Pub Date : 2024-02-28DOI: 10.14233/ajchem.2024.31028
D. Satheesh, V. Muthulakshmi, A. Jagadesan, A. Venkatesan, K. Suresh, K. Parthipan, Savarinathan Maria Rayappan, G. Senthilkumar, S. Sudhahar
Biomass burning is a complex process, encircling chemical and physical responses covering, transmission of mass and warmth. A large number of investigations were accumulated on the significant emissions from various kinds of anthropogenic biomass burning in the recent decade. In India, an increasing trend of biomass burning is an important cause to release a large volume of reactive gases with other impurities and intensify the level of invisible particles into the troposphere, which affects humans health and leads to the probable alteration of the weather and global climate. The present review looks at the interpretations for a diverse investigation of distinct body and monitoring interventions, pertinent to our country, relating to the significance of particulate matter emissions, sources of aerosols and their health implications. This study also discusses numerous persuaded investigations, conducted on the impact of aerosol, attributed to climate change and also points out precise matters such as spatio-temporal variability of fire occurrences detected in India. Furthermore, the present study reveals that substantial quantities of data, along with a variety of enhanced simulation models and investigational validations, are essential for the development of efficient mitigation strategies with the objective of protecting the environment of the Indian Peninsula.
{"title":"A Review on Anthropogenic Biomass Burning: Emission of Aerosol Pollutants, Impact on Climate Change, Human Health and its Mitigation Strategies","authors":"D. Satheesh, V. Muthulakshmi, A. Jagadesan, A. Venkatesan, K. Suresh, K. Parthipan, Savarinathan Maria Rayappan, G. Senthilkumar, S. Sudhahar","doi":"10.14233/ajchem.2024.31028","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31028","url":null,"abstract":"Biomass burning is a complex process, encircling chemical and physical responses covering, transmission of mass and warmth. A large number of investigations were accumulated on the significant emissions from various kinds of anthropogenic biomass burning in the recent decade. In India, an increasing trend of biomass burning is an important cause to release a large volume of reactive gases with other impurities and intensify the level of invisible particles into the troposphere, which affects humans health and leads to the probable alteration of the weather and global climate. The present review looks at the interpretations for a diverse investigation of distinct body and monitoring interventions, pertinent to our country, relating to the significance of particulate matter emissions, sources of aerosols and their health implications. This study also discusses numerous persuaded investigations, conducted on the impact of aerosol, attributed to climate change and also points out precise matters such as spatio-temporal variability of fire occurrences detected in India. Furthermore, the present study reveals that substantial quantities of data, along with a variety of enhanced simulation models and investigational validations, are essential for the development of efficient mitigation strategies with the objective of protecting the environment of the Indian Peninsula.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"97 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.14233/ajchem.2024.30734
Aruna Jyothi Chatla, J. Yerrabelly, Nagaraju Dharavath, Panga Shyam
A new series of substituted (E)-2-morpholinoquinoline-3-carbaldehyde-O-((-1-phenyl-1H-1,2,3-triazol-4-yl)methyl)oxime scaffolds were synthesized from involving alkynyl quinoline oximes with various aryl azides by click reaction obtained corresponding compounds with high yields. The synthesized compounds were characterized by using IR, 1H NMR, 13C NMR and HRMS data. All the synthesized compounds screened anticancer activity against MCF-7, HeLa, PC-3 cell lines. All the compounds exhibited good results among them 8b, 8g and 8i compounds have shown prominent anticancer activity are compared to standard drug doxorubicin.
{"title":"Design, Synthesis and Anticancer Activity of Novel Substituted (E)-2-Morpholinoquinoline- 3-carbaldehyde-O-((-1-aryl-1H-1,2,3-triazol-4-yl)methyl)oxime Derivatives","authors":"Aruna Jyothi Chatla, J. Yerrabelly, Nagaraju Dharavath, Panga Shyam","doi":"10.14233/ajchem.2024.30734","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30734","url":null,"abstract":"A new series of substituted (E)-2-morpholinoquinoline-3-carbaldehyde-O-((-1-phenyl-1H-1,2,3-triazol-4-yl)methyl)oxime scaffolds were synthesized from involving alkynyl quinoline oximes with various aryl azides by click reaction obtained corresponding compounds with high yields. The synthesized compounds were characterized by using IR, 1H NMR, 13C NMR and HRMS data. All the synthesized compounds screened anticancer activity against MCF-7, HeLa, PC-3 cell lines. All the compounds exhibited good results among them 8b, 8g and 8i compounds have shown prominent anticancer activity are compared to standard drug doxorubicin.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"132 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.14233/ajchem.2024.31102
N. Jamunasri, Aswetha Iyer, M. L. Prabha, R. Issac, S. Murugan
The release of metals into the environment raises serious concerns about their harmful effects on both the wildlife and human health. The biosphere is experiencing with the pervasive presence of heavy metal pollutants such as arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb), chromium (Cr), copper (Cu) and nickel (Ni), which pose significant environmental challenges. While certain metals are essential for regulating fundamental metabolic processes and upholding the overall physiology of microorganisms, excessive exposure to heavy metals can be detrimental to their survival and function. As a result of their remarkable adaptability, microorganisms, particularly bacteria such as Pseudomonas fluorescens, Escherichia coli, Serratia marcescens, Bacillus cereus and Alcaligenes sp., have evolved sophisticated defence mechanisms to combat the stress caused by heavy metals. One such process is the creation of metal-binding proteins (MBPs), which may bind and sequester metals, thus significantly lowering their toxicity in bacteria. Metalloproteomics, a subfield of metallomics, focuses on the discovery and characterization of such metal-binding proteins (MBPs) in metal-resistant bacteria, resulting in the opening of the doors for innovative bioremediation techniques and therapeutic treatments against bacterial diseases. This review explores the intriguing world of MBPs in metal-resistant bacteria and emphasizes their significant role in metal resistance, detoxification and homeostasis. Furthermore, metallochaperones in bacteria have been extensively studied using the metalloproteomic methodologies and techniques utilized in metal-binding proteins. This study also provides useful information on the interactions between these metallochaperones and different MBPs, which advances our understanding of how bacteria respond to exposure to such heavy metals.
{"title":"Metalloproteomics: Unraveling the Metal Binding Proteins of Diverse Metal-Resistant Bacteria","authors":"N. Jamunasri, Aswetha Iyer, M. L. Prabha, R. Issac, S. Murugan","doi":"10.14233/ajchem.2024.31102","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31102","url":null,"abstract":"The release of metals into the environment raises serious concerns about their harmful effects on both the wildlife and human health. The biosphere is experiencing with the pervasive presence of heavy metal pollutants such as arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb), chromium (Cr), copper (Cu) and nickel (Ni), which pose significant environmental challenges. While certain metals are essential for regulating fundamental metabolic processes and upholding the overall physiology of microorganisms, excessive exposure to heavy metals can be detrimental to their survival and function. As a result of their remarkable adaptability, microorganisms, particularly bacteria such as Pseudomonas fluorescens, Escherichia coli, Serratia marcescens, Bacillus cereus and Alcaligenes sp., have evolved sophisticated defence mechanisms to combat the stress caused by heavy metals. One such process is the creation of metal-binding proteins (MBPs), which may bind and sequester metals, thus significantly lowering their toxicity in bacteria. Metalloproteomics, a subfield of metallomics, focuses on the discovery and characterization of such metal-binding proteins (MBPs) in metal-resistant bacteria, resulting in the opening of the doors for innovative bioremediation techniques and therapeutic treatments against bacterial diseases. This review explores the intriguing world of MBPs in metal-resistant bacteria and emphasizes their significant role in metal resistance, detoxification and homeostasis. Furthermore, metallochaperones in bacteria have been extensively studied using the metalloproteomic methodologies and techniques utilized in metal-binding proteins. This study also provides useful information on the interactions between these metallochaperones and different MBPs, which advances our understanding of how bacteria respond to exposure to such heavy metals.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"12 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.14233/ajchem.2024.30957
P. Prasada Rao, N. Usha Rani
This study presents a simple, biocompatible and eco-friendly Au-doped ZnO nanoparticles were fabricated by employing root aqueous extract of Kigelia africana (Lam.) Benth. root as reducing, stabilizing and capping agent. The nanoparticles were identified by showing characteristic UV-visible wavelength maxima at 361 nm (ZnO NPs) and 569 nm (Au NPs). The nanoparticles possess polycrystalline structure with circular to oval in shape having 34 nm size that contains ~24.74 % and ~52.16 % of Au and Zn content. The FT-IR analysis confirmed the functional groups correspond to terpenoids, flavonoids and phenolics present in aqueous root extract of of Kigelia africana (Lam.) were actively participated in nanoparticles capping. The cytotoxic applicability of fabricated nanoparticles was assessed by performing MTT assay against human lung cancer (A549) cells, melanoma cancer (A375) cells and skin or epidermoid cancer (A431) cells. The nanoparticles were proved to show potential anticancer activity with IC50 concentration of 206.13 µg/mL, 152.73 µg/mL and 295.49 µg/mL against A549, A375 and A431 cell lines respectively. The IC50 concentration of nanoparticles in DPPH assay was noticed as 43.75 µg/mL, whereas 33.95 µg/mL and 81.10 µg/mL respectively noticed for standard and aqueous root extract suggest that the nanoparticles possess potential antioxidant capability. Based on findings, it was suggested that the fabricated Au-doped ZnO NPs were treated as promising biocompatible candidate that can having remarkable applicability in therapeutic applications.
{"title":"Anticancer Potential of Gold doped ZnO Nanoparticles Fabricated using Root Extract of Kigelia africana (Lam.) Benth. against Lung (A549), Melanoma (A375) and Epidermoid (A431) Cancer Cells","authors":"P. Prasada Rao, N. Usha Rani","doi":"10.14233/ajchem.2024.30957","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30957","url":null,"abstract":"This study presents a simple, biocompatible and eco-friendly Au-doped ZnO nanoparticles were fabricated by employing root aqueous extract of Kigelia africana (Lam.) Benth. root as reducing, stabilizing and capping agent. The nanoparticles were identified by showing characteristic UV-visible wavelength maxima at 361 nm (ZnO NPs) and 569 nm (Au NPs). The nanoparticles possess polycrystalline structure with circular to oval in shape having 34 nm size that contains ~24.74 % and ~52.16 % of Au and Zn content. The FT-IR analysis confirmed the functional groups correspond to terpenoids, flavonoids and phenolics present in aqueous root extract of of Kigelia africana (Lam.) were actively participated in nanoparticles capping. The cytotoxic applicability of fabricated nanoparticles was assessed by performing MTT assay against human lung cancer (A549) cells, melanoma cancer (A375) cells and skin or epidermoid cancer (A431) cells. The nanoparticles were proved to show potential anticancer activity with IC50 concentration of 206.13 µg/mL, 152.73 µg/mL and 295.49 µg/mL against A549, A375 and A431 cell lines respectively. The IC50 concentration of nanoparticles in DPPH assay was noticed as 43.75 µg/mL, whereas 33.95 µg/mL and 81.10 µg/mL respectively noticed for standard and aqueous root extract suggest that the nanoparticles possess potential antioxidant capability. Based on findings, it was suggested that the fabricated Au-doped ZnO NPs were treated as promising biocompatible candidate that can having remarkable applicability in therapeutic applications.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.14233/ajchem.2024.31092
Bhargavi Posinasetty, Ashish Ashokkumar Jaiswal, Rajendra Prasad Yejjella, Hari Veluru, Kishore Bandarapalle, R. K. Kumarachari
This study emphasizes the synthesis and characterization of a novel series of oxa cyano pyridine heterocyclic molecular hybrids (OCP 1-6), integrating pyridine and benzofuran motifs. Meticulously designed from 5-chlorosalicylaldehyde in a multistep process, the synthesized compounds were structurally confirmed through IR spectroscopy, 1H NMR spectroscopy, and mass spectrometry. Computational predictions highlighted diverse properties, including antitubercular and antibacterial attributes, bioactivity scores, toxicity profiles and potential molecular targets. In vitro assessments and Schrödinger docking simulations revealed binding affinities to enzymes viz. Mycobacterium tuberculosis enoyl-ACP reductase and Escherichia coli Topoisomerase IV. Compounds, particularly OCP 2, 3, 4 and 5, exhibited significant antitubercular and antibacterial activities in both in vitro assessments and docking simulations. This study underscores the substantial potential of the synthesized hybrids as promising candidates for further lead optimization, positioning them as valuable contributors to the development of pharmaceutical agents with heightened potency and enhanced safety profiles.
{"title":"Oxacyanopyridine-Benzofuran Hybrids: Synthesis, in silico Toxicity Assessment, in vitro Antimicrobial Activity and Dual Target Docking Studies","authors":"Bhargavi Posinasetty, Ashish Ashokkumar Jaiswal, Rajendra Prasad Yejjella, Hari Veluru, Kishore Bandarapalle, R. K. Kumarachari","doi":"10.14233/ajchem.2024.31092","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31092","url":null,"abstract":"This study emphasizes the synthesis and characterization of a novel series of oxa cyano pyridine heterocyclic molecular hybrids (OCP 1-6), integrating pyridine and benzofuran motifs. Meticulously designed from 5-chlorosalicylaldehyde in a multistep process, the synthesized compounds were structurally confirmed through IR spectroscopy, 1H NMR spectroscopy, and mass spectrometry. Computational predictions highlighted diverse properties, including antitubercular and antibacterial attributes, bioactivity scores, toxicity profiles and potential molecular targets. In vitro assessments and Schrödinger docking simulations revealed binding affinities to enzymes viz. Mycobacterium tuberculosis enoyl-ACP reductase and Escherichia coli Topoisomerase IV. Compounds, particularly OCP 2, 3, 4 and 5, exhibited significant antitubercular and antibacterial activities in both in vitro assessments and docking simulations. This study underscores the substantial potential of the synthesized hybrids as promising candidates for further lead optimization, positioning them as valuable contributors to the development of pharmaceutical agents with heightened potency and enhanced safety profiles.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
vicinal Diaryl scaffold possessing various heterocycles displayed versatile pharmacological activities ranging from antibacterial to antiviral. Herein, the synthesis of novel vicinal diaryl pyrazole ethyl carboxylate analogs as central ring and evaluated for their antiproliferative activity against pancreatic cancer line, PANC-1. Among the synthesized 27 compounds, six compounds displayed the IC50 value for antiproliferative activity in single digit micromolar. The cytotoxicity results of the synthesized compounds especially compound 25 (IC50 = 4.8 µM) confirms that these analogs may require further investigation.
{"title":"Synthesis and Biological Evaluation of vicinal-Diaryl Pyrazole Ethyl Carboxylate Analogs as Antiproliferative Agent against Pancreatic Cancer","authors":"Sandeep Singh, Rajeev Kumar Sharma, Aishwarya Singh, Manoj Garg, R. Ramajayam","doi":"10.14233/ajchem.2024.31173","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31173","url":null,"abstract":"vicinal Diaryl scaffold possessing various heterocycles displayed versatile pharmacological activities ranging from antibacterial to antiviral. Herein, the synthesis of novel vicinal diaryl pyrazole ethyl carboxylate analogs as central ring and evaluated for their antiproliferative activity against pancreatic cancer line, PANC-1. Among the synthesized 27 compounds, six compounds displayed the IC50 value for antiproliferative activity in single digit micromolar. The cytotoxicity results of the synthesized compounds especially compound 25 (IC50 = 4.8 µM) confirms that these analogs may require further investigation.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"26 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.14233/ajchem.2024.31059
J.T. Kurian, K. S. Joseph
The current study focused on the bioreduction synthesis of ZnO nanoparticles using Garcinia gummi-gutta leaf extracts. The UV-vis analysis of the nanoparticles has reported the formation of an SPR peak at 379 nm. The functional groups taking part in the reduction reaction were analyzed using the FTIR technique and the average crystalline size of ZnO nanoparticles were found to be 22.27 nm from XRD measurements. The SEM and TEM images revealed the hexagonal shape of the nanoparticles with an average size 72.78 nm and 71.91 nm, respectively. Further, the synthesized nanoparticles were reported to be efficient degradation reactive textile dyes. The photodegradation results reported 92-100% degradation of the reactive dyes within 80-320 min. The antibacterial efficacy of the nanoparticles was investigated and the MIC of the nanoparticles was found to be 100 µg/mL. The synthesized ZnO nanoparticles have exhibited significant cytotoxic effects on the MCF and HEP-G2 cell lines.
{"title":"Biogenic ZnO Nanoparticles Derived from Garcinia gummi-gutta Leaves: Synthesis, Characterization and its Multifaceted Applications","authors":"J.T. Kurian, K. S. Joseph","doi":"10.14233/ajchem.2024.31059","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31059","url":null,"abstract":"The current study focused on the bioreduction synthesis of ZnO nanoparticles using Garcinia gummi-gutta leaf extracts. The UV-vis analysis of the nanoparticles has reported the formation of an SPR peak at 379 nm. The functional groups taking part in the reduction reaction were analyzed using the FTIR technique and the average crystalline size of ZnO nanoparticles were found to be 22.27 nm from XRD measurements. The SEM and TEM images revealed the hexagonal shape of the nanoparticles with an average size 72.78 nm and 71.91 nm, respectively. Further, the synthesized nanoparticles were reported to be efficient degradation reactive textile dyes. The photodegradation results reported 92-100% degradation of the reactive dyes within 80-320 min. The antibacterial efficacy of the nanoparticles was investigated and the MIC of the nanoparticles was found to be 100 µg/mL. The synthesized ZnO nanoparticles have exhibited significant cytotoxic effects on the MCF and HEP-G2 cell lines.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.14233/ajchem.2024.30274
J. Srinivasu, K. Narendra, Ch. Kavitha, B. Subbarao
Density (ρ) and ultrasonic velocity (u) of liquid binary mixtures of 1,4-butanediol (1,4-BD), o-cresol (OC), m-cresol (MC) and p-cresol (PC) have been measured at four distinct temperatures (303.15 K, 308.15 K, 313.15 K and 318.15 K) as a function of composition. Using data, significant thermodynamic and thermophysical parameters viz., internal pressure-IP (πi), free volume-FV (Vf), enthalpy-EH (H), entropy-ET (Ts) and their excess counterparts have been evaluated. The excess parameter functions EFV (VfE), EEH (HE), EFE (GE) and EET (TsE) were observed to be primarily negative, while πiE is positive indicating that the constituent molecules in these mixtures have discernible interactions with one another.
{"title":"Study of Thermophysical Properties of Binary Mixtures of 1,4-Butanediol + Cresols at Different Temperatures","authors":"J. Srinivasu, K. Narendra, Ch. Kavitha, B. Subbarao","doi":"10.14233/ajchem.2024.30274","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30274","url":null,"abstract":"Density (ρ) and ultrasonic velocity (u) of liquid binary mixtures of 1,4-butanediol (1,4-BD), o-cresol (OC), m-cresol (MC) and p-cresol (PC) have been measured at four distinct temperatures (303.15 K, 308.15 K, 313.15 K and 318.15 K) as a function of composition. Using data, significant thermodynamic and thermophysical parameters viz., internal pressure-IP (πi), free volume-FV (Vf), enthalpy-EH (H), entropy-ET (Ts) and their excess counterparts have been evaluated. The excess parameter functions EFV (VfE), EEH (HE), EFE (GE) and EET (TsE) were observed to be primarily negative, while πiE is positive indicating that the constituent molecules in these mixtures have discernible interactions with one another.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"115 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.14233/ajchem.2024.31106
T. Sravani, Sunitha Katta
In present investigation, the aerial parts of two fern species viz. Polystichum acrostichoides (PA) and Adiantum lunulatum (AL) were used to evaluate the potent antidiabetic activity. Methanol solvent was used for extraction by soxhlation method followed by LC-MS analysis to identify the presence of compounds in both the extracts. Further, isolation of the major compounds was carried out and characterized by IR, mass and NMR techniques. Thereafter, in vitro α-amylase inhibitory activity for both the extracts was determined by comparing with acarbose as standard. Thereafter, α-glucosidase inhibition activity followed by glucose uptake was studied using L6 cell line study. Practical yield for both the fern extracts was calculated and observed A. lunulatum extract showed more yield (7 g) than P. acrostichoides (3 g). Based on the analytical data, isolated compound was identified as quercetin and kaempferol from the A. lunulatum and P. acrostichoides extracts, respectively. A. lunulatum extract even showed better dose dependent α-amylase inhibition and α-glucosidase inhibition activity than P. acrostichoides furthermore, L6 cell line study showed increased glucose uptake by A. lunulatum extract than P. acrostichoides extract when compared with standard insulin. Based on the findings, it appears that the both A. lunulatum and P. acrostichoides have the potential to be used as antidiabetic drugs due to presence of major isolated flavonoids i.e. quercetin and kaempferol as among the bioactive compounds. Antidiabetic efficacy was dosage dependent and A. lunulatum extract was more effective in inhibiting glucose uptake than P. acrostichoides extract.
{"title":"Efficacy of Quercetin and Kaempferol from Methanolic Extracts of Adiantum lunulatum Burm. F. and Polystichum acrostichoides as Antidiabetic Activity","authors":"T. Sravani, Sunitha Katta","doi":"10.14233/ajchem.2024.31106","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31106","url":null,"abstract":"In present investigation, the aerial parts of two fern species viz. Polystichum acrostichoides (PA) and Adiantum lunulatum (AL) were used to evaluate the potent antidiabetic activity. Methanol solvent was used for extraction by soxhlation method followed by LC-MS analysis to identify the presence of compounds in both the extracts. Further, isolation of the major compounds was carried out and characterized by IR, mass and NMR techniques. Thereafter, in vitro α-amylase inhibitory activity for both the extracts was determined by comparing with acarbose as standard. Thereafter, α-glucosidase inhibition activity followed by glucose uptake was studied using L6 cell line study. Practical yield for both the fern extracts was calculated and observed A. lunulatum extract showed more yield (7 g) than P. acrostichoides (3 g). Based on the analytical data, isolated compound was identified as quercetin and kaempferol from the A. lunulatum and P. acrostichoides extracts, respectively. A. lunulatum extract even showed better dose dependent α-amylase inhibition and α-glucosidase inhibition activity than P. acrostichoides furthermore, L6 cell line study showed increased glucose uptake by A. lunulatum extract than P. acrostichoides extract when compared with standard insulin. Based on the findings, it appears that the both A. lunulatum and P. acrostichoides have the potential to be used as antidiabetic drugs due to presence of major isolated flavonoids i.e. quercetin and kaempferol as among the bioactive compounds. Antidiabetic efficacy was dosage dependent and A. lunulatum extract was more effective in inhibiting glucose uptake than P. acrostichoides extract.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"33 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.14233/ajchem.2024.31054
S. Lekshmi, P.V. Anjima, K.V. Anagha, K. Dhanasree, A. Abraham
A simple room temperature synthesis of CuO nanostructures was developed over SnO2 for the catalytic reduction of p-nitrophenol. The prepared nanocomposite shows remarkable efficiency in reducing p-nitrophenol displaying an apparent rate constant of 0.3026 and 1.4763 min-1, which was approximately 1.3 and 7.3 times higher than that achieved by the CuO and SnO2 counterparts, respectively. This study paves the way for exploring the potential of metal oxide composite materials as highly effective catalysts for p-nitrophenol reduction.
{"title":"Synthesis and Characterization of CuO/SnO2 Nanocomposite for Catalytic Reduction of p-Nitrophenol","authors":"S. Lekshmi, P.V. Anjima, K.V. Anagha, K. Dhanasree, A. Abraham","doi":"10.14233/ajchem.2024.31054","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31054","url":null,"abstract":"A simple room temperature synthesis of CuO nanostructures was developed over SnO2 for the catalytic reduction of p-nitrophenol. The prepared nanocomposite shows remarkable efficiency in reducing p-nitrophenol displaying an apparent rate constant of 0.3026 and 1.4763 min-1, which was approximately 1.3 and 7.3 times higher than that achieved by the CuO and SnO2 counterparts, respectively. This study paves the way for exploring the potential of metal oxide composite materials as highly effective catalysts for p-nitrophenol reduction.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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