Unlabelled: The purpose of the study was to compare Quasi-Static (QS) and harmonic (CSM) methods of indentation testing. Bone sections were obtained from mid-femoral diaphyses of dogs which received a pair of calcein labels. Labeled (n = 35) and unlabeled (n = 112) osteons were identified. Indentation modulus (IM) and hardness (H) for the CSM method were collected during the entire loading cycle to peak depth, while IM and H for QS method were calculated at a peak depth of 500 nm.
Results: The mean (SD) of the IM and H for labeled osteons were as follows: QS IM = 15.3 GPa (3.85) versus CSM IM = 14.7 GPa (3.58); P = .52 and QS H = .39 GPa (.171) versus CSM H = .42 GPa (.146); P = .32. The mean (SD) of the IM and H for unlabeled osteons were as follows: QS IM = 21.5 GPa (2.80) versus CSM IM = 20.6 GPa (2.53); P = .054 and QS H = .64 GPa (.117) versus CSM H = .70 GPa (.120); P = .017. There was no difference in IM and H for the two methods, except for H of the unlabeled osteons. In addition, for the CSM method, IM at 100 nm, 200 nm, 300 nm, 400 nm and 500 nm were not statistically significant different (P = .06). Bone is viscoelastic at an organ level. However, this component of its behavior was not detected at the length scale examined.
未标记:本研究的目的是比较准静态(QS)和谐波(CSM)压痕检测方法。从接受一对钙黄蛋白标签的狗的股骨干中获得骨切片。鉴定标记骨(n = 35)和未标记骨(n = 112)。CSM法的压痕模量(IM)和硬度(H)是在整个加载周期至峰值深度时采集的,而QS法的压痕模量(IM)和硬度(H)是在峰值深度为500 nm时计算的。结果:标记骨的IM和H的平均值(SD)为:QS IM = 15.3 GPa (3.85), CSM IM = 14.7 GPa (3.58);P = 0.52, QS H = 0.39 GPa(0.171),而CSM H = 0.42 GPa (0.146);P = .32。未标记骨的IM和H的平均值(SD)如下:QS IM = 21.5 GPa (2.80), CSM IM = 20.6 GPa (2.53);P = 0.054, QS H = 0.64 GPa(0.117),而CSM H = 0.70 GPa (0.120);P = 0.017。除了未标记骨的H外,两种方法的IM和H均无差异。此外,CSM法在100 nm、200 nm、300 nm、400 nm和500 nm处的IM差异无统计学意义(P = 0.06)。骨在器官水平上具有粘弹性。然而,在检查的长度尺度上没有检测到其行为的这一组成部分。
{"title":"Quasi-static and harmonic indentation of osteonal bone.","authors":"S S Huja, J L Hay, A M Rummel, F M Beck","doi":"10.4061/2010/736830","DOIUrl":"https://doi.org/10.4061/2010/736830","url":null,"abstract":"<p><strong>Unlabelled: </strong>The purpose of the study was to compare Quasi-Static (QS) and harmonic (CSM) methods of indentation testing. Bone sections were obtained from mid-femoral diaphyses of dogs which received a pair of calcein labels. Labeled (n = 35) and unlabeled (n = 112) osteons were identified. Indentation modulus (IM) and hardness (H) for the CSM method were collected during the entire loading cycle to peak depth, while IM and H for QS method were calculated at a peak depth of 500 nm.</p><p><strong>Results: </strong>The mean (SD) of the IM and H for labeled osteons were as follows: QS IM = 15.3 GPa (3.85) versus CSM IM = 14.7 GPa (3.58); P = .52 and QS H = .39 GPa (.171) versus CSM H = .42 GPa (.146); P = .32. The mean (SD) of the IM and H for unlabeled osteons were as follows: QS IM = 21.5 GPa (2.80) versus CSM IM = 20.6 GPa (2.53); P = .054 and QS H = .64 GPa (.117) versus CSM H = .70 GPa (.120); P = .017. There was no difference in IM and H for the two methods, except for H of the unlabeled osteons. In addition, for the CSM method, IM at 100 nm, 200 nm, 300 nm, 400 nm and 500 nm were not statistically significant different (P = .06). Bone is viscoelastic at an organ level. However, this component of its behavior was not detected at the length scale examined.</p>","PeriodicalId":88916,"journal":{"name":"Journal of dental biomechanics","volume":"2010 ","pages":"736830"},"PeriodicalIF":0.0,"publicationDate":"2010-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29382559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01Epub Date: 2009-11-17DOI: 10.4061/2010/902537
Clarice Field, Qing Li, Wei Li, Michael Swain
An understanding of functional responses in oral bone is a crucial component of dental biomechanics. The purpose of this study was to investigate the potential biological remodelling response during mastication on the mandibular pre- and post-insertion of a fixed partial denture (FPD). A series of three-dimensional (3D) finite element analysis (FEA) models were presented pre- and postextraction to determine the biomechanical responses to masticatory loading in the anterior mandible. Equivalent strains were analysed at lingual/buccal and mesial/distal areas of the premolar to molar region and quantified to anticipate bone remodelling response. Mandibular bone incorporating an FPD experienced substantially greater stress/strain magnitudes than that prior to placement of fixed prosthodontics, which is suggestive of engagements of bone remodelling. The results suggest similar outcomes to those reported clinically. Developing a simulation reflecting the outcomes of restorative treatment can provide meaningful insight into restorative treatment planning, clinical outcomes, and fixed prosthodontics designs.
{"title":"Biomechanical Response in Mandibular Bone due to Mastication Loading on 3-Unit Fixed Partial Dentures.","authors":"Clarice Field, Qing Li, Wei Li, Michael Swain","doi":"10.4061/2010/902537","DOIUrl":"https://doi.org/10.4061/2010/902537","url":null,"abstract":"<p><p>An understanding of functional responses in oral bone is a crucial component of dental biomechanics. The purpose of this study was to investigate the potential biological remodelling response during mastication on the mandibular pre- and post-insertion of a fixed partial denture (FPD). A series of three-dimensional (3D) finite element analysis (FEA) models were presented pre- and postextraction to determine the biomechanical responses to masticatory loading in the anterior mandible. Equivalent strains were analysed at lingual/buccal and mesial/distal areas of the premolar to molar region and quantified to anticipate bone remodelling response. Mandibular bone incorporating an FPD experienced substantially greater stress/strain magnitudes than that prior to placement of fixed prosthodontics, which is suggestive of engagements of bone remodelling. The results suggest similar outcomes to those reported clinically. Developing a simulation reflecting the outcomes of restorative treatment can provide meaningful insight into restorative treatment planning, clinical outcomes, and fixed prosthodontics designs.</p>","PeriodicalId":88916,"journal":{"name":"Journal of dental biomechanics","volume":"2010 ","pages":"902537"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4061/2010/902537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29380186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01Epub Date: 2009-08-12DOI: 10.4061/2010/256903
R R Gallagher, M Balooch, G Balooch, R S Wilson, S J Marshall, G W Marshall
The dentino-enamel junction (DEJ) connects enamel, that covers the outer surface of a tooth, to a thicker underlying dentin. The DEJ is a critical interface that permits joining these materials that have widely dissimilar mechanical properties. AFM-based nanoindentation and Raman microspectroscopy were used to define the width and composition of human molar DEJ. Indentation elastic modulus and hardness of enamel, dentin, and DEJ were determined along lines of indents made at 2 μm intervals across the DEJ. Indents made at maximum loads at each end of the indent lines were used to make visible markers allowing Raman microspectroscopy at 1 μm intervals across the DEJ, while using the nanoindent markers for orientation and location. Functional DEJ width estimates were made based on results from nanoindentation and Raman microspectroscopy. DEJ width estimates ranged from 4.7 (±1.2) μm to 6.1 (±1.9) μm based on hardness and 4.9 (±1.1) μm to 6.9 (±1.9) μm based on modulus. DEJ width based on Raman peak intensity variations were 8.0 (±3.2) μm to 8.5 (±3.1) μm based on the phosphate peak, and 7.6 (±3.2) μm to 8.0 (±2.6) μm for C-H stretching mode. These estimates are in the range of DEJ width estimates reported using nanoindentation.
{"title":"Coupled Nanomechanical and Raman Microspectroscopic Investigation of Human Third Molar DEJ.","authors":"R R Gallagher, M Balooch, G Balooch, R S Wilson, S J Marshall, G W Marshall","doi":"10.4061/2010/256903","DOIUrl":"https://doi.org/10.4061/2010/256903","url":null,"abstract":"<p><p>The dentino-enamel junction (DEJ) connects enamel, that covers the outer surface of a tooth, to a thicker underlying dentin. The DEJ is a critical interface that permits joining these materials that have widely dissimilar mechanical properties. AFM-based nanoindentation and Raman microspectroscopy were used to define the width and composition of human molar DEJ. Indentation elastic modulus and hardness of enamel, dentin, and DEJ were determined along lines of indents made at 2 μm intervals across the DEJ. Indents made at maximum loads at each end of the indent lines were used to make visible markers allowing Raman microspectroscopy at 1 μm intervals across the DEJ, while using the nanoindent markers for orientation and location. Functional DEJ width estimates were made based on results from nanoindentation and Raman microspectroscopy. DEJ width estimates ranged from 4.7 (±1.2) μm to 6.1 (±1.9) μm based on hardness and 4.9 (±1.1) μm to 6.9 (±1.9) μm based on modulus. DEJ width based on Raman peak intensity variations were 8.0 (±3.2) μm to 8.5 (±3.1) μm based on the phosphate peak, and 7.6 (±3.2) μm to 8.0 (±2.6) μm for C-H stretching mode. These estimates are in the range of DEJ width estimates reported using nanoindentation.</p>","PeriodicalId":88916,"journal":{"name":"Journal of dental biomechanics","volume":"2010 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4061/2010/256903","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29356012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01Epub Date: 2009-12-15DOI: 10.4061/2010/502318
Koichiro Komatsu
The mechanical strength of the periodontal ligament (PDL) was first measured as force required to extract a tooth from its socket using human specimens. Thereafter, tooth-PDL-bone preparations have extensively been used for measurement of the mechanical response of the PDL. In vitro treatments of such specimens with specific enzymes allowed one to investigate into the roles of the structural components in the mechanical support of the PDL. The viscoelastic responses of the PDL may be examined by analysis of the stress-relaxation. Video polarised microscopy suggested that the collagen molecules and fibrils in the stretched fibre bundles progressively align along the deformation direction during the relaxation. The stress-relaxation process of the PDL can be well expressed by a function with three exponential decay terms. Analysis after in vitro digestion of the collagen fibres by collagenase revealed that the collagen fibre components may play an important role in the long-term relaxation component of the stress-relaxation process of the PDL. The dynamic measurements of the viscoelastic properties of the PDL have recently suggested that the PDL can absorb more energy in compression than in shear and tension. These viscoelastic mechanisms of the PDL tissue could reduce the risk of injury to the PDL.
{"title":"Mechanical strength and viscoelastic response of the periodontal ligament in relation to structure.","authors":"Koichiro Komatsu","doi":"10.4061/2010/502318","DOIUrl":"https://doi.org/10.4061/2010/502318","url":null,"abstract":"<p><p>The mechanical strength of the periodontal ligament (PDL) was first measured as force required to extract a tooth from its socket using human specimens. Thereafter, tooth-PDL-bone preparations have extensively been used for measurement of the mechanical response of the PDL. In vitro treatments of such specimens with specific enzymes allowed one to investigate into the roles of the structural components in the mechanical support of the PDL. The viscoelastic responses of the PDL may be examined by analysis of the stress-relaxation. Video polarised microscopy suggested that the collagen molecules and fibrils in the stretched fibre bundles progressively align along the deformation direction during the relaxation. The stress-relaxation process of the PDL can be well expressed by a function with three exponential decay terms. Analysis after in vitro digestion of the collagen fibres by collagenase revealed that the collagen fibre components may play an important role in the long-term relaxation component of the stress-relaxation process of the PDL. The dynamic measurements of the viscoelastic properties of the PDL have recently suggested that the PDL can absorb more energy in compression than in shear and tension. These viscoelastic mechanisms of the PDL tissue could reduce the risk of injury to the PDL.</p>","PeriodicalId":88916,"journal":{"name":"Journal of dental biomechanics","volume":"2010 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4061/2010/502318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29352171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01Epub Date: 2009-09-30DOI: 10.4061/2010/131630
Luis Felipe J Schneider, Larissa Maria Cavalcante, Nick Silikas
Many developments have been made in the field of resin composites for dental applications. However, the manifestation of shrinkage due to the polymerization process continues to be a major problem. The material's shrinkage, associated with dynamic development of elastic modulus, creates stresses within the material and its interface with the tooth structure. As a consequence, marginal failure and subsequent secondary caries, marginal staining, restoration displacement, tooth fracture, and/or post-operative sensitivity are clinical drawbacks of resin-composite applications. The aim of the current paper is to present an overview about the shrinkage stresses created during resin-composite applications, consequences, and advances. The paper is based on results of many researches that are available in the literature.
{"title":"Shrinkage Stresses Generated during Resin-Composite Applications: A Review.","authors":"Luis Felipe J Schneider, Larissa Maria Cavalcante, Nick Silikas","doi":"10.4061/2010/131630","DOIUrl":"https://doi.org/10.4061/2010/131630","url":null,"abstract":"<p><p>Many developments have been made in the field of resin composites for dental applications. However, the manifestation of shrinkage due to the polymerization process continues to be a major problem. The material's shrinkage, associated with dynamic development of elastic modulus, creates stresses within the material and its interface with the tooth structure. As a consequence, marginal failure and subsequent secondary caries, marginal staining, restoration displacement, tooth fracture, and/or post-operative sensitivity are clinical drawbacks of resin-composite applications. The aim of the current paper is to present an overview about the shrinkage stresses created during resin-composite applications, consequences, and advances. The paper is based on results of many researches that are available in the literature.</p>","PeriodicalId":88916,"journal":{"name":"Journal of dental biomechanics","volume":"2010 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4061/2010/131630","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29356013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01Epub Date: 2009-12-13DOI: 10.4061/2010/397037
Ryan A Lacoursiere, David S Nobes, Darren L N Homeniuk, Jason P Carey, Hisham H Badawi, Paul W Major
Orthodontic lingual root movement (torque) is an important aspect of treatment biomechanics and is typically achieved by torsion of a rectangular wire within the orthodontic bracket slot which introduces a force couple. The magnitude of the force moment achieved by wire torsion may be influenced by deformation of the orthodontic bracket. A device utilizing an optical image correlation technique has been developed to accurately quantify bracket slot dimensional changes during application of wire torsion. Simultaneous torque moment magnitude, degrees of wire twist, and bracket slot dimension data can be gathered. Bracket tie wing elastic deformation when loaded was demonstrated and plastic deformation was also observed with a single rotation of the wire.
{"title":"Measurement of orthodontic bracket tie wing elastic and plastic deformation by arch wire torque expression utilizing an optical image correlation technique.","authors":"Ryan A Lacoursiere, David S Nobes, Darren L N Homeniuk, Jason P Carey, Hisham H Badawi, Paul W Major","doi":"10.4061/2010/397037","DOIUrl":"https://doi.org/10.4061/2010/397037","url":null,"abstract":"<p><p>Orthodontic lingual root movement (torque) is an important aspect of treatment biomechanics and is typically achieved by torsion of a rectangular wire within the orthodontic bracket slot which introduces a force couple. The magnitude of the force moment achieved by wire torsion may be influenced by deformation of the orthodontic bracket. A device utilizing an optical image correlation technique has been developed to accurately quantify bracket slot dimensional changes during application of wire torsion. Simultaneous torque moment magnitude, degrees of wire twist, and bracket slot dimension data can be gathered. Bracket tie wing elastic deformation when loaded was demonstrated and plastic deformation was also observed with a single rotation of the wire.</p>","PeriodicalId":88916,"journal":{"name":"Journal of dental biomechanics","volume":"2010 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4061/2010/397037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29355564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01Epub Date: 2009-12-20DOI: 10.4061/2010/613142
Natalie Reznikov, Gilad Har-Zion, Idit Barkana, Yosef Abed, Meir Redlich
Objectives. The aim of this study was to assess the influence of resistance to sliding on expression of superelastic properties of NiTi wires. Methods and Materials. A three-point bending test was performed for 0.014 NiTi wire engaged in self-ligating (Damon, SmartClip, In-Ovation) and conventional brackets (Victory) ligated with regular and reduced friction modules (Slide). The wire was deflected in the buccal direction and allowed to straighten. The maximum load, unloading plateau and unloading capacity were registered. Results. The lowest activation load was required in the active self-ligating group (In-Ovation 2.2 ± 0.4 N) and reduced friction module group (Victory/Slide 2.9 ± 0.4 N), followed by the passive self-ligating systems (Damon 3.6 ± 0.7 N, SmartClip 3.7 ± 0.4 N). Higher activation load was obtained in the conventionally ligated group (Victory/module 4.5 ± 0.4 N). Unloading plateau phase with the load magnitude ranging from 1.27 ± 0.4 N (In-Ovation) to 1.627 ± 0.4 N (Slide) was distinct in all groups but one (Victory). Conclusions. Higher friction at flanking points reduces the net force delivered by the wire. Unloading plateau phase of NiTi load-deflection curve disappears in the conventionally ligated group thus indicating to an incomplete expression of NiTi superelastic properties. A rigid passive bracket clip amplifies resistance to sliding in an active configuration and produces a permanent deflection of the wire.
目标。本研究的目的是评估抗滑动对镍钛丝超弹性性能表达的影响。方法与材料。0.014 NiTi金属丝采用自结扎(Damon、SmartClip、in - ovation)和常规托架(Victory)进行三点弯曲测试,托架采用规则和减少摩擦模块(Slide)结扎。将金属丝向颊方向偏转并使其拉直。记录了最大荷载、卸载平台和卸载能力。结果。主动自结扎组(in - ovation 2.2±0.4 N)和减少摩擦模块组(Victory/Slide 2.9±0.4 N)所需的激活负荷最低,其次是被动自结扎系统(Damon 3.6±0.7 N, SmartClip 3.7±0.4 N)。常规结扎组(Victory/module 4.5±0.4 N)激活负荷较高。除Victory组外,其余各组的卸载平台阶段的负荷值范围为1.27±0.4 N (in - ovation)至1.627±0.4 N (Slide)。结论。在侧翼点较高的摩擦减少了导线传递的净力。NiTi荷载-挠度曲线的卸载平台阶段在常规结扎组中消失,表明NiTi超弹性性能表达不完全。刚性被动支架夹在主动配置中放大对滑动的阻力,并产生导线的永久偏转。
{"title":"Influence of Friction Resistance on Expression of Superelastic Properties of Initial NiTi Wires in \"Reduced Friction\" and Conventional Bracket Systems.","authors":"Natalie Reznikov, Gilad Har-Zion, Idit Barkana, Yosef Abed, Meir Redlich","doi":"10.4061/2010/613142","DOIUrl":"https://doi.org/10.4061/2010/613142","url":null,"abstract":"<p><p>Objectives. The aim of this study was to assess the influence of resistance to sliding on expression of superelastic properties of NiTi wires. Methods and Materials. A three-point bending test was performed for 0.014 NiTi wire engaged in self-ligating (Damon, SmartClip, In-Ovation) and conventional brackets (Victory) ligated with regular and reduced friction modules (Slide). The wire was deflected in the buccal direction and allowed to straighten. The maximum load, unloading plateau and unloading capacity were registered. Results. The lowest activation load was required in the active self-ligating group (In-Ovation 2.2 ± 0.4 N) and reduced friction module group (Victory/Slide 2.9 ± 0.4 N), followed by the passive self-ligating systems (Damon 3.6 ± 0.7 N, SmartClip 3.7 ± 0.4 N). Higher activation load was obtained in the conventionally ligated group (Victory/module 4.5 ± 0.4 N). Unloading plateau phase with the load magnitude ranging from 1.27 ± 0.4 N (In-Ovation) to 1.627 ± 0.4 N (Slide) was distinct in all groups but one (Victory). Conclusions. Higher friction at flanking points reduces the net force delivered by the wire. Unloading plateau phase of NiTi load-deflection curve disappears in the conventionally ligated group thus indicating to an incomplete expression of NiTi superelastic properties. A rigid passive bracket clip amplifies resistance to sliding in an active configuration and produces a permanent deflection of the wire.</p>","PeriodicalId":88916,"journal":{"name":"Journal of dental biomechanics","volume":"2010 ","pages":"613142"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4061/2010/613142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29380185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}