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Environmental impacts on brain functions: Low dose effects of bisphenol A during perinatal critical period 环境对脑功能的影响:围产期关键时期双酚A的低剂量效应
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2006.12.002
T. Fujimoto , K. Kubo , S. Aou

It is well known that the perinatal developing brain is vulnerable to environmental chemicals such as bisphenol A (BPA). Recent studies have focused on the low dose effects of BPA on the central nervous system (CNS). Sexual dimorphism in the rat's brain and behaviors, such as locus coeruleus (LC) and open-field behaviors, were sensitively altered by BPA in a sex-dependent manner. This chemical also enhanced the depressive response. It suggests that the developing brain, including the noradrenergic LC cell, is highly sensitive to environmental chemicals, which induces diverse behavioral alterations.

众所周知,围产期发育中的大脑容易受到环境化学物质如双酚A (BPA)的影响。最近的研究集中在双酚a对中枢神经系统(CNS)的低剂量影响上。双酚a以性别依赖的方式敏感地改变了大鼠脑内的性别二态性和行为,如蓝斑区(LC)和开放区域行为。这种化学物质也增强了抑郁反应。这表明,发育中的大脑,包括去甲肾上腺素能LC细胞,对环境化学物质高度敏感,从而导致各种行为改变。
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引用次数: 15
A dish-spinning robot using a neural oscillator 用神经振荡器旋转盘子的机器人
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2006.12.036
K. Matsuoka, M. Ooshima

Recently, models of neural oscillators have been applied to many robots that perform various rhythmic movements. This paper describes a robot that performs a dish-spinning trick using a neural oscillator model. Two oscillators actuate a two-link manipulator to whirl a vertical rod on top of which a dish is hanged, while the angular position of the dish is fed back to the oscillators as input. Essentially, the controlled system has two different dynamic modes, i.e., a low-speed, large-radius whirl and a high-speed, small-radius one. A main difficulty in the control is that the oscillators must adapt to both the modes and change its mode from one to the other. Though there exists no direct interaction between the oscillators, the robot achieves the dish-spinning trick by making use of indirect interaction by way of the mechanical system.

近年来,神经振荡器模型已应用于许多机器人执行各种有节奏的运动。本文描述了一种利用神经振荡器模型完成旋转盘子动作的机器人。两个振荡器驱动一个双连杆机械手旋转一根垂直杆,上面悬挂着一个盘子,而盘子的角度位置作为输入反馈给振荡器。从本质上讲,被控系统具有两种不同的动态模式,即低速、大半径旋转和高速、小半径旋转。控制的一个主要困难是振荡器必须适应两种模式,并从一种模式转换到另一种模式。虽然振荡器之间不存在直接的相互作用,但机器人通过机械系统利用间接的相互作用来实现旋转盘的动作。
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引用次数: 7
Real-time motion detection with a mixed analogue–digital neuromorphic vision system 模拟-数字混合神经形态视觉系统的实时运动检测
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2006.12.032
Keisuke Inoue, Seiji Kameda , Tetsuya Yagi

We fabricated a novel vision system consisting of a neuromorphic silicon retina and FPGA circuits. The silicon retina executes two classes of fundamental image pre-processing: a Laplacian–Gaussian-like spatial filtering and a subtraction of consecutive image frames. The output images of the silicon retina are fed to FPGA circuits, with which image cues, i.e., contours, motion, direction of motion and centre of moving objects, are extracted within a single frame sampling time of the silicon retina. The system has compact hardware and low power consumption and therefore is suitable for controlling autonomous robots.

我们制作了一个由神经形态硅视网膜和FPGA电路组成的新型视觉系统。硅视网膜执行两类基本图像预处理:类拉普拉斯-高斯空间滤波和连续图像帧的减法。硅视网膜的输出图像被馈送到FPGA电路,通过FPGA电路,在硅视网膜的单帧采样时间内提取图像线索,即轮廓、运动、运动方向和运动物体的中心。该系统硬件紧凑,功耗低,适用于自主机器人的控制。
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引用次数: 0
Block-splitting type morphological associative memory for practical applications 分块型形态联想记忆的实际应用
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2006.12.008
Takashi Saeki, Tsutomu Miki

From an engineering viewpoint, associative memory is one of the most valuable brain functions. A new type of associative memory, morphological associative memory (MAM), has been proposed. The MAM achieves a high perfect recall rate by using a kernel image as an index for pattern recalling. The kernel images, however, are difficult to design for a large number of stored patterns. We developed a block-splitting type morphological associative memory (BMAM) with no need of kernel images. In this paper, the architecture of the BMAM is described and its performance is discussed based on the results of autoassociation experiments.

从工程学的角度来看,联想记忆是最有价值的大脑功能之一。一种新的联想记忆类型——形态联想记忆(MAM)被提出。该方法利用核图像作为模式召回的指标,实现了较高的完美召回率。然而,很难为大量存储模式设计内核映像。我们开发了一种不需要核图像的分块型形态联想记忆(BMAM)。本文描述了BMAM的体系结构,并根据自关联实验结果对其性能进行了讨论。
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引用次数: 0
Towards manipulative neuroscience based on Brain Network Interface 基于脑网络接口的操作神经科学研究
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2007.02.063
Mitsuo Kawato

In ATR Computational Neuroscience Laboratories, we proposed several computational models such as cerebellar internal models, MOSAIC, and modular and hierarchical reinforcement-learning models. Some of these models can quantitatively reproduce subject behaviors given sensory inputs and reward and action sequences that subjects received and generated. These computational models possess putative information representation such as error signals for internal models and action stimulus dependent reward prediction, and they can be used as explanatory variables in neuroimaging and neurophysiology experiments. We named this approach computational-model-based neuroimaging, as well as computational-model-based neurophysiology. This new approach is very appealing since it is likely the only method with which we can explore neural representations remotely from either sensory or motor interfaces. However, sometimes the limitation of a mere temporal correlation between the theory and data became apparent, so we started to develop a new paradigm, “manipulative neuroscience”, where physical causality is guaranteed.

在ATR计算神经科学实验室,我们提出了几个计算模型,如小脑内部模型,马赛克,模块化和分层强化学习模型。其中一些模型可以定量地再现被试者的行为,给出被试者接受和产生的感官输入、奖励和行动序列。这些计算模型具有假定的信息表征,如内部模型的错误信号和动作刺激依赖的奖励预测,它们可以作为神经影像学和神经生理学实验的解释变量。我们将这种方法命名为基于计算模型的神经成像,以及基于计算模型的神经生理学。这种新方法非常吸引人,因为它可能是我们可以从感觉或运动接口远程探索神经表征的唯一方法。然而,有时理论和数据之间的时间相关性的局限性变得明显,因此我们开始开发一种新的范式,“操纵神经科学”,其中物理因果关系得到保证。
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引用次数: 1
A new selection circuit based on rough comparison method for GA hardware 基于粗糙比较法的遗传算法硬件选择电路
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2006.12.031
Tomokazu Hiratsuka, Hakaru Tamukoh, Keiichi Horio, Takeshi Yamakawa

Genetic algorithm (GA) is search algorithm based on the mechanics of natural selection and natural genetics. By the way, hardware accelerators for GA are required to reduce an execution time of GA. In the hardware implementation of GA, a circuit design of roulette wheel selection influences the performance of the GA hardware. In this paper, we propose a new roulette wheel selection circuit based on a rough comparison method (RCM), and evaluate effects of the proposed circuit in terms of the execution time and a circuit size.

遗传算法是一种基于自然选择和自然遗传学原理的搜索算法。同时,为了减少遗传算法的执行时间,需要硬件加速器。在遗传算法的硬件实现中,轮盘选择电路的设计直接影响到遗传算法硬件的性能。本文提出了一种基于粗糙比较法(RCM)的轮盘选择电路,并从执行时间和电路尺寸两方面评价了该电路的效果。
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引用次数: 3
A simple computational model for classifying small string sets 小串集分类的简单计算模型
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2006.11.006
Yoshihiko Suhara, Akito Sakurai

Recent research hypothesizes that the capacity for syntactic recursions forms the computational core of a uniquely human language faculty. Contrary to this hypothesis, Gentner et al. claimed that the capacity to classify sequences from recursive, center-embedded grammar is not uniquely human. We show in this paper that the patterns Gentner used are classified by a Bayesian classifier, a simple and fundamental classifier in machine learning, and consequently we claim that their argument is flawed.

最近的研究假设,语法递归的能力形成了独特的人类语言能力的计算核心。与这一假设相反,genner等人声称,从递归的、中心嵌入的语法中对序列进行分类的能力并不是人类独有的。我们在论文中表明,genner使用的模式是由贝叶斯分类器分类的,这是机器学习中简单而基本的分类器,因此我们声称他们的论点是有缺陷的。
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引用次数: 2
Modular network self-organizing map: Can it be an artificial cortex? 模块化网络自组织图:它能成为人工皮层吗?
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2006.12.003
T. Furukawa, K. Tokunaga, S. Yasui, H. Tamukoh, K. Ishii, M. Ishikawa, K. Horio, K. Natsume

This paper reports on novel developments brought by combining the self-organizing map (SOM) with a modular network. This is called modular network SOM (mnSOM). The mnSOM has an arrayed structure of functional modules aligned on a lattice, and the architecture looks similar to the column structure of our cortex. One of the advantages of the mnSOM is that the user can design the module architecture flexibly depending on the user's purpose, while the backbone algorithm of SOM is kept untouched. This advantage of mnSOM has brought us many variations and applications. In this paper, the concept of mnSOM is first introduced, and variations of mnSOM and their applications are overviewed.

本文报道了自组织映射(SOM)与模块化网络相结合所带来的新进展。这被称为模块化网络SOM (mnSOM)。mnSOM具有排列在晶格上的功能模块的阵列结构,其结构看起来类似于我们大脑皮层的柱状结构。mnSOM的优点之一是用户可以根据用户的目的灵活地设计模块体系结构,而SOM的主干算法则保持不变。mnSOM的这一优点给我们带来了许多变化和应用。本文首先介绍了mnSOM的概念,并概述了mnSOM的各种变体及其应用。
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引用次数: 1
Noise-shaping pulse-density modulation in inhibitory neural networks with subthreshold neuron circuits 阈下神经元回路抑制神经网络中的噪声整形脉冲密度调制
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2006.12.041
Akira Utagawa, Tetsuya Asai, Tetsuya Hirose, Yoshihito Amemiya

We designed subthreshold analog MOS circuits implementing an inhibitory network model that performs noise-shaping pulse-density modulation (PDM) with noisy neural elements. The aim of our research is to develop a possible ultralow-power delta–sigma type one-bit analog-to-digital converter. Through circuit simulations we confirmed that the signal-to-noise ratio (SNR) of the network was improved by 7.9 dB compared with that of the uncoupled network as a result of noise shaping.

我们设计了亚阈值模拟MOS电路,实现了一个抑制网络模型,该模型使用带噪声的神经元件执行噪声整形脉冲密度调制(PDM)。我们的研究目的是开发一种可能的超低功耗δ - σ型1位模数转换器。通过电路仿真,我们证实了由于噪声整形,网络的信噪比(SNR)比未耦合网络提高了7.9 dB。
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引用次数: 0
Simple dynamical system model of selective cue responding cell development 选择性线索反应细胞发育的简单动力系统模型
Pub Date : 2007-07-01 DOI: 10.1016/j.ics.2006.12.100
Adam Ponzi

In a recent experimental paper, Foster and Wilson [D.A. Foster, M.A. Wilson, Nature 440 (2006) 680–683] reported reverse replay of recent behavioural sequences in rat hippocampal place cells during the awake state immediately after spatial experience at the reward location. A simple dynamical system firing rate neuron model, illustrating how such replay can generate a map of the environment, selectively linking the replay location with other functionally relevant locations, is presented. Numerical simulations show the rapid development of a cell with receptive field corresponding to the reward location and only one of two cues in a cued T-maze task.

在最近的一篇实验论文中,福斯特和威尔逊[d.aFoster, M.A. Wilson, Nature 440(2006) 680-683]报道了大鼠海马位置细胞在清醒状态下的近期行为序列的反向重放。提出了一个简单的动态系统放电速率神经元模型,说明了这种重播如何生成环境地图,并有选择地将重播位置与其他功能相关的位置联系起来。数值模拟显示,在提示t迷宫任务中,一个细胞的接受野与奖励位置相对应,只有两个线索中的一个。
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