International journal of gynecological obstetrical and reproductive medicine research最新文献

{"title":"Impact of Paternal Genome with a High DNA Fragmentation Index (>60%) on Early Embryonic Development","authors":"M. Hachemi","doi":"10.31907/2309-4400.2021.09.03","DOIUrl":"https://doi.org/10.31907/2309-4400.2021.09.03","url":null,"abstract":": Objectives: The objective of this study is to propose thresholds of the sperm DNA fragmentation rate (IFA≤30% IFA31%-60% IFA>60%), in order to assess the clinical effects of the paternal genome on intra cytoplasmic sperm injection parameters, in particular the effect of the latter on early embryonic development. Materials and Methods: The procedure is a retrospective study, which involved 101 patients enrolled in an ICSI program with their partners. The index of spermatic DNA fragmentation rate was measured using the Sperm Chromatin Dispersion assay. Results: There is a negative correlation between high levels of the spermatic DNA fragmentation index and spermiological characteristics: Concentration P=0.002 and mobility P=0.0001. For ICSI results, there are different observations on the existence of a correlation between the spermatic DNA fragmentation index and fertility rate. On the other hand, the rate of sperm DNA fragmentation does not seem to influence early embryonic development, and even couples whose partners have a high fragmentation index manage to obtain the best quality embryos (P=0.002). We observe a decrease in the rate of implantation with an increase in the rate of alteration of the sperm genome, but this remains insignificant P > 0.05. Conclusion: ICSI remains the only alternative for men with a high rate of sperm DNA fragmentation. Moreover, the operator seems to influence the results more than is suggested. This does not exclude the paternal effect which may influence the quality of the concepltus later on. Keywords: DNA Fragmentation Index, ICSI, Fertilization Rate, Embryos Quality.","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73148568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal Outcomes After Undergoing External Cephalic Version","authors":"J. Duro Gómez","doi":"10.31907/2309-4400.2021.09.02","DOIUrl":"https://doi.org/10.31907/2309-4400.2021.09.02","url":null,"abstract":": The external cephalic version (ECV) represents the standard for pregnancies at term with a non-cephalic presentation as it avoids planned caesareans. The aim of this study was to assess the caesarean rate and prognostic factors at birth after undergoing ECV, which was compared with scheduled caesareans for a non-cephalic presentation (SCG) and spontaneous cephalic presentations at birth (GG). No difference was observed between the caesarean rate of the ECV (n=65) and the GG (n=3711) groups (9.84% and 14.47%, respectively, p-value=0.30), and neither was found between the ECV group and both the GG and SCG (n=76) groups in the Apgar scores and postpartum pH, but for the five-minute Apgar score (9.98 and 9.84 in the ECV and SCG groups, respectively, p-value=0.04). This study provides further evidence for clinical practice regarding good perinatal outcomes after undergoing ECV. Further research is required to consistently prove the increase in the intrapartum caesarean rate after ECV that has been previously described in the literature, which has not been found in the present study. Keywords: External Cephalic Version, Breech Presentation, Caesarean Rate, Perinatal Outcomes, Apgar Score, Postpartum Ph.","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91298212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Ovarian Tissue Cryopreservation and Autotransplantation in Patients with Malignancies in Hungary – Report of the First Three Cases","authors":"A. Vereczkey","doi":"10.31907/2309-4400.2020.08.11","DOIUrl":"https://doi.org/10.31907/2309-4400.2020.08.11","url":null,"abstract":"Fertility Preservation, Cryopreservation, Ovarian Tissue Autotransplantation and Malignancies. Abstract: Autotransplantation of cryopreserved ovarian tissue is one of the most advanced methods for fertility preservation of patients suffering from malignant diseases. Even though the method itself is still experimental, nearly a hundred live births have been documented worldwide, and its efficacy is comparable with the efficacy of any other assisted reproductive technology. Our prospective, nonrandomized study was the first in Hungary that aimed to examine the safety and efficacy of fertility preservation based on ovarian tissue cryopreservation and autotransplantation. Patients were included only with stage I-III malignancy confirmed by histological diagnosis with a high risk for post-treatment infertility. 13 patients met the inclusion criteria and were enrolled in the study. After successful treatment and recovery, cryopreserved ovarian tissue was thawed and autotransplanted in three cases. The ultrathin slices of ovarian cortex were transplanted on the remaining ovaries with laparoscopic or minilaparotomic intervention. Patients were discharged home after an uneventful postoperative period and are followed up currently. In summary, cryopreservation and autotransplantation of ovarian tissue is a safe technology for fertility preservation, which should be considered to offer and perform prior to gonadotoxic treatment, after individual evaluation of patients","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90072450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact and Repercussion of the SARS-CoV-2 Pandemic in the Assisted Reproduction Units in Spain","authors":"Koldo Carbonero Martínez","doi":"10.31907/2309-4400.2020.08.08","DOIUrl":"https://doi.org/10.31907/2309-4400.2020.08.08","url":null,"abstract":"Summary: During the months of March, April and May of 2020 the Spanish Assisted Reproduction Units had to stop their assistance activity due to the health situation caused by the COVID-19 pandemic. Its reactivation has required a substantial modification in the way of working in them, changing the assistance routines and designing protocols that guarantee, as much as possible, the security of patients and staff of the centers devoted to reproductive medicine.It is analyzed the medical and biological arguments that have been assessed in order to advise the reopening of the Assisted Reproduction Units within the current context of the pandemic in Spain and the European Union.","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86433937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruptured Ectopic Pregnancy in a Nigerian Tertiary Hospital: What has Changed?","authors":"Charlotte B. Oguejiofor, Chinedu J. Ezugwu, George U. Eleje, Ekene A Emeka","doi":"10.31907/2309-4400.2020.08.04","DOIUrl":"https://doi.org/10.31907/2309-4400.2020.08.04","url":null,"abstract":"s: Background : Ruptured ectopic pregnancy continues to be a major surgical emergency in gynecology. Due to the contribution of ectopic pregnancy in maternal mortality indices in Nigeria, an intervallic review of it has become very necessary. Objectives : This is to determine the prevalence, clinical presentation, risk factors, and the management outcomes of ectopic pregnancies. Methods : This is a retrospective study of cases of ectopic gestations managed in the gynecological unit of Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, South-east Nigeria from January 1st 2013 to December 31st, 2017. Information was obtained from the case files, theatre and labor ward registers. We only included women with ruptured ectopic pregnancy that were managed surgically. Cases that were managed medically or conservatively were excluded. The proforma was initially used for retrieving data from case files obtained from the Medical Record department of the hospital. The data was later transferred to SPSS version 23 for analysis. Results : During the period, there were a total of 5301 deliveries, 901 gynecological admissions and 67 ectopic pregnancies recorded. This gives a prevalence of 1.3% of total deliveries and 6.7 of gynecological admissions. However, only 56 case files were available with complete information for the study, and could be used for further analysis. The majority were in the age group of 25-29 years. The prevalence was highest among the secundigravida 17, (30.4%) followed by and primigravidas, 13(23.2%). Previous pelvic inflammatory disease 30(53.6%), previous induced abortion 16(35.7%), and previous abdominopelvic surgery 10(26.8%) were the most common associated risk factors. Lower abdominal pain 54(96.4%), amenorrhea 50(89.3%), vaginal bleeding 40(71.4%) and syncope/shock attack 38(67.9%) were the predominant symptoms at presentation. Majority 34(60.7%) of the tubal rupture occurred at gestational age of 8-10weeks. Thirty (53.6%) cases occurred at the right tubes. Most, 71.4% (40) of the tubal ectopic gestations were ampullary. Majority of the patients 51(91.1%) had unilateral salpingectomy, 14(25.0%) had total salpingectomy while 5(8.9%) had cornual repair. Forty six (85.7%) women received blood transfusion. The case fatality rate was 1.8% which was exclusively due to anesthetic complication. Conclusion : The prevalence of ruptured ectopic pregnancy is still high in Nigeria with pelvic infection being the most common associated risk factor. Only tubal ectopic pregnancy was reported. There are no reported cases for abdominal pregnancies, ovarian pregnancies and heterotopic pregnancies within the last half decade, although with first mortality from ectopic pregnancy being recorded, which appears to signify a changing pattern.","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80794472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Lead Follicle Size on Day of Trigger with the Outcome of Invitro Fertilization (IVF) – A Retrospective Study","authors":"Blessy John, Lakshmanan Saravanan, M. Saravanan, Nidhi Sharma","doi":"10.31907/2309-4400.2019.07.05","DOIUrl":"https://doi.org/10.31907/2309-4400.2019.07.05","url":null,"abstract":": Introduction : IVF treatment involves the administration of supra-physiological doses of follicle stimulating hormone (FSH) to induce the growth of multiple ovarian follicles. Once ovarian follicles grow to an appropriate size, a trigger is administered to mature the oocytes in preparation for oocyte retrieval. However, no definite data exist to establish which follicle size on the day of trigger is most likely to yield a mature oocyte and successful IVF outcome. Knowledge of the size of follicles on day of trigger from which one could reasonably expect to retrieve a mature oocyte could enable the accurate determination of trigger efficacy. Therefore we sought to determine the size of the follicles on the day of trigger that would be most likely to yield a mature oocyte with increased blastocyst conversion rate after invitro fertilization thereby increasing the clinical pregnancy rate. Methodology : This retrospective study analysed 371 records of infertile women who underwent In-vitro fertilization in ARC International Fertility Center, Saveetha Medical College and Hospital, Chennai from March 2017 to March 2019. Results : In our study, highest ooctye maturation was observed when trigger was given when the lead follicle size was 22.1 to 24mm. a larger number of transferable good quality embryos are harvested from the group with lead follicle size of 22.1to 24mm (74 %). The 18 to 20mm group had 21% and 20.1 to 22mm group had 40%. The more than 24mm group had 50 % of good embryos. Finally in this study we did not have a statistically significant increase in the clinical viable pregnancy rate among the four groups. Though not statistically significant, we observed a slight increase in the clinical viable pregnancy rate among 22.1 to 24mm group 79% compared to other groups. Conclusion : In this study we observed that an early trigger(less than 22mm lead follicle size) or a very late trigger (>24mm) decreased the oocyte maturation rate thereby reducing the blastocyst conversion rate and clinical pregnancy rate. In this study we observed the ideal size of the lead follicle at the time of triggerto be 22 to 24 mm.","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88514882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the E2/P Ratio Predictor have a Role in the IVF Outcome during Ovulation İnduction?","authors":"M. Yaman, M. Alan, Hakkı Aytaç, Y. Alan, B. Yilmaz","doi":"10.31907/2309-4400.2019.07.04","DOIUrl":"https://doi.org/10.31907/2309-4400.2019.07.04","url":null,"abstract":": Objective : The present study investigates the role of hCG day serum P/E ratio in predicting the chemical pregnancy rate in cycles subject to in vitro fertilization - intracytoplasmic sperm injection - embryo transfer (IVF-ICSI-ET) following controlled ovarian stimulation (COS) accompanied by gonadotropin-releasing hormone agonists (GnRH). Methods : The study retrospectively examined a total of 2,517 patients treated with IVF.All patients underwent an oocyte pick-up (OPU) procedure, and subjects were included in the GnRH-agonist short protocol study upon a total of 140 fresh embryo transfers based on inclusion/exclusion criteria. Findings : The hCG day P/E ratio of the patients that did not end in chemical pregnancy was found 0.7415 ± 0.0010285, which was 2.4637 ± 0.0099075 for those ended in chemical pregnancy. The P/E ratio of patients with and without chemical pregnancy was not statistically significant (p=0.718). Conclusion : In IVF patients subject to fresh embryo transfer and administered an agonist cycle, the ratio of serum P level to the E level on the same day does not seem to be an effective parameter in predicting the rate of chemical pregnancy. Further studies with wider series of patient populations are required to clarify this matter.","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83105835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tubal Ectopic Pregnancy: Effect of ß-hCG Change in Treatment","authors":"M. Özer, Y. Alan, A. Dogan, M. Alan","doi":"10.31907/2309-4400.2019.07.03","DOIUrl":"https://doi.org/10.31907/2309-4400.2019.07.03","url":null,"abstract":"Objective: To evaluate the effect of β-hCG of treating prediction in tubal ectopic pregnancies (TEP). Materials and Methods: 758 patients receiving only one dose of methotrexate (mtx) treatment protocol for CAP were included in the study between January 2009 and December 2017. Patients' age, gravity, parity, ultrasonography findings, β-hCG values, and factors that may affect treatming process were recorded. Results: It was determined that medical treatment success was predicted with 77%, 81% sensitivity and 61% and 68% specificity when the initial β-hCG value was 1435 mIU / mL and the β-hCG level on the 4th day was 1539 mIU / mL cut off value. In our study, when β-hCG values decreased by 7% between 0-4 days were taken as cut off value, medical treatment with 84% sensitivity and 77% specificity was shown to be successful. The mean β-hCG levels on the 4th and 7th days were significantly lower in the medical treatment group than in the unsuccessful group. Conclusion: We found that patients with lower β-hCG values at baseline and day 4 had higher chances of success, and when cut off values were taken as 1435 mIU / mL and 1539 mIU / mL, success rate was significantly decreased. According to β-hCG level on day 0, day 4, and β-hCG change level between 0-4 days, we think ectopic pregnancy approach will decrease the unnecessary hospital stay.","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73892692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric Outcomes of Position Abnormalities Detected by Intrapartum Suprapubic Transabdominal Ultrasound","authors":"E. A. Mendoza, J. Niño, Aldo Toriz Prado","doi":"10.31907/2309-4400.2019.07.02","DOIUrl":"https://doi.org/10.31907/2309-4400.2019.07.02","url":null,"abstract":"Materials and Methods: Prospective, cross-sectional, descriptive study, carried out in term pregnant patients, carried out in a second level of care in December 2018 to July 2019, the population was divided into group 1 (it included 15 patients with evolution abnormal labor in which no ultrasound was performed to detect position abnormalities) and group 2 (15 patients with abnormal evolution of labor and ultrasound detection of position anomaly were included) to determine the usefulness of diagnosis by ultrasound and its association with maternal-fetal morbidity and mortality.","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90426830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgelin, a Novel Marker of Smooth Muscle Differentiation, Effectively Distinguishes Endometrial Stromal Tumors from Uterine Smooth Muscle Tumors.","authors":"Ossama Tawfik,&nbsp;Deepthi Rao,&nbsp;Warren B Nothnick,&nbsp;Amanda Graham,&nbsp;Brian Mau,&nbsp;Fang Fan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Differentiation between endometrial stromal sarcomas (ESSs) and smooth muscle tumors of the uterus can be challenging. Transgelin, a 22 kDa actin-binding protein has recently been shown to be a smooth muscle specific marker. The goal of this study was to determine whether transgelin could accurately distinguish ESSs from smooth muscle tumors. The expression of transgelin, CD10 and smooth muscle actin (SMA) in 13 ESSs (4 low grade, 6 undifferentiated and 3 metastatic), 9 smooth muscle tumors (1 leiomyoma and 8 leiomyosarcomas (LMSs) and 15 soft tissue LMSs was studied. The diagnostic performance of transgelin compared to the other smooth muscle markers was assessed. Transgelin was diffusely strongly positive in all myometria, leiomyoma, and uterine and soft tissue LMSs. In contrast, transgelin expression was totally absent in all endometria, primary and metastatic ESSs. SMA positivity was noticed in 4 of the 13 ESSs. CD10 was positive in most ESSs. Transgelin appears to be a specific marker of smooth muscle differentiation in the uterus with 100% sensitivity and specificity and may be useful for distinguishing LMS from ESS. It could be used as an additional marker useful for decision making, especially in those tumors with questionable histology.</p>","PeriodicalId":90861,"journal":{"name":"International journal of gynecological obstetrical and reproductive medicine research","volume":"1 1","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443873/pdf/nihms-683929.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33223693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}