{"title":"Effect of complexes of natural oligoribonucleotides with D-mannitol on the viability of cell cultures of different origin","authors":"I. M. Kraievska, Z. Yu. Tkachuk","doi":"10.7124/bc.000a93","DOIUrl":"https://doi.org/10.7124/bc.000a93","url":null,"abstract":"","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135817162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. O. Pokholenko, P. O. Pikus, M. V. Kovalchuk, O. K. Toporova, S. Y. Rymar, V. A. Kordium
{"title":"Effects of transplantation of preconditioned mesenchymal stem cells seeded on a biomimetic 3D scaffold","authors":"I. O. Pokholenko, P. O. Pikus, M. V. Kovalchuk, O. K. Toporova, S. Y. Rymar, V. A. Kordium","doi":"10.7124/bc.000a9a","DOIUrl":"https://doi.org/10.7124/bc.000a9a","url":null,"abstract":"","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135816879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keywords: carcinogenesis, models and hypothesis, oncogenic factors, molecular mechanisms, genetic and epigenetic alterations, mutations, tumor microenvironment
关键词:癌变，模型和假设，致癌因素，分子机制，遗传和表观遗传改变，突变，肿瘤微环境
{"title":"Key models and theories of carcinogenesis","authors":"G. V. Gerashchenko, V. I. Kashuba, M. A. Tukalo","doi":"10.7124/bc.000a99","DOIUrl":"https://doi.org/10.7124/bc.000a99","url":null,"abstract":"Keywords: carcinogenesis, models and hypothesis, oncogenic factors, molecular mechanisms, genetic and epigenetic alterations, mutations, tumor microenvironment","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135815579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. G. Alkhimova, M. O. Twardovska, P. A. Portova, V. A. Kunakh
Keywords: Secale cereale L., Dasypyrum species, Agropyron cristatum L., subtelomeres, tandem repeats, fluorescence in situ hybridization
关键词:黑麦，水草属，冰稻，亚端粒，串联重复序列，荧光原位杂交
{"title":"Variation in highly repetitive DNA composition in rye and wild relatives discovered by FISH","authors":"O. G. Alkhimova, M. O. Twardovska, P. A. Portova, V. A. Kunakh","doi":"10.7124/bc.000a8f","DOIUrl":"https://doi.org/10.7124/bc.000a8f","url":null,"abstract":"Keywords: Secale cereale L., Dasypyrum species, Agropyron cristatum L., subtelomeres, tandem repeats, fluorescence in situ hybridization","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135816048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Khetsuriani, T. I. Drevytska, L. Tumanovska, G. V. Portnichenko, Y. Hegel-Valentych, V. O. Niekrasova, A. M. Shysh, V. Ie. Dosenko
{"title":"Alterations in lncRNAs H19 and TUG1 expression and their correlation with hemodynamics in myocardial infarction","authors":"M. Khetsuriani, T. I. Drevytska, L. Tumanovska, G. V. Portnichenko, Y. Hegel-Valentych, V. O. Niekrasova, A. M. Shysh, V. Ie. Dosenko","doi":"10.7124/bc.000a9b","DOIUrl":"https://doi.org/10.7124/bc.000a9b","url":null,"abstract":"","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135817453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. M. Voloshyna, L. O. Lastovetska, A. A. Zurnadzhian, L. V. Shkotova
{"title":"\"Green\" synthesis of metal nanoparticles. Application and future perspective","authors":"I. M. Voloshyna, L. O. Lastovetska, A. A. Zurnadzhian, L. V. Shkotova","doi":"10.7124/bc.000a98","DOIUrl":"https://doi.org/10.7124/bc.000a98","url":null,"abstract":"","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135815572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. M. Garifulin, I. V. Zaiets, V. R. Kosach, I. R. Horak, A. I. Khoruzhenko, N. Ya. Gotsulyak, L. O. Savinska, I. V. Kroupskaya, M. Ye. Martsynyuk, L. B. Drobot, V. V. Filonenko
{"title":"Alterations in S6K1 isoforms expression induce Epithelial to Mesenchymal Transition and Estrogen Receptor 1 Silencing in human breast adenocarcinoma MCF-7 cells","authors":"O. M. Garifulin, I. V. Zaiets, V. R. Kosach, I. R. Horak, A. I. Khoruzhenko, N. Ya. Gotsulyak, L. O. Savinska, I. V. Kroupskaya, M. Ye. Martsynyuk, L. B. Drobot, V. V. Filonenko","doi":"10.7124/bc.000a9d","DOIUrl":"https://doi.org/10.7124/bc.000a9d","url":null,"abstract":"","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135815582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Hryshchenko, V. Gordiyuk, S. Kravchenko, S. Arbuzova, V. Kashuba
The success of immunotherapy for ovarian cancer is determined by the effectiveness of the patient’s immune response, as well as the qualitative and quantitative representation of antigens of the main histocompatibility complex in tumor cells and microenvironment. The level of the HLA (Human Leukocyte Antigens) genes expression in tumor tissue does not always correctly reflect the expression of these genes in different populations of tumor cells. Aim. To analyze the frequency and range of somatic deletions and duplications in the HLA locus. Methods. LOH-analysis (Loss of Heterozyhosity) of the STR-markers (Short Tandem Repeats) in the ovarian tumors of affected patients. Results. We have shown that complex somatic genomic reorganizations, involving several HLA loci, are quite common in ovarian tumors. The detected genetic alterations vary by both the type (deletions and mutations in STR alleles) and proportion of the sub-population of cells with the alterations. Conclusion. The results obtained allow us to propose the LOH-analysis for highly effective detection of aneuploidy and different types of somatic genomic reorganizations in the HLA region even in minor cell populations. This analysis provides the additional prognostic information for predic ting the effectiveness of different types of ovarian cancer immunotherapy at the indi vidual level.
{"title":"Somatic genomic rearrangements in human leucocyte antigens region in solid ovarian tumors","authors":"N. Hryshchenko, V. Gordiyuk, S. Kravchenko, S. Arbuzova, V. Kashuba","doi":"10.7124/BC.000A50","DOIUrl":"https://doi.org/10.7124/BC.000A50","url":null,"abstract":"The success of immunotherapy for ovarian cancer is determined by the effectiveness of the patient’s immune response, as well as the qualitative and quantitative representation of antigens of the main histocompatibility complex in tumor cells and microenvironment. The level of the HLA (Human Leukocyte Antigens) genes expression in tumor tissue does not always correctly reflect the expression of these genes in different populations of tumor cells. Aim. To analyze the frequency and range of somatic deletions and duplications in the HLA locus. Methods. LOH-analysis (Loss of Heterozyhosity) of the STR-markers (Short Tandem Repeats) in the ovarian tumors of affected patients. Results. We have shown that complex somatic genomic reorganizations, involving several HLA loci, are quite common in ovarian tumors. The detected genetic alterations vary by both the type (deletions and mutations in STR alleles) and proportion of the sub-population of cells with the alterations. Conclusion. The results obtained allow us to propose the LOH-analysis for highly effective detection of aneuploidy and different types of somatic genomic reorganizations in the HLA region even in minor cell populations. This analysis provides the additional prognostic information for predic ting the effectiveness of different types of ovarian cancer immunotherapy at the indi vidual level.","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"1 1","pages":"105-116"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75631721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Voloshyna, K. Soloshenko, V. Krasinko, I. Lych, L. Shkotova
{"title":"Bacteriocins Lactobacillus — an alternative to antimicrobial drugs","authors":"I. Voloshyna, K. Soloshenko, V. Krasinko, I. Lych, L. Shkotova","doi":"10.7124/BC.000A4E","DOIUrl":"https://doi.org/10.7124/BC.000A4E","url":null,"abstract":"","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"53 1","pages":"85-97"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88622194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Lozynskyi, H. Derkach, V. Zasidko, Y. Konechnyi, N. Finiuk, Y. Len, R. Kutsyk, M. Regeda, R. Lesyk
Aim. The screening of antimicrobial and cytotoxic activities of thiazolo[4,5- b ]pyridine derivatives was accomplished. Methods. The antibacterial and antifungal activities of synthesized thiazolopyridines were evaluated in vitro with the agar diffusion and broth microdilution methods using clinical and reference strains of Gram-positive, Gram-negative bacteria and yeasts. The structure-antibacterial/antifungal activity relationships of the screened compounds were established. The target compounds were screened for their cytotoxicity effects on HaCaT and HEK293 cells using MTT assay. Results. The highest antimicrobial activity was observed for compound V 2-oxo-7-thiophen-2-yl-2,3-dihydrothiazolo[4,5- b ]pyridine-5-carboxylic acid with minimal inhibitory concentration (MIC) 12.5 μg/mL against Candida albicans . At the same time, the synthesized compounds were explored in the interaction with amoxicillin against multidrug resistant clinical isolates of ESβL + Klebsiella pneumonie and Staphylococcus haemolyticus (MRSH). The best synergistic activity with amoxicillin was exhibited by compound VI. HaCaT human keratinocytes and HEK293 human embryonic kidney cells demonstrated resistance to the thiazolopyridine derivatives treatment and did not reach the IC 50 value up to 100 µM. Conclusions. The tested thiazolopyridines constitute an interesting background for further development of new chemotherapeutic agents.
{"title":"Antimicrobial and cytotoxic activities of thiazolo[4,5-b]pyridine derivatives","authors":"A. Lozynskyi, H. Derkach, V. Zasidko, Y. Konechnyi, N. Finiuk, Y. Len, R. Kutsyk, M. Regeda, R. Lesyk","doi":"10.7124/BC.000A53","DOIUrl":"https://doi.org/10.7124/BC.000A53","url":null,"abstract":"Aim. The screening of antimicrobial and cytotoxic activities of thiazolo[4,5- b ]pyridine derivatives was accomplished. Methods. The antibacterial and antifungal activities of synthesized thiazolopyridines were evaluated in vitro with the agar diffusion and broth microdilution methods using clinical and reference strains of Gram-positive, Gram-negative bacteria and yeasts. The structure-antibacterial/antifungal activity relationships of the screened compounds were established. The target compounds were screened for their cytotoxicity effects on HaCaT and HEK293 cells using MTT assay. Results. The highest antimicrobial activity was observed for compound V 2-oxo-7-thiophen-2-yl-2,3-dihydrothiazolo[4,5- b ]pyridine-5-carboxylic acid with minimal inhibitory concentration (MIC) 12.5 μg/mL against Candida albicans . At the same time, the synthesized compounds were explored in the interaction with amoxicillin against multidrug resistant clinical isolates of ESβL + Klebsiella pneumonie and Staphylococcus haemolyticus (MRSH). The best synergistic activity with amoxicillin was exhibited by compound VI. HaCaT human keratinocytes and HEK293 human embryonic kidney cells demonstrated resistance to the thiazolopyridine derivatives treatment and did not reach the IC 50 value up to 100 µM. Conclusions. The tested thiazolopyridines constitute an interesting background for further development of new chemotherapeutic agents.","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"30 1","pages":"153-164"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90078855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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