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PATHOGENESIS OF THE INTESTINAL LESIONS IN RADIATION CHIMERAS 辐射嵌合体肠道病变的发病机制
Pub Date : 1962-07-01 DOI: 10.1097/00006534-196207000-00042
M. de Vries
Irradiated mice treated with homologous lymph node suspensions were serially killed for histological examination. Beginning at the 4th day following irradiation and transplantation, repopulation of the lymphatic tissues by lymphoid cells occurred. Concurrently excessive disintegration of crypt cells in the intestines was observed. The intestinal damage is considered to be the result of a cytotoxic action of the antibody-producing foreign lymphoid cells against the intestinal crypt cells. The intestinal lesons resemble those found in irradiated primates treated with bone marrow, but differ from those found in irradiated mice treated with bone marrow only. The implications of these findings with regard to the mortality pattern and the pathogenesis of secondary disease in radiation chimeras are discussed. (auth)
用同源淋巴结悬浮液处理辐照小鼠,连续处死进行组织学检查。从照射和移植后第4天开始,淋巴组织开始出现淋巴样细胞的再生。同时观察到肠内隐窝细胞的过度解体。肠道损伤被认为是产生抗体的外来淋巴细胞对肠隐窝细胞的细胞毒性作用的结果。肠道病变与接受骨髓治疗的受辐射灵长类动物相似,但与仅接受骨髓治疗的受辐射小鼠不同。这些发现的意义,关于死亡模式和继发性疾病的发病机制的辐射嵌合体讨论。(认证)
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引用次数: 2
Effects of heredity on reaction to skin grafts in guinea pigs. 遗传对豚鼠皮肤移植反应的影响。
Pub Date : 1962-07-01 DOI: 10.1097/00006534-196207000-00048
Deb Rn, Wheat Jd, Spies Hg
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引用次数: 0
Bibliography of bone transplantation. Addendum No. IV. 骨移植参考文献。附录。4
Pub Date : 1962-01-01 DOI: 10.1097/00006534-196204000-00049
Bassett Ca
A list is presented of 144 references to recent literature covering various aspects of bone transplantation.
列出了144个参考文献,涵盖了骨移植的各个方面。
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引用次数: 2
Bibliography of tumor transplantation. Addendum No. 3. 肿瘤移植参考文献。附录3。
Pub Date : 1961-10-01 DOI: 10.1097/00006534-196110000-00050
A. Handler, E. Eichwald
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引用次数: 0
Studies on the effect of isoantiserum on mouse sarcoma cells. 异抗血清对小鼠肉瘤细胞作用的研究。
Pub Date : 1960-10-01 DOI: 10.1097/00006534-196010000-00035
E KLEIN, H O SJOGREN
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引用次数: 8
Bibliography of liver transplantation. 肝移植参考文献。
Pub Date : 1960-10-01 DOI: 10.1097/00006534-196010000-00042
E O GOODRICH
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引用次数: 2
Origin of the infiltrating cells in skin and kidney homografts. 皮肤和肾脏同种移植物浸润细胞的来源。
Pub Date : 1960-10-01 DOI: 10.1097/00006534-196010000-00041
K A PORTER, R Y CALNE
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引用次数: 45
Attempts to induce tolerance to maternal tissue by irradiation of fetal mice. 试图通过照射胎鼠诱导对母体组织的耐受。
Pub Date : 1960-10-01 DOI: 10.1097/00006534-196010000-00039
M A MOULTON, J STIMPFLING, J B STORER
Lengerova's work, which reported radioinduced tolerance in rats to maternal tissue by irradiation of embryonic rats with low doses of x rays, was repeated using mice with tissue incompatibilities between the mother and offspring and controlled by the H-2 locus. The pregnant mice were exposed to 200 r of x rays at 15? 1 days of gestation, and skin grafts from the maternal strain and other strains were applied to normal and irradiated hybrids at ages of 43 to 67 days, the grafts being examined daily for 30 days for evidence of a homograft reaction. There was no difference between the normal and irradiated mice in their rejection of unrelated strain grafts, and for maternal strain grafts the irradiated mice were found to reject their grafts a little earlier and to have a more severe reaction to the graft than the normal mice. Some of the differences between these experiments and those of Lengerovs are discussed, along with possible explanations of the disagreement. (D.L.C.)
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引用次数: 9
Bibliography on cartilage transplantation. Addendum No. 6. 软骨移植参考文献。附录6
Pub Date : 1960-10-01 DOI: 10.1097/00006534-196010000-00044
L A PEER
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引用次数: 0
Synergic action between isoantibody and immune cells in graft rejection. 同种抗体与免疫细胞在移植物排斥反应中的协同作用。
Pub Date : 1960-10-01 DOI: 10.1097/00006534-196010000-00037
J R BATCHELOR, E A BOYSE, P A GORER
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引用次数: 38
期刊
Transplantation bulletin
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