Pub Date : 2006-01-01DOI: 10.1177/8756087906063340
Chad Waldschmidt
This department offers industry announcements covering new contracts, events, awards, studies and regulations.
该部门提供有关新合同、活动、奖励、研究和法规的行业公告。
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The 21st Annual Interdisciplinary Health Care Team Conference took place in Louisville, Kentucky, 23± 26 September, 1999. On the banks of the beautiful Ohio River with clear skies and mild temperatures, academics and practitioners passionately discussed the rewards and challenges of interdisciplinary collaboration in education and practice. Unique among meetings, this annual conference provides educators the opportunity to present and discuss interdisciplinary training and practice solely among others engaged in similar activities. While this conference remains fairly small and intimate (approximately 200 people participated this year), interdisciplinary training is gaining increasing prominence in the US. The Health Resources and Services Administration (HRSA), part of the US Department of Health and Human Services, has just established a new Division of Interdisciplinary and CommunityBased Programs in the Bureau of Health Profession (BHPr). Under the leadership of Bernice A. Parlak, the new Division brings together many of the programs funding interdisciplinary training for health care professionals including the Geriatrics Training programs, Rural interdisciplinary Training, and the Area Health Education Centers. Many BHPr grantees were among the presenters at the conference, which included two full days of presentations addressing the numerous successes, challenges, lessons learned and nitty-gritty work of training students and already practicing professionals to work in interdisciplinary health care teams. Several presentations were devoted to interdisciplinary training and care of older persons. The training programs use a variety of methods and sites for education including home-based geriatric assessment, clinic-based assessment, evaluation of nursing home practices, rural health care settings, participation in public health prevention efforts and the use of videos and CD-ROMS in training. Participants in the John E. Hartford Foundation’s Geriatric Interdisciplinary Team Training (GITT) program also discussed work in progress. These programs involve training of teams consisting of a minimum of a physician, nurse and social worker to serve the elderly. The 12 GITT sites around the US have approached team training in different ways and are working with different clinical sites. One group, the UCLA/Kaiser Permanente team, is working to rationalise care of the elderly in managed care settings. They are conducting t̀rain the trainer’ sessions so that their teaching will have a snowball effect throughout the local Kaiser system. They are enticing even the most reticent of practitioners to be teachers and to do their teaching in relatively brief segments, an accommodation to the requirements of a busy managed care setting. Presenters gave a t̀rue-to-life’ and amusing demonstration of rationalising telephone communications between professionals so that non-case relevant information is kept to a minimum and all the essentials of the case are inclu
第21届跨学科保健小组年度会议于1999年9月23±26日在肯塔基州路易斯维尔举行。在美丽的俄亥俄河畔，晴朗的天空和温和的气温，学者和实践者热情地讨论了教育和实践中跨学科合作的回报和挑战。独一无二的是，这个年度会议为教育工作者提供了展示和讨论跨学科培训和实践的机会，仅在其他从事类似活动的人中进行。虽然这个会议仍然是相当小而亲密的(今年大约有200人参加)，但跨学科培训在美国越来越受到重视。隶属于美国卫生与公众服务部的卫生资源与服务管理局(HRSA)刚刚在卫生专业局(BHPr)设立了一个新的跨学科和基于社区的项目司。在Bernice A. Parlak的领导下，新部门汇集了许多资助卫生保健专业人员跨学科培训的项目，包括老年病学培训项目、农村跨学科培训和地区健康教育中心。许多BHPr受助人出席了会议，其中包括整整两天的演讲，讨论了培训学生和已经执业的专业人员在跨学科卫生保健团队中工作的众多成功、挑战、经验教训和具体工作。有几次专题介绍专门讨论了老年人的跨学科培训和护理问题。培训方案使用各种方法和地点进行教育，包括以家庭为基础的老年评估、以诊所为基础的评估、对养老院做法的评估、农村保健设施、参与公共卫生预防工作以及在培训中使用录像和光盘。约翰·e·哈特福德基金会老年医学跨学科团队培训(git)项目的参与者也讨论了正在进行的工作。这些项目包括培训至少由一名医生、护士和社会工作者组成的团队来为老年人服务。美国的12个git站点以不同的方式进行团队培训，并与不同的临床站点合作。加州大学洛杉矶分校(UCLA) /凯撒医疗机构(Kaiser Permanente)团队正在努力使管理式医疗机构对老年人的护理合理化。他们正在进行培训课程，以便他们的教学将在整个当地凯撒系统中产生滚雪球效应。他们甚至吸引最沉默寡言的从业者成为教师，并在相对较短的时间内进行教学，以适应繁忙的管理式护理环境的要求。讲者以生动有趣的方式，示范如何合理化专业人士之间的电话沟通，使与个案无关的资讯减至最少，并涵盖个案的所有要点。加州大学洛杉矶分校和贝勒(德克萨斯)git网站都在使用录像带来辅助教育。其他几位发言者着重讨论了农村保健服务提供的跨学科培训。在一所卫生专业学校的一个农村住院医师方案中，培训人员描述了居民与在学校接受培训的各种卫生专业人员之间的合作如何导致相互转诊获得保健服务，专业学校工作人员对居民进行教学，住院医师对卫生专业学生进行教学。另一个
{"title":"Conference report","authors":"A. Jeske","doi":"10.1080/jic.14.1.95.96","DOIUrl":"https://doi.org/10.1080/jic.14.1.95.96","url":null,"abstract":"The 21st Annual Interdisciplinary Health Care Team Conference took place in Louisville, Kentucky, 23± 26 September, 1999. On the banks of the beautiful Ohio River with clear skies and mild temperatures, academics and practitioners passionately discussed the rewards and challenges of interdisciplinary collaboration in education and practice. Unique among meetings, this annual conference provides educators the opportunity to present and discuss interdisciplinary training and practice solely among others engaged in similar activities. While this conference remains fairly small and intimate (approximately 200 people participated this year), interdisciplinary training is gaining increasing prominence in the US. The Health Resources and Services Administration (HRSA), part of the US Department of Health and Human Services, has just established a new Division of Interdisciplinary and CommunityBased Programs in the Bureau of Health Profession (BHPr). Under the leadership of Bernice A. Parlak, the new Division brings together many of the programs funding interdisciplinary training for health care professionals including the Geriatrics Training programs, Rural interdisciplinary Training, and the Area Health Education Centers. Many BHPr grantees were among the presenters at the conference, which included two full days of presentations addressing the numerous successes, challenges, lessons learned and nitty-gritty work of training students and already practicing professionals to work in interdisciplinary health care teams. Several presentations were devoted to interdisciplinary training and care of older persons. The training programs use a variety of methods and sites for education including home-based geriatric assessment, clinic-based assessment, evaluation of nursing home practices, rural health care settings, participation in public health prevention efforts and the use of videos and CD-ROMS in training. Participants in the John E. Hartford Foundation’s Geriatric Interdisciplinary Team Training (GITT) program also discussed work in progress. These programs involve training of teams consisting of a minimum of a physician, nurse and social worker to serve the elderly. The 12 GITT sites around the US have approached team training in different ways and are working with different clinical sites. One group, the UCLA/Kaiser Permanente team, is working to rationalise care of the elderly in managed care settings. They are conducting t̀rain the trainer’ sessions so that their teaching will have a snowball effect throughout the local Kaiser system. They are enticing even the most reticent of practitioners to be teachers and to do their teaching in relatively brief segments, an accommodation to the requirements of a busy managed care setting. Presenters gave a t̀rue-to-life’ and amusing demonstration of rationalising telephone communications between professionals so that non-case relevant information is kept to a minimum and all the essentials of the case are inclu","PeriodicalId":8713,"journal":{"name":"BDJ","volume":"73 1","pages":"394-394"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76773030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1988-09-01DOI: 10.1177/026119298801600124
B. Tweedle
1. Impact of global issues on women and children 9-11 January, Manipal, India Manipal University, India.
1. 全球问题对妇女和儿童的影响1月9日至11日，印度马尼帕尔马尼帕尔大学，印度。
{"title":"Around the world","authors":"B. Tweedle","doi":"10.1177/026119298801600124","DOIUrl":"https://doi.org/10.1177/026119298801600124","url":null,"abstract":"1. Impact of global issues on women and children 9-11 January, Manipal, India Manipal University, India.","PeriodicalId":8713,"journal":{"name":"BDJ","volume":"31 1","pages":"47-47"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84836927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
development of visual prosthetic devices. Dr. Goodrich disagreed with the statement, "comparisons of various methods of interfacing visual information has revealed most accurate and rapid recognition has been achieved through the skin." I suspect that there was a misunderstanding about what this statement means, apparently even when he read it in the context of the article. By recognition of visual information was meant literally the person's recognition of the spatial elements of an image within a given field of view. Such recognition is often measured by 2 point acuity and vernier acuity in the simple case. In larger fields with sophisticated systems, more complex images are used to measure resolution, such as Snellen letters and bigrams. Such was the nature of the given research and the focus of the article. This is in contrast to what Dr. Goodrich's letter indicates by statements that imply similar information is transferred by synthetic speech, etc. Spatial-visual information is different from the information relayed by synthetic speech, etc. Said another way, the experience of recognizing visual information is different than the experience of recognizing information usually relayed by vision. There was comment that my conclusions about the tactual system in general were not supported by appropriate references, and it was suggested that I ignored literature on "synthetic speech," etc. Most of the literature on "synthetic speech," etc., was not crddressed because it was not
{"title":"News in brief","authors":"A. cenic","doi":"10.1586/erc.09.162","DOIUrl":"https://doi.org/10.1586/erc.09.162","url":null,"abstract":"development of visual prosthetic devices. Dr. Goodrich disagreed with the statement, \"comparisons of various methods of interfacing visual information has revealed most accurate and rapid recognition has been achieved through the skin.\" I suspect that there was a misunderstanding about what this statement means, apparently even when he read it in the context of the article. By recognition of visual information was meant literally the person's recognition of the spatial elements of an image within a given field of view. Such recognition is often measured by 2 point acuity and vernier acuity in the simple case. In larger fields with sophisticated systems, more complex images are used to measure resolution, such as Snellen letters and bigrams. Such was the nature of the given research and the focus of the article. This is in contrast to what Dr. Goodrich's letter indicates by statements that imply similar information is transferred by synthetic speech, etc. Spatial-visual information is different from the information relayed by synthetic speech, etc. Said another way, the experience of recognizing visual information is different than the experience of recognizing information usually relayed by vision. There was comment that my conclusions about the tactual system in general were not supported by appropriate references, and it was suggested that I ignored literature on \"synthetic speech,\" etc. Most of the literature on \"synthetic speech,\" etc., was not crddressed because it was not","PeriodicalId":8713,"journal":{"name":"BDJ","volume":"99 1","pages":"268-268"},"PeriodicalIF":0.0,"publicationDate":"1980-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77517914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1976-06-01DOI: 10.1177/146642409511500317
C. Mills
most frequent origin are not similarly innervated. The area up to approximately the mid-transverse colon is ’wired’ to a large extent by the parasympathetic vagus nerve, of cranial origin. The more distal regions of the colon derive parasympathetic innervation from the spinal nervi erigentes (from sacral segments 2-4), whose branches may reach as far proximally as the distal transverse colon (Cannon’s point), (Sleisenger, 1981). The differing roles of smoking in these conditions might be based on different reactions of these two systems
{"title":"Society news","authors":"C. Mills","doi":"10.1177/146642409511500317","DOIUrl":"https://doi.org/10.1177/146642409511500317","url":null,"abstract":"most frequent origin are not similarly innervated. The area up to approximately the mid-transverse colon is ’wired’ to a large extent by the parasympathetic vagus nerve, of cranial origin. The more distal regions of the colon derive parasympathetic innervation from the spinal nervi erigentes (from sacral segments 2-4), whose branches may reach as far proximally as the distal transverse colon (Cannon’s point), (Sleisenger, 1981). The differing roles of smoking in these conditions might be based on different reactions of these two systems","PeriodicalId":8713,"journal":{"name":"BDJ","volume":"65 1","pages":"144-144"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84587229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A large multicenter study carried out by clinicians of the Experimental and Clinical Research Center (Berlin, Germany), a joint cooperation between the Max Delbruck Center for Molecular Medicine (Berlin-Buch, Germany) and the Charite Universitatsmedizin (Berlin, Germany), the Helios Hospital (Berlin, Germany), and two hospitals in the USA, has demonstrated that two potential biomarkers, NGAL and KIM-1, may be useful in providing an early risk assessment for patients presenting with kidney disorders. The study found that high levels of NGAL and KIM-1 indicate an increased risk of acute kidney damage, which in turn increases the risk of patients dying in the hospital or requiring dialysis treatment. “In the initial stage of acute kidney injury, we may have most room for improvement of our current clinical practice,” suggests Kai Schmidt-Ott from the Experimental and Clinical Research Center. He recommends that clinicians should base their diagnoses on the NGAL and KIM-1 biomarker readings as well as the serum creatinine levels to give a more exact assessment of the individual patient’s risk. Jonathan Barasch, (Columbia University, NY, USA), the senior author of the paper, explained that, “When a patient presents to the emergency department and a blood test identifies an abnormal creatinine value, it is difficult to know whether the patient needs to be hospitalized because of ongoing intrinsic acute kidney injury (a potentially fatal disease) or whether the patient needs to be sent home after intravenous or oral fluids and later examined at an outpatient clinic.” At present, the serum creatinine level alone is used for the diagnosis of acute kidney injury. Owing to creatinine being a molecule that is normally excreted via the kidney, it accumulates in the blood when kidney function is impaired. However, high levels of serum creatinine are not immediately indicative of acute kidney injury; the level could have built up over a longer period of time, and therefore may not indicate tissue damage. Measuring serum creatinine levels alone is not particularly helpful to doctors in deciding how to proceed with treatment. Damaged kidneys synthesize several other specific proteins. This large-scale study involved taking a single measure of five of these proteins used as urinary biomarkers from almost 1635 emergency room patients at the time of hospital admission, in order to determine which could be used to evaluate patient risk. The findings are hoped to help tackle a real problem: in the USA alone, 1 million patients are diagnosed every year with severe acute kidney injury. Further research is needed to determine whether or not all patients admitted to an emergency room should be tested for the biomarkers. It also remains to been seen whether or not these biomarkers influence the individual treatment outcome.
{"title":"News in brief","authors":"S. Hocken","doi":"10.1586/erm.12.11","DOIUrl":"https://doi.org/10.1586/erm.12.11","url":null,"abstract":"A large multicenter study carried out by clinicians of the Experimental and Clinical Research Center (Berlin, Germany), a joint cooperation between the Max Delbruck Center for Molecular Medicine (Berlin-Buch, Germany) and the Charite Universitatsmedizin (Berlin, Germany), the Helios Hospital (Berlin, Germany), and two hospitals in the USA, has demonstrated that two potential biomarkers, NGAL and KIM-1, may be useful in providing an early risk assessment for patients presenting with kidney disorders. The study found that high levels of NGAL and KIM-1 indicate an increased risk of acute kidney damage, which in turn increases the risk of patients dying in the hospital or requiring dialysis treatment. “In the initial stage of acute kidney injury, we may have most room for improvement of our current clinical practice,” suggests Kai Schmidt-Ott from the Experimental and Clinical Research Center. He recommends that clinicians should base their diagnoses on the NGAL and KIM-1 biomarker readings as well as the serum creatinine levels to give a more exact assessment of the individual patient’s risk. Jonathan Barasch, (Columbia University, NY, USA), the senior author of the paper, explained that, “When a patient presents to the emergency department and a blood test identifies an abnormal creatinine value, it is difficult to know whether the patient needs to be hospitalized because of ongoing intrinsic acute kidney injury (a potentially fatal disease) or whether the patient needs to be sent home after intravenous or oral fluids and later examined at an outpatient clinic.” At present, the serum creatinine level alone is used for the diagnosis of acute kidney injury. Owing to creatinine being a molecule that is normally excreted via the kidney, it accumulates in the blood when kidney function is impaired. However, high levels of serum creatinine are not immediately indicative of acute kidney injury; the level could have built up over a longer period of time, and therefore may not indicate tissue damage. Measuring serum creatinine levels alone is not particularly helpful to doctors in deciding how to proceed with treatment. Damaged kidneys synthesize several other specific proteins. This large-scale study involved taking a single measure of five of these proteins used as urinary biomarkers from almost 1635 emergency room patients at the time of hospital admission, in order to determine which could be used to evaluate patient risk. The findings are hoped to help tackle a real problem: in the USA alone, 1 million patients are diagnosed every year with severe acute kidney injury. Further research is needed to determine whether or not all patients admitted to an emergency room should be tested for the biomarkers. It also remains to been seen whether or not these biomarkers influence the individual treatment outcome.","PeriodicalId":8713,"journal":{"name":"BDJ","volume":"29 6 1","pages":"264-264"},"PeriodicalIF":0.0,"publicationDate":"1975-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81010360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"News in brief","authors":"Roxanne Nelson","doi":"10.1586/ehm.11.16","DOIUrl":"https://doi.org/10.1586/ehm.11.16","url":null,"abstract":"A roundup of the latest nursing news.","PeriodicalId":8713,"journal":{"name":"BDJ","volume":"11 1","pages":"7-7"},"PeriodicalIF":0.0,"publicationDate":"1969-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84138827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The results of a retrospective study carried out at the University of California, Los Angeles, USA, and published in BMC Cancer, suggest that targeting stem cells with radiation could double the progression-free survival time in patients with glioblastoma. Cancer stem cells have been implicated in many cancer types. Frank Pajonk and his team hypothesized that, in addition to healthy stem cells, the neural stem cell niche may also harbor cancer stem cells and that eliminating or damaging these cells may delay the onset of cancer recurrence. Neural stem cells reside in the subventricular zone (SVZ). In order to analyze the impact of irradiating this region, Pajonk and his colleagues compared the outcomes of 55 patients with grade 3 or 4 glioblastoma, treated with radiation between 2003 and 2009. They found that patients who received greater than the median dose (43 Gy) to the bilateral SVZ had a significantly longer survival than those who received less than 43 Gy to the SVZ (progression-free survival: 15.0 vs 7.2 months; p = 0.028), and a mean dose of more than 43 Gy yielded a hazard ratio of 0.73 (p = 0.019). A similar ana lysis of total radiation dose failed to identify a significant impact on survival, suggesting that the improved survival was not due to increased overall dose. However, the authors cautioned that prospective studies are needed to confirm these results. “Our study found that if you irradiated a part of the brain that was not necessarily part of the tumor, the patients did better,” Pajonk commented. “We have been struggling for years to come up with new combinations of drugs and targeted therapies that would improve survival for patients with glioblastoma. It may be that by reshaping our radiation techniques we can extend survival for these patients.”
{"title":"News in brief","authors":"Dr Jacques Monnot","doi":"10.1586/era.10.143","DOIUrl":"https://doi.org/10.1586/era.10.143","url":null,"abstract":"The results of a retrospective study carried out at the University of California, Los Angeles, USA, and published in BMC Cancer, suggest that targeting stem cells with radiation could double the progression-free survival time in patients with glioblastoma. Cancer stem cells have been implicated in many cancer types. Frank Pajonk and his team hypothesized that, in addition to healthy stem cells, the neural stem cell niche may also harbor cancer stem cells and that eliminating or damaging these cells may delay the onset of cancer recurrence. Neural stem cells reside in the subventricular zone (SVZ). In order to analyze the impact of irradiating this region, Pajonk and his colleagues compared the outcomes of 55 patients with grade 3 or 4 glioblastoma, treated with radiation between 2003 and 2009. They found that patients who received greater than the median dose (43 Gy) to the bilateral SVZ had a significantly longer survival than those who received less than 43 Gy to the SVZ (progression-free survival: 15.0 vs 7.2 months; p = 0.028), and a mean dose of more than 43 Gy yielded a hazard ratio of 0.73 (p = 0.019). A similar ana lysis of total radiation dose failed to identify a significant impact on survival, suggesting that the improved survival was not due to increased overall dose. However, the authors cautioned that prospective studies are needed to confirm these results. “Our study found that if you irradiated a part of the brain that was not necessarily part of the tumor, the patients did better,” Pajonk commented. “We have been struggling for years to come up with new combinations of drugs and targeted therapies that would improve survival for patients with glioblastoma. It may be that by reshaping our radiation techniques we can extend survival for these patients.”","PeriodicalId":8713,"journal":{"name":"BDJ","volume":"1 1","pages":"7-7"},"PeriodicalIF":0.0,"publicationDate":"1968-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76259985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Published in the July issue of Cell, two new studies have revealed further details regarding the relationship between bone and blood sugar regulation, through signaling pathways that operate via insulin and osteocalcin, a hormone secreted exclusively by osteoblasts. Gerard Karsenty of Columbia University (NY, USA) has announced that his group has revealed “a key molecular link between bone remodeling and metabolism.” Their study has presented independent evidence for the crucial role of insulin in bone in regulating glucose via osteocalcin. Thomas Clemens of John Hopkins University School of Medicine (MD, USA) and colleagues were surprised by their observations after they engineered a mouse that lacked insulin receptors in their osteoblasts. “The mice started to get fat,” he said. They showed changes in their biochemistry that were consistent with insulin resistance. They also had low osteocalacin levels and fewer osteoblasts to produce less bone.” As the animals aged, developing more severe blood sugar problems, glucose intolerance and insulin resistance, their symptoms were seen to improve with osteocalcin treatment.” According to the researchers, mice whose bones were unable to respond to insulin developed high blood sugar levels as well as insulin resistance – classic symptoms of diabetes. However, these were found to be tied to a drop in osteocalcin levels. Both teams have suggested that their findings could point to osteocalacin, or an alternative drug that is able to target bone, potentially being able to provide a novel treatment in the fight against Type 2 diabetes.
{"title":"News in brief","authors":"David Orme-Smith Bds","doi":"10.1586/eem.10.55","DOIUrl":"https://doi.org/10.1586/eem.10.55","url":null,"abstract":"Published in the July issue of Cell, two new studies have revealed further details regarding the relationship between bone and blood sugar regulation, through signaling pathways that operate via insulin and osteocalcin, a hormone secreted exclusively by osteoblasts. Gerard Karsenty of Columbia University (NY, USA) has announced that his group has revealed “a key molecular link between bone remodeling and metabolism.” Their study has presented independent evidence for the crucial role of insulin in bone in regulating glucose via osteocalcin. Thomas Clemens of John Hopkins University School of Medicine (MD, USA) and colleagues were surprised by their observations after they engineered a mouse that lacked insulin receptors in their osteoblasts. “The mice started to get fat,” he said. They showed changes in their biochemistry that were consistent with insulin resistance. They also had low osteocalacin levels and fewer osteoblasts to produce less bone.” As the animals aged, developing more severe blood sugar problems, glucose intolerance and insulin resistance, their symptoms were seen to improve with osteocalcin treatment.” According to the researchers, mice whose bones were unable to respond to insulin developed high blood sugar levels as well as insulin resistance – classic symptoms of diabetes. However, these were found to be tied to a drop in osteocalcin levels. Both teams have suggested that their findings could point to osteocalacin, or an alternative drug that is able to target bone, potentially being able to provide a novel treatment in the fight against Type 2 diabetes.","PeriodicalId":8713,"journal":{"name":"BDJ","volume":"15 1","pages":"332-332"},"PeriodicalIF":0.0,"publicationDate":"1967-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89460841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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