Studies were undertaken to investigate vaginal response to progesterone plus estradiol in neonatally estrogenized or androgenized, ovariectomized adult mice showing estrogen-independent persistent alterations in the vaginal epithelium. Group 1 of C57BL/Tw strain mice were controls receiving only the oil vehicle. For 5 days from day of birth, Group 2 was given sc injections of 50 mcg of estradiol-17beta (E2) and Group 3 was given 100 mcg of 5alpha-dihydrotestosterone (DHT). All mice were ovariectomized at 10 days of age. 10 animals of each group were sacrificed at 60 days of age (Groups 1a, 2a, and 3a). 10 other animals in each group were given daily sc injections of 2 mg of progesterone plus .01 mcg of E2 for 5 consecutive days beginning at 60 days of age; they were killed on the day following the last injection (Groups 1b, 2b, and 3b). Vaginas were removed for examination. In the 60-day-old ovariectomized control group, the vagina epithelium was atrophic. In mice given E2 or DHT neonatially (Groups 2a and 2b) the epithelium was markedly proliferated. Superficial layers of the epithelium were undergoing cornification or parakeratosis in some areas in all E2-treated and in 5 of 10 DHT-treated mice. The remaining 5 androgenized mice had both mucified and cornified areas of the superficial epithelium. In mice given DHT neonatally, vaginal cornification varied with the age at ovariectomy. The presence of the ovaries for a longer period enhanced proliferation and cornification. Findings appear to indicate that, except in the fornico-cervical region, the response of epithelial cells to progesterone plus E2 was markedly affected by neonatal injections of E2 or DHT. The changes induced by neonatal injections of E2 or DHT.
{"title":"Effects of progesterone plus estradiol on vaginal epithelium showing estrogen-independent proliferation and cornification in neonatally estrogenized and androgenized mice.","authors":"Y. Ohta, T. Iguchi","doi":"10.2183/PJAB1945.52.583","DOIUrl":"https://doi.org/10.2183/PJAB1945.52.583","url":null,"abstract":"\u0000 Studies were undertaken to investigate vaginal response to progesterone plus estradiol in neonatally estrogenized or androgenized, ovariectomized adult mice showing estrogen-independent persistent alterations in the vaginal epithelium. Group 1 of C57BL/Tw strain mice were controls receiving only the oil vehicle. For 5 days from day of birth, Group 2 was given sc injections of 50 mcg of estradiol-17beta (E2) and Group 3 was given 100 mcg of 5alpha-dihydrotestosterone (DHT). All mice were ovariectomized at 10 days of age. 10 animals of each group were sacrificed at 60 days of age (Groups 1a, 2a, and 3a). 10 other animals in each group were given daily sc injections of 2 mg of progesterone plus .01 mcg of E2 for 5 consecutive days beginning at 60 days of age; they were killed on the day following the last injection (Groups 1b, 2b, and 3b). Vaginas were removed for examination. In the 60-day-old ovariectomized control group, the vagina epithelium was atrophic. In mice given E2 or DHT neonatially (Groups 2a and 2b) the epithelium was markedly proliferated. Superficial layers of the epithelium were undergoing cornification or parakeratosis in some areas in all E2-treated and in 5 of 10 DHT-treated mice. The remaining 5 androgenized mice had both mucified and cornified areas of the superficial epithelium. In mice given DHT neonatally, vaginal cornification varied with the age at ovariectomy. The presence of the ovaries for a longer period enhanced proliferation and cornification. Findings appear to indicate that, except in the fornico-cervical region, the response of epithelial cells to progesterone plus E2 was markedly affected by neonatal injections of E2 or DHT. The changes induced by neonatal injections of E2 or DHT.\u0000","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"52 10 1","pages":"583-6"},"PeriodicalIF":0.0,"publicationDate":"1976-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68427461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of progesterone plus estradiol on vaginal epithelium showing estrogen-independent proliferation and cornification in neonatally estrogenized and androgenized mice.","authors":"Y Ohta, T Iguchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"52 10","pages":"583-6"},"PeriodicalIF":0.0,"publicationDate":"1976-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22033514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of ATP on Calcium Release Mechanisms in the Sarcoplasmic Reticulum of Skinned Muscle Fibers","authors":"M. Endo, Toshio Kitazawa","doi":"10.2183/PJAB1945.52.595","DOIUrl":"https://doi.org/10.2183/PJAB1945.52.595","url":null,"abstract":"","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"52 1","pages":"595-598"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68427519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Some critical aspects on prenatal diagnosis of sex in leucocyte cultures from pregnant women.","authors":"H Takahara, T Kadotani, I Kusumi, S Makino","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"48 8","pages":"603-7"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22032959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An attempt was made to assess fetal sex by means of chromosome analysis following the procedure of Walkonowska, Conte, and Grumbach (1969). Peripheral venous blood was obtained from 23 pregnant women between 11 and 38 weeks of gestation. Leucocyte cultures were prepared and more than 50 well-defined metaphase plates for each blood sample were examined. Karotype analysis was carried out on the plates with small acrocentrics of G groups. 4 out of 23 women showed 1 or 2 metaphase figures with 46 or 47 chromosomes including 5 acrocentrics. 1 of the 5 small acrocentrics was thought to be the Y chromosome. 3 of the 4 women with 5 acrocentrics containing 4 G-autosomes and a Y gave birth to male infants. It appears that the prenatal diagnosis of sex in maternal blood is theoretically possible but its practical application seems to be unadvisable at the present status of methodology.
{"title":"Some critical aspects on prenatal diagnosis of sex in leucocyte cultures from pregnant women.","authors":"H. Takahara, T. Kadotani, I. Kusumi, S. Makino","doi":"10.2183/PJAB1945.48.603","DOIUrl":"https://doi.org/10.2183/PJAB1945.48.603","url":null,"abstract":"An attempt was made to assess fetal sex by means of chromosome analysis following the procedure of Walkonowska, Conte, and Grumbach (1969). Peripheral venous blood was obtained from 23 pregnant women between 11 and 38 weeks of gestation. Leucocyte cultures were prepared and more than 50 well-defined metaphase plates for each blood sample were examined. Karotype analysis was carried out on the plates with small acrocentrics of G groups. 4 out of 23 women showed 1 or 2 metaphase figures with 46 or 47 chromosomes including 5 acrocentrics. 1 of the 5 small acrocentrics was thought to be the Y chromosome. 3 of the 4 women with 5 acrocentrics containing 4 G-autosomes and a Y gave birth to male infants. It appears that the prenatal diagnosis of sex in maternal blood is theoretically possible but its practical application seems to be unadvisable at the present status of methodology.","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"48 8 1","pages":"603-7"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68426977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1949-01-01DOI: 10.2183/pjab1945.25.11_19
Terutaro Ogata
In continuation of studies of Cyanine dyes which have been prepared previously1•2>, the new method of preparation of Krypto·cyanine OA 1 (KCOA 1)> and of Thiazolocyanine OA 1 (TCOA 1) is herein described. As to the question of the structures of the trinuclear cyanine dyes, which is of interest, the ,8-methyl-trimethine · type (1)> is conceivable on basis of the formation of the tri-mesomethyl-acridylmethane tri-iodide, which was obtained by the reaction -of 9-methyl-acridine-alkyl-iodide and orthoformic acid ethylester>. In this paper I report on the new preparative methods for TCOA 1 as an additional example. The tri-nuclear dyes have been indicated to have the structure of the a-vinyl-trimethine type (II)>. The a'vinyl-trimethine type (IIIf> may be tautometric isomer of type {II). I suppose that the ,8-vinyl-trimethine type (IV)8> may be obtainable when the hydrogen of aand of a'-position are replaced by less :active radicals.
{"title":"On Cyanine Dyes. X. Conformation of the Structures of the Tri-nuclear Cyanine Dyes","authors":"Terutaro Ogata","doi":"10.2183/pjab1945.25.11_19","DOIUrl":"https://doi.org/10.2183/pjab1945.25.11_19","url":null,"abstract":"In continuation of studies of Cyanine dyes which have been prepared previously1•2>, the new method of preparation of Krypto·cyanine OA 1 (KCOA 1)> and of Thiazolocyanine OA 1 (TCOA 1) is herein described. As to the question of the structures of the trinuclear cyanine dyes, which is of interest, the ,8-methyl-trimethine · type (1)> is conceivable on basis of the formation of the tri-mesomethyl-acridylmethane tri-iodide, which was obtained by the reaction -of 9-methyl-acridine-alkyl-iodide and orthoformic acid ethylester>. In this paper I report on the new preparative methods for TCOA 1 as an additional example. The tri-nuclear dyes have been indicated to have the structure of the a-vinyl-trimethine type (II)>. The a'vinyl-trimethine type (IIIf> may be tautometric isomer of type {II). I suppose that the ,8-vinyl-trimethine type (IV)8> may be obtainable when the hydrogen of aand of a'-position are replaced by less :active radicals.","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68426552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1949-01-01DOI: 10.2183/pjab1945.25.11_17
Terutaro Ogata
{"title":"On Cyanine Dyes. IX. Syntheses of the Components of Kryptocyanine OA","authors":"Terutaro Ogata","doi":"10.2183/pjab1945.25.11_17","DOIUrl":"https://doi.org/10.2183/pjab1945.25.11_17","url":null,"abstract":"","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68426544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1949-01-01DOI: 10.2183/pjab1945.25.11_1
M. Suda, O. Hayaishi, Y. Oda
{"title":"Studies on Enzymatic Adaptation","authors":"M. Suda, O. Hayaishi, Y. Oda","doi":"10.2183/pjab1945.25.11_1","DOIUrl":"https://doi.org/10.2183/pjab1945.25.11_1","url":null,"abstract":"","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68426524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1949-01-01DOI: 10.2183/pjab1945.25.11_6
S. Akabori, Kozo Narita
{"title":"On the Splitting of the Side Chain from Tryptophane by the Action of Aldehydes","authors":"S. Akabori, Kozo Narita","doi":"10.2183/pjab1945.25.11_6","DOIUrl":"https://doi.org/10.2183/pjab1945.25.11_6","url":null,"abstract":"","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68426707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recentry Mr. Terada1> has proved the following generalized principal theorem : Theorem. Let K be the absolute class field over k, and Q a. cycic intermediate field of K/k, then all the ambigous ideal classes of Q will become principal in K. I also generalized this theorem to the case of ray class field.2> By using Artin's law of reciprocity we can state above theorem in terms of the Galois group, and we have Theorem. Let G be a metabelian group with commutator subgroup G', H be an invariant subgroup of G with the cyclic quotient group G/H, and A element of H with ASA -ls-1eH' (S being a generator of G/H), then the "Verlagerung" V(A) = IITATAfrom H to G' is the unit element of G. Thereby T runs over a fixed representative system of G/ H, and T A means the representative corresponding to the coset TAG'. At first we tried to solve this by means of Iyanaga's method depending upon Artin's splitting group,3> which is generated by G' and the symbols Aa(A1 = 1, u~r = G/G'), and with r as operator system by rules (1) (2) U" = SaUS; 1 (U€G'), A~ = A;1A"'"D;,~ , S" being the representative of GIG' corresponding to usr, and . (3)
{"title":"An Alternative Proof of a Generalized Principal Ideal Theorem","authors":"Tadao Tannaka","doi":"10.3792/PJA/1195571871","DOIUrl":"https://doi.org/10.3792/PJA/1195571871","url":null,"abstract":"Recentry Mr. Terada1> has proved the following generalized principal theorem : Theorem. Let K be the absolute class field over k, and Q a. cycic intermediate field of K/k, then all the ambigous ideal classes of Q will become principal in K. I also generalized this theorem to the case of ray class field.2> By using Artin's law of reciprocity we can state above theorem in terms of the Galois group, and we have Theorem. Let G be a metabelian group with commutator subgroup G', H be an invariant subgroup of G with the cyclic quotient group G/H, and A element of H with ASA -ls-1eH' (S being a generator of G/H), then the \"Verlagerung\" V(A) = IITATAfrom H to G' is the unit element of G. Thereby T runs over a fixed representative system of G/ H, and T A means the representative corresponding to the coset TAG'. At first we tried to solve this by means of Iyanaga's method depending upon Artin's splitting group,3> which is generated by G' and the symbols Aa(A1 = 1, u~r = G/G'), and with r as operator system by rules (1) (2) U\" = SaUS; 1 (U€G'), A~ = A;1A\"'\"D;,~ , S\" being the representative of GIG' corresponding to usr, and . (3)","PeriodicalId":85351,"journal":{"name":"Proceedings of the Japan Academy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70207438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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