a ...","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140591325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-13DOI: 10.1080/07853890.2024.2337712
Chen Li, Xiaoyan Guo, Yan He, Jing Wang, Jianyu Hao, Xinjuan Liu
Background: Ulcerative colitis (UC), which is characterized by chronic relapsing inflammation of the colon, results from a complex interaction of factors involving the host, environment, and microb...
{"title":"Cohabiting with ulcerative colitis patients decreases differences of gut microbiome between healthy individuals and the patients","authors":"Chen Li, Xiaoyan Guo, Yan He, Jing Wang, Jianyu Hao, Xinjuan Liu","doi":"10.1080/07853890.2024.2337712","DOIUrl":"https://doi.org/10.1080/07853890.2024.2337712","url":null,"abstract":"Background: Ulcerative colitis (UC), which is characterized by chronic relapsing inflammation of the colon, results from a complex interaction of factors involving the host, environment, and microb...","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140591328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1080/07853890.2024.2329132
Jing Ma, Yafei Wang
Myeloid neoplasms post cytotoxic therapy (MN-pCT) are a category includes AML, MDS, and MDS/MPN arising in patients exposed to cytotoxic (DNA-damaging) therapy for an unrelated condition in 2022 ve...
{"title":"Myeloid neoplasms post cytotoxic therapy: epidemiology, pathogenesis outcomes, prognostic factors, and treatment options","authors":"Jing Ma, Yafei Wang","doi":"10.1080/07853890.2024.2329132","DOIUrl":"https://doi.org/10.1080/07853890.2024.2329132","url":null,"abstract":"Myeloid neoplasms post cytotoxic therapy (MN-pCT) are a category includes AML, MDS, and MDS/MPN arising in patients exposed to cytotoxic (DNA-damaging) therapy for an unrelated condition in 2022 ve...","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140603191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thalassemia is the most prevalent hereditary anaemia worldwide. Severe forms of thalassemia can lead to reduced life expectancy due to disease-related complications.To investigate the survival of t...
地中海贫血是全球最常见的遗传性贫血。严重的地中海贫血会因疾病相关并发症而导致预期寿命缩短。
{"title":"Survival and causes of death in patients with alpha and beta-thalassemia in Northern Thailand","authors":"Adisak Tantiworawit, Thansita Kamolsripat, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada, Kanda Fanhchaksai, Pimlak Charoenkwan","doi":"10.1080/07853890.2024.2338246","DOIUrl":"https://doi.org/10.1080/07853890.2024.2338246","url":null,"abstract":"Thalassemia is the most prevalent hereditary anaemia worldwide. Severe forms of thalassemia can lead to reduced life expectancy due to disease-related complications.To investigate the survival of t...","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140591839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.1080/07853890.2024.2338242
Areesha Moiz, Tetiana Zolotarova, Mark J. Eisenberg
Background: Essential hypertension, a prevalent cardiovascular condition, poses a significant health burden worldwide. Based on the latest American clinical guidelines, half of adults in the United...
{"title":"Outpatient management of essential hypertension: a review based on the latest clinical guidelines","authors":"Areesha Moiz, Tetiana Zolotarova, Mark J. Eisenberg","doi":"10.1080/07853890.2024.2338242","DOIUrl":"https://doi.org/10.1080/07853890.2024.2338242","url":null,"abstract":"Background: Essential hypertension, a prevalent cardiovascular condition, poses a significant health burden worldwide. Based on the latest American clinical guidelines, half of adults in the United...","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140591410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1080/07853890.2024.2334907
Robert H. Mann, Bryan C. Clift, Jo Day, Alan R. Barker
This study assessed the knowledge, behavior, and needs of competitive adolescent (16–18 years) distance runners and distance running coaches enrolled as part of England Athletics’ Youth Talent Prog...
{"title":"Co-creation of injury prevention measures for competitive adolescent distance runners: knowledge, behavior, and needs of athletes and coaches enrolled on England Athletics’ Youth Talent Programme","authors":"Robert H. Mann, Bryan C. Clift, Jo Day, Alan R. Barker","doi":"10.1080/07853890.2024.2334907","DOIUrl":"https://doi.org/10.1080/07853890.2024.2334907","url":null,"abstract":"This study assessed the knowledge, behavior, and needs of competitive adolescent (16–18 years) distance runners and distance running coaches enrolled as part of England Athletics’ Youth Talent Prog...","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140591324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1080/07853890.2024.2338604
Qun Li, Lisha Ai, Liping Zuo, Junying Li, Fei Zhao, Aoshuang Xu, Bo Zhang, Li Cai, Yu Hu, Chunyan Sun
Circulating plasma cells (CPCs) are defined by the presence of peripheral blood clonal plasma cells, which would contribute to the progression and dissemination of multiple myeloma (MM). An increas...
{"title":"Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis","authors":"Qun Li, Lisha Ai, Liping Zuo, Junying Li, Fei Zhao, Aoshuang Xu, Bo Zhang, Li Cai, Yu Hu, Chunyan Sun","doi":"10.1080/07853890.2024.2338604","DOIUrl":"https://doi.org/10.1080/07853890.2024.2338604","url":null,"abstract":"Circulating plasma cells (CPCs) are defined by the presence of peripheral blood clonal plasma cells, which would contribute to the progression and dissemination of multiple myeloma (MM). An increas...","PeriodicalId":8371,"journal":{"name":"Annals of medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140591323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：