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Hydroxocobalamin Administration After Inhalation Injury Is Not Associated With Mesenteric Ischemia. 吸入性损伤后服用羟钴胺与肠系膜缺血无关
Q3 Medicine Pub Date : 2021-09-30
A J Engwall, A Blache, A Lintner, A Bright, S Kahn

Hydroxocobalamin has been administered in the United States since 2006 by first responders and burn centers as a safe antidote for cyanide toxicity, a serious complication of smoke inhalation. There are no current contraindications to the use of this rescue measure. A recent retrospective French publication reported a potential correlation between hydroxcobalamin administration and acute mesenteric ischemia (AMI) in critically ill burn and inhalation injury patients. The purpose of this study is to characterize the risk of AMI related to hydroxocobalamin. A retrospective review of hydroxocobalamin administration among adult burn patients was conducted at a regional burn center over a 2-year period. Injury characteristics, demographics, and outcomes including presence of mesenteric ischemia (defined as presence of pneumatosis or perforation on CT scan or necrotic bowel on laparotomy) were recorded. Of 17 confirmed inhalation injuries, patients had a median (interquartile range) age, total body surface area (TBSA), and abbreviated burn severity (ABSI) index as follows: 60 (45, 65 IQR), 8.5 (1.8, 39 IQR), and 6 (5,7 IQR). Inhalation injury was diagnosed with bronchoscopy, carboxyhemoglobin, or clinical suspicion. Eighty-two percent of those with bronchoscopy had an inhalation grade of 2 or greater. None (0%) of the patients showed signs of mesenteric ischemia, tube feeding intolerance, pneumatosis/perforation on CT, or necrotic bowel on laparotomy. Aware of the study limitations, we conclude that hydroxocobalamin does not increase risk for AMI.

自 2006 年以来,美国急救人员和烧伤中心一直在使用羟钴胺作为氰化物中毒的安全解毒剂,氰化物中毒是一种严重的烟雾吸入并发症。目前还没有使用这种抢救措施的禁忌症。法国最近发表的一份回顾性报告称,在烧伤和吸入性损伤的重症患者中,服用羟钴胺与急性肠系膜缺血(AMI)之间可能存在关联。本研究的目的是确定与羟钴胺有关的急性肠系膜缺血风险。一家地区烧伤中心对成年烧伤患者在两年内服用羟钴胺的情况进行了回顾性研究。该研究记录了烧伤特征、人口统计学特征和结果,包括是否存在肠系膜缺血(定义为 CT 扫描中出现气肿或穿孔,或开腹手术中出现坏死肠管)。在 17 例确诊的吸入性损伤中,患者的中位(四分位间)年龄、总体表面积(TBSA)和缩写烧伤严重程度(ABSI)指数如下:60(45,65 IQR)、8.5(1.8,39 IQR)和 6(5,7 IQR)。吸入性损伤是通过支气管镜检查、碳氧血红蛋白或临床怀疑诊断出来的。在接受支气管镜检查的患者中,82%的吸入等级为 2 级或以上。没有一名患者(0%)出现肠系膜缺血、管饲不耐受、CT 显示气肿/穿孔或开腹手术显示肠管坏死的症状。考虑到研究的局限性,我们得出结论:羟钴胺不会增加急性肠梗阻的风险。
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引用次数: 0
Versatility Of Square Flaps In Post-Burn Contractures Involving Upper Limb. 方形皮瓣在上肢烧伤后挛缩中的多功能性。
Q3 Medicine Pub Date : 2021-09-30
G Dutta, S Dey, S Singh, A Rai, R N Bhattacharya

Post-burn contractures are a common problem and functionally limiting for upper limbs. Many different techniques have been described in the literature for their treatment. Z-plasty and release with SSG cover are the commonest procedures done for post-burn contractures. In this study we assess the use of the square flap technique in post-burn contractures of upper limb. Eleven patients with a total number of twelve upper limb contractures (mild to moderate) involving axilla, elbow and finger underwent release by standard square flap technique. All cases were followed up for at least 6 months and analyzed for range of motion and aesthetic outcome. Patient and surgeon satisfaction was recorded. All operated cases achieved a satisfactory range of movement post-operatively without any recurrence. The number of patients who were satisfied with the surgery were 7 out of 11, and 4 patients were somewhat satisfied with the results obtained. In contrast, the surgeons were satisfied in all cases. Square flap is shown to be an easy and reliable flap for mild to moderate contractures of the anterior or posterior axillary folds, elbow contractures and finger contractures with low recurrence rate.

烧伤后挛缩是上肢的常见问题和功能限制。文献中描述了许多不同的治疗方法。z形成形术和带SSG盖的松解术是治疗烧伤后挛缩最常见的方法。在这项研究中,我们评估了正方形皮瓣技术在烧伤后上肢挛缩中的应用。11例上肢挛缩(轻至中度)累及腋窝、肘关节和手指,采用标准方瓣松解术。所有病例随访至少6个月,并分析活动范围和美学结果。记录患者和外科医生的满意度。所有手术病例术后均获得满意的活动范围,无复发。11例患者中有7例患者对手术满意,4例患者对手术结果比较满意。相比之下,所有病例的外科医生都很满意。方形皮瓣是治疗腋襞前后轻、中度挛缩、肘关节挛缩、手指挛缩的一种简便可靠的皮瓣,复发率低。
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引用次数: 0
Toxic Epidermal Necrolysis Syndrome: Management And Outcomes. 中毒性表皮坏死综合征:管理与结果。
Q3 Medicine Pub Date : 2021-09-30
S Al-Benna

Toxic epidermal necrolysis syndrome (TENS) is a rare medical emergency associated with high morbidity and mortality. At present, there is no agreement regarding specific treatments for this disease. The aim of this study is to determine the outcome of patients with TENS using a treatment protocol that did not include the use of intravenous immunoglobulin or systemic steroids. This is a retrospective study of all patients diagnosed with TENS admitted to a tertiary burns centre from 2015-2017. Twelve cases were identified with a mean age of 46±8 years. Mean total body surface area affected was 51±9%. The SCORTEN index was 3.4±0.3 (range 2-5) and predicted 3 deaths in this cohort. Overall mortality was 25%. This study casts no doubt on the prognostic validity of SCORTEN. No specific TENS treatment has been unequivocally proven to be effective.

中毒性表皮坏死综合征(TENS)是一种罕见的急症,发病率和死亡率都很高。目前,关于这种疾病的具体治疗方法还没有达成一致意见。本研究旨在确定采用不包括静脉注射免疫球蛋白或全身性类固醇的治疗方案的 TENS 患者的治疗效果。这是一项回顾性研究,研究对象是 2015-2017 年期间在一家三级烧伤中心住院的所有确诊为 TENS 的患者。共发现 12 例患者,平均年龄为 46±8 岁。平均受累体表总面积为 51±9%。SCORTEN指数为3.4±0.3(范围2-5),预测该组群中有3人死亡。总死亡率为 25%。这项研究对 SCORTEN 的预后有效性没有任何疑问。目前还没有任何一种特定的 TENS 治疗方法被明确证明有效。
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引用次数: 0
Future Study Of Fire Disaster Risk In Iran Using A Scenario Planning Approach. 使用情景规划方法对伊朗火灾风险的未来研究。
Q3 Medicine Pub Date : 2021-09-30
H Jafari, H Sheikhbardsiri, M Mohammadi

Fire disasters are one of the most common technological disasters in Iran. These disasters have killed many people and resulted in significant economic loss. The "Plasco" building fire in 2017 is one example of these catastrophic disasters, when most of Iran was affected by its tragic news. Regarding the increasing number of risk factors for fire disasters, we aimed to study future scenarios for such disasters in the country. The present study is a futuristic study with an exploratory approach that uses an intuitive logic scenario development approach. We used document analysis, semi-structured interviews, and the Delphi technique to identify driving forces and develop scenario stories, and finally those scenario stories were validated. In the document analysis phase, 22 documents were identified and analysed. After collecting information related to documents and analysing ten interviews, 41 of the driving forces were identified. By drawing the scenario matrix, four alternative scenarios for the future of fire disasters were developed. Two dimensions for scenario development were the correct application of fire prevention laws and access to driving technologies. Policymakers can concentrate on these key factors for best planning in the mitigation of fire disasters. In addition, studying scenarios can help managers and officials to better develop strategic plans for disaster risk reduction.

火灾是伊朗最常见的技术灾害之一。这些灾害造成许多人死亡,并造成重大经济损失。2017年的“普拉斯科”建筑火灾就是这些灾难性灾难的一个例子,当时伊朗大部分地区都受到了这一悲惨消息的影响。鉴于火灾的风险因素越来越多,我们的目标是研究该国未来发生此类灾害的情景。本研究是一项前瞻性的探索性研究,采用直观的逻辑场景开发方法。我们使用文档分析、半结构化访谈和德尔菲技术来识别驱动力并开发情景故事,最后对这些情景故事进行验证。在文件分析阶段,识别和分析了22份文件。在收集了与文件相关的信息并分析了10个访谈后,确定了41个驱动因素。通过绘制情景矩阵,开发了未来火灾的四种可选情景。场景开发的两个方面是正确应用防火法律和获得驾驶技术。决策者可以把注意力集中在这些关键因素上,以便在减轻火灾灾害方面进行最佳规划。此外,研究情景可以帮助管理人员和官员更好地制定减少灾害风险的战略计划。
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引用次数: 0
Rifle Criteria For Acute Kidney Injury In Burn Patients: Prevalence And Risk Factors. 烧伤患者急性肾损伤的步枪标准:患病率和危险因素。
Q3 Medicine Pub Date : 2021-09-30
O N Putra, I D Saputro, D Diana

Acute kidney injury is one of the severe complications after burns. The purpose of this study was to identify prevalence, risk factors to the development of acute kidney injury (AKI) in burn patients and mortality, using RIFLE classification: risk (R), injury (I), failure (F), loss (L), and end-stage kidney disease (E). This 3-year retrospective study was conducted in burn patients admitted to the Dr. Soetomo Hospital Burn Center between January 2018 and September 2020. Burn patients aged >18 years old and diagnosed with acute kidney injury during hospitalization were enrolled in this study. Factors influencing AKI and its mortality were assessed using bivariate and multivariate logistic regression analysis. Eighty-nine burn patients were available for analysis, and 18 (20%) of them developed AKI according to the RIFLE classification: risk in 6 (33%), injury in 7 (39%) and failure in 5 (28%). Patients with AKI had a significantly higher age and % of TBSA than those without AKI (p-value <0.05). Age more than 60 years old was significantly associated as a risk factor to develop AKI (OR=25.553, p value=0.014). The mortality rate of patients with AKI was 83% (15 deaths from 18 patients), with the overall mortality of patients 16.8%. Chi-square analysis indicated inhalation injury, % of TBSA, and age as risk factors for mortality (p-value < 0.05). The conclusion of our study was that the incidence of AKI in burn patients was relatively high. Older age as a risk factor to develop AKI and inhalation injury, TBSA, and age were associated with mortality.

急性肾损伤是烧伤后的严重并发症之一。本研究的目的是确定烧伤患者急性肾损伤(AKI)的发生率、危险因素和死亡率,使用RIFLE分类:风险(R)、损伤(I)、衰竭(F)、损失(L)和终末期肾病(E)。这项为期3年的回顾性研究是在2018年1月至2020年9月期间对Soetomo医生医院烧伤中心收治的烧伤患者进行的。年龄>18岁且在住院期间被诊断为急性肾损伤的烧伤患者被纳入本研究。使用双变量和多变量逻辑回归分析评估影响AKI及其死亡率的因素。89名烧伤患者可供分析,根据RIFLE分类,其中18人(20%)出现AKI:6人有风险(33%),7人受伤(39%),5人失败(28%)。AKI患者的年龄和TBSA的%明显高于无AKI患者(p值
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引用次数: 0
Effective Management Of Topical Nosocomial Aspergillus Spp. Infections In Three Severely Burned Patients. 3例严重烧伤患者局部医院曲霉感染的有效处理。
Q3 Medicine Pub Date : 2021-09-30
O Pantet, A Laurent, P Abdel-Sayed, N Hirt-Burri, M Michetti, W Raffoul, M Monod, L A Applegate, A S de Buys Roessingh

Nosocomial opportunistic fungal infections by Aspergillus spp. represent increasing morbidity and mortality factors for severely burned patients, who are fragile and immunocompromised. Voriconazole (VRC), a modern antifungal drug, is used as a first-line therapy against systemic mold and yeast infections. Little has been published about the place, relative importance and efficacy of voriconazole in the treatment protocols involving Aspergillus spp. in Burn Centers. The objective of the present work was to assess the place and importance of voriconazole for the treatment of burn patients presenting superficial Aspergillus spp. infections. We performed a retrospective evaluation of VRC treatment in three severely burned patients with superficial nosocomial Aspergillus spp. infections in our Burn Center. Results showed that VRC allowed for control and cure of topical nosocomial Aspergillus spp. infections. In two cases, treatment with VRC had to be discontinued because of hepatotoxicity. In two cases, following or during systemic treatment with VRC, a 1% terbinafine cream was applied to resolve the infection in order to continue standard wound management. Overall, VRC has been shown to be an effective antifungal agent and is an alternative to amphotericin B to fight Aspergillus spp. infections developing in the wounds of severely burned patients.

医院内由曲霉菌引起的机会性真菌感染是严重烧伤患者发病率和死亡率增加的因素,这些患者身体脆弱,免疫功能低下。伏立康唑(Voriconazole, VRC)是一种现代抗真菌药物,被用作治疗全身霉菌和酵母菌感染的一线药物。很少有关于伏立康唑在烧伤中心曲霉菌治疗方案中的地位、相对重要性和疗效的报道。本研究的目的是评估伏立康唑在烧伤患者表现为浅表曲霉感染的治疗中的地位和重要性。我们对烧伤中心3例浅表医院曲霉感染的严重烧伤患者进行了VRC治疗的回顾性评估。结果表明,VRC可有效控制和治愈局部医院曲霉感染。在两个病例中,由于肝毒性,必须停止使用VRC治疗。在两个病例中,在用VRC进行全身治疗之后或期间,应用1%特比萘芬乳膏来解决感染,以便继续进行标准的伤口管理。总体而言,VRC已被证明是一种有效的抗真菌剂,是两性霉素B的替代品,可用于对抗严重烧伤患者伤口中发生的曲霉感染。
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引用次数: 0
Electric Scooter Battery Detonation: A Case Series And Review Of Literature. 电动踏板车电池爆震:个案系列及文献回顾。
Q3 Medicine Pub Date : 2021-09-30
M K H Hsieh, M C Lai, H S N Sim, X Lim, S F D Fok, J Joethy, T Y Kong, G J S Lim

Since 2016 there has been a 20-fold increase in known burns injury from personal mobility device (PMD) related fires. The root cause is the failure of high-density lithium ion (Li-ion) battery packs powering the PMDs. This failure process, known as thermal runaway, is well documented in applied science journals. Importantly, the liberation of hydrogen fluoride from failing Li-ion batteries may contribute to unrecognized chemical burns. A clinical gap in knowledge exists in the understanding of the explosive nature of Li-ion batteries. We reviewed the electrochemical pathophysiology of a failing Li-ion cell as it impacts clinical management of burn injuries. This retrospective study was carried out in two major institutions in Singapore. All admitted PMD-related burns and follow up appointments were captured and reviewed from 2016 - 2020. Thirty patients were admitted to tertiary hospitals, 43% of patients were in the pediatric population and 57% were adult patients, aged from 0.3 to 77 years. TBSA of burns ranged from 0 to 80% with a mean 14.5%. 73% of cases presented with inhalation injury, 8 of whom did not suffer any cutaneous burns. 50% of patients sustained both cutaneous and inhalation burn injuries. 27% of patients sustained major burns of >20% TBSA, with 2 in the pediatric group. Mortali ty rate was 10% from PMD-related fires. This cause of burn injury has proven to be fa tal. Prevention of PMD-related fires by ensuring proper battery utilization, adherence to PMD sanctions for battery standards and public education is vital to reducing the morbidity and mortality of this unique type of thermal injury.

自2016年以来,与个人移动设备(PMD)相关的火灾造成的已知烧伤增加了20倍。根本原因是为PMD供电的高密度锂离子电池组故障。这种被称为热失控的失效过程在应用科学期刊上有很好的记录。重要的是,失效的锂离子电池释放出的氟化氢可能会导致未被识别的化学灼伤。在对锂离子电池爆炸性的理解方面,存在着临床知识空白。我们回顾了失效的锂离子电池的电化学病理生理学,因为它影响烧伤的临床管理。这项回顾性研究在新加坡的两个主要机构进行。从2016年到2020年,记录并审查了所有入院的PMD相关烧伤和随访预约。三级医院收治了30名患者,43%的患者为儿科患者,57%为成年患者,年龄在0.3至77岁之间。烧伤的TBSA在0~80%之间,平均14.5%。73%的病例表现为吸入性损伤,其中8例没有皮肤烧伤。50%的患者同时遭受皮肤和吸入性烧伤。27%的患者严重烧伤超过20%的TBSA,其中2例在儿科组。PMD相关火灾造成的死亡率为10%。这种烧伤的原因已被证明是致命的。通过确保正确使用电池、遵守PMD对电池标准的制裁和公众教育来预防PMD相关火灾,对于降低这种独特类型的热损伤的发病率和死亡率至关重要。
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引用次数: 0
Ljubljana Marshes Hot Air Balloon Crash: A Multiple Casualty Incident. 卢布尔雅那沼泽热气球坠毁:多人伤亡事件。
Q3 Medicine Pub Date : 2021-09-30
A Kisilak, A Fischinger, A Kristan

On August 23rd, 2012 at 7:54 am a hot air balloon crashed in Ljubljana Marshes, leaving 32 injured on site. This case report analyses the biggest multiple casualty incident attended by University Medical Centre Ljubljana in recent history. Analysis of all segments regarding the incident was conducted: mobilisation, arrivals, triage, work-up, identification, public relations and outcome. Issues such as mobilisation, diagnostics, communication, documentation and intensive care unit space are discussed. Twenty-one patients arrived over 63 minutes, 8 of those were immediate resuscitation cases and 10 of those suffered burns. The average Injury Severity Score was 15.7 (ranging 3 to 50), 28.1 for admitted patients. 90% of patients had x-ray, 23% CT and 38% ultrasound diagnostic procedures. 33% of patients required urgent surgery and 60% of admitted cases required intensive care units. A relatives and media territory was established. CT location, loss of communication, inadequate documentation and intensive care bed space were most problematic. At 7-year follow up, we had a roughly 5% hospital fatality rate, 74% of patients gained full recovery and 21% good recovery. Even though the event occurred on a weekday during regular hours, it still exposed many weaknesses. A new radio frequency system for intra-hospital communication has been implemented, the multiple casualty incident protocol has been revised, and regular drills are now performed. Our emergency department is currently undergoing renovation to include CT diagnostics on the same floor. Plans have been made to ease documentation with dictation modules, whereas bed space remains unchanged.

2012 年 8 月 23 日上午 7 时 54 分,一个热气球在卢布尔雅那沼泽地坠毁,现场有 32 人受伤。本病例报告分析了卢布尔雅那大学医疗中心近期处理的最大一起多人伤亡事件。报告对事件的各个环节进行了分析:动员、到达、分诊、检查、鉴定、公共关系和结果。其中讨论了动员、诊断、沟通、文件和重症监护室空间等问题。21 名病人在 63 分钟内到达,其中 8 人立即进行了抢救,10 人烧伤。平均受伤严重程度评分为 15.7(3 至 50 分不等),入院患者的平均受伤严重程度评分为 28.1。90%的患者接受了X光诊断,23%接受了CT诊断,38%接受了超声波诊断。33%的患者需要进行紧急手术,60%的入院患者需要接受重症监护。建立了亲属和媒体领地。CT位置、失去沟通、文件记录不足和重症监护病床空间是最棘手的问题。在 7 年的随访中,住院死亡率约为 5%,74% 的患者完全康复,21% 恢复良好。尽管事件发生在工作日的正常时间,但仍暴露出许多弱点。我们采用了新的无线电频率系统进行院内通讯,修订了多人伤亡事件协议,并定期进行演习。我们的急诊部目前正在进行翻修,以便在同一层楼配备 CT 诊断设备。我们已计划利用口述记录模块来简化文件记录,但病床空间保持不变。
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引用次数: 0
L’Utilisation De La Poudre À Canon Dans La Fantasia: Accidents Et Prévention. 幻想曲中火药的使用:事故与预防。
Q3 Medicine Pub Date : 2021-06-30
Y I, Z Badaoui, N Elhafidi, A Achbouk, M K El Khatib

Gunpowder is an exploding compound, frequently used in Morocco during fantasia shows for loading guns. If not deadly, its explosion is responsible for various and serious wounds, for which emergent care is difficult. We report two cases of such incidents and discuss wound aspects and prevention.

火药是一种爆炸性的化合物,在摩洛哥的幻想曲表演中经常被用来装枪。即使不是致命的,它的爆炸也会造成各种严重的伤口,急救护理是困难的。我们报告两个这样的事件,并讨论伤口方面和预防。
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引用次数: 0
MBC REPORT. MBC报道。
Q3 Medicine Pub Date : 2021-06-30
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引用次数: 0
期刊
Annals of burns and fire disasters
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