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Predictive Genetic Testing, Autonomy and Responsibility for Future Health 预测性基因检测,自主和未来健康的责任
Pub Date : 2009-08-21 DOI: 10.1007/S12376-009-0017-5
E. Hildt
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引用次数: 13
Coming to Grips with Genetic Exceptionalism: Roots and Reach of an Explanatory Model 遗传例外论:一个解释模型的根源和范围
Pub Date : 2009-08-08 DOI: 10.1007/S12376-009-0015-7
I. Ilkilic
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引用次数: 6
Eugenics, the Genome, and Human Rights 优生学、基因组和人权
Pub Date : 2009-07-25 DOI: 10.1007/S12376-009-0010-Z
D. Kevles
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引用次数: 7
Thresholds of Coercion in Genetic Testing 基因检测中的强制阈值
Pub Date : 2009-06-19 DOI: 10.1007/S12376-009-0012-X
D. Birnbacher
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引用次数: 3
Genetic Determinism and the Innate-Acquired Distinction in Medicine. 遗传决定论与医学的先天获得性区别。
Pub Date : 2009-06-01 Epub Date: 2009-09-10 DOI: 10.1007/s12376-009-0014-8
Maria E Kronfeldner

This article illustrates in which sense genetic determinism is still part of the contemporary interactionist consensus in medicine. Three dimensions of this consensus are discussed: kinds of causes, a continuum of traits ranging from monogenetic diseases to car accidents, and different kinds of determination due to different norms of reaction. On this basis, this article explicates in which sense the interactionist consensus presupposes the innate-acquired distinction. After a descriptive Part 1, Part 2 reviews why the innate-acquired distinction is under attack in contemporary philosophy of biology. Three arguments are then presented to provide a limited and pragmatic defense of the distinction: an epistemic, a conceptual, and a historical argument. If interpreted in a certain manner, and if the pragmatic goals of prevention and treatment (ideally specifying what medicine and health care is all about) are taken into account, then the innate-acquired distinction can be a useful epistemic tool. It can help, first, to understand that genetic determination does not mean fatalism, and, second, to maintain a system of checks and balances in the continuing nature-nurture debates.

这篇文章说明在某种意义上,遗传决定论仍然是当代医学中相互作用共识的一部分。讨论了这一共识的三个维度:各种原因,从单基因疾病到车祸的连续特征,以及由于不同反应规范而产生的不同种类的决定。在此基础上,本文阐述了在何种意义上,互动主义共识预设了先天与后天的区别。在第一部分的描述之后,第二部分回顾了为什么先天与后天的区分在当代生物学哲学中受到攻击。然后提出了三个论点,为这种区别提供了有限的和实用的辩护:认识论的、概念的和历史的论点。如果以某种方式解释,如果考虑到预防和治疗的实用目标(理想情况下指定医学和卫生保健的全部内容),那么先天-后天区分可以成为有用的认识工具。首先,它有助于理解基因决定并不意味着宿命论;其次,它有助于在持续不断的先天-后天辩论中维持一种制衡体系。
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引用次数: 7
From Utopia to Science: Challenges of Personalised Genomics Information for Health Management and Health Enhancement. 从乌托邦到科学:个性化基因组学信息对健康管理和健康促进的挑战。
Pub Date : 2009-06-01 Epub Date: 2009-07-24 DOI: 10.1007/s12376-009-0013-9
Hub Zwart

From 1900 onwards, scientists and novelists have explored the contours of a future society based on the use of "anthropotechnologies" (techniques applicable to human beings for the purpose of performance enhancement ranging from training and education to genome-based biotechnologies). Gradually but steadily, the technologies involved migrated from (science) fiction into scholarly publications, and from "utopia" (or "dystopia") into science. Building on seminal ideas borrowed from Nietzsche, Peter Sloterdijk has outlined the challenges inherent in this development. Since time immemorial, and at least since the days of Plato's Academy, human beings have been interested in possibilities for (physical or mental) performance enhancement. We are constantly trying to improve ourselves, both collectively and individually, for better or for worse. At present, however, new genomics-based technologies are opening up new avenues for self-amelioration. Developments in research facilities using animal models may to a certain extent be seen as expeditions into our own future. Are we able to address the bioethical and biopolitical issues awaiting us? After analyzing and assessing Sloterdijk's views, attention will shift to a concrete domain of application, namely sport genomics. For various reasons, top athletes are likely to play the role of genomics pioneers by using personalized genomics information to adjust diet, life-style, training schedules and doping intake to the strengths and weaknesses of their personalized genome information. Thus, sport genomics may be regarded as a test bed where the contours of genomics-based self-management are tried out.

从1900年起,科学家和小说家就开始探索基于“人类技术”(从培训和教育到基于基因组的生物技术等适用于人类的技术,目的是提高人类的表现)的未来社会的轮廓。相关技术逐渐但稳步地从(科幻)小说转移到学术出版物,从“乌托邦”(或“反乌托邦”)转移到科学。彼得·斯洛特戴克借鉴了尼采的开创性思想,概述了这一发展中固有的挑战。自古以来,至少从柏拉图学院开始,人类就对(身体或精神)性能增强的可能性感兴趣。无论是集体还是个人,我们都在不断努力提高自己,不管是好是坏。然而,目前基于基因组学的新技术正在为自我改良开辟新的途径。在某种程度上,使用动物模型的研究设施的发展可能被视为对我们自己未来的探索。我们能够解决等待我们的生物伦理和生物政治问题吗?在分析和评估Sloterdijk的观点之后,注意力将转移到一个具体的应用领域,即运动基因组学。出于各种原因,顶尖运动员很可能会扮演基因组学先驱的角色,利用个性化基因组信息,根据自己个性化基因组信息的优势和劣势,调整饮食、生活方式、训练计划和兴奋剂摄入。因此,运动基因组学可以被视为一个试验台,在那里,基于基因组学的自我管理的轮廓被尝试。
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引用次数: 15
Genetics and the Value of Life: Historical Dimensions 遗传学和生命的价值:历史维度
Pub Date : 2009-04-25 DOI: 10.1007/S12376-009-0011-Y
H. Fangerau
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引用次数: 1
Regenerative Medicine: Past and Present 再生医学:过去与现在
Pub Date : 2009-03-19 DOI: 10.1007/S12376-009-0008-6
A. Atala
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引用次数: 3
Jane Maienschein, Whose View of Life?: Embryos, Cloning, and Stem Cells 简·迈恩沙因《谁的人生观?》:胚胎、克隆和干细胞
Pub Date : 2009-02-26 DOI: 10.1007/S12376-009-0007-7
H. Fangerau
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引用次数: 1
Tissue Culture and Tissue Culture Technologies at the Rockefeller Institute for Medical Research: Roots of Regenerative Medicine, 1910–1950 洛克菲勒医学研究所的组织培养和组织培养技术:再生医学的根源,1910-1950
Pub Date : 2009-02-19 DOI: 10.1007/S12376-008-0003-3
D. Stapleton
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引用次数: 0
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