In order to examine the causes of endometrial bleeding following IUD insertion, 22 samples of endometrium from women with an IUD in place for between 1-20 years or more and 10 cases of endometrium without an IUD and with normal menstrual cycles as controls were studied. The quantitative histologic method was utilized to demonstrate the correlation between vascular changes and clinical bleeding. The results indicate that the concentration and expansion of microvascularity, especially the capillary, venule, and venous sinus, increased significantly in most of the IUD-exposed endometriums (75%) as compared with controls (p0.01). The remarkable changes in vessels correlated with clinical bleeding were increased density, obvious dilatation, defect, and rupture of the superficial venous sinus. Mechanical damage, degeneration, necrosis, and denudation of surface endometrium exposed to the IUD could be the direct cause of clinical bleeding.
{"title":"[The effect of IUD on endometrial blood vessels--correlation between vascular changes and bleeding].","authors":"Q W Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to examine the causes of endometrial bleeding following IUD insertion, 22 samples of endometrium from women with an IUD in place for between 1-20 years or more and 10 cases of endometrium without an IUD and with normal menstrual cycles as controls were studied. The quantitative histologic method was utilized to demonstrate the correlation between vascular changes and clinical bleeding. The results indicate that the concentration and expansion of microvascularity, especially the capillary, venule, and venous sinus, increased significantly in most of the IUD-exposed endometriums (75%) as compared with controls (p0.01). The remarkable changes in vessels correlated with clinical bleeding were increased density, obvious dilatation, defect, and rupture of the superficial venous sinus. Mechanical damage, degeneration, necrosis, and denudation of surface endometrium exposed to the IUD could be the direct cause of clinical bleeding.</p>","PeriodicalId":85518,"journal":{"name":"Sheng zhi yu bi yun = Reproduction and contraception","volume":"8 1","pages":"17-21"},"PeriodicalIF":0.0,"publicationDate":"1988-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22012401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A study on the release rate of contraceptive vaginal ring (CVR) containing megestrol acetate in vitro].","authors":"Z Y Wu, L M Liu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85518,"journal":{"name":"Sheng zhi yu bi yun = Reproduction and contraception","volume":"8 1","pages":"13-6, 8"},"PeriodicalIF":0.0,"publicationDate":"1988-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22012400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A brief introduction to a new method of inserting TCu220C type IUD].","authors":"C T Zhao","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85518,"journal":{"name":"Sheng zhi yu bi yun = Reproduction and contraception","volume":"8 1","pages":"69-70"},"PeriodicalIF":0.0,"publicationDate":"1988-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22012404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Gossypol and its related compounds as contraceptive drugs and drugs for gynecological diseases].","authors":"G P Wu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85518,"journal":{"name":"Sheng zhi yu bi yun = Reproduction and contraception","volume":"8 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"1988-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22012403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effect of megestrol acetate compound (injectable contraceptive) on human blood coagulation, anticoagulation activity, fibrinolysis and platelet aggregation].","authors":"X F Cheng, H Z Shao, Z P Chen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85518,"journal":{"name":"Sheng zhi yu bi yun = Reproduction and contraception","volume":"8 1","pages":"22-6"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22025847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A clinical study on the comparison of the performance of stainless steel ring (SSR), uterine cavity-shaped device (UCD), MLCu250 and TCu220C].","authors":"Y Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85518,"journal":{"name":"Sheng zhi yu bi yun = Reproduction and contraception","volume":"8 4","pages":"7-10"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22036720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Spermatic duct diameter in Chinese normal male adults and its significance in male sterilization].","authors":"S M Chen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85518,"journal":{"name":"Sheng zhi yu bi yun = Reproduction and contraception","volume":"8 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22025848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[An epidemiological investigation on the effect of tubal ligation in Henan province].","authors":"Z J Tong","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85518,"journal":{"name":"Sheng zhi yu bi yun = Reproduction and contraception","volume":"7 4","pages":"8-12"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22012560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Changes of peroxidase, plasminogen and fibrinolytic activity on menorrhagia induced by IUDS and the effect of treatment with vitamin E].","authors":"P C Zhang, R Q Fan, X M Chen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85518,"journal":{"name":"Sheng zhi yu bi yun = Reproduction and contraception","volume":"7 3","pages":"59-61, 23"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22026694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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