Pub Date : 2005-09-30DOI: 10.2174/156801405774330394
R. Benedetti
{"title":"Development of New H1 Antihistamines: The Importance of Pharmacokinetics in the Evaluation of Safe and Therapeutically Effective Agents","authors":"R. Benedetti","doi":"10.2174/156801405774330394","DOIUrl":"https://doi.org/10.2174/156801405774330394","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 1","pages":"451-464"},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/156801405774330394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67903076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-09-30DOI: 10.2174/156801405774330349
M. A. Hafiz
{"title":"The Role of Antihistamines in the Management of Allergic Rhinitis","authors":"M. A. Hafiz","doi":"10.2174/156801405774330349","DOIUrl":"https://doi.org/10.2174/156801405774330349","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"47 1","pages":"477-480"},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/156801405774330349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67902994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-07-31DOI: 10.2174/1568014054546272
R. Verhagen
{"title":"IAPs, their Antagonists and their Role in Neurological Disease and Cancer","authors":"R. Verhagen","doi":"10.2174/1568014054546272","DOIUrl":"https://doi.org/10.2174/1568014054546272","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 1","pages":"393-406"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568014054546272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67902170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-07-31DOI: 10.2174/1568014054546281
Mohammad Hashemi and Tadeusz J. Kroczak
{"title":"Apoptosis and Autoimmune Disease","authors":"Mohammad Hashemi and Tadeusz J. Kroczak","doi":"10.2174/1568014054546281","DOIUrl":"https://doi.org/10.2174/1568014054546281","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 1","pages":"429-437"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568014054546281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67902181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-07-31DOI: 10.2174/1568014054546254
E. Booy, D. Johar, K. Kadkhoda, G. H. Bay, M. Los
This short review was designed to draw the readership's attention to the following articles in the volume. In- stead of providing a full summary of topics such as ageing of the immune system and the role of the immune system in ageing, the role of the immune system in the development of cancer and neurodegenerative diseases, it signalizes these topics and provides links to articles that follow as well as to other available literature. Our intention was to provide a new perspective and strengthen the associations between inflammation, cancer, neuro-degenerative diseases, ageing and autoimmunity. The relationship between inflammation, oxidative stress, apoptosis, neurodegeneration and cancer is al- ready, to a certain extend, mirrored by attempts of the pharmacologic industry to cross-apply our current knowledge from these fields to develop new treatment modalities. For instance, strategies that modulate cellular redox potential are being applied to restrain inflammation (antioxidants), or to kill cancer cells (prooxidants). Activation of apoptosis or attenuation of resistance of transformed cells towards cell death induction is perhaps the most promising direction chosen by many pharmaceutical companies to develop new classes of drugs. Furthermore, rapidly developing areas of immunology and vi- rology, combined with the tremendous progress in the field of cancer biology and pharmacogenomics, may lead to the oc- currence of an unique treatment, based on anti-cancer viral vectors and even anti-inflammatory strategies, which combine multiple pharmacologic activities in a single bio-molecule.
{"title":"The Immune System, Involvement in Neurodegenerative Diseases, Ageing and Cancer","authors":"E. Booy, D. Johar, K. Kadkhoda, G. H. Bay, M. Los","doi":"10.2174/1568014054546254","DOIUrl":"https://doi.org/10.2174/1568014054546254","url":null,"abstract":"This short review was designed to draw the readership's attention to the following articles in the volume. In- stead of providing a full summary of topics such as ageing of the immune system and the role of the immune system in ageing, the role of the immune system in the development of cancer and neurodegenerative diseases, it signalizes these topics and provides links to articles that follow as well as to other available literature. Our intention was to provide a new perspective and strengthen the associations between inflammation, cancer, neuro-degenerative diseases, ageing and autoimmunity. The relationship between inflammation, oxidative stress, apoptosis, neurodegeneration and cancer is al- ready, to a certain extend, mirrored by attempts of the pharmacologic industry to cross-apply our current knowledge from these fields to develop new treatment modalities. For instance, strategies that modulate cellular redox potential are being applied to restrain inflammation (antioxidants), or to kill cancer cells (prooxidants). Activation of apoptosis or attenuation of resistance of transformed cells towards cell death induction is perhaps the most promising direction chosen by many pharmaceutical companies to develop new classes of drugs. Furthermore, rapidly developing areas of immunology and vi- rology, combined with the tremendous progress in the field of cancer biology and pharmacogenomics, may lead to the oc- currence of an unique treatment, based on anti-cancer viral vectors and even anti-inflammatory strategies, which combine multiple pharmacologic activities in a single bio-molecule.","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 1","pages":"349-352"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568014054546254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67902122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-07-31DOI: 10.2174/1568014054546326
C. Ghavami
{"title":"Induction of Apoptotic Cell Death in Tumor Cells by S100A8/A9 Released from Inflammatory Cells Upon Cellular Activation","authors":"C. Ghavami","doi":"10.2174/1568014054546326","DOIUrl":"https://doi.org/10.2174/1568014054546326","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"1 1","pages":"383-391"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568014054546326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67902881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-07-31DOI: 10.2174/1568014054546308
H. Pour-Jafari, S. Ghavami, S. Maddika
{"title":"Mitochondrial Physiology and Toxicity (Mitotoxicity); Importance for the Immune System, Programmed Cell Death and Cancer","authors":"H. Pour-Jafari, S. Ghavami, S. Maddika","doi":"10.2174/1568014054546308","DOIUrl":"https://doi.org/10.2174/1568014054546308","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 1","pages":"439-448"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568014054546308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67902255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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