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Hydrops fetalis: Incidence, Etiologies, Management Strategies, and Outcomes 胎儿水肿:发病率、病因、管理策略和结果
Q4 PEDIATRICS Pub Date : 2023-12-01 DOI: 10.2147/rrn.s411736
Tamiko Younge, Katherine Ottolini, Huda Al-Kouatly, Seth Berger
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引用次数: 0
The Global Crisis of Congenital Syphilis: Vulnerable and Disenfranchised Women Most at Risk 先天性梅毒的全球危机:弱势和无权妇女面临的风险最大
Q4 PEDIATRICS Pub Date : 2023-12-01 DOI: 10.2147/rrn.s428322
Aoife Moore, Bridget Freyne, Clare Nourse
: Congenital syphilis (CS), previously considered by many paediatricians as a “historical disease”, has re-emerged as a significant preventable neonatal infection. While low-income countries have the highest burden of disease globally, notifications have increased in many high-income countries (HIC) in recent years. This literature report provides an overview of the current strategies for testing and treating syphilis in pregnancy (SIP) and CS and describes the changing global epidemiology of SIP. National SIP guidelines are reviewed with reference to testing in pregnancy and treatment of CS. The report highlights that there is an ongoing crisis of CS in HICs worldwide and a disproportionate burden is being experienced by vulnerable populations in these countries. Action is needed to address this crisis, and interventions aimed at overcoming social and structural barriers to antenatal care access for vulnerable populations should be prioritised.
先天性梅毒(CS),以前被许多儿科医生认为是一种“历史疾病”,现已重新成为一种重要的可预防的新生儿感染。虽然低收入国家在全球范围内的疾病负担最重,但近年来,许多高收入国家的通报情况有所增加。本文献报告概述了目前检测和治疗妊娠期梅毒(SIP)和CS的策略,并描述了SIP全球流行病学的变化。国家SIP指南参考妊娠检测和治疗CS进行了审查。报告强调指出,全球高收入国家的卫生危机持续存在,这些国家的弱势群体正承受着不成比例的负担。需要采取行动解决这一危机,并应优先考虑旨在克服弱势群体获得产前保健的社会和结构性障碍的干预措施。
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引用次数: 0
Neonatal Hydrometrocolpos Secondary to Imperforate Hymen Presented with Acute Urinary Retention: Case Report 继发于处女膜闭锁的新生儿水性直肠畸形伴急性尿潴留1例报告
Q4 PEDIATRICS Pub Date : 2023-11-01 DOI: 10.2147/rrn.s433727
Dereje Tegene, Tesfalem Assefa, Abdurahman Edris
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引用次数: 0
Magnitude of Neonatal Admission Diagnosis and Associated Factors at Selected Hospitals in Wollo, Northeast Ethiopia 埃塞俄比亚东北部沃罗选定医院新生儿入院诊断程度及相关因素
Q4 PEDIATRICS Pub Date : 2023-11-01 DOI: 10.2147/rrn.s418964
Shambel Asmamaw, Shiferaw Getachew, Tamrat Demeke, Hailu Hankarso, Birhan Alemnew, Shambel Wedajo, Asressie Molla
Background: Neonates are commonly admitted to neonatal intensive care units, and the type(s) of admission determine the outcome of the neonate. Therefore, we sought to assess the magnitude of neonatal admission and associated factors at selected hospitals in Wollo, northeast Ethiopia in 2022. Methods: A cross-sectional study on 422 admitted mother–neonate pairs was conducted. Data were collected by face-to-face interviews and reviewing patient records and then entered and analyzed using EpiData version 3.1 and Stata version 14, respectively. Binary logistic regression analyses were employed, and P < 0.05 was considered statistically significant on multivariate analysis. Results: The prevalence of neonatal sepsis was 53.4% (95% CI 48.5%– 58.2%), low birth weight 36.9% (95% CI 32.3%– 41.7%), prematurity 24.2% (95% CI 20.3%– 28.5%), and hypoglycemia 9.7% (95% CI 7.2%– 13%). Urinary tract infection (AOR 2.22, 95% CI 1.13– 4.34), history of abortion (AOR 1.95, 95% CI 1.002– 3.78), and twin pregnancy (AOR 6.34, 95% CI 1.84– 11.83) were associated with low birth weight. Premature rupture of membrane (AOR 2.87 95% CI 1.31– 6.28), history of abortion (AOR 2.36, 95% CI 1.20– 4.61), and instrumental delivery (AOR 5.25, 95% CI 1.65– 16.71) were associated with neonatal sepsis. Male sex (AOR 2.78, 95% CI 1.45– 5.34), pregnancy-induced hypertension (AOR 2.73, 95% CI 1.13– 6.60), antepartum hemorrhage (AOR 3.24, 95% CI 1.03– 10.20), and premature rupture of membrane (AOR 2.77, 95% CI 1.23– 6.24) were associated with prematurity. Conclusion: The prevalence of low birth weight, prematurity, and neonatal sepsis was high, but neonatal hypoglycemia was low. Urinary tract infection, history of abortion, and twin pregnancy were associated with low birth weight. Premature rupture of membrane, history of abortion, and instrumental delivery were associated with neonatal sepsis. Male sex, pregnancy-induced hypertension, antepartum hemorrhage, and premature ruptures of membrane were associated with prematurity. Keywords: admission diagnosis, discriminant analysis, Ethiopia, neonatal admission, neonate
背景:新生儿通常入住新生儿重症监护病房,入院类型决定了新生儿的预后。因此,我们试图评估2022年埃塞俄比亚东北部沃罗选定医院的新生儿入院率及其相关因素。方法:对422对住院母亲-新生儿进行横断面研究。通过面对面访谈和查阅病历收集数据,分别使用EpiData 3.1版本和Stata 14版本进行录入和分析。采用二元logistic回归分析,多因素分析以P < 0.05为差异有统计学意义。结果:新生儿败血症发生率为53.4% (95% CI 48.5% ~ 58.2%),低出生体重发生率为36.9% (95% CI 32.3% ~ 41.7%),早产发生率为24.2% (95% CI 20.3% ~ 28.5%),低血糖发生率为9.7% (95% CI 7.2% ~ 13%)。尿路感染(AOR 2.22, 95% CI 1.13 ~ 4.34)、流产史(AOR 1.95, 95% CI 1.002 ~ 3.78)和双胎妊娠(AOR 6.34, 95% CI 1.84 ~ 11.83)与低出生体重相关。胎膜早破(AOR 2.87 95% CI 1.31 ~ 6.28)、流产史(AOR 2.36, 95% CI 1.20 ~ 4.61)和器械分娩(AOR 5.25, 95% CI 1.65 ~ 16.71)与新生儿脓毒症相关。男性(AOR 2.78, 95% CI 1.45 ~ 5.34)、妊高征(AOR 2.73, 95% CI 1.13 ~ 6.60)、产前出血(AOR 3.24, 95% CI 1.03 ~ 10.20)、胎膜早破(AOR 2.77, 95% CI 1.23 ~ 6.24)与早产相关。结论:低出生体重、早产、新生儿败血症发生率高,新生儿低血糖发生率低。尿路感染、流产史和双胎妊娠与低出生体重有关。胎膜早破、流产史和器械分娩与新生儿败血症有关。男性、妊高征、产前出血、胎膜早破与早产有关。关键词:入院诊断,判别分析,埃塞俄比亚,新生儿入院,新生儿
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引用次数: 0
Updated Perspectives on the Diagnosis and Management of Neonatal Invasive Candidiasis 新生儿侵袭性念珠菌病诊断和治疗的最新进展
Q4 PEDIATRICS Pub Date : 2023-11-01 DOI: 10.2147/rrn.s409779
Katherine Daniel, Rachel G Greenberg, Angelique Boutzoukas, Lakshmi Katakam
Abstract: Invasive candidiasis can cause severe illness in immunocompromised hosts, such as premature infants. Clinical presentation in neonates is variable and often characterized by non-specific signs with potential to involve several organ systems. Awareness of risk factors for Candida infections in the neonatal intensive care unit (NICU) can aid in screening infants with signs and symptoms of generalized illness. Cultures of blood, urine, and cerebrospinal fluid are the main diagnostic tools available in this population of infants, but several biomarkers and alternate identification methodologies such as 1,3-β-D-glucan, serum mannan or anti-mannan, and T2 magnetic resonance testing are being studied in the neonatal population. Prompt diagnosis of Candida infection, in conjunction with a comprehensive assessment of disease progression and organ involvement, is critical for optimizing treatment and patient outcomes. Supportive care and systemic antifungal medications remain the mainstay of treatment, and the efficacy and safety of newer therapeutic agents continue to be evaluated in neonates. Disease prevention strategies must be thoughtfully implemented and customized to each individual NICU based on local incidence of Candida infection, practice patterns, and risk factors, and may include prophylactic antifungal therapy. This review summarizes the evidence for current approaches to diagnosis and management of neonatal invasive candidiasis and provides an overview of the newer diagnostic tools and therapeutic agents on the horizon. Keywords: Candida , infant, biomarkers, amphotericin B, fluconazole, prophylaxis
摘要:侵袭性念珠菌病可引起免疫功能低下的宿主,如早产儿的严重疾病。新生儿的临床表现是多变的,通常以非特异性体征为特征,可能涉及多个器官系统。在新生儿重症监护病房(NICU)了解念珠菌感染的危险因素有助于筛查具有全身性疾病体征和症状的婴儿。血液、尿液和脑脊液培养是这一婴儿群体中可用的主要诊断工具,但在新生儿群体中正在研究几种生物标志物和替代鉴定方法,如1,3-β- d -葡聚糖、血清甘露聚糖或抗甘露聚糖,以及T2磁共振检测。念珠菌感染的及时诊断,结合疾病进展和器官受累的综合评估,对于优化治疗和患者预后至关重要。支持性护理和全身性抗真菌药物治疗仍然是治疗的主要手段,新的治疗药物的有效性和安全性仍在对新生儿进行评估。疾病预防策略必须根据当地念珠菌感染的发生率、实践模式和风险因素,为每个新生儿重症监护室精心实施和定制,并可能包括预防性抗真菌治疗。本文综述了目前诊断和治疗新生儿侵袭性念珠菌病的证据,并概述了新的诊断工具和治疗药物。关键词:念珠菌,婴儿,生物标志物,两性霉素B,氟康唑,预防
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引用次数: 0
Antenatal Kratom Exposure: Literature Review and Clinical Management Recommendations 产前Kratom暴露:文献回顾和临床管理建议
Q4 PEDIATRICS Pub Date : 2023-10-01 DOI: 10.2147/rrn.s419864
Alice Ordean
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引用次数: 0
Lived Experience of Mothers Having Preterm Newborns in a Neonatal Intensive Care Unit at Wolaita Sodo University Comprehensive Specialized Hospital Southern Ethiopia: A Phenomenological Study 埃塞俄比亚南部Wolaita Sodo大学综合专科医院新生儿重症监护室早产新生儿母亲的生活经历:一项现象学研究
Q4 PEDIATRICS Pub Date : 2023-08-01 DOI: 10.2147/rrn.s417173
Worku Mimani Minuta, Temesgen Lera Abiso, D. Haile, Abebe sorsa Badacho, Befekadu Bekele, Abera Gezume Ganta, Getachew Nigussie Bolado, Begidu Bashe
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引用次数: 0
Examining Practice Variation Used for Packed Red Blood Cell Transfusions for Preterm Infants in Neonatal Intensive Care Units Across the United States 在美国新生儿重症监护病房检查用于早产儿包装红细胞输注的实践差异
Q4 PEDIATRICS Pub Date : 2022-10-01 DOI: 10.2147/rrn.s379367
Kayla C. Everhart, S. Donevant, V. Iskersky, M. Wirth, Robin B. Dail
Purpose: Researchers report associations between packed red blood cell (PRBC) transfusions and morbid outcomes in preterm infants. Published standards are lacking for giving PRBC transfusions to preterm infants in the neonatal intensive care unit (NICU). This study examined standard practices reported by nurses across the United States (US) for administering PRBC transfusions to preterms to identify variation in practice which may contribute to the relationship of PRBC transfusions and morbidity. Design and Methods: A 23-item questionnaire developed using REDCap based on literature and nursing experience of experts on the procedure of administering PRBC transfusions to preterm infants was distributed via social media and email to NICU nurses across the US. Results: A total of 757 responses received and 518 completed responses were analyzed from level IV (48%) and level III (49%) NICU nurses in 47/50 US states. Most (94%) report PRBCs are ordered for anemia. Most (74%) report NICU policies do not specify warming PRBC transfusions prior to infusing; 10% (n = 53) specifically indicate they warm PRBC transfusions. Only 2% report using a blood warmer device. NICU nurses in the US (66%) reported feedings are altered during the PRBC transfusion. A 97% of nurses reported their NICU employs a specific physiologic assessment policy during PRBC transfusions. The two most common infusion sites used are (99%) peripheral IV as preferred and an umbilical venous catheter (74.5%) as next best option. Conclusion: This study reveals inconsistencies in PRBC transfusion practices in US NICUs. Vast inconsistencies were shown in warming transfusions and in feeding practices surrounding PRBC transfusions. Future research should examine these variations in PRBC transfusion practices for any contributions to the relationship of PRBC transfusions and morbidity in preterm infants. A standard guideline should be developed based on the research evidence to guide nurses in administering preterm PRBC transfusions.
目的:研究人员报告了填充红细胞(PRBC)输注与早产儿疾病结局之间的关系。在新生儿重症监护室(NICU)为早产儿输注PRBC缺乏已公布的标准。本研究调查了美国各地护士报告的给学龄前儿童输注PRBC的标准做法,以确定可能导致PRBC输注与发病率关系的做法差异。设计和方法:根据文献和专家对早产儿输注PRBC程序的护理经验,使用REDCap编制了一份23项问卷,通过社交媒体和电子邮件分发给美国各地的新生儿重症监护室护士。结果:美国47/50个州的四级(48%)和三级(49%)新生儿重症监护室护士共收到757份回复,518份已完成回复。大多数(94%)报告称,PRBC是为贫血而订购的。大多数(74%)报告新生儿重症监护室的政策没有规定在输注前暖注PRBC;10%(n=53)明确表示他们进行了暖性PRBC输注。只有2%的人报告使用了血液加温器。美国新生儿重症监护室护士(66%)报告称,在PRBC输注过程中,喂养发生了变化。97%的护士报告说,他们的新生儿重症监护室在PRBC输血期间采用了特定的生理评估政策。最常用的两个输注部位是(99%)首选外周静脉输液,其次是脐静脉导管(74.5%)。结论:本研究揭示了美国新生儿重症监护室PRBC输血实践的不一致性。在加温输血和围绕PRBC输血的喂养实践中显示出巨大的不一致性。未来的研究应该检查PRBC输血实践中的这些变化是否对早产儿PRBC输血与发病率的关系有任何贡献。应根据研究证据制定标准指南,指导护士进行早产PRBC输血。
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引用次数: 0
Saving the Lives of Asphyxiated Newborns in Public Health Facilities: An Implementation Research 公共卫生机构抢救窒息新生儿生命的实施研究
Q4 PEDIATRICS Pub Date : 2022-08-01 DOI: 10.2147/rrn.s366328
Sanjay Shinde, Firew Tiruneh, Dinaol Abdissa
Back Ground: Globally, 2.6 million children died in their first month of life—approximately 7 000 newborn deaths per day—with approximately one million dying on the first day and nearly one million dying within the next six days. Perinatal asphyxia plays a significant role in this mortality. Even those who survive will suffer from mental retardation and other complications. One programme to save the lives of asphyxiated newborns is “Helping Baby Breathe.” However, it has yet to be successful in Ethiopia. Objective: To assess the status of implementation of helping baby breath and to design alternative best way to improve the service, in public hospitals of Bench-Maji, Kaffa and Sheka zones. Methods: Concurrent triangulation was used in the design. We used a phenomenological and descriptive cross-sectional study design. The subjects of the study were key informants, postnatal mothers, and health care providers in the delivery ward. Atlas Ti and SPSS software were used to analyze qualitative and quantitative data, respectively. Results: We reported on the knowledge and skills of health care providers in neonatal resuscitation in this study. The findings revealed that participants with good knowledge and skill were 54% and 27%, respectively. A number of contextual factors that may be impeding neonatal resuscitation were also identified qualitatively. Conclusion: The majority of health care providers’ skill and knowledge of neonatal resuscitation were far below the minimum expected competency. mocking me, hahaha, who cares about the quality of a specific service?” Let me be bold and state that newborn resuscitation has never been on the agenda of a meeting. “We’re doing everything we can to assist baby breathe”, said the participant. According to specialists, however, the newborn may face challenges such as cold stress or illness. Due to the fact that these two elements are commonly disregarded. Our rash is designed to help us breathe and begin breathing.
背景:在全球范围内,有260万儿童在出生的第一个月死亡,每天约有7000名新生儿死亡,其中约有100万儿童在第一天死亡,近100万人在接下来的六天内死亡。围产期窒息在这种死亡率中起着重要作用。即使那些幸存下来的人也会遭受智力迟钝和其他并发症的折磨。拯救窒息新生儿生命的一个项目是“帮助婴儿呼吸”。然而,该项目在埃塞俄比亚尚未成功。目的:评估Bench Maji、Kaffa和Sheka地区公立医院帮助婴儿呼吸的实施情况,并设计改进服务的替代最佳方式。方法:采用并行三角测量法进行设计。我们采用了现象学和描述性的横断面研究设计。这项研究的受试者是关键的信息提供者、产后母亲和产房的医疗保健提供者。使用Atlas Ti和SPSS软件分别对数据进行定性和定量分析。结果:本研究报告了医护人员在新生儿复苏方面的知识和技能。研究结果显示,具有良好知识和技能的参与者分别占54%和27%。还定性地确定了可能阻碍新生儿复苏的一些背景因素。结论:大多数医护人员的新生儿复苏技能和知识远低于最低预期能力。嘲笑我,哈哈哈,谁在乎特定服务的质量?”让我大胆地说,新生儿复苏从未列入会议议程。参与者说:“我们正在尽一切努力帮助婴儿呼吸。”。然而,根据专家的说法,新生儿可能会面临冷应激或疾病等挑战。由于这两个要素通常被忽略。我们的皮疹是为了帮助我们呼吸和开始呼吸。
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引用次数: 0
Neonatal Sucking Blister and Sucking Pads: Coexisting Simultaneously in a 24 Hour Old Newborn 新生儿吸吮泡和吸吮垫:在24小时大的新生儿中同时存在
Q4 PEDIATRICS Pub Date : 2022-08-01 DOI: 10.2147/rrn.s374095
Gashaw Arega, Selamawit Daniel Admasse, Desalegn Alemneh
: Neonatal suckling blisters usually present as benign skin erosions involving the distal upper extremities at birth presumably induced by vigorous sucking in utero, whereas sucking pads commonly appear as hyperkeratotic thickening of the lips indicating effective neonatal sucking reflex. These benign neonatal conditions should be differentiated from other serious systemic and dermatological diseases in newborns through their clinical manifestations and self-limited course. Here, we report a 24 hour old male newborn with a sucking blister and sucking pads present at birth coexisting simultaneously, diagnosed based on the presentation and benign course. A high index of clinical suspicion is required to avoid unnecessary investigations and treatment.
:新生儿乳泡通常表现为出生时累及上肢远端的良性皮肤侵蚀,可能是由子宫内剧烈吮吸引起的,而吸吮垫通常表现为嘴唇角化过度增厚,表明新生儿的吸吮反射有效。这些良性新生儿疾病应通过其临床表现和自限病程与其他严重的新生儿系统性和皮肤病进行区分。在这里,我们报告了一名24小时大的男性新生儿,出生时吸吮泡和吸吮垫同时存在,根据表现和良性病程进行诊断。需要高指数的临床怀疑,以避免不必要的调查和治疗。
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引用次数: 0
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Research and reports in neonatology
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