首页 > 最新文献

Arthritis Care & Research最新文献

英文 中文
Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study 探索膝关节骨性关节炎患者接受物理治疗师提供的饮食减肥和运动干预的经验:一项混合方法研究。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-07-11 DOI: 10.1002/acr.25401
Belinda J. Lawford, Kim Allison, Rachel Nelligan, Penny Campbell, Rana S. Hinman, Sarah E. Jones, Jesse Pardo, Jonathan G. Quicke, Priya Sumithran, Jodie Prendergast, Elena S. George, Melanie A. Holden, Nadine E. Foster, Kim L. Bennell

Objective

Explore the experiences of people with knee osteoarthritis (OA) who received a very low energy diet (VLED) and exercise program from a physiotherapist.

Methods

Mixed methods study involving questionnaires (n = 42) and semistructured interviews (n = 22) with randomized control trial participants with knee OA who had received a 6-month physiotherapist-delivered VLED weight loss and exercise intervention. Questionnaires measured participant satisfaction and perceptions about physiotherapist's skills/knowledge in delivery of the dietary intervention (measured on 5–7 point Likert scales). Interviews explored participant's experiences and were analyzed based on the principles of reflexive thematic analysis.

Results

Questionnaire response: 90%. Participants were satisfied with the program (95%), confident their physiotherapist had the required skills (84%) and knowledge (79%) to deliver the dietary intervention, felt comfortable talking to the physiotherapist about weight (74%), and would recommend others see a physiotherapist for the intervention they undertook (71%). The following four themes were developed from the interviews: (1) one-stop-shop of exercise and diet; (2) physiotherapist-delivered weight loss works (unsure initially; successfully lost weight); (3) physiotherapists knowledge and skills (exercise is forte; most thought physiotherapists had the necessary weight loss skills/knowledge, but some disagreed); and (4) physiotherapists have a role in weight loss (physiotherapists are intelligent, credible, and trustworthy; specific training in weight loss necessary).

Conclusion

This study provides, to our knowledge, the first documented perspectives from people with OA who have received a physiotherapist-delivered weight loss intervention. Findings suggest physiotherapists may have a role in delivering a protocolized dietary intervention for some people with knee OA with overweight and obesity.

目的探索接受物理治疗师提供的极低能量饮食(VLED)和锻炼计划的膝骨关节炎患者的经历:混合方法研究,包括问卷调查(42 人)和半结构式访谈(22 人),对象是接受过物理治疗师提供的为期 6 个月的 VLED 减肥和运动干预的膝骨关节炎随机对照试验参与者。调查问卷测量了参与者的满意度,以及对物理治疗师提供饮食干预的技能/知识的看法(以 5-7 分的李克特量表测量)。访谈探讨了参与者的经验,并根据反思性主题分析原则进行了分析:问卷回复率90%.参与者对该计划表示满意(95%),相信他们的物理治疗师具备进行饮食干预所需的技能(84%)和知识(79%),在与物理治疗师谈论体重问题时感到轻松自如(74%),并会推荐其他人去看物理治疗师,以进行干预(71%)。访谈形成了四个主题:1) 运动和饮食一站式服务;2) 物理治疗师提供的减肥方法有效(最初不确定;成功减肥);3) 物理治疗师的知识和技能(运动是强项;大多数人认为物理治疗师具备必要的减肥技能/知识,但有些人不同意);4) 物理治疗师在减肥中发挥作用(物理治疗师聪明、可信、值得信赖;有必要接受专门的减肥培训):据我们所知,本研究首次记录了接受过物理治疗师提供的减肥干预的骨关节炎患者的观点。研究结果表明,物理治疗师可以为一些超重和肥胖的膝关节骨性关节炎患者提供规范的饮食干预。
{"title":"Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study","authors":"Belinda J. Lawford,&nbsp;Kim Allison,&nbsp;Rachel Nelligan,&nbsp;Penny Campbell,&nbsp;Rana S. Hinman,&nbsp;Sarah E. Jones,&nbsp;Jesse Pardo,&nbsp;Jonathan G. Quicke,&nbsp;Priya Sumithran,&nbsp;Jodie Prendergast,&nbsp;Elena S. George,&nbsp;Melanie A. Holden,&nbsp;Nadine E. Foster,&nbsp;Kim L. Bennell","doi":"10.1002/acr.25401","DOIUrl":"10.1002/acr.25401","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Explore the experiences of people with knee osteoarthritis (OA) who received a very low energy diet (VLED) and exercise program from a physiotherapist.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Mixed methods study involving questionnaires (n = 42) and semistructured interviews (n = 22) with randomized control trial participants with knee OA who had received a 6-month physiotherapist-delivered VLED weight loss and exercise intervention. Questionnaires measured participant satisfaction and perceptions about physiotherapist's skills/knowledge in delivery of the dietary intervention (measured on 5–7 point Likert scales). Interviews explored participant's experiences and were analyzed based on the principles of reflexive thematic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Questionnaire response: 90%. Participants were satisfied with the program (95%), confident their physiotherapist had the required skills (84%) and knowledge (79%) to deliver the dietary intervention, felt comfortable talking to the physiotherapist about weight (74%), and would recommend others see a physiotherapist for the intervention they undertook (71%). The following four themes were developed from the interviews: (1) one-stop-shop of exercise and diet; (2) physiotherapist-delivered weight loss works (unsure initially; successfully lost weight); (3) physiotherapists knowledge and skills (exercise is forte; most thought physiotherapists had the necessary weight loss skills/knowledge, but some disagreed); and (4) physiotherapists have a role in weight loss (physiotherapists are intelligent, credible, and trustworthy; specific training in weight loss necessary).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study provides, to our knowledge, the first documented perspectives from people with OA who have received a physiotherapist-delivered weight loss intervention. Findings suggest physiotherapists may have a role in delivering a protocolized dietary intervention for some people with knee OA with overweight and obesity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":"76 11","pages":"1479-1492"},"PeriodicalIF":3.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.25401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coordination and Collaboration to Support Exposome Research in Autoimmune Diseases. 协调与合作,支持自身免疫性疾病的暴露体研究。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-07-11 DOI: 10.1002/acr.25402
Victoria K Shanmugam, Sarah M Temkin, Janine A Clayton, Yuxia Cui, Michael C Humble, Lisa G Rider, Susana Serrate-Sztein, Ricardo Cibotti, Lindsey A Criswell
{"title":"Coordination and Collaboration to Support Exposome Research in Autoimmune Diseases.","authors":"Victoria K Shanmugam, Sarah M Temkin, Janine A Clayton, Yuxia Cui, Michael C Humble, Lisa G Rider, Susana Serrate-Sztein, Ricardo Cibotti, Lindsey A Criswell","doi":"10.1002/acr.25402","DOIUrl":"10.1002/acr.25402","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases 2023 美国风湿病学会 (ACR)/ 美国胸科医师学会 (CHEST) 《系统性自身免疫性风湿病患者间质性肺病的筛查和监测指南》。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-07-08 DOI: 10.1002/acr.25347
Sindhu R. Johnson, Elana J. Bernstein, Marcy B. Bolster, Jonathan H. Chung, Sonye K. Danoff, Michael D. George, Dinesh Khanna, Gordon Guyatt, Reza D. Mirza, Rohit Aggarwal, Aberdeen Allen Jr, Shervin Assassi, Lenore Buckley, Hassan A. Chami, Douglas S. Corwin, Paul F. Dellaripa, Robyn T. Domsic, Tracy J. Doyle, Catherine Marie Falardeau, Tracy M. Frech, Fiona K. Gibbons, Monique Hinchcliff, Cheilonda Johnson, Jeffrey P. Kanne, John S. Kim, Sian Yik Lim, Scott Matson, Zsuzsanna H. McMahan, Samantha J. Merck, Kiana Nesbitt, Mary Beth Scholand, Lee Shapiro, Christine D. Sharkey, Ross Summer, John Varga, Anil Warrier, Sandeep K. Agarwal, Danielle Antin-Ozerkis, Bradford Bemiss, Vaidehi Chowdhary, Jane E. Dematte D'Amico, Robert Hallowell, Alicia M. Hinze, Patil A. Injean, Nikhil Jiwrajka, Elena K. Joerns, Joyce S. Lee, Ashima Makol, Gregory C. McDermott, Jake G. Natalini, Justin M. Oldham, Didem Saygin, Kimberly Showalter Lakin, Namrata Singh, Joshua J. Solomon, Jeffrey A. Sparks, Marat Turgunbaev, Samera Vaseer, Amy Turner, Stacey Uhl, Ilya Ivlev

Objective

We provide evidence-based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring for ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, and Sjögren disease.

Methods

We developed clinically relevant population, intervention, comparator, and outcomes questions related to screening and monitoring for ILD in patients with SARDs. A systematic literature review was performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A Voting Panel of interdisciplinary clinician experts and patients achieved consensus on the direction and strength of each recommendation.

Results

Fifteen recommendations were developed. For screening people with these SARDs at risk for ILD, we conditionally recommend pulmonary function tests (PFTs) and high-resolution computed tomography of the chest (HRCT chest); conditionally recommend against screening with 6-minute walk test distance (6MWD), chest radiography, ambulatory desaturation testing, or bronchoscopy; and strongly recommend against screening with surgical lung biopsy. We conditionally recommend monitoring ILD with PFTs, HRCT chest, and ambulatory desaturation testing and conditionally recommend against monitoring with 6MWD, chest radiography, or bronchoscopy. We provide guidance on ILD risk factors and suggestions on frequency of testing to evaluate for the development of ILD in people with SARDs.

Conclusion

This clinical practice guideline presents the first recommendations endorsed by the American College of Rheumatology and American College of Chest Physicians for the screening and monitoring of ILD in people with SARDs.

目的:我们就系统性自身免疫性风湿病(SARDs),特别是类风湿性关节炎、系统性硬化症、特发性炎症性肌病、混合性结缔组织病和Sjögren病患者的间质性肺病(ILD)筛查和ILD进展监测提出了循证建议:我们提出了与 SARDs 患者 ILD 筛查和监测相关的临床相关人群、干预措施、比较对象和结果问题。我们进行了系统的文献综述,并采用建议分级、评估、开发和评价方法对现有证据进行了评级。由跨学科临床专家和患者组成的投票小组就每项建议的方向和力度达成了共识:结果:提出了 15 项建议。对于筛查有 ILD 风险的 SARDs 患者,我们有条件地建议进行肺功能检查 (PFT) 和胸部高分辨率计算机断层扫描 (HRCT);有条件地建议不要进行 6 分钟步行距离 (6MWD)、胸部放射摄影、非卧床低饱和度测试或支气管镜检查;强烈建议不要进行外科肺活检筛查。我们有条件地建议使用 PFT、胸部 HRCT 和非卧床饱和度检测对 ILD 进行监测,并有条件地建议不要使用 6MWD、胸片或支气管镜进行监测。我们提供了有关 ILD 危险因素的指导,并建议进行检查的频率,以评估 SARDs 患者 ILD 的发展情况:本临床实践指南首次提出了美国风湿病学会和美国胸科医师学会认可的筛查和监测 SARDs 患者 ILD 的建议。
{"title":"2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases","authors":"Sindhu R. Johnson,&nbsp;Elana J. Bernstein,&nbsp;Marcy B. Bolster,&nbsp;Jonathan H. Chung,&nbsp;Sonye K. Danoff,&nbsp;Michael D. George,&nbsp;Dinesh Khanna,&nbsp;Gordon Guyatt,&nbsp;Reza D. Mirza,&nbsp;Rohit Aggarwal,&nbsp;Aberdeen Allen Jr,&nbsp;Shervin Assassi,&nbsp;Lenore Buckley,&nbsp;Hassan A. Chami,&nbsp;Douglas S. Corwin,&nbsp;Paul F. Dellaripa,&nbsp;Robyn T. Domsic,&nbsp;Tracy J. Doyle,&nbsp;Catherine Marie Falardeau,&nbsp;Tracy M. Frech,&nbsp;Fiona K. Gibbons,&nbsp;Monique Hinchcliff,&nbsp;Cheilonda Johnson,&nbsp;Jeffrey P. Kanne,&nbsp;John S. Kim,&nbsp;Sian Yik Lim,&nbsp;Scott Matson,&nbsp;Zsuzsanna H. McMahan,&nbsp;Samantha J. Merck,&nbsp;Kiana Nesbitt,&nbsp;Mary Beth Scholand,&nbsp;Lee Shapiro,&nbsp;Christine D. Sharkey,&nbsp;Ross Summer,&nbsp;John Varga,&nbsp;Anil Warrier,&nbsp;Sandeep K. Agarwal,&nbsp;Danielle Antin-Ozerkis,&nbsp;Bradford Bemiss,&nbsp;Vaidehi Chowdhary,&nbsp;Jane E. Dematte D'Amico,&nbsp;Robert Hallowell,&nbsp;Alicia M. Hinze,&nbsp;Patil A. Injean,&nbsp;Nikhil Jiwrajka,&nbsp;Elena K. Joerns,&nbsp;Joyce S. Lee,&nbsp;Ashima Makol,&nbsp;Gregory C. McDermott,&nbsp;Jake G. Natalini,&nbsp;Justin M. Oldham,&nbsp;Didem Saygin,&nbsp;Kimberly Showalter Lakin,&nbsp;Namrata Singh,&nbsp;Joshua J. Solomon,&nbsp;Jeffrey A. Sparks,&nbsp;Marat Turgunbaev,&nbsp;Samera Vaseer,&nbsp;Amy Turner,&nbsp;Stacey Uhl,&nbsp;Ilya Ivlev","doi":"10.1002/acr.25347","DOIUrl":"10.1002/acr.25347","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We provide evidence-based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring for ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, and Sjögren disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We developed clinically relevant population, intervention, comparator, and outcomes questions related to screening and monitoring for ILD in patients with SARDs. A systematic literature review was performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A Voting Panel of interdisciplinary clinician experts and patients achieved consensus on the direction and strength of each recommendation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifteen recommendations were developed. For screening people with these SARDs at risk for ILD, we conditionally recommend pulmonary function tests (PFTs) and high-resolution computed tomography of the chest (HRCT chest); conditionally recommend against screening with 6-minute walk test distance (6MWD), chest radiography, ambulatory desaturation testing, or bronchoscopy; and strongly recommend <i>against</i> screening with surgical lung biopsy. We conditionally recommend monitoring ILD with PFTs, HRCT chest, and ambulatory desaturation testing and conditionally recommend <i>against</i> monitoring with 6MWD, chest radiography, or bronchoscopy. We provide guidance on ILD risk factors and suggestions on frequency of testing to evaluate for the development of ILD in people with SARDs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This clinical practice guideline presents the first recommendations endorsed by the American College of Rheumatology and American College of Chest Physicians for the screening and monitoring of ILD in people with SARDs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":"76 8","pages":"1070-1082"},"PeriodicalIF":3.7,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.25347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases 2023 美国风湿病学会 (ACR)/ 美国胸科医师学会 (CHEST) 《系统性自身免疫性风湿病患者间质性肺病治疗指南》。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-07-08 DOI: 10.1002/acr.25348
Sindhu R. Johnson, Elana J. Bernstein, Marcy B. Bolster, Jonathan H. Chung, Sonye K. Danoff, Michael D. George, Dinesh Khanna, Gordon Guyatt, Reza D. Mirza, Rohit Aggarwal, Aberdeen Allen Jr, Shervin Assassi, Lenore Buckley, Hassan A. Chami, Douglas S. Corwin, Paul F. Dellaripa, Robyn T. Domsic, Tracy J. Doyle, Catherine Marie Falardeau, Tracy M. Frech, Fiona K. Gibbons, Monique Hinchcliff, Cheilonda Johnson, Jeffrey P. Kanne, John S. Kim, Sian Yik Lim, Scott Matson, Zsuzsanna H. McMahan, Samantha J. Merck, Kiana Nesbitt, Mary Beth Scholand, Lee Shapiro, Christine D. Sharkey, Ross Summer, John Varga, Anil Warrier, Sandeep K. Agarwal, Danielle Antin-Ozerkis, Bradford Bemiss, Vaidehi Chowdhary, Jane E. Dematte D'Amico, Robert Hallowell, Alicia M. Hinze, Patil A. Injean, Nikhil Jiwrajka, Elena K. Joerns, Joyce S. Lee, Ashima Makol, Gregory C. McDermott, Jake G. Natalini, Justin M. Oldham, Didem Saygin, Kimberly Showalter Lakin, Namrata Singh, Joshua J. Solomon, Jeffrey A. Sparks, Marat Turgunbaev, Samera Vaseer, Amy Turner, Stacey Uhl, Ilya Ivlev

Objective

We provide evidence-based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs).

Methods

We developed clinically relevant population, intervention, comparator, and outcomes questions. A systematic literature review was then performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A panel of clinicians and patients reached consensus on the direction and strength of the recommendations.

Results

Thirty-five recommendations were generated (including two strong recommendations) for first-line SARD-ILD treatment, treatment of SARD-ILD progression despite first-line ILD therapy, and treatment of rapidly progressive ILD. The strong recommendations were against using glucocorticoids in systemic sclerosis–ILD as a first-line ILD therapy and after ILD progression. Otherwise, glucocorticoids are conditionally recommended for first-line ILD treatment in all other SARDs.

Conclusion

This clinical practice guideline presents the first recommendations endorsed by the American College of Rheumatology and American College of Chest Physicians for the treatment of ILD in people with SARDs.

摘要我们就系统性自身免疫性风湿病(SARDs)成人患者间质性肺病(ILD)的治疗提供循证建议:方法:我们提出了与临床相关的人群、干预措施、参照物和结果等问题。然后进行了系统的文献综述,并采用建议分级、评估、开发和评价方法对现有证据进行了评级。一个由临床医生和患者组成的小组就建议的方向和力度达成了共识:结果:针对一线 SARD-ILD 治疗、一线 ILD 治疗后 SARD-ILD 进展的治疗以及快速进展性 ILD 的治疗提出了 35 项建议(包括两项强力建议)。强烈建议反对将糖皮质激素用于系统性硬化-ILD 的一线 ILD 治疗和 ILD 进展后的治疗。否则,有条件地推荐糖皮质激素用于所有其他 SARDs 的一线 ILD 治疗:本临床实践指南首次提出了美国风湿病学会和美国胸科医师学会认可的治疗 SARDs 患者 ILD 的建议。
{"title":"2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases","authors":"Sindhu R. Johnson,&nbsp;Elana J. Bernstein,&nbsp;Marcy B. Bolster,&nbsp;Jonathan H. Chung,&nbsp;Sonye K. Danoff,&nbsp;Michael D. George,&nbsp;Dinesh Khanna,&nbsp;Gordon Guyatt,&nbsp;Reza D. Mirza,&nbsp;Rohit Aggarwal,&nbsp;Aberdeen Allen Jr,&nbsp;Shervin Assassi,&nbsp;Lenore Buckley,&nbsp;Hassan A. Chami,&nbsp;Douglas S. Corwin,&nbsp;Paul F. Dellaripa,&nbsp;Robyn T. Domsic,&nbsp;Tracy J. Doyle,&nbsp;Catherine Marie Falardeau,&nbsp;Tracy M. Frech,&nbsp;Fiona K. Gibbons,&nbsp;Monique Hinchcliff,&nbsp;Cheilonda Johnson,&nbsp;Jeffrey P. Kanne,&nbsp;John S. Kim,&nbsp;Sian Yik Lim,&nbsp;Scott Matson,&nbsp;Zsuzsanna H. McMahan,&nbsp;Samantha J. Merck,&nbsp;Kiana Nesbitt,&nbsp;Mary Beth Scholand,&nbsp;Lee Shapiro,&nbsp;Christine D. Sharkey,&nbsp;Ross Summer,&nbsp;John Varga,&nbsp;Anil Warrier,&nbsp;Sandeep K. Agarwal,&nbsp;Danielle Antin-Ozerkis,&nbsp;Bradford Bemiss,&nbsp;Vaidehi Chowdhary,&nbsp;Jane E. Dematte D'Amico,&nbsp;Robert Hallowell,&nbsp;Alicia M. Hinze,&nbsp;Patil A. Injean,&nbsp;Nikhil Jiwrajka,&nbsp;Elena K. Joerns,&nbsp;Joyce S. Lee,&nbsp;Ashima Makol,&nbsp;Gregory C. McDermott,&nbsp;Jake G. Natalini,&nbsp;Justin M. Oldham,&nbsp;Didem Saygin,&nbsp;Kimberly Showalter Lakin,&nbsp;Namrata Singh,&nbsp;Joshua J. Solomon,&nbsp;Jeffrey A. Sparks,&nbsp;Marat Turgunbaev,&nbsp;Samera Vaseer,&nbsp;Amy Turner,&nbsp;Stacey Uhl,&nbsp;Ilya Ivlev","doi":"10.1002/acr.25348","DOIUrl":"10.1002/acr.25348","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We provide evidence-based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We developed clinically relevant population, intervention, comparator, and outcomes questions. A systematic literature review was then performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A panel of clinicians and patients reached consensus on the direction and strength of the recommendations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-five recommendations were generated (including two strong recommendations) for first-line SARD-ILD treatment, treatment of SARD-ILD progression despite first-line ILD therapy, and treatment of rapidly progressive ILD. The strong recommendations were against using glucocorticoids in systemic sclerosis–ILD as a first-line ILD therapy and after ILD progression. Otherwise, glucocorticoids are conditionally recommended for first-line ILD treatment in all other SARDs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This clinical practice guideline presents the first recommendations endorsed by the American College of Rheumatology and American College of Chest Physicians for the treatment of ILD in people with SARDs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":"76 8","pages":"1051-1069"},"PeriodicalIF":3.7,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.25348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucosamine and Cancer Incidence in Osteoarthritis: A Prevalent New-User Cohort Design 氨基葡萄糖与骨关节炎的癌症发病率:新用户队列设计。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-07-08 DOI: 10.1002/acr.25399
Karine Suissa, Sophie Dell'Aniello, Eros Comin, Marie Hudson, Samy Suissa

Objective

Observational studies have associated glucosamine, used to treat joint pain and osteoarthritis, with reductions in cancer incidence, although their study design was affected by selection bias. We assessed this association using a study design that mitigates this selection bias.

Methods

We used the UK Clinical Practice Research Datalink to identify a cohort of patients diagnosed with osteoarthritis during 1995 through 2017. The prevalent new-user cohort design was employed to match glucosamine initiators with non-users on time-conditional propensity scores, who were observed until cancer incidence. Hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer incidence were estimated to compare glucosamine initiators with non-users.

Results

The study cohort of patients with osteoarthritis included 20,541 glucosamine initiators who were matched to 20,541 non-users. Over an average follow-up of eight years, the overall incidence rate of any cancer was 16.4 per 1,000 per year. The HR of any cancer incidence with glucosamine treatment was 0.97 (95% CI 0.91–1.02) compared with non-users. For lung cancer, the HR with glucosamine treatment was 0.99 (95% CI 0.83–1.18), whereas it was 1.11 (95% CI 0.93–1.33) for colorectal cancer, 1.07 (95% CI 0.93–1.23) for breast cancer in women, and 1.03 (95% CI 0.88–1.22) for prostate cancer.

Conclusion

In this large, real-world study of patients with osteoarthritis, designed to emulate a trial, treatment with glucosamine did not reduce the incidence of cancer. This finding reinforces that previous studies, not based on glucosamine initiators, were affected by selection bias. Our study does not support the prescription of glucosamine to prevent cancer in patients with osteoarthritis.

背景:观察性研究发现,用于治疗关节疼痛和骨关节炎的氨基葡萄糖与癌症发病率的降低有关,但其研究设计受到了选择偏倚的影响。我们采用一种可减轻这种选择偏差的研究设计来评估这种关联:我们利用英国临床实践研究数据链(UK Clinical Practice Research Datalink)确定了 1995-2017 年期间诊断为骨关节炎的患者队列。我们采用流行的新用户队列设计,根据时间条件倾向评分将氨基葡萄糖的初始使用者与非使用者进行匹配,并随访至癌症发生。通过估算癌症发病率的危险比(HR)和95%置信区间(CI)来比较氨基葡萄糖的使用和不使用情况:骨关节炎患者研究队列包括 20,541 名开始使用氨基葡萄糖的患者和 20,541 名未使用氨基葡萄糖的患者。在平均 8 年的随访期间,癌症总发病率为每年 16.4‰。使用氨基葡萄糖与不使用相比,任何癌症发病率的HR值为0.97(95% CI 0.91-1.02)。就肺癌而言,使用氨基葡萄糖的HR值为0.99(95% CI 0.83-1.18),而结肠直肠癌的HR值为1.11(95% CI 0.93-1.33),女性乳腺癌的HR值为1.07(95% CI 0.93-1.23),前列腺癌的HR值为1.03(95% CI 0.88-1.22):在这项针对骨关节炎患者的大型真实世界研究中,使用氨基葡萄糖治疗并没有降低癌症的发病率。这一发现进一步说明,以往的研究并非基于新用户,而是受到了选择偏差的影响。我们的研究不支持骨关节炎患者使用氨基葡萄糖预防癌症。
{"title":"Glucosamine and Cancer Incidence in Osteoarthritis: A Prevalent New-User Cohort Design","authors":"Karine Suissa,&nbsp;Sophie Dell'Aniello,&nbsp;Eros Comin,&nbsp;Marie Hudson,&nbsp;Samy Suissa","doi":"10.1002/acr.25399","DOIUrl":"10.1002/acr.25399","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Observational studies have associated glucosamine, used to treat joint pain and osteoarthritis, with reductions in cancer incidence, although their study design was affected by selection bias. We assessed this association using a study design that mitigates this selection bias.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used the UK Clinical Practice Research Datalink to identify a cohort of patients diagnosed with osteoarthritis during 1995 through 2017. The prevalent new-user cohort design was employed to match glucosamine initiators with non-users on time-conditional propensity scores, who were observed until cancer incidence. Hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer incidence were estimated to compare glucosamine initiators with non-users.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study cohort of patients with osteoarthritis included 20,541 glucosamine initiators who were matched to 20,541 non-users. Over an average follow-up of eight years, the overall incidence rate of any cancer was 16.4 per 1,000 per year. The HR of any cancer incidence with glucosamine treatment was 0.97 (95% CI 0.91–1.02) compared with non-users. For lung cancer, the HR with glucosamine treatment was 0.99 (95% CI 0.83–1.18), whereas it was 1.11 (95% CI 0.93–1.33) for colorectal cancer, 1.07 (95% CI 0.93–1.23) for breast cancer in women, and 1.03 (95% CI 0.88–1.22) for prostate cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this large, real-world study of patients with osteoarthritis, designed to emulate a trial, treatment with glucosamine did not reduce the incidence of cancer. This finding reinforces that previous studies, not based on glucosamine initiators, were affected by selection bias. Our study does not support the prescription of glucosamine to prevent cancer in patients with osteoarthritis.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":"76 11","pages":"1493-1500"},"PeriodicalIF":3.7,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.25399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Patient Values and Preferences to Inform the 2023 American College of Rheumatology/American College of Chest Physicians Interstitial Lung Disease Guidelines 评估患者的价值观和偏好,为 2023 年美国风湿病学会/美国胸科医师学会间质性肺病指南提供依据。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-07-08 DOI: 10.1002/acr.25346
Reza D. Mirza, Marcy B. Bolster, Sindhu R. Johnson, Aberdeen Allen Jr, Elana J. Bernstein, Jonathan H. Chung, Sonye K. Danoff, Catherine Falardeau, Gordon Guyatt, Ilya Ivlev, Dinesh Khanna, Kiana T. Nesbitt, Amy Turner, Stacey Uhl, Michael D. George

Objective

Patient engagement is critical to clinical practice guideline (CPG) development. This work presents our approach to ascertaining patients’ values and preferences to inform the American College of Rheumatology guidelines for screening, monitoring, and treatment of interstitial lung disease (ILD) in people with systemic autoimmune rheumatic diseases (SARDs).

Methods

We conducted a cross-sectional qualitative study of a purposefully sampled Patient Panel using a modified content analytic approach. The study team reviewed text transcripts from the Patient Panel discussion to identify themes and develop a clustered thematic schema.

Results

Twenty-one patients (75% women) participated, with a mean age of 53 years (range 33–73). Patients had one or more SARDs: systemic sclerosis (38%), Sjögren disease (38%), idiopathic inflammatory myopathy (33%), rheumatoid arthritis (24%), and mixed connective tissue disease (10%). We identified 10 themes in 4 thematic clusters: communication, screening and monitoring, treatment goals, and treatment adverse effects. Patients prioritized recognizing ILD symptoms, importance of ILD screening and close monitoring, goals of survival and improving quality of life, and willingness to accept treatment risks provided that there is close communication with providers. Patient representatives shared patients’ priorities and insight at the Voting Panel meeting, influencing multiple guideline recommendations.

Conclusion

Patient engagement fosters a holistic approach to CPG development, leading to recommendations aiming for the best clinical outcomes while prioritizing outcomes important for patients. The patient-identified themes played a critical role in ILD guideline development and provide core elements for shared decision-making as clinicians make management and therapeutic decisions with patients with SARD-associated ILD.

目的:患者的参与对于临床实践指南(CPG)的制定至关重要。本研究介绍了我们确定患者价值观和偏好的方法,以便为美国风湿病学会关于系统性自身免疫性风湿病(SARDs)患者间质性肺病(ILD)的筛查、监测和治疗指南提供信息:我们采用改良的内容分析法对有目的抽样的患者小组进行了横断面定性研究。研究小组审阅了患者小组讨论的文字记录,以确定主题并建立聚类主题模式:21 名患者(75% 为女性)参与了研究,平均年龄为 53 岁(33-73 岁不等)。患者患有一种或多种 SARDs:系统性硬化症(38%)、斯约格伦病(38%)、特发性炎症性肌病(33%)、类风湿性关节炎(24%)和混合性结缔组织病(10%)。我们确定了 4 个主题群中的 10 个主题:沟通、筛查和监测、治疗目标和治疗不良反应。患者优先考虑识别 ILD 症状、ILD 筛查和密切监测的重要性、生存和提高生活质量的目标以及接受治疗风险的意愿,前提是与医疗服务提供者保持密切沟通。患者代表在投票小组会议上分享了患者的优先事项和见解,对多项指南建议产生了影响:结论:患者的参与促进了制定 CPG 的整体方法,从而提出了旨在获得最佳临床效果的建议,同时优先考虑对患者重要的效果。患者确定的主题在 ILD 指南的制定过程中发挥了关键作用,并为临床医生对 SARD 相关 ILD 患者做出管理和治疗决策时的共同决策提供了核心要素。
{"title":"Assessing Patient Values and Preferences to Inform the 2023 American College of Rheumatology/American College of Chest Physicians Interstitial Lung Disease Guidelines","authors":"Reza D. Mirza,&nbsp;Marcy B. Bolster,&nbsp;Sindhu R. Johnson,&nbsp;Aberdeen Allen Jr,&nbsp;Elana J. Bernstein,&nbsp;Jonathan H. Chung,&nbsp;Sonye K. Danoff,&nbsp;Catherine Falardeau,&nbsp;Gordon Guyatt,&nbsp;Ilya Ivlev,&nbsp;Dinesh Khanna,&nbsp;Kiana T. Nesbitt,&nbsp;Amy Turner,&nbsp;Stacey Uhl,&nbsp;Michael D. George","doi":"10.1002/acr.25346","DOIUrl":"10.1002/acr.25346","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Patient engagement is critical to clinical practice guideline (CPG) development. This work presents our approach to ascertaining patients’ values and preferences to inform the American College of Rheumatology guidelines for screening, monitoring, and treatment of interstitial lung disease (ILD) in people with systemic autoimmune rheumatic diseases (SARDs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a cross-sectional qualitative study of a purposefully sampled Patient Panel using a modified content analytic approach. The study team reviewed text transcripts from the Patient Panel discussion to identify themes and develop a clustered thematic schema.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-one patients (75% women) participated, with a mean age of 53 years (range 33–73). Patients had one or more SARDs: systemic sclerosis (38%), Sjögren disease (38%), idiopathic inflammatory myopathy (33%), rheumatoid arthritis (24%), and mixed connective tissue disease (10%). We identified 10 themes in 4 thematic clusters: communication, screening and monitoring, treatment goals, and treatment adverse effects. Patients prioritized recognizing ILD symptoms, importance of ILD screening and close monitoring, goals of survival and improving quality of life, and willingness to accept treatment risks provided that there is close communication with providers. Patient representatives shared patients’ priorities and insight at the Voting Panel meeting, influencing multiple guideline recommendations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patient engagement fosters a holistic approach to CPG development, leading to recommendations aiming for the best clinical outcomes while prioritizing outcomes important for patients. The patient-identified themes played a critical role in ILD guideline development and provide core elements for shared decision-making as clinicians make management and therapeutic decisions with patients with SARD-associated ILD.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":"76 8","pages":"1083-1089"},"PeriodicalIF":3.7,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.25346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Labor Force Participation in Adults With Osteoarthritis or Joint Symptoms Typical of Osteoarthritis: Findings From a Canadian Longitudinal Study on Aging 患有骨关节炎 (OA) 或有典型 OA 关节症状的成年人的劳动力参与情况:加拿大老龄问题纵向研究的结果。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-07-04 DOI: 10.1002/acr.25398
Elizabeth M. Badley, Shatabdy Zahid, Jessica M. Wilfong, Anthony V. Perruccio

Objective

The purpose of the study is to examine the relationship between osteoarthritis (OA) and joint symptoms typical of OA and labor force participation.

Methods

Data are from the baseline questionnaire of the Canadian Longitudinal Study on Aging for respondents aged 45 to 74 years at baseline (n = 24,427). Individuals were categorized into one of five mutually exclusive arthritis status groups: diagnosed OA, diagnosed other type of arthritis, two to three symptomatic joint sites and no diagnosed arthritis, one symptomatic joint site and no diagnosed arthritis, and no arthritis and no joint symptoms. Age-stratified robust log-Poisson regression analysis was used to examine the association between arthritis status and labor force participation.

Results

Overall, 39% of the analytic sample reported being out of the labor force. Those with OA aged 45 to 54 and 55 to 64 years were significantly more likely to be out of the labor force than those with no arthritis or no joint symptoms, with prevalence ratios (PRs) of 1.34 (95% confidence interval [CI] 1.10–1.65) and 1.13 (95% CI 1.06–1.21), respectively, with similar results for those with two to three joint symptoms and no OA in the 45 to 54 years age group (PR 1.37 [95% CI 1.07–1.76]). There was no difference for those aged 65 to 74 years. Being an informal caregiver increased the likelihood of nonparticipation in the labor force for those aged 55 to 64 years (PR 1.09 [95% CI 1.04–1.15]).

Conclusion

Our results suggest that an exclusive reliance on an OA diagnosis to understand impact on labor force participation may miss a large segment of the middle-aged population, which may have undiagnosed OA or be at greater risk of OA because of joint problems.

研究目的本研究旨在探讨骨关节炎(OA)和典型关节症状与劳动力参与之间的关系:数据来自加拿大老龄化纵向研究(Canadian Longitudinal Study on Aging)的基线问卷,受访者基线年龄为 45-74 岁(n=24,427)。受调查者被分为五个相互排斥的关节炎状态组:确诊为 OA;确诊为其他类型的关节炎;2-3 个有症状的关节部位/未确诊为关节炎;1 个有症状的关节部位/未确诊为关节炎;无关节炎/无关节症状。采用年龄分层稳健对数-泊松回归分析来研究关节炎状况与劳动力参与之间的关系:总体而言,39%的分析样本报告说自己没有参加工作。与无关节炎/无关节症状者相比,45-54 岁和 55-64 岁有 OA 者失业的可能性明显更高,患病率比(PR)分别为 1.34 [95% CI 1.10-1.65] 和 1.13 [95% CI 1.06-1.21],45-54 岁年龄组中有 2-3 个关节症状/无 OA 者的患病率比(PR 1.37 [95% CI 1.07-1.76])与之类似。65-74 岁年龄组没有差异。在 55-64 岁年龄组中,非正式护理人员增加了不加入劳动力队伍的可能性,PR 为 1.09 [95% CI 1.04-1.15]:我们的研究结果表明,如果仅仅依赖于 OA 诊断来了解对劳动力参与的影响,可能会忽略很大一部分中年人群,他们可能患有未确诊的 OA,或者由于关节问题而面临更大的 OA 风险。
{"title":"Labor Force Participation in Adults With Osteoarthritis or Joint Symptoms Typical of Osteoarthritis: Findings From a Canadian Longitudinal Study on Aging","authors":"Elizabeth M. Badley,&nbsp;Shatabdy Zahid,&nbsp;Jessica M. Wilfong,&nbsp;Anthony V. Perruccio","doi":"10.1002/acr.25398","DOIUrl":"10.1002/acr.25398","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The purpose of the study is to examine the relationship between osteoarthritis (OA) and joint symptoms typical of OA and labor force participation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data are from the baseline questionnaire of the Canadian Longitudinal Study on Aging for respondents aged 45 to 74 years at baseline (n = 24,427). Individuals were categorized into one of five mutually exclusive arthritis status groups: diagnosed OA, diagnosed other type of arthritis, two to three symptomatic joint sites and no diagnosed arthritis, one symptomatic joint site and no diagnosed arthritis, and no arthritis and no joint symptoms. Age-stratified robust log-Poisson regression analysis was used to examine the association between arthritis status and labor force participation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 39% of the analytic sample reported being out of the labor force. Those with OA aged 45 to 54 and 55 to 64 years were significantly more likely to be out of the labor force than those with no arthritis or no joint symptoms, with prevalence ratios (PRs) of 1.34 (95% confidence interval [CI] 1.10–1.65) and 1.13 (95% CI 1.06–1.21), respectively, with similar results for those with two to three joint symptoms and no OA in the 45 to 54 years age group (PR 1.37 [95% CI 1.07–1.76]). There was no difference for those aged 65 to 74 years. Being an informal caregiver increased the likelihood of nonparticipation in the labor force for those aged 55 to 64 years (PR 1.09 [95% CI 1.04–1.15]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results suggest that an exclusive reliance on an OA diagnosis to understand impact on labor force participation may miss a large segment of the middle-aged population, which may have undiagnosed OA or be at greater risk of OA because of joint problems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":"76 11","pages":"1471-1478"},"PeriodicalIF":3.7,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.25398","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultraprocessed Food Intake and Risk of Systemic Lupus Erythematosus Among Women Observed in the Nurses' Health Study Cohorts. 超加工食品摄入量与护士健康研究队列中妇女患系统性红斑狼疮的风险。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-06-27 DOI: 10.1002/acr.25395
Sinara Rossato, Emily G Oakes, Medha Barbhaiya, Jeffrey A Sparks, Susan Malspeis, Walter C Willett, Neha Khandpur, Karen H Costenbader

Objective: We assessed ultraprocessed food (UPF) intake and systemic lupus erythematosus (SLE) incidence within the prospective Nurses' Health Study (NHS) cohorts.

Methods: A total of 204,175 women were observed (NHS 1984-2016; NHSII 1991-2017). Semiquantitative food frequency questionnaires were completed every two to four years. UPF intake was determined as per the Nova classification. Nurses self-reported new doctor-diagnosed SLE, confirmed by medical records. Time-varying Cox regressions estimated hazard ratios (HRs; 95% confidence intervals [CIs]) for patients with incident SLE and SLE by anti-double-stranded DNA (dsDNA) antibody at diagnosis, according to cumulatively updated daily (a) UPF servings, (b) total intake (in grams and milliliters), and (c) percentage of total intake. Analyses adjusted for age, race, cohort, caloric and alcohol intakes, household income, smoking, body mass index (BMI), physical activity, menarchal age, and oral contraceptive use. We tested for interaction with BMI and examined UPF categories.

Results: Mean baseline age was ~50 years (NHS) and ~36 years (NHSII); 93% self-reported White race. A total of 212 patients with incident SLE were identified. SLE risk was higher in the third versus first UPF tertile (servings per day pooled multivariable [MV] HR 1.56, 95% CI 1.04-2.32; P = 0.03). Results were stronger for dsDNA antibody in patients with SLE (servings per day pooled MV HR 2.05, 95% CI 1.15-3.65; P = 0.01) and for absolute (servings or total) than percentage of total intake. Sugar-sweetened/artificially sweetened beverages were associated with SLE risk (third vs first tertile MV HR 1.45, 95% CI 1.01-2.09). No BMI interactions were observed.

Conclusion: Higher cumulative average daily UPF intake was associated with >50% increased SLE risk and with doubled risk for anti-dsDNA antibody in patients with SLE. Many deleterious effects on systemic inflammation and immunity are postulated.

目的:我们评估了前瞻性护士健康研究队列中超加工食品(UPF)的摄入量和系统性红斑狼疮的发病率。方法:我们对204175名女性进行了跟踪调查,NHS:1984-2016年;NHSII:1991-2017年。每2-4年填写一次半定量食物频率问卷。根据诺瓦分类法确定 UPF 摄入量。护士自我报告新的医生诊断的系统性红斑狼疮,并由医疗记录确认。时变 Cox 回归估算了诊断时抗双链 DNA 抗体(dsDNA)的系统性红斑狼疮和系统性红斑狼疮的发病危险比(HR,95% 置信区间),根据每天累计更新的 a) UPF 份数、b) 总摄入量(克+毫升)和 c) 总摄入量百分比。分析调整了年龄、种族、队列、热量和酒精摄入量、家庭收入、吸烟、体重指数 (BMI)、体力活动、男性年龄和口服避孕药使用情况。我们测试了与体重指数的交互作用,并检查了 UPF 类别:平均基线年龄约为 50 岁(NHS)和约为 36 岁(NHSII);93% 的自述者为白种人。共发现 212 例系统性红斑狼疮病例。UPF三等分位数第三位与第一位相比,系统性红斑狼疮风险更高(份数/天集合多变量[MV] HR 1.56 (1.04-2.32);P趋势 0.03)。dsDNA+系统性红斑狼疮的结果更明显(份数/天集合多变量 HR 2.05 (1.15-3.65);P 趋势 0.01),绝对摄入量(份数或总量)比总摄入量百分比的结果更明显。糖/人工加糖饮料与系统性红斑狼疮风险有关(第 3 与第 1 三等分MV HR 1.45 (1.01-2.09))。没有观察到体重指数之间的相互作用:结论:较高的累积平均每日UPF摄入量与系统性红斑狼疮风险增加50%以上有关,与抗dsDNA+系统性红斑狼疮风险加倍有关。推测UPF对全身炎症和免疫有许多有害影响。
{"title":"Ultraprocessed Food Intake and Risk of Systemic Lupus Erythematosus Among Women Observed in the Nurses' Health Study Cohorts.","authors":"Sinara Rossato, Emily G Oakes, Medha Barbhaiya, Jeffrey A Sparks, Susan Malspeis, Walter C Willett, Neha Khandpur, Karen H Costenbader","doi":"10.1002/acr.25395","DOIUrl":"10.1002/acr.25395","url":null,"abstract":"<p><strong>Objective: </strong>We assessed ultraprocessed food (UPF) intake and systemic lupus erythematosus (SLE) incidence within the prospective Nurses' Health Study (NHS) cohorts.</p><p><strong>Methods: </strong>A total of 204,175 women were observed (NHS 1984-2016; NHSII 1991-2017). Semiquantitative food frequency questionnaires were completed every two to four years. UPF intake was determined as per the Nova classification. Nurses self-reported new doctor-diagnosed SLE, confirmed by medical records. Time-varying Cox regressions estimated hazard ratios (HRs; 95% confidence intervals [CIs]) for patients with incident SLE and SLE by anti-double-stranded DNA (dsDNA) antibody at diagnosis, according to cumulatively updated daily (a) UPF servings, (b) total intake (in grams and milliliters), and (c) percentage of total intake. Analyses adjusted for age, race, cohort, caloric and alcohol intakes, household income, smoking, body mass index (BMI), physical activity, menarchal age, and oral contraceptive use. We tested for interaction with BMI and examined UPF categories.</p><p><strong>Results: </strong>Mean baseline age was ~50 years (NHS) and ~36 years (NHSII); 93% self-reported White race. A total of 212 patients with incident SLE were identified. SLE risk was higher in the third versus first UPF tertile (servings per day pooled multivariable [MV] HR 1.56, 95% CI 1.04-2.32; P = 0.03). Results were stronger for dsDNA antibody in patients with SLE (servings per day pooled MV HR 2.05, 95% CI 1.15-3.65; P = 0.01) and for absolute (servings or total) than percentage of total intake. Sugar-sweetened/artificially sweetened beverages were associated with SLE risk (third vs first tertile MV HR 1.45, 95% CI 1.01-2.09). No BMI interactions were observed.</p><p><strong>Conclusion: </strong>Higher cumulative average daily UPF intake was associated with >50% increased SLE risk and with doubled risk for anti-dsDNA antibody in patients with SLE. Many deleterious effects on systemic inflammation and immunity are postulated.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Childhood Arthritis and Rheumatology Research Alliance Biologic Disease-Modifying Antirheumatic Drug Consensus Treatment Plans for Refractory Moderately Severe Juvenile Dermatomyositis 儿童关节炎和风湿病学研究联盟针对难治性中度严重幼年皮肌炎的生物 DMARD 共识治疗方案。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-06-27 DOI: 10.1002/acr.25393
Stacey E. Tarvin, Matthew A. Sherman, Hanna Kim, Nayimisha Balmuri, Amanda G. Brown, Albert Chow, Harry L. Gewanter, Marietta M. de Guzman, Adam M. Huber, Susan Kim, Marisa S Klein-Gitelman, Megan M. Perron, Angela Byun Robinson, Sara E. Sabbagh, Sonia Savani, Susan Shenoi, Jacob Spitznagle, Cory Stingl, Grant Syverson, Heather Tory, Charles Spencer, for the Childhood Arthritis and Rheumatology Research Alliance Juvenile Dermatomyositis Workgroup

Objective

The objective was to develop consensus treatment plans (CTPs) for patients with refractory moderately severe juvenile dermatomyositis (JDM) treated with biologic disease-modifying antirheumatic drugs (bDMARDs).

Methods

The Biologics Workgroup of the Childhood Arthritis and Rheumatology Research Alliance JDM Research Committee used case-based surveys, consensus framework, and nominal group technique to produce bDMARD CTPs for patients with refractory moderately severe JDM.

Results

Four bDMARD CTPs were proposed: tumor necrosis factor α (TNFα) inhibitor (adalimumab or infliximab), abatacept, rituximab, and tocilizumab. Each CTP has different options for dosing and/or route. Among 76 respondents, consensus was achieved for the proposed CTPs (93% [67 of 72]) as well as for patient characteristics, assessments, outcome measures, and follow-up. By weighted average, respondents indicated that they would most likely administer rituximab, followed by abatacept, TNFα inhibitor, and tocilizumab.

Conclusion

CTPs for the administration of bDMARDs in refractory moderately severe JDM were developed using consensus methodology. The implementation of the bDMARD CTPs will lay the groundwork for registry-based prospective comparative effectiveness studies.

目标:目的是为接受生物制剂改善病情抗风湿药物(bDMARDs)治疗的难治性中重度幼年皮肌炎(JDM)患者制定共识治疗方案(CTPs):方法:儿童关节炎和风湿病学研究联盟(CARRA)JDM研究委员会的生物制剂工作组采用病例调查、共识框架和名义小组技术,为难治性中重度幼年皮肌炎患者制定了bDMARD CTP:结果:提出了四种 bDMARD CTP:结果:提出了四种 bDMARD CTP:TNF-α 抑制剂(阿达木单抗或英夫利昔单抗)、阿巴他赛普、利妥昔单抗和托珠单抗。每种 CTP 都有不同的剂量和/或途径选择。在 76 位受访者中,就建议的 CTP(93% [67/72])以及患者特征、评估、结果测量和随访达成了共识。通过加权平均,受访者表示他们最有可能使用利妥昔单抗,其次是阿巴他赛、TNF-α抑制剂和托珠单抗:结论:针对难治性中重度 JDM 使用 bDMARDs 的 CTP 是采用共识方法制定的。bDMARD CTPs 的实施将为以登记为基础的前瞻性疗效比较研究奠定基础。
{"title":"Childhood Arthritis and Rheumatology Research Alliance Biologic Disease-Modifying Antirheumatic Drug Consensus Treatment Plans for Refractory Moderately Severe Juvenile Dermatomyositis","authors":"Stacey E. Tarvin,&nbsp;Matthew A. Sherman,&nbsp;Hanna Kim,&nbsp;Nayimisha Balmuri,&nbsp;Amanda G. Brown,&nbsp;Albert Chow,&nbsp;Harry L. Gewanter,&nbsp;Marietta M. de Guzman,&nbsp;Adam M. Huber,&nbsp;Susan Kim,&nbsp;Marisa S Klein-Gitelman,&nbsp;Megan M. Perron,&nbsp;Angela Byun Robinson,&nbsp;Sara E. Sabbagh,&nbsp;Sonia Savani,&nbsp;Susan Shenoi,&nbsp;Jacob Spitznagle,&nbsp;Cory Stingl,&nbsp;Grant Syverson,&nbsp;Heather Tory,&nbsp;Charles Spencer,&nbsp;for the Childhood Arthritis and Rheumatology Research Alliance Juvenile Dermatomyositis Workgroup","doi":"10.1002/acr.25393","DOIUrl":"10.1002/acr.25393","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective was to develop consensus treatment plans (CTPs) for patients with refractory moderately severe juvenile dermatomyositis (JDM) treated with biologic disease-modifying antirheumatic drugs (bDMARDs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Biologics Workgroup of the Childhood Arthritis and Rheumatology Research Alliance JDM Research Committee used case-based surveys, consensus framework, and nominal group technique to produce bDMARD CTPs for patients with refractory moderately severe JDM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four bDMARD CTPs were proposed: tumor necrosis factor α (TNFα) inhibitor (adalimumab or infliximab), abatacept, rituximab, and tocilizumab. Each CTP has different options for dosing and/or route. Among 76 respondents, consensus was achieved for the proposed CTPs (93% [67 of 72]) as well as for patient characteristics, assessments, outcome measures, and follow-up. By weighted average, respondents indicated that they would most likely administer rituximab, followed by abatacept, TNFα inhibitor, and tocilizumab.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CTPs for the administration of bDMARDs in refractory moderately severe JDM were developed using consensus methodology. The implementation of the bDMARD CTPs will lay the groundwork for registry-based prospective comparative effectiveness studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":"76 11","pages":"1532-1539"},"PeriodicalIF":3.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing DAPSA, DAPSA28, and DAS28-CRP in Patients With Psoriatic Arthritis Initiating a First Tumor Necrosis Factor Inhibitor Across Nine European Countries 比较九个欧洲国家首次使用 TNF 抑制剂的银屑病关节炎患者的 DAPSA、DAPSA28 和 DAS28-CRP。
IF 3.7 2区 医学 Q1 RHEUMATOLOGY Pub Date : 2024-06-26 DOI: 10.1002/acr.25396
Louise Linde, Stylianos Georgiadis, Lykke M. Ørnbjerg, Simon H. Rasmussen, Brigitte Michelsen, Johan Askling, Daniela Di Giuseppe, Johan K. Wallman, Jakub Závada, Karel Pavelka, Miguel Bernardes, Carolina O. Matos, Bente Glintborg, Anne Gitte Loft, Dan Nordström, Laura Kuusalo, Burkhard Möller, Michael J. Nissen, Catalin Codreanu, Corina Mogosan, Bjorn Gudbjornsson, Thorvardur Jon Love, Cansu Akleylek, Florenzo Iannone, Tore K. Kvien, Ziga Rotar, Isabel Castrejon, Gary J. Macfarlane, Merete L. Hetland, Mikkel Østergaard

Objective

Because 66/68 joint counts are not always performed in routine care, we aimed to determine which of the modified 28-joint disease activity index for psoriatic arthritis (DAPSA28) or 28-joint disease activity score with C-reactive protein (DAS28-CRP) should be preferred for monitoring disease activity in psoriatic arthritis (PsA) when the original DAPSA (66/68 joints) is not available.

Methods

Prospectively collected real-world data of European bionaive patients with PsA initiating a first tumor necrosis factor inhibitor were pooled. Remission and response status were evaluated at 6 months by remission (DAPSA ≤ 4, DAPSA28 ≤ 4, and DAS28-CRP < 2.6), response (75% improvement for DAPSA and DAPSA28), and combined EULAR good/moderate responses for DAS28-CRP. Logistic regression analyses on multiple imputed data were used to identify baseline predictors.

Results

Remission and response cohorts included 3,159 and 1,866 patients, respectively. The 6-month proportions achieving remission/response were DAPSA (27%/44%), DAPSA28 (28%/44%), and DAS28-CRP (59%/80%). Of 14 possible baseline predictors, 11 predicted both DAPSA and DAPSA28 remission (8 of which also predicted their response, indicated by “*”): longer disease duration*, male sex*, and higher CRP* were positive, whereas older age*, higher body mass index*, patient fatigue*, and global, physician global, health assessment questionnaire score*, and tender and swollen* joint counts were negative predictors. Eight and five of these predicted DAS28-CRP remission and response, respectively.

Conclusion

In patients with PsA, DAPSA28 should be preferred over DAS28-CRP as a substitute for DAPSA when 66/68 joint counts are not available because of the large overlap in remission and response status and in predictors between DAPSA and DAPSA28.

目的:由于在常规治疗中并不总是进行 66/68 个关节计数,因此我们旨在确定在无法使用原始 DAPSA(66/68 个关节)监测银屑病关节炎(PsA)的疾病活动性时,应首选改良的银屑病关节炎 28 个关节疾病活动性指数(DAPSA28)还是带 C 反应蛋白的 28 个关节疾病活动性评分(DAS28-CRP):方法:汇集了前瞻性收集的首次使用肿瘤坏死因子抑制剂的欧洲仿生PsA患者的真实世界数据。通过缓解(DAPSA ≤ 4,DAPSA28 ≤ 4,DAS28-CRP < 2.6)、应答(DAPSA 和 DAPSA28 改善 75%)以及 DAS28-CRP 的 EULAR 良好/中度应答组合,在 6 个月时对缓解和应答状态进行评估。对多重估算数据进行逻辑回归分析,以确定基线预测因素:缓解组和应答组分别包括3159名和1866名患者。6个月缓解/应答比例分别为DAPSA(27%/44%)、DAPSA28(28%/44%)和DAS28-CRP(59%/80%)。在 14 个可能的基线预测因子中,有 11 个可预测 DAPSA 和 DAPSA28 缓解(其中 8 个也可预测其反应,用 "*"表示):病程较长*、男性*和较高的 CRP* 是阳性预测因子,而年龄较大*、体重指数较高*、患者疲劳*、总体评分、医生总体评分、健康评估问卷评分*以及关节触痛和肿胀*计数是阴性预测因子。其中8项和5项分别预测了DAS28-CRP的缓解和反应:结论:在PsA患者中,当无法获得66/68个关节计数时,DAPSA28应优先于DAS28-CRP作为DAPSA的替代指标,因为DAPSA和DAPSA28在缓解和反应状态以及预测指标方面存在大量重叠。
{"title":"Comparing DAPSA, DAPSA28, and DAS28-CRP in Patients With Psoriatic Arthritis Initiating a First Tumor Necrosis Factor Inhibitor Across Nine European Countries","authors":"Louise Linde,&nbsp;Stylianos Georgiadis,&nbsp;Lykke M. Ørnbjerg,&nbsp;Simon H. Rasmussen,&nbsp;Brigitte Michelsen,&nbsp;Johan Askling,&nbsp;Daniela Di Giuseppe,&nbsp;Johan K. Wallman,&nbsp;Jakub Závada,&nbsp;Karel Pavelka,&nbsp;Miguel Bernardes,&nbsp;Carolina O. Matos,&nbsp;Bente Glintborg,&nbsp;Anne Gitte Loft,&nbsp;Dan Nordström,&nbsp;Laura Kuusalo,&nbsp;Burkhard Möller,&nbsp;Michael J. Nissen,&nbsp;Catalin Codreanu,&nbsp;Corina Mogosan,&nbsp;Bjorn Gudbjornsson,&nbsp;Thorvardur Jon Love,&nbsp;Cansu Akleylek,&nbsp;Florenzo Iannone,&nbsp;Tore K. Kvien,&nbsp;Ziga Rotar,&nbsp;Isabel Castrejon,&nbsp;Gary J. Macfarlane,&nbsp;Merete L. Hetland,&nbsp;Mikkel Østergaard","doi":"10.1002/acr.25396","DOIUrl":"10.1002/acr.25396","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Because 66/68 joint counts are not always performed in routine care, we aimed to determine which of the modified 28-joint disease activity index for psoriatic arthritis (DAPSA28) or 28-joint disease activity score with C-reactive protein (DAS28-CRP) should be preferred for monitoring disease activity in psoriatic arthritis (PsA) when the original DAPSA (66/68 joints) is not available.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospectively collected real-world data of European bionaive patients with PsA initiating a first tumor necrosis factor inhibitor were pooled. Remission and response status were evaluated at 6 months by remission (DAPSA ≤ 4, DAPSA28 ≤ 4, and DAS28-CRP &lt; 2.6), response (75% improvement for DAPSA and DAPSA28), and combined EULAR good/moderate responses for DAS28-CRP. Logistic regression analyses on multiple imputed data were used to identify baseline predictors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Remission and response cohorts included 3,159 and 1,866 patients, respectively. The 6-month proportions achieving remission/response were DAPSA (27%/44%), DAPSA28 (28%/44%), and DAS28-CRP (59%/80%). Of 14 possible baseline predictors, 11 predicted both DAPSA and DAPSA28 remission (8 of which also predicted their response, indicated by “*”): longer disease duration*, male sex*, and higher CRP* were positive, whereas older age*, higher body mass index*, patient fatigue*, and global, physician global, health assessment questionnaire score*, and tender and swollen* joint counts were negative predictors. Eight and five of these predicted DAS28-CRP remission and response, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In patients with PsA, DAPSA28 should be preferred over DAS28-CRP as a substitute for DAPSA when 66/68 joint counts are not available because of the large overlap in remission and response status and in predictors between DAPSA and DAPSA28.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":"76 11","pages":"1558-1565"},"PeriodicalIF":3.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.25396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Arthritis Care & Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1