Pub Date : 2025-11-25DOI: 10.1038/s41408-025-01418-2
Shlomo Elias, Samantha Brown, Ogechukwu Egini, Moneeza Walji, Sylvester Homsy, Arash Velayati, Sean Devlin, Doris M. Ponce, Vanessa Kennedy, Sushma Bharadwaj, Parveen Shiraz, Ann A. Jakubowski, Esperanza B. Papadopoulos, Lori Muffly, Miguel-Angel Perales, Sergio A. Giralt, Melody Smith, Boglarka Gyurkocza
{"title":"Allogeneic hematopoietic cell transplantation in acute myeloid leukemia not in complete remission: outcomes and prognostic factors in a contemporary cohort","authors":"Shlomo Elias, Samantha Brown, Ogechukwu Egini, Moneeza Walji, Sylvester Homsy, Arash Velayati, Sean Devlin, Doris M. Ponce, Vanessa Kennedy, Sushma Bharadwaj, Parveen Shiraz, Ann A. Jakubowski, Esperanza B. Papadopoulos, Lori Muffly, Miguel-Angel Perales, Sergio A. Giralt, Melody Smith, Boglarka Gyurkocza","doi":"10.1038/s41408-025-01418-2","DOIUrl":"https://doi.org/10.1038/s41408-025-01418-2","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"12 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145593614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1038/s41408-025-01429-z
Wei-Ying Jen, Curtis A. Lachowiez, Jennifer Marvin-Peek, Jessica K. Altman, Musa Yilmaz, Jacqueline S. Garcia, Yasmin Abaza, Nicholas J. Short, Joshua F. Zeidner, Naval G. Daver, Andrew H. Wei, Ghayas C. Issa, Courtney D. DiNardo
Venetoclax-based doublets with azacitidine or low dose cytarabine are the standard of care for the treatment of acute myeloid leukemia (AML) in older patients or those unfit for intensive chemotherapy. However, some patients do not attain complete remission, and over time, most patients relapse. Frontline triplet therapy incorporating a targeted therapy (FLT3, IDH or menin inhibitor) is an emerging treatment concept under investigation for this population. Initial triplet regimens have yielded encouraging composite complete remission and measurable residual disease negativity rates, enabling the transition to allogeneic stem cell transplantation for eligible patients. While effective, triplets are associated with myelosuppression and cytopenia-related toxicities, which can affect treatment tolerability and quality of life. In this review, we summarize the available evidence for triplet therapy in AML and offer our recommendations on the practical application of triplets in clinical practice, with particular focus on adjustments to dosing schedules in induction and continuation cycles. We also outline drug-specific adverse effects and interactions based on emerging clinical data to help guide the clinician, given the increasing use of novel combination therapies.
{"title":"Optimizing lower intensity triplet therapy in acute myeloid leukemia: a practical guide","authors":"Wei-Ying Jen, Curtis A. Lachowiez, Jennifer Marvin-Peek, Jessica K. Altman, Musa Yilmaz, Jacqueline S. Garcia, Yasmin Abaza, Nicholas J. Short, Joshua F. Zeidner, Naval G. Daver, Andrew H. Wei, Ghayas C. Issa, Courtney D. DiNardo","doi":"10.1038/s41408-025-01429-z","DOIUrl":"https://doi.org/10.1038/s41408-025-01429-z","url":null,"abstract":"Venetoclax-based doublets with azacitidine or low dose cytarabine are the standard of care for the treatment of acute myeloid leukemia (AML) in older patients or those unfit for intensive chemotherapy. However, some patients do not attain complete remission, and over time, most patients relapse. Frontline triplet therapy incorporating a targeted therapy (FLT3, IDH or menin inhibitor) is an emerging treatment concept under investigation for this population. Initial triplet regimens have yielded encouraging composite complete remission and measurable residual disease negativity rates, enabling the transition to allogeneic stem cell transplantation for eligible patients. While effective, triplets are associated with myelosuppression and cytopenia-related toxicities, which can affect treatment tolerability and quality of life. In this review, we summarize the available evidence for triplet therapy in AML and offer our recommendations on the practical application of triplets in clinical practice, with particular focus on adjustments to dosing schedules in induction and continuation cycles. We also outline drug-specific adverse effects and interactions based on emerging clinical data to help guide the clinician, given the increasing use of novel combination therapies.","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"171 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-24DOI: 10.1038/s41408-025-01423-5
Sanne J. J. P. M. Metsemakers, Geneviève I. C. G. Ector, Avinash G. Dinmohamed, Rosella P. M. G. Hermens, Nicole M. A. Blijlevens
{"title":"Real-world decline in survival with poor guideline adherence in chronic myeloid leukemia care","authors":"Sanne J. J. P. M. Metsemakers, Geneviève I. C. G. Ector, Avinash G. Dinmohamed, Rosella P. M. G. Hermens, Nicole M. A. Blijlevens","doi":"10.1038/s41408-025-01423-5","DOIUrl":"https://doi.org/10.1038/s41408-025-01423-5","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"113 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145583107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-24DOI: 10.1038/s41408-025-01381-y
Monia Marchetti, Alessandro Maria Vannucchi, John O. Mascarenhas, Alberto Alvarez-Larran, Prithviraj Bose, Robert Peter Gale, Claire Harrison, Rűdiger Hehlmann, Jean-Jacques Kiladjian, Steffen Koschmieder, Ruben Mesa, Francesco Passamonti, Alessandro Rambaldi, Ayalew Tefferi, Tiziano Barbui
{"title":"European LeukemiaNet criteria for safety and efficacy evaluation of new drugs for myelofibrosis","authors":"Monia Marchetti, Alessandro Maria Vannucchi, John O. Mascarenhas, Alberto Alvarez-Larran, Prithviraj Bose, Robert Peter Gale, Claire Harrison, Rűdiger Hehlmann, Jean-Jacques Kiladjian, Steffen Koschmieder, Ruben Mesa, Francesco Passamonti, Alessandro Rambaldi, Ayalew Tefferi, Tiziano Barbui","doi":"10.1038/s41408-025-01381-y","DOIUrl":"https://doi.org/10.1038/s41408-025-01381-y","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"1 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145593615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-24DOI: 10.1038/s41408-025-01428-0
Nadine Wolgast, Eric Amelunxen, Lars Fransecky, Philipp Altrock, Thomas Beder, Julian Ronnacker, Frederik Peters, Soo-Zin Kim-Wanner, Monika Brüggemann, Christiane Pott, Alexander Katalinic, Claudia D. Baldus, David Baden
{"title":"Epidemiology and survival of patients with T-cell prolymphocytic leukemia","authors":"Nadine Wolgast, Eric Amelunxen, Lars Fransecky, Philipp Altrock, Thomas Beder, Julian Ronnacker, Frederik Peters, Soo-Zin Kim-Wanner, Monika Brüggemann, Christiane Pott, Alexander Katalinic, Claudia D. Baldus, David Baden","doi":"10.1038/s41408-025-01428-0","DOIUrl":"https://doi.org/10.1038/s41408-025-01428-0","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"27 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145583106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-23DOI: 10.1038/s41408-025-01425-3
Sarah Dingli, Paul Rothweiler, Stephen M. Ansell, N. Nora Bennani, Urshila Durani, Patrick B. Johnston, Arushi Khurana, Jonas Paludo, J. C. Villasboas Bisneto, Yucai Wang, Yi Lin, Jason R. Young, Stephen M. Broski, Arthur G. Erdman, David Dingli
{"title":"The ratio of brain to liver glucose activity and prognosis with CAR-T in non-Hodgkin lymphoma","authors":"Sarah Dingli, Paul Rothweiler, Stephen M. Ansell, N. Nora Bennani, Urshila Durani, Patrick B. Johnston, Arushi Khurana, Jonas Paludo, J. C. Villasboas Bisneto, Yucai Wang, Yi Lin, Jason R. Young, Stephen M. Broski, Arthur G. Erdman, David Dingli","doi":"10.1038/s41408-025-01425-3","DOIUrl":"https://doi.org/10.1038/s41408-025-01425-3","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"96 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1038/s41408-025-01419-1
Manisha Bhutani, Alma Habib, Andrew Vegel, Ami Ndiaye, Emily Struble, Hira Shaikh, Darryl Chang, Christopher Strouse, Kimberly M. Green, Kevin Graf, Muhammad Umair Mushtaq, Zahra Mahmoudjafari, Joseph P. McGuirk, Peter Voorhees, Abdullah Mohammad Khan, Al-Ola Abdallah, Nausheen Ahmed, Shebli Atrash
{"title":"Outcomes of CAR T-Cell therapy in relapsed/refractory multiple myeloma by race: a multicenter real-world study","authors":"Manisha Bhutani, Alma Habib, Andrew Vegel, Ami Ndiaye, Emily Struble, Hira Shaikh, Darryl Chang, Christopher Strouse, Kimberly M. Green, Kevin Graf, Muhammad Umair Mushtaq, Zahra Mahmoudjafari, Joseph P. McGuirk, Peter Voorhees, Abdullah Mohammad Khan, Al-Ola Abdallah, Nausheen Ahmed, Shebli Atrash","doi":"10.1038/s41408-025-01419-1","DOIUrl":"https://doi.org/10.1038/s41408-025-01419-1","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"1 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145559821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1038/s41408-025-01424-4
Malak Munir, John L. Vaughn, Sravani Rimmalapudi, Narendranath Epperla
{"title":"Site-specific prognosis and temporal trends in extranodal marginal zone lymphoma patients in the United States","authors":"Malak Munir, John L. Vaughn, Sravani Rimmalapudi, Narendranath Epperla","doi":"10.1038/s41408-025-01424-4","DOIUrl":"https://doi.org/10.1038/s41408-025-01424-4","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"1 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1038/s41408-025-01417-3
Joel-Sean Hsu, Udit Yadav, Kishore Garapati, Kiran K. Mangalaparthi, Yogesh Chawla, J. Erin Wiedmeier-Nutor, Rafael Fonseca, P. Leif Bergsagel, S. Vincent Rajkumar, Shaji Kumar, Wilson I. Gonsalves, Akhilesh Pandey, Richard K. Kandasamy
{"title":"Defining the proteome of bone marrow plasma in multiple myeloma and monoclonal gammopathy of undetermined significance","authors":"Joel-Sean Hsu, Udit Yadav, Kishore Garapati, Kiran K. Mangalaparthi, Yogesh Chawla, J. Erin Wiedmeier-Nutor, Rafael Fonseca, P. Leif Bergsagel, S. Vincent Rajkumar, Shaji Kumar, Wilson I. Gonsalves, Akhilesh Pandey, Richard K. Kandasamy","doi":"10.1038/s41408-025-01417-3","DOIUrl":"https://doi.org/10.1038/s41408-025-01417-3","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"1 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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