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Assessment of changes in extra-cellular water and total body water using multi-frequency bio-electrical impedance. 利用多频生物电阻抗评估细胞外水和全身水的变化。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4899-1268-8_29
P Deurenberg, F J Schouten, A Andreoli, A de Lorenzo
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引用次数: 28
Characteristics of an accelerator based system for in vivo aluminium measurement in peripheral bone. 基于加速器的外周骨体内铝测量系统的特性。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4899-1268-8_64
S Green, D A Bradley, P J Mountford, W D Morgan, D R Chettle, D R Weaver
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引用次数: 4
Performance of the bismuth germanate total body chlorine analyzer. 锗酸铋总氯分析仪的性能。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4899-1268-8_82
N Blagojevic, B J Allen, J Russell
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引用次数: 0
Prevention of genotoxic effects by dietary constituents in various organs of mice treated with nitrosamines. 饮食成分对亚硝胺处理小鼠各器官遗传毒性的预防作用。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4615-2984-2_39
S Knasmüller, W Huber, R Schulte-Hermann
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引用次数: 4
Extracellular interception of mutagens. 诱变剂的细胞外拦截。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4615-2984-2_5
D M Shankel, S Kuo, C Haines, L A Mitscher

Extracellular interception of mutagens by excreted enzymes or by chemical agents that react with or bind to formed mutagens provides an important means of defense against chemical mutagens/carcinogens. Kada and Shimoi have classified molecules that function in this manner as "desmutagens," and many of them are natural cellular metabolites. Among the specific mechanisms that such agents may employ are: prevention of the activation of "promutagens" to mutagens; stimulation of enzymes (e.g., glutathione-S-transferase) that catalyze the binding/inactivation of damaging electrophiles; direct binding and concomitant inactivation of promutagens or mutagens; interference with uptake of mutagens into cells; etc. De Flora and Ramel have provided an excellent discussion of the mechanisms of these agents and a proposed classification scheme. Drawing on work from our own laboratories and other recent examples in the literature, several examples of mechanistic approaches to these studies using natural plant-derived materials, e.g., humic acid, Glycyrrhiza glabra extract, glutathione, and bioflavonoids, are also described. Antioxidants and agents that conjugate electrophiles will be among the modes of action described for obtaining the goal of intercepting mutagens/carcinogens.

通过分泌的酶或与形成的诱变剂发生反应或结合的化学制剂在细胞外拦截诱变剂，是防御化学诱变剂/致癌物质的重要手段。Kada和Shimoi将以这种方式发挥作用的分子分类为“去突变剂”，其中许多是天然的细胞代谢物。这些药物可能采用的具体机制包括:防止“促生剂”对诱变剂的激活;刺激酶(如谷胱甘肽- s -转移酶)，催化破坏性亲电试剂的结合/失活;促生剂或诱变剂的直接结合和伴随的失活;干扰诱变剂进入细胞的摄取;等。De Flora和Ramel对这些药物的作用机制进行了很好的讨论，并提出了一种分类方案。根据我们自己实验室的工作和其他近期文献中的例子，本文还描述了使用天然植物衍生材料(如腐植酸、甘草提取物、谷胱甘肽和生物类黄酮)进行这些研究的几个机械方法的例子。抗氧化剂和结合亲电试剂的试剂将是实现拦截诱变剂/致癌物的目标所描述的作用模式。
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引用次数: 17
Mechanisms of inhibition of tumor progression. 抑制肿瘤进展的机制。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4615-2984-2_26
B S Warren, T J Slaga
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引用次数: 18
Histopathology of human intraepithelial neoplasia with implications for chemoprevention strategy. 人上皮内瘤变的组织病理学与化学预防策略的意义。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4615-2984-2_27
C W Boone, G J Kelloff, V E Steele
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引用次数: 0
Spontaneous mutations and fidelogens. 自发突变和基因原。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4615-2984-2_41
R C von Borstel, U G Hennig
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引用次数: 3
Blocking the plant activation of promutagenic aromatic amines by peroxidase inhibitors. 过氧化物酶抑制剂阻断植物促生芳香胺的激活。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4615-2984-2_19
M J Plewa
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引用次数: 2
Comparisons between Hologic, Norland and Lunar dual-energy X-ray bone absorptiometers. Hologic、Norland和Lunar双能x线骨吸收仪的比较。
Basic life sciences
Pub Date : 1993-01-01 DOI: 10.1007/978-1-4899-1268-8_90
P Tothill, D M Reid, A Avenell, J A Fenner
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引用次数: 7
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