Pub Date : 2024-02-01DOI: 10.1016/j.autneu.2024.103156
Karen C. Peebles, Charl Jacobs, Logan Makaroff, Verity Pacey
{"title":"The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review","authors":"Karen C. Peebles, Charl Jacobs, Logan Makaroff, Verity Pacey","doi":"10.1016/j.autneu.2024.103156","DOIUrl":"https://doi.org/10.1016/j.autneu.2024.103156","url":null,"abstract":"","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139818159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1016/j.autneu.2022.102997
Ahmed M. Eldokla, Sara T. Ali
{"title":"Autonomic function testing in long-COVID syndrome patients with orthostatic intolerance","authors":"Ahmed M. Eldokla, Sara T. Ali","doi":"10.1016/j.autneu.2022.102997","DOIUrl":"https://doi.org/10.1016/j.autneu.2022.102997","url":null,"abstract":"","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72904943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1016/j.autneu.2022.102989
P. Drummond
{"title":"Asymmetry of the pupillary light reflex during a cold pressor test","authors":"P. Drummond","doi":"10.1016/j.autneu.2022.102989","DOIUrl":"https://doi.org/10.1016/j.autneu.2022.102989","url":null,"abstract":"","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90905793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1016/j.autneu.2022.102986
P. Castro, J. Serrador, Farzaneh A. Sorond, E. Azevedo, Isabel Rocha
{"title":"Sympathovagal imbalance in early ischemic stroke is linked to impaired cerebral autoregulation and increased infarct volumes","authors":"P. Castro, J. Serrador, Farzaneh A. Sorond, E. Azevedo, Isabel Rocha","doi":"10.1016/j.autneu.2022.102986","DOIUrl":"https://doi.org/10.1016/j.autneu.2022.102986","url":null,"abstract":"","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89518604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1016/j.autneu.2022.102987
Wi Jin Kim, M. Dacey, Milan Samarage, D. Zarrin, K. Goel, Christopher A Chan, Xin Qi, Anthony C. Wang, K. Shivkumar, J. Ardell, G. Colby
{"title":"Sympathetic nervous system hyperactivity results in potent cerebral hypoperfusion in swine","authors":"Wi Jin Kim, M. Dacey, Milan Samarage, D. Zarrin, K. Goel, Christopher A Chan, Xin Qi, Anthony C. Wang, K. Shivkumar, J. Ardell, G. Colby","doi":"10.1016/j.autneu.2022.102987","DOIUrl":"https://doi.org/10.1016/j.autneu.2022.102987","url":null,"abstract":"","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73723094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1249/01.mss.0000561508.53212.ea
A. C. Felix, A. Gastaldi, S. G. Dutra, Ana Caroline Silva de Freitas, S. V. Philbois, Tábata de Paula Facioli, V. J. D. da Silva, T. H. Fares, H. C. D. de Souza
OBJECTIVES We investigated the effects of early ovarian hormones deprivation on morphology and cardiac function and the effects of aerobic training on these parameters, in old rats. METHODS Female Wistar rats (N = 48) were divided into two groups, at 10 weeks of life: early ovarian hormones deprivation by ovariectomy (OVX; N = 24) and sham (SHAM; N = 24). Between weeks 62 and 82, 12 animals of each group underwent aerobic training (OVX-T and SHAM-T, N = 12). At the end of week 82, all were evaluated by echocardiography, cardiac function (Langendorff technique) and cardiac β-adrenergic receptor expression quantification. RESULTS Echocardiography showed slight changes in morphology between OVX and SHAM groups. OVX group (Δ = 101 ± 4.7 mmHg) showed higher values for maximal left intraventricular pressure in response to dobutamine, when compared to SHAM group (Δ = 55 ± 11.8 mmHg). Both OVX-T (Δ = 70 ± 4.0 mmHg) and SHAM-T (Δ = 22 ± 6.6 mmHg) groups showed a reduction in this response. While, β-adrenergic receptor expression was not different between the untrained groups, SHAM-T (0.23 ± 0.02 AU) and OVX-T (0.29 ± 0.01 AU), showed decreased expression of these receptors. CONCLUSION Early ovarian hormones deprivation associated with aging, promotes discrete changes in cardiac morphology and increasing cardiac contractility. Aerobic training decreases β-adrenergic receptors expression, influencing the cardiac contractility.
{"title":"Early ovarian hormone deprivation increases cardiac contractility in old female rats—Role of physical training","authors":"A. C. Felix, A. Gastaldi, S. G. Dutra, Ana Caroline Silva de Freitas, S. V. Philbois, Tábata de Paula Facioli, V. J. D. da Silva, T. H. Fares, H. C. D. de Souza","doi":"10.1249/01.mss.0000561508.53212.ea","DOIUrl":"https://doi.org/10.1249/01.mss.0000561508.53212.ea","url":null,"abstract":"OBJECTIVES\u0000We investigated the effects of early ovarian hormones deprivation on morphology and cardiac function and the effects of aerobic training on these parameters, in old rats.\u0000\u0000\u0000METHODS\u0000Female Wistar rats (N = 48) were divided into two groups, at 10 weeks of life: early ovarian hormones deprivation by ovariectomy (OVX; N = 24) and sham (SHAM; N = 24). Between weeks 62 and 82, 12 animals of each group underwent aerobic training (OVX-T and SHAM-T, N = 12). At the end of week 82, all were evaluated by echocardiography, cardiac function (Langendorff technique) and cardiac β-adrenergic receptor expression quantification.\u0000\u0000\u0000RESULTS\u0000Echocardiography showed slight changes in morphology between OVX and SHAM groups. OVX group (Δ = 101 ± 4.7 mmHg) showed higher values for maximal left intraventricular pressure in response to dobutamine, when compared to SHAM group (Δ = 55 ± 11.8 mmHg). Both OVX-T (Δ = 70 ± 4.0 mmHg) and SHAM-T (Δ = 22 ± 6.6 mmHg) groups showed a reduction in this response. While, β-adrenergic receptor expression was not different between the untrained groups, SHAM-T (0.23 ± 0.02 AU) and OVX-T (0.29 ± 0.01 AU), showed decreased expression of these receptors.\u0000\u0000\u0000CONCLUSION\u0000Early ovarian hormones deprivation associated with aging, promotes discrete changes in cardiac morphology and increasing cardiac contractility. Aerobic training decreases β-adrenergic receptors expression, influencing the cardiac contractility.","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"6 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79790709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Gray, Kawasi M. Lett, V. B. Garcia, Cindy W. Kyi, K. Pennington, L. Schulz, D. Schulz
Bladder cystopathy is a common urological complication of diabetes, and has been associated with changes in parasympathetic ganglionic transmission and some measures of neuronal excitability in male mice. To determine whether type II diabetes also impacts excitability of parasympathetic ganglionic neurons in females, we investigated neuronal excitability and firing properties, as well as underlying ion channel expression, in major pelvic ganglion (MPG) neurons in control, 10-week, and 21-week db/db mice. Type II diabetes in Leprdb/db animals caused a non-linear change in excitability and firing properties of MPG neurons. At 10 weeks, cells exhibited increased excitability as demonstrated by an increased likelihood of firing multiple spikes upon depolarization, decreased rebound spike latency, and overall narrower action potential half-widths as a result of increased depolarization and repolarization slopes. Conversely, at 21 weeks MPG neurons of db/db mice reversed these changes, with spiking patterns and action-potential properties largely returning to control levels. These changes are associated with numerous time-specific changes in calcium, sodium, and potassium channel subunit mRNA levels. However, Principal Components Analysis of channel expression patterns revealed that the rectification of excitability is not simply a return to control levels, but rather a distinct ion channel expression profile in 21-week db/db neurons. These data indicate that type II diabetes can impact the excitability of post-ganglionic, parasympathetic bladder-innervating neurons of female mice, and suggest that the non-linear progression of these properties with diabetes may be the result of compensatory changes in channel expression that act to rectify disrupted firing patterns of db/db MPG neurons.
{"title":"Changes in excitability and ion channel expression in neurons of the major pelvic ganglion in female type II diabetic mice","authors":"Michael Gray, Kawasi M. Lett, V. B. Garcia, Cindy W. Kyi, K. Pennington, L. Schulz, D. Schulz","doi":"10.1101/360826","DOIUrl":"https://doi.org/10.1101/360826","url":null,"abstract":"Bladder cystopathy is a common urological complication of diabetes, and has been associated with changes in parasympathetic ganglionic transmission and some measures of neuronal excitability in male mice. To determine whether type II diabetes also impacts excitability of parasympathetic ganglionic neurons in females, we investigated neuronal excitability and firing properties, as well as underlying ion channel expression, in major pelvic ganglion (MPG) neurons in control, 10-week, and 21-week db/db mice. Type II diabetes in Leprdb/db animals caused a non-linear change in excitability and firing properties of MPG neurons. At 10 weeks, cells exhibited increased excitability as demonstrated by an increased likelihood of firing multiple spikes upon depolarization, decreased rebound spike latency, and overall narrower action potential half-widths as a result of increased depolarization and repolarization slopes. Conversely, at 21 weeks MPG neurons of db/db mice reversed these changes, with spiking patterns and action-potential properties largely returning to control levels. These changes are associated with numerous time-specific changes in calcium, sodium, and potassium channel subunit mRNA levels. However, Principal Components Analysis of channel expression patterns revealed that the rectification of excitability is not simply a return to control levels, but rather a distinct ion channel expression profile in 21-week db/db neurons. These data indicate that type II diabetes can impact the excitability of post-ganglionic, parasympathetic bladder-innervating neurons of female mice, and suggest that the non-linear progression of these properties with diabetes may be the result of compensatory changes in channel expression that act to rectify disrupted firing patterns of db/db MPG neurons.","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76812379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-30DOI: 10.1016/j.autneu.2015.07.240
C. Gibbons, Ningshan Wang, Jenniffer Garcia, L. Shih, R. Freeman
{"title":"Alpha-Synuclein and Autonomic Neuropathy Progression in a Longitudinal Study of Parkinson’s Disease","authors":"C. Gibbons, Ningshan Wang, Jenniffer Garcia, L. Shih, R. Freeman","doi":"10.1016/j.autneu.2015.07.240","DOIUrl":"https://doi.org/10.1016/j.autneu.2015.07.240","url":null,"abstract":"","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"7 1","pages":"129-130"},"PeriodicalIF":0.0,"publicationDate":"2015-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79016423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-30DOI: 10.1016/j.autneu.2015.07.084
F. R. Moraes, G. A. Galdino, G. V. Silva, A. Sant'Ana, M. Accioly
{"title":"Autonomic Heart Modulation in Chronic Kidney Disease","authors":"F. R. Moraes, G. A. Galdino, G. V. Silva, A. Sant'Ana, M. Accioly","doi":"10.1016/j.autneu.2015.07.084","DOIUrl":"https://doi.org/10.1016/j.autneu.2015.07.084","url":null,"abstract":"","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"35 1","pages":"79-80"},"PeriodicalIF":0.0,"publicationDate":"2015-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81415298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-30DOI: 10.1016/j.autneu.2015.07.017
E. Fox, J. Biddinger, J. McAdams
{"title":"Smooth muscle-derived neurotrophins regulate development and function of vagal gastrointestinal (GI) afferents","authors":"E. Fox, J. Biddinger, J. McAdams","doi":"10.1016/j.autneu.2015.07.017","DOIUrl":"https://doi.org/10.1016/j.autneu.2015.07.017","url":null,"abstract":"","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":"227 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80290359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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