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Implications of Recent Drug Approvals for Older Adults. 近期药物批准对老年人的影响。
Christine Eisenhower, Michael Koronkowski, Zachary Marcum

More than 100 medications were approved by the US Food and Drug Administration as new drugs or for new indications in 2014 and 2015. Several of the new drugs may benefit older adults, but adverse events and pharmacokinetic changes due to aging must be considered. This article will focus on three recently approved drugs that are marketed for chronic conditions that can affect older adults: suvorexant, for treatment of insomnia; edoxaban, for prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation and for treatment of venous thromboembolism; and droxidopa, for treatment of symptomatic neurogenic orthostatic hypotension. Information about indications, mechanisms of action, dosing, efficacy, and safety are reviewed. The place of each agent in therapy for older adults is also discussed.

2014年和2015年,超过100种药物被美国食品和药物管理局批准为新药或新适应症。一些新药可能对老年人有益,但必须考虑到衰老引起的不良事件和药代动力学变化。本文将重点介绍最近获准上市的三种治疗老年人慢性疾病的药物:用于治疗失眠的suvorexant;依多沙班用于预防非瓣膜性房颤患者的卒中和全身性栓塞以及静脉血栓栓塞的治疗;还有羟多巴,用于治疗症状性神经源性直立性低血压。有关适应症,作用机制,剂量,疗效和安全性的信息进行了审查。本文还讨论了每种药物在老年人治疗中的作用。
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引用次数: 0
A response from 来自
Lillian Min
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引用次数: 1
Older adult drivers living in residential care facilities. 居住在养老院的老年驾驶员。
Hillary D Lum, Adit A Ginde, Marian E Betz

Residential care facilities (RCF) provide assistance to older adults who cannot live independently, but it is unclear whether these residents have retired from driving. Here, we characterize older adults living in RCFs who still drive from a national cross-sectional survey of residents (2010 National Survey of Residential Care Facilities), representing ~733,000 adults living in RCFs such as assisted living facilities and personal care homes. Key resident characteristics were health, function, mobility and community activity indicators, which could be associated with increased driving risk. Of 8,087 residents, 4.5% (95%CI=3.9-5.1) were current drivers. Many drivers were older than 80 years (74%, 95%CI=67-79), in very good health (31%, 95%CI=25-38) or good health (35%, 95%CI=29-42), and had a median of two medical conditions. Most were independent with activities of daily living, though some needed assistance with walking and used gait devices. Given these results, RCF staff and healthcare providers need a heightened awareness of factors associated with driving risk to promote safety of older drivers and provide resources for likely transition to other transportation.

寄宿式护理设施(RCF)为无法独立生活的老年人提供帮助,但目前尚不清楚这些住户是否已不再开车。在此,我们通过一项全国居民横断面调查(2010 年全国寄宿式护理机构调查)了解了居住在寄宿式护理机构中仍在开车的老年人的特征,该调查代表了居住在生活辅助设施和个人护理之家等寄宿式护理机构中的约 73.3 万名成年人。居民的主要特征包括健康、功能、活动能力和社区活动指标,这些可能与驾驶风险的增加有关。在 8087 名住院者中,4.5%(95%CI=3.9-5.1)是当前的驾驶者。许多驾驶者的年龄在 80 岁以上(74%,95%CI=67-79),健康状况非常好(31%,95%CI=25-38)或良好(35%,95%CI=29-42),患有两种疾病的中位数。大多数人都能独立进行日常生活活动,但也有一些人在行走时需要帮助,并使用步态器。鉴于上述结果,RCF 工作人员和医疗保健提供者需要提高对驾驶风险相关因素的认识,以促进老年驾驶者的安全,并为可能过渡到其他交通工具提供资源。
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引用次数: 0
Pain Management in Long-Term Care Communities: A Quality Improvement Initiative. 长期护理社区的疼痛管理:质量改进倡议。
Manney C Reid, Kevin W O'Neil, JaNeen Dancy, Carolyn A Berry, Stephanie A Stowell

Pain is underrecognized and undertreated in the long-term care (LTC) setting. To improve the management of pain for LTC residents, the authors implemented a quality improvement (QI) initiative at one LTC facility. They conducted a needs assessment to identify areas for improvement and designed a 2-hour educational workshop for facility staff and local clinicians. Participants were asked to complete a survey before and after the workshop, which showed significant improvement in their knowledge of pain management and confidence in their ability to recognize and manage residents' pain. To measure the effectiveness of the QI initiative, the authors performed a chart review at baseline and at 3 and 8 months after the workshop and evaluated relevant indicators of adequate pain assessment and management. The post-workshop chart reviews showed significant improvement in how consistently employees documented pain characteristics (ie, location, intensity, duration) in resident charts and in their use of targeted pain assessments for residents with cognitive dysfunction. The proportion of charts that included a documented plan for pain assessment was high at baseline and remained stable throughout the study. Overall, the findings suggest a QI initiative is an effective way to improve pain care practices in the LTC setting.

在长期护理(LTC)环境中,疼痛未被充分认识和治疗。为了改善LTC居民的疼痛管理,作者在一家LTC设施实施了质量改进(QI)计划。他们进行了需求评估,以确定需要改进的领域,并为设施工作人员和当地临床医生设计了一个2小时的教育讲习班。参与者被要求在研讨会前后完成一项调查,这表明他们对疼痛管理的知识和对他们识别和管理居民疼痛的能力的信心有了显著的提高。为了衡量QI倡议的有效性,作者在基线和研讨会后3个月和8个月进行了图表回顾,并评估了适当的疼痛评估和管理的相关指标。工作坊后的图表回顾显示,员工在住院医师图表中记录疼痛特征(即位置、强度、持续时间)的一致性以及他们对认知功能障碍住院医师进行针对性疼痛评估的程度有了显著改善。包括疼痛评估文件计划的图表比例在基线时很高,并且在整个研究过程中保持稳定。总的来说,研究结果表明QI倡议是改善LTC环境中疼痛护理实践的有效方法。
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引用次数: 0
Using Standardized Case Vignettes to Evaluate Nursing Home Staff Recognition of Delirium and Delirium Superimposed on Dementia. 用标准化案例小图评价养老院工作人员对谵妄和谵妄合并痴呆的认知。
Donna M Fick, Ann M Kolanowski, Nikki L Hill, Andrea Yevchak, Brittney DiMeglio, Paula M Mulhall

The purpose of this study is to describe nursing home staff knowledge regarding delirium detection and the most common causes of delirium. Specific aims that guided this study include identifying the rate of nurse recognition of delirium and delirium superimposed on dementia (DSD), including different motoric subtypes of delirium, using standardized case vignettes, and exploring what nursing home staff describe as the potential causes of delirium. The study showed overall poor recognition of delirium and DSD, which did not improve over time. Interventions have the potential to increase the early detection of delirium and DSD by the staff and warrant development.

本研究的目的是描述疗养院工作人员关于谵妄检测和谵妄的最常见原因的知识。指导本研究的具体目的包括确定护士对谵妄和谵妄叠加痴呆(DSD)的认知率,包括谵妄的不同运动亚型,使用标准化的病例小图,并探索养老院工作人员描述的谵妄的潜在原因。该研究显示,谵妄和DSD的识别能力总体较差,并没有随着时间的推移而改善。干预措施有可能增加工作人员对谵妄和DSD的早期发现,并保证发展。
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引用次数: 0
Challenges Associated With Managing Suicide Risk in Long-Term Care Facilities. 管理长期护理机构自杀风险的相关挑战。
Alisa O'Riley, Michael R Nadorff, Yeates Conwell, Barry Edelstein

Little information about suicidal ideation and behavior in long-term care (LTC) facilities is available. Nonetheless, the implementation of the Minimum Data Set 3.0 requires that LTC facilities screen their residents for suicide risk and have protocols in place to effectively manage residents' responses. In this article, the authors briefly discuss the risk factors of suicide in the elderly and the problems that suicidal ideation and behavior pose in the LTC environment. The authors explain issues that arise when trying to manage suicide risk in the elderly LTC population with general, traditional approaches. These inherent issues make it difficult to develop an effective protocol for managing suicide risk in LTC facilities, leading the authors to propose their own framework for assessing and managing suicide risk in the LTC setting.

关于长期护理(LTC)设施中自杀意念和行为的信息很少。尽管如此,最小数据集3.0的实施要求LTC设施筛选其居民的自杀风险,并制定有效管理居民反应的协议。本文就LTC环境中老年人自杀的危险因素以及自杀意念和行为所带来的问题进行了简要的探讨。作者解释了当试图用一般的传统方法管理老年LTC人群的自杀风险时出现的问题。这些固有的问题使得很难制定一个有效的协议来管理LTC设施的自杀风险,这使得作者提出了他们自己的框架来评估和管理LTC环境中的自杀风险。
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引用次数: 0
Urinary Tract Infections in Older Adults Residing in Long-Term Care Facilities. 居住在长期护理机构的老年人尿路感染。
Liza Genao, Gwendolen T Buhr

Urinary tract infections (UTIs) are commonly suspected in residents of long-term care (LTC) facilities, and it has been common practice to prescribe antibiotics to these patients, even when they are asymptomatic. This approach, however, often does more harm than good, leading to increased rates of adverse drug effects and more recurrent infections with drug-resistant bacteria. It also does not improve genitourinary symptoms (eg, polyuria or malodorous urine) or lead to improved mortality rates; thus, distinguishing UTIs from asymptomatic bacteriuria is imperative in the LTC setting. This article provides a comprehensive overview of UTI in the LTC setting, outlining the epidemiology, risk factors and pathophysiology, microbiology, diagnosis, laboratory assessment, and management of symptomatic UTI.

长期护理(LTC)设施的居民通常怀疑尿路感染(uti),即使在这些患者没有症状的情况下,也通常会给他们开抗生素。然而,这种方法往往弊大于利,导致药物不良反应的发生率增加,耐药细菌的复发性感染也更多。它也不能改善泌尿生殖系统症状(如多尿或尿臭)或降低死亡率;因此,区分尿路感染和无症状细菌尿在LTC的设置是必要的。本文提供了LTC环境下尿路感染的全面概述,概述了流行病学、危险因素和病理生理学、微生物学、诊断、实验室评估和症状性尿路感染的管理。
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引用次数: 0
Incorporating INTERACT II Clinical Decision Support Tools into Nursing Home Health Information Technology. 将INTERACT II临床决策支持工具纳入养老院健康信息技术。
Steven M Handler, Siobhan S Sharkey, Sandra Hudak, Joseph G Ouslander

A substantial reduction in hospitalization rates has been associated with the implementation of the Interventions to Reduce Acute Care Transfers (INTERACT) quality improvement intervention using the accompanying paper-based clinical practice tools (INTERACT II). There is significant potential to further increase the impact of INTERACT by integrating INTERACT II tools into nursing home (NH) health information technology (HIT) via standalone or integrated clinical decision support (CDS) systems. This article highlights the process of translating INTERACT II tools from paper to NH HIT. The authors believe that widespread dissemination and integration of INTERACT II CDS tools into various NH HIT products could lead to sustainable improvement in resident and clinician process and outcome measures, including enhanced interclinician communication and a reduction in potentially avoidable hospitalizations.

住院率的大幅降低与使用随附的基于纸张的临床实践工具(INTERACT II)实施减少急性护理转移的干预措施(INTERACT)质量改进干预措施有关。通过独立或集成的临床决策支持(CDS)系统将INTERACT II工具集成到养老院(NH)健康信息技术(HIT)中,进一步增加INTERACT的影响有很大的潜力。本文重点介绍了将INTERACT II工具从纸上翻译成NH HIT的过程。作者认为,将INTERACT II CDS工具广泛传播和整合到各种NH HIT产品中,可能会导致住院医生和临床医生的过程和结果测量的持续改善,包括加强临床医生之间的沟通和减少潜在可避免的住院治疗。
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引用次数: 0
Detecting Adverse Drug Events Using a Nursing Home Specific Trigger Tool. 使用养老院专用触发工具检测药物不良事件。
Steven M Handler, Joseph T Hanlon
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引用次数: 0
Recognizing the Risks of Chronic Nonsteroidal Anti-Inflammatory Drug Use in Older Adults. 认识到老年人慢性使用非甾体抗炎药的风险。
Zachary A Marcum, Joseph T Hanlon

Older adults commonly take nonsteroidal anti-inflammatory drugs (NSAIDs) chronically. Studies of older adults show that chronic NSAID use increases the risk of peptic ulcer disease, acute renal failure, and stroke/myocardial infarction. Moreover, chronic NSAID use can exacerbate a number of chronic diseases including heart failure and hypertension, and can interact with a number of drugs (eg, warfarin, corticosteroids). Preferred analgesics in older adults that may have a lower risk of these adverse drug reactions include acetaminophen, a nonacetylated salicylate (eg, salsalate), a short half-life NSAID (eg, ibuprofen), or low-dose opioid/opioid-like agents in combination with acetaminophen (in appropriate patients).

老年人通常长期服用非甾体抗炎药(NSAIDs)。对老年人的研究表明,长期使用非甾体抗炎药会增加消化性溃疡疾病、急性肾功能衰竭和中风/心肌梗死的风险。此外,长期使用非甾体抗炎药可加重包括心力衰竭和高血压在内的许多慢性疾病,并可与许多药物(如华法林、皮质类固醇)相互作用。老年人的首选镇痛药可能具有较低的药物不良反应风险,包括对乙酰氨基酚,非乙酰化水杨酸盐(如水杨酸盐),短半衰期非甾体抗炎药(如布洛芬),或低剂量阿片类药物/阿片类药物与对乙酰氨基酚联合使用(适用于适当的患者)。
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引用次数: 0
期刊
The annals of long-term care : the official journal of the American Medical Directors Association
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