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Inositol 1,4,5-triphosphate-associated cGMP kinase substrate: Basis Sequence: Mouse. 肌醇1,4,5-三磷酸相关cGMP激酶底物:基础序列:小鼠。
The AFCS-nature molecule pages
Pub Date : 2008-01-01 DOI: 10.1038/mp.a001275.01
Sarabeth M Graham, Sandra Longoria, Pabak Sarkar, Peter Koulen

Inositol 1, 4, 5-trisphosphate (IP3) receptor associated cyclic GMP (cGMP) kinase substrate (IRAG, also known as Mrv1) is a type-2 integral membrane endoplasmic reticulum (ER) protein, which interacts with IP3 Receptor type 1 (IP3R1), cGMP kinase I-β (cGKI β) and other associated proteins. It plays a key role in NO, cGMP, and cGKI β mediated inhibition of IP3R1 activity and thus relaxes smooth muscle tone and inhibits platelet aggregation. As a scaffolding protein Mrv1 maintains the conformation of a heteroprotein complex containing cGKI β, IP3R1 and other proteins and enables efficient activity of cGKI β within the complex. Increased expression of Mrv1 or IRAG in the absence of tumor related transcription factor in pancreatic cancer cells suggest that it might be involved in tumorigenesis. Downregulation of Mrv1 during megakaryocyte maturation indicates that it is involved in cell growth and differentiation.

肌醇1,4,5 -三磷酸(IP3)受体相关环GMP (cGMP)激酶底物(IRAG，也称为Mrv1)是一种2型整体膜内质网(ER)蛋白，它与IP3受体1型(IP3R1)、cGMP激酶I-β (cGKI β)和其他相关蛋白相互作用。它在NO、cGMP和cGKI β介导的IP3R1活性抑制中起关键作用，从而放松平滑肌张力并抑制血小板聚集。Mrv1作为支架蛋白维持含有cGKI β、IP3R1和其他蛋白的异蛋白复合物的构象，并使复合物内的cGKI β有效活性。胰腺癌细胞在肿瘤相关转录因子缺失的情况下，Mrv1或IRAG表达增加，提示其可能参与肿瘤发生。巨核细胞成熟过程中Mrv1的下调表明它参与细胞生长和分化。
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引用次数: 1
Luteinizing hormone receptor 黄体生成素受体
The AFCS-nature molecule pages
Pub Date : 2007-12-14 DOI: 10.1038/MP.A001403.01
T. Buech, P. Nurwakagari, D. Ben-Menahem, T. Gudermann
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引用次数: 3
AP-3 sigma1 AP-3信号1
The AFCS-nature molecule pages
Pub Date : 2007-12-11 DOI: 10.1038/MP.A000300.01
Esteban C. Dell'Angelica
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引用次数: 0
AP-3 sigma2 AP-3信号2
The AFCS-nature molecule pages
Pub Date : 2007-12-11 DOI: 10.1038/MP.A000301.01
E. C. Dell'Angelica
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引用次数: 0
G protein gamma 8 G蛋白- 8
The AFCS-nature molecule pages
Pub Date : 2007-11-27 DOI: 10.1038/MP.A000996.01
C. Kleuss
{"title":"G protein gamma 8","authors":"C. Kleuss","doi":"10.1038/MP.A000996.01","DOIUrl":"https://doi.org/10.1038/MP.A000996.01","url":null,"abstract":"","PeriodicalId":90978,"journal":{"name":"The AFCS-nature molecule pages","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57550439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Sphingosine kinase 1 鞘氨酸激酶
The AFCS-nature molecule pages
Pub Date : 2007-11-08 DOI: 10.1038/MP.A002219.01
S. Paugh, D. Kapitonov, S. Spiegel
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引用次数: 10
Mapkap kinase 3 Mapkap激酶
The AFCS-nature molecule pages
Pub Date : 2007-11-01 DOI: 10.1038/MP.A001455.01
M. Gaestel, N. Ronkina
{"title":"Mapkap kinase 3","authors":"M. Gaestel, N. Ronkina","doi":"10.1038/MP.A001455.01","DOIUrl":"https://doi.org/10.1038/MP.A001455.01","url":null,"abstract":"","PeriodicalId":90978,"journal":{"name":"The AFCS-nature molecule pages","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57550947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AP-4 mu1 AP-4 mu1
The AFCS-nature molecule pages
Pub Date : 2007-10-09 DOI: 10.1038/MP.A002925.01
Esteban C. Dell'Angelica
{"title":"AP-4 mu1","authors":"Esteban C. Dell'Angelica","doi":"10.1038/MP.A002925.01","DOIUrl":"https://doi.org/10.1038/MP.A002925.01","url":null,"abstract":"","PeriodicalId":90978,"journal":{"name":"The AFCS-nature molecule pages","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57551597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AP-4 epsilon AP-4ε
The AFCS-nature molecule pages
Pub Date : 2007-10-09 DOI: 10.1038/MP.A002923.01
Esteban C. Dell'Angelica
{"title":"AP-4 epsilon","authors":"Esteban C. Dell'Angelica","doi":"10.1038/MP.A002923.01","DOIUrl":"https://doi.org/10.1038/MP.A002923.01","url":null,"abstract":"","PeriodicalId":90978,"journal":{"name":"The AFCS-nature molecule pages","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57551563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AP-4 sigma1 AP-4信号1
The AFCS-nature molecule pages
Pub Date : 2007-10-09 DOI: 10.1038/MP.A002926.01
Esteban C. Dell'Angelica
{"title":"AP-4 sigma1","authors":"Esteban C. Dell'Angelica","doi":"10.1038/MP.A002926.01","DOIUrl":"https://doi.org/10.1038/MP.A002926.01","url":null,"abstract":"","PeriodicalId":90978,"journal":{"name":"The AFCS-nature molecule pages","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57551615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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