Interdisciplinary topics in gerontology最新文献

英文中文

Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice. 饮食限制对长寿突变小鼠胰岛素信号相关基因表达的影响。

Interdisciplinary topics in gerontology

Pub Date : 2007-01-01 DOI: 10.1159/000096556

Andrzej Bartke, Michal M Masternak, Khalid A Al-Regaiey, Michael S Bonkowski

Hypopituitary Ames dwarf mice and growth-hormone-resistant (growth hormone receptor knockout, GHRKO) mice have reduced plasma levels of insulin-like growth factor 1 and insulin, enhanced insulin sensitivity and a remarkably increased life span. This resembles the phenotypic characteristics of genetically normal animals subjected to dietary restriction (DR). Interestingly, DR leads to further increases in insulin sensitivity and longevity in Ames dwarfs but not in GHRKO mice. It was therefore of interest to examine the effects of DR on the expression of insulin-related genes in these two types of long-lived mutant mice. The effects of DR partially overlapped but did not duplicate the effects of Ames dwarfism or GHR deletion on the expression of genes related to insulin signaling and cell responsiveness to insulin. Moreover, the effects of DR on the expression of the examined genes in different insulin target organs were not identical. Some of the insulin-related genes were similarly affected by DR in both GHRKO and normal mice, some were affected only in GHRKO mice and some only in normal animals. This last category is of particular interest since genes affected in normal but not GHRKO mice may be related to mechanisms by which DR extends longevity.

垂体功能低下的Ames侏儒小鼠和生长激素抵抗(生长激素受体敲除，GHRKO)小鼠血浆中胰岛素样生长因子1和胰岛素水平降低，胰岛素敏感性增强，寿命显著延长。这类似于受饮食限制(DR)的基因正常动物的表型特征。有趣的是，DR导致Ames矮子的胰岛素敏感性和寿命进一步增加，而GHRKO小鼠则没有。因此，研究DR对这两种长寿突变小鼠胰岛素相关基因表达的影响是很有意义的。DR的影响部分重叠，但不重复Ames侏儒症或GHR缺失对胰岛素信号传导和细胞对胰岛素反应性相关基因表达的影响。此外，DR对不同胰岛素靶器官中所检测基因表达的影响也不相同。一些胰岛素相关基因在GHRKO和正常小鼠中同样受到DR的影响，一些仅在GHRKO小鼠中受到影响，一些仅在正常动物中受到影响。最后一类是特别有趣的，因为正常而非GHRKO小鼠中受影响的基因可能与DR延长寿命的机制有关。

{"title":"Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice.","authors":"Andrzej Bartke, Michal M Masternak, Khalid A Al-Regaiey, Michael S Bonkowski","doi":"10.1159/000096556","DOIUrl":"https://doi.org/10.1159/000096556","url":null,"abstract":"<p><p>Hypopituitary Ames dwarf mice and growth-hormone-resistant (growth hormone receptor knockout, GHRKO) mice have reduced plasma levels of insulin-like growth factor 1 and insulin, enhanced insulin sensitivity and a remarkably increased life span. This resembles the phenotypic characteristics of genetically normal animals subjected to dietary restriction (DR). Interestingly, DR leads to further increases in insulin sensitivity and longevity in Ames dwarfs but not in GHRKO mice. It was therefore of interest to examine the effects of DR on the expression of insulin-related genes in these two types of long-lived mutant mice. The effects of DR partially overlapped but did not duplicate the effects of Ames dwarfism or GHR deletion on the expression of genes related to insulin signaling and cell responsiveness to insulin. Moreover, the effects of DR on the expression of the examined genes in different insulin target organs were not identical. Some of the insulin-related genes were similarly affected by DR in both GHRKO and normal mice, some were affected only in GHRKO mice and some only in normal animals. This last category is of particular interest since genes affected in normal but not GHRKO mice may be related to mechanisms by which DR extends longevity.</p>","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"35 ","pages":"69-82"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000096556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26328817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Metabolic reprogramming in dietary restriction. 饮食限制中的代谢重编程。

Interdisciplinary topics in gerontology

Pub Date : 2007-01-01 DOI: 10.1159/000096554

Rozalyn M Anderson, Richard Weindruch

It is widely accepted that energy intake restriction without essential nutrient deficiency delays the onset of aging and extends life span. The mechanism underlying this phenomenon is still unknown though a number of different, nonmutually exclusive explanations have been proposed. In each of these, different facets of physiology play the more significant role in the mechanism of aging retardation. Some examples include the altered lipid composition model, the immune response model and models describing changes in endocrine function. In this paper we propose the hypothesis that metabolic reprogramming is the key event in the mechanism of dietary restriction, and the physiological effects at the cellular, tissue and organismal level may be understood in terms of this initial event.

人们普遍认为，在不缺乏必需营养素的情况下，限制能量摄入可以延缓衰老，延长寿命。尽管提出了许多不同的、不相互排斥的解释，但这种现象背后的机制仍然未知。在每一种情况下，生理的不同方面在延缓衰老的机制中起着更重要的作用。一些例子包括脂质组成改变模型、免疫反应模型和描述内分泌功能变化的模型。在本文中，我们提出代谢重编程是饮食限制机制的关键事件的假设，并且在细胞、组织和有机体水平上的生理效应可以从这一初始事件来理解。

引用次数: 54

Dietary restriction in aging nonhuman primates. 老龄非人类灵长类动物的饮食限制。

Interdisciplinary topics in gerontology

Pub Date : 2007-01-01 DOI: 10.1159/000096560

Julie A Mattison, George S Roth, Mark A Lane, Donald K Ingram

Dietary restriction (DR) has been shown to benefit health and longevity in a wide variety of species, although most have maximal life spans of only a few years. In 1987, the National Institute on Aging began the first well-controlled long-term study in a species with a considerably longer life span and a closer physiology to humans. Using rhesus monkeys (Macaca mulatta), an extensive array of physiological measures have been conducted in both males and females to evaluate the effects of DR. Monkeys benefit from DR with a lower body weight, body fat, blood glucose and thus are at lower risk for developing diabetes. Changes in several endocrine measures indicate an altered hormonal axis; however, circadian patterns and timing relative to the onset of DR can obscure the differences. Despite the caloric deficit, female monkeys are not reproductively compromised, and both males and females may benefit immunologically. There remains much to be learned from this model of DR including whether long-term DR will increase life span in a primate species.

饮食限制(DR)已被证明有益于多种物种的健康和长寿，尽管大多数物种的最长寿命只有几年。1987年，美国国家衰老研究所(National Institute on Aging)开始了第一个控制良好的长期研究，研究对象是一种寿命更长、生理机能与人类更接近的物种。研究人员利用恒河猴(Macaca mulatta)对雄性和雌性进行了一系列广泛的生理测量，以评估DR的效果。服用DR的猴子体重、体脂和血糖较低，因此患糖尿病的风险较低。几种内分泌指标的变化表明激素轴发生了改变;然而，与DR发病相关的昼夜节律模式和时间可能会模糊这些差异。尽管热量不足，但雌性猴子的生殖能力并没有受到损害，雄性和雌性都可能在免疫方面受益。从这种DR模型中还有很多东西需要学习，包括长期DR是否会增加灵长类物种的寿命。

引用次数: 71

Anti-inflammatory mechanisms of dietary restriction in slowing aging processes. 饮食限制在延缓衰老过程中的抗炎机制。

Interdisciplinary topics in gerontology

Pub Date : 2007-01-01 DOI: 10.1159/000096557

T E Morgan, A M Wong, C E Finch

Dietary restriction (DR) remains the most powerful and general environmental manipulation of aging processes in laboratory animals with strong beneficial effects on most age-related degenerative changes throughout the body. Underlying the beneficial effects of DR is the attenuation of system-wide inflammatory processes including those occurring within the central nervous system. During normal aging a progressive neuroinflammatory state builds in the brain involving astrocytes and microglia, the primary cellular components of neuroinflammation. DR attenuates the age-related activation of astrocytes and microglia with concomitant beneficial effects on neurodegeneration and cognition. Increasing evidence suggests that common pathways are emerging that link many normal aging inflammatory processes with age-related diseases such as Alzheimer, cancer, diabetes and cardiovascular disease.

饮食限制(DR)仍然是实验室动物衰老过程中最强大和最普遍的环境操纵，对大多数与年龄相关的全身退行性变化具有强大的有益影响。DR的潜在有益作用是全身炎症过程的衰减，包括发生在中枢神经系统内的炎症过程。在正常的衰老过程中，大脑中的星形胶质细胞和小胶质细胞(神经炎症的主要细胞成分)会逐渐形成神经炎症状态。DR减弱星形胶质细胞和小胶质细胞的年龄相关激活，同时对神经变性和认知产生有益影响。越来越多的证据表明，将许多正常的衰老炎症过程与老年痴呆症、癌症、糖尿病和心血管疾病等与年龄相关的疾病联系起来的共同途径正在出现。

引用次数: 95

首页上一页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Interdisciplinary topics in gerontology

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀