Pub Date : 2018-09-01DOI: 10.15744/2454-3284.4.206
L. Flores-Hernández, Ramírez-Uribe Rd, Villegas-González Lf, Serrano-Arévalo Ml, Cordoba-Gonzalez, Barquet-Muñoz Sa
Conclusion: Considering no statistically differences in the results and the outlay of LBC, implementation of LBC should be used for molecular-based detection and genotyping when human papillomavirus may offer additional benefits when screening for cervical carcinoma. Introduction: Cervical carcinoma is the fourth most common gynecologic cancer. Screening assays that include the conventional cytology (CC) have a sensitivity and specificity far from optimal; however, liquid-based cytology (LBC) may overcome some limitations. The objective is to compare the screening accuracy of LBC and CC in individuals suspected of having precancerous lesions.
{"title":"Liquid-Based Cytology Compared to Conventional Cytology for Diagnosis of Cervical Intraepithelial Neoplasia: A Single-Center Experience","authors":"L. Flores-Hernández, Ramírez-Uribe Rd, Villegas-González Lf, Serrano-Arévalo Ml, Cordoba-Gonzalez, Barquet-Muñoz Sa","doi":"10.15744/2454-3284.4.206","DOIUrl":"https://doi.org/10.15744/2454-3284.4.206","url":null,"abstract":"Conclusion: Considering no statistically differences in the results and the outlay of LBC, implementation of LBC should be used for molecular-based detection and genotyping when human papillomavirus may offer additional benefits when screening for cervical carcinoma. Introduction: Cervical carcinoma is the fourth most common gynecologic cancer. Screening assays that include the conventional cytology (CC) have a sensitivity and specificity far from optimal; however, liquid-based cytology (LBC) may overcome some limitations. The objective is to compare the screening accuracy of LBC and CC in individuals suspected of having precancerous lesions.","PeriodicalId":91315,"journal":{"name":"Journal of gynecology research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78994583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-01DOI: 10.15744/2454-3284.4.201
I. I, Cohen R, Berkovitch M, Koren G
{"title":"Determinants of Medication Adherence in Nausea and Vomiting of Pregnancy","authors":"I. I, Cohen R, Berkovitch M, Koren G","doi":"10.15744/2454-3284.4.201","DOIUrl":"https://doi.org/10.15744/2454-3284.4.201","url":null,"abstract":"","PeriodicalId":91315,"journal":{"name":"Journal of gynecology research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76911673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-01DOI: 10.15744/2454-3284.4.207
Nesterova Iv, Kovaleva Sv, Chudilova Ga, Lomtatidze Lv, Krutova Va, Shuvalov An, Malinovskaya Vv
Nonspecific chronic vulvovaginites (NCVV) are a frequent clinical sign of immune deficiency, especially in young girls. The established problems with the functioning of various parts of the immune system (IS) in this pathology dictate the need to include immunomodulatory therapy into the complex. The developed program of combined immunotherapy for immunocompromised girls allows reducing the severity and duration of exacerbation of NCVV, their frequency against the background of a significant reduction in ARVI incidence. Positive clinical effects were observed with underlying restoration in IS functioning. A protective effect was obtained (observation in a catamnesis for 1 year): the duration of a clinically safe period increased from 6 to 11-11.5 months per year. Introduction Vulvovaginitis takes the first place in the structure of gynaecological disorders in girls of primary school age and preschool age, with the peak share at the age of 2-7 years old. Acute and chronic genital inflammations in childhood may later cause serious infections and inflammations in women of various ages and result in reproductive disorders in women of childbearing age. Therefore tackling the challenge of protecting the reproductive health of children and teenagers, preventing and treating gynaecological disorders in children is a burning issue; it is of huge practical significance and of a certain interest both for scientists and practitioners.
{"title":"Positive Efficiency of Combine Immunotherapy in Immunocompromised Girls with Recurrent Nonspecific Chronic Vulvovaginitis","authors":"Nesterova Iv, Kovaleva Sv, Chudilova Ga, Lomtatidze Lv, Krutova Va, Shuvalov An, Malinovskaya Vv","doi":"10.15744/2454-3284.4.207","DOIUrl":"https://doi.org/10.15744/2454-3284.4.207","url":null,"abstract":"Nonspecific chronic vulvovaginites (NCVV) are a frequent clinical sign of immune deficiency, especially in young girls. The established problems with the functioning of various parts of the immune system (IS) in this pathology dictate the need to include immunomodulatory therapy into the complex. The developed program of combined immunotherapy for immunocompromised girls allows reducing the severity and duration of exacerbation of NCVV, their frequency against the background of a significant reduction in ARVI incidence. Positive clinical effects were observed with underlying restoration in IS functioning. A protective effect was obtained (observation in a catamnesis for 1 year): the duration of a clinically safe period increased from 6 to 11-11.5 months per year. Introduction Vulvovaginitis takes the first place in the structure of gynaecological disorders in girls of primary school age and preschool age, with the peak share at the age of 2-7 years old. Acute and chronic genital inflammations in childhood may later cause serious infections and inflammations in women of various ages and result in reproductive disorders in women of childbearing age. Therefore tackling the challenge of protecting the reproductive health of children and teenagers, preventing and treating gynaecological disorders in children is a burning issue; it is of huge practical significance and of a certain interest both for scientists and practitioners.","PeriodicalId":91315,"journal":{"name":"Journal of gynecology research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76895444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-01DOI: 10.15744/2454-3284.4.208
M. Alalfy, A. E. lithy, Z. Ezzeldin, Y. Mansi, A. Hamed, Marwa Mostafa, A. Adel
Role of Bilirubin and Albumin in Cord Blood as Predictors for Neonatal Hyperbilirubinemia Mahmoud Alalfy*1, Ahmed el lithy2, Zahraa Mohamed EzzEldin3, Yasmeen Amr Mansi3, Alaa Hamed4, Marwa basher Mostafa5 and Ahmed Adel6 1Lecturer, Researcher, Reproductive health and family planning department, National Research Centre, Egypt, and The senior Fellow in cairo fetal medicine unit, Egypt and Consultant OB/Gyn, Aljazeerah Hospital, Egypt 2Assistant professor Obstetrics and Gynecology, Kasralainy faculty of medicine, Cairo university, Egypt 3Professor of Pediatrics & NeonatologyFaculty of Medicine, Cairo University, Egypt 4Lecturer of obstetrics and Gynecology, Alazhar faculty of medicine, Alazhar university 5Specialist of Obstetrics Pediatrics and neonatology, Egypt 6Assistant Researcher, Child Health department, National Research Centre, Egypt *Corresponding author: Mahmoud Alalfy, PhD. Lecturer, Researcher, Reproductive Health and family planning department, national Research Centre, Egypt, and Consultant OB/Gyn, Aljazeerah Hospital, Egypt, Tel: +201002611058, E-mail: mahmoudalalfy@ymail.com
脐带血中胆红素和白蛋白在新生儿高胆红素血症预测中的作用Mahmoud Alalfy*1, Ahmed el lithy2, Zahraa Mohamed EzzEldin3, Yasmeen Amr Mansi3, Alaa Hamed4, Marwa basher Mostafa5和Ahmed Adel6埃及国家研究中心生殖健康和计划生育部讲师，研究员，埃及开罗胎儿医学部门高级研究员，埃及Aljazeerah医院妇产科顾问2，妇产科助理教授，埃及开罗大学Kasralainy医学院3埃及开罗大学医学院儿科和新生儿学教授4埃及阿拉资哈尔大学医学院妇产科讲师5埃及产科儿科和新生儿学专家6埃及国家研究中心儿童卫生部门助理研究员*通讯作者:Mahmoud Alalfy，博士。埃及国家研究中心生殖健康和计划生育部讲师，研究员，埃及阿拉伯半岛医院妇产科顾问，电话:+201002611058，电子邮件:mahmoudalalfy@ymail.com
{"title":"Role of Bilirubin and Albumin in Cord Blood as Predictors for Neonatal Hyperbilirubinemia","authors":"M. Alalfy, A. E. lithy, Z. Ezzeldin, Y. Mansi, A. Hamed, Marwa Mostafa, A. Adel","doi":"10.15744/2454-3284.4.208","DOIUrl":"https://doi.org/10.15744/2454-3284.4.208","url":null,"abstract":"Role of Bilirubin and Albumin in Cord Blood as Predictors for Neonatal Hyperbilirubinemia Mahmoud Alalfy*1, Ahmed el lithy2, Zahraa Mohamed EzzEldin3, Yasmeen Amr Mansi3, Alaa Hamed4, Marwa basher Mostafa5 and Ahmed Adel6 1Lecturer, Researcher, Reproductive health and family planning department, National Research Centre, Egypt, and The senior Fellow in cairo fetal medicine unit, Egypt and Consultant OB/Gyn, Aljazeerah Hospital, Egypt 2Assistant professor Obstetrics and Gynecology, Kasralainy faculty of medicine, Cairo university, Egypt 3Professor of Pediatrics & NeonatologyFaculty of Medicine, Cairo University, Egypt 4Lecturer of obstetrics and Gynecology, Alazhar faculty of medicine, Alazhar university 5Specialist of Obstetrics Pediatrics and neonatology, Egypt 6Assistant Researcher, Child Health department, National Research Centre, Egypt *Corresponding author: Mahmoud Alalfy, PhD. Lecturer, Researcher, Reproductive Health and family planning department, national Research Centre, Egypt, and Consultant OB/Gyn, Aljazeerah Hospital, Egypt, Tel: +201002611058, E-mail: mahmoudalalfy@ymail.com","PeriodicalId":91315,"journal":{"name":"Journal of gynecology research","volume":"79 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83440101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-01DOI: 10.15744/2454-3284.4.203
F. Sorà, I. Innocenti, P. Chiusolo, F. Autore, Rotarescu Ca, M. Luigetti, S. Sica, L. Laurenti
Volume 4 | Issue 2 Introduction Hirsutism will be not Considered as Sign of Progressive Disease after Autologous Transplant in POEMS Syndrome Sorà F*1, Innocenti I1, Chiusolo P1, Autore F1, Rota CA2, Luigetti M3, Sica S1, and Laurenti L1 1Fondazione Policlinico universitario A.Gemelli IRCSS istituto di Ematologia, Rome, Italy 2Fondazione Policlinico universitario A.Gemelli IRCSS istituto di Endocrinologia, Rome, Italy 3Fondazione Policlinico Universitario Agostino, Gemelli, UOC Neurologia, Rome, Italy *Corresponding author: Sorà F, MD, Fondazione Policlinico universitario A.Gemelli IRCSS istituto di Ematologia, Rome, Italy, Fax: +396-3017319, Tel: +39-6-30154278, E-mail: federica.sora@unicatt.it
第4卷2引言Hirsutism will be not |问题案例as of累进疾病之后产卵Autologous Transplant POEMS综合症SoràF * 1,“无辜”,Chiusolo P1,作者F1, Rota CA2, Luigetti立方米、卢森堡:和Laurenti L1大学综合医院基金会A .双胞胎IRCSS血液学研究所,罗马,意大利2Fondazione A .双胞胎IRCSS大学综合医院内分泌学研究所,罗马,意大利3Fondazione奥古斯丁、双胞胎、UOC大学综合医院神经内科,罗马，意大利*通信author: sora F, MD，多学科大学基金会A.格梅里IRCSS血液学研究所，罗马，意大利，传真:+396-3017319，电话:+39-6-30154278，电子邮件:federica.sora@unicatt.it
{"title":"Hirsutism will be not Considered as Sign of Progressive Disease after Autologous Transplant in POEMS Syndrome","authors":"F. Sorà, I. Innocenti, P. Chiusolo, F. Autore, Rotarescu Ca, M. Luigetti, S. Sica, L. Laurenti","doi":"10.15744/2454-3284.4.203","DOIUrl":"https://doi.org/10.15744/2454-3284.4.203","url":null,"abstract":"Volume 4 | Issue 2 Introduction Hirsutism will be not Considered as Sign of Progressive Disease after Autologous Transplant in POEMS Syndrome Sorà F*1, Innocenti I1, Chiusolo P1, Autore F1, Rota CA2, Luigetti M3, Sica S1, and Laurenti L1 1Fondazione Policlinico universitario A.Gemelli IRCSS istituto di Ematologia, Rome, Italy 2Fondazione Policlinico universitario A.Gemelli IRCSS istituto di Endocrinologia, Rome, Italy 3Fondazione Policlinico Universitario Agostino, Gemelli, UOC Neurologia, Rome, Italy *Corresponding author: Sorà F, MD, Fondazione Policlinico universitario A.Gemelli IRCSS istituto di Ematologia, Rome, Italy, Fax: +396-3017319, Tel: +39-6-30154278, E-mail: federica.sora@unicatt.it","PeriodicalId":91315,"journal":{"name":"Journal of gynecology research","volume":"365 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86804602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-01DOI: 10.15744/2454-3284.4.205
M. Alalfy, Amr Abbassy, Yossra Lasheen
{"title":"Impact of Inverted Interrupted Skin Suturing Versus Continous Suturing in Episiotomy on Postpartum Pain in Primigravida","authors":"M. Alalfy, Amr Abbassy, Yossra Lasheen","doi":"10.15744/2454-3284.4.205","DOIUrl":"https://doi.org/10.15744/2454-3284.4.205","url":null,"abstract":"","PeriodicalId":91315,"journal":{"name":"Journal of gynecology research","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86216791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-01DOI: 10.15744/2454-3284.4.204
M. Alalfy, Ahmed M. Hassan, M. Saleh
{"title":"Ultrasound Criteria for Expecting Mode of Delivery after Induction of Labour in Primigravida with Postdates","authors":"M. Alalfy, Ahmed M. Hassan, M. Saleh","doi":"10.15744/2454-3284.4.204","DOIUrl":"https://doi.org/10.15744/2454-3284.4.204","url":null,"abstract":"","PeriodicalId":91315,"journal":{"name":"Journal of gynecology research","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82216645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-01DOI: 10.15744/2454-3284.4.202
Huang J, Z. Z, S. N, Yao S, L. D
Case report: A 26-year-old woman who was previously diagnosed as immature, right ovarian teratoma, was presented to Hangzhou obstetrics and gynecology hospital. The patient had previously undergone a laparotomy and right salpingo-oophorectomy with partial omentectomy 14-year before. Initial laboratory tests showed the serum markers: cancer antigen (CA)-125 was 44.5IU/ml (increased) and CA199, AFP levels were normal. Sonographic examination revealed a complex mass, measuring 12.6cmx10.5cm x8.5 cm, behind the uterus. Magnetic resonance imaging (MRI) findings were in favour of teratoma, originated from the right adnexa, occupying pouch of Douglas. The patient underwent exploratory laparotomy with a right intraligamentary teratoma cystectomy along with residual omentectomy,andrandom peritoneal biopsies. The pathology revealed mature teratoma, glioma, with no malignant components.
{"title":"A Rare Recurrence of an Immature Teratoma: A Case Report","authors":"Huang J, Z. Z, S. N, Yao S, L. D","doi":"10.15744/2454-3284.4.202","DOIUrl":"https://doi.org/10.15744/2454-3284.4.202","url":null,"abstract":"Case report: A 26-year-old woman who was previously diagnosed as immature, right ovarian teratoma, was presented to Hangzhou obstetrics and gynecology hospital. The patient had previously undergone a laparotomy and right salpingo-oophorectomy with partial omentectomy 14-year before. Initial laboratory tests showed the serum markers: cancer antigen (CA)-125 was 44.5IU/ml (increased) and CA199, AFP levels were normal. Sonographic examination revealed a complex mass, measuring 12.6cmx10.5cm x8.5 cm, behind the uterus. Magnetic resonance imaging (MRI) findings were in favour of teratoma, originated from the right adnexa, occupying pouch of Douglas. The patient underwent exploratory laparotomy with a right intraligamentary teratoma cystectomy along with residual omentectomy,andrandom peritoneal biopsies. The pathology revealed mature teratoma, glioma, with no malignant components.","PeriodicalId":91315,"journal":{"name":"Journal of gynecology research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78134458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-24DOI: 10.15744/2454-3284.1.103
A. Desai, J. Xu, K. Aysola, O. Akinbobuyi, M. White, V. Reddy, J. Okoli, C. Clark, E. Partridge, E. Childs, D. Beech, M. Rice, E. Reddy, V. Rao
Ovarian cancer constitutes the second most common gynecological cancer with a five-year survival rate of 40%. Among the various histotypes associated with hereditary ovarian cancer, high-grade serous epithelial ovarian carcinoma (HGSEOC) is the most predominant and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. HGSEOC is a challenge for clinical oncologists, due to late presentation of patient, diagnosis and high rate of relapse. Ovarian tumors have a wide range of clinical presentations including development of ascites as a result of deregulated endothelial function thereby causing increased vascular permeability of peritoneal vessels. The molecular mechanisms remain elusive. Studies have shown that fallopian tube cancers develop in women with BRCA1 gene mutations more often than previously suspected. Recent studies suggest that many primary peritoneal cancers and some high-grade serous epithelial ovarian carcinomas actually start in the fallopian tubes. In this article we have addressed the molecular pathway of a recently identified potential biomarker Ubc9 whose deregulated expression due to BRCA1 dysfunction can result in HGSEOC with peritoneal permeability and formation of ascites. We also discuss the role of downstream targets Caveolin-1 and Vascular Endothelial Growth Factor (VEGF) in the pathogenesis of ascites in ovarian carcinomas. Finally we hypothesize a signaling axis between Ubc9 over expression, loss of Caveolin-1 and induction of VEGF in BRCA1 mutant HGSEOC cells. We suggest that Ubc9-mediated stimulation of VEGF as a novel mechanism underlying ovarian cancer aggressiveness and ascites formation. Agents that target Ubc9 and VEGF signaling may represent a novel therapeutic strategy to impede peritoneal growth and spread of HGSEOC.
{"title":"Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites.","authors":"A. Desai, J. Xu, K. Aysola, O. Akinbobuyi, M. White, V. Reddy, J. Okoli, C. Clark, E. Partridge, E. Childs, D. Beech, M. Rice, E. Reddy, V. Rao","doi":"10.15744/2454-3284.1.103","DOIUrl":"https://doi.org/10.15744/2454-3284.1.103","url":null,"abstract":"Ovarian cancer constitutes the second most common gynecological cancer with a five-year survival rate of 40%. Among the various histotypes associated with hereditary ovarian cancer, high-grade serous epithelial ovarian carcinoma (HGSEOC) is the most predominant and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. HGSEOC is a challenge for clinical oncologists, due to late presentation of patient, diagnosis and high rate of relapse. Ovarian tumors have a wide range of clinical presentations including development of ascites as a result of deregulated endothelial function thereby causing increased vascular permeability of peritoneal vessels. The molecular mechanisms remain elusive. Studies have shown that fallopian tube cancers develop in women with BRCA1 gene mutations more often than previously suspected. Recent studies suggest that many primary peritoneal cancers and some high-grade serous epithelial ovarian carcinomas actually start in the fallopian tubes. In this article we have addressed the molecular pathway of a recently identified potential biomarker Ubc9 whose deregulated expression due to BRCA1 dysfunction can result in HGSEOC with peritoneal permeability and formation of ascites. We also discuss the role of downstream targets Caveolin-1 and Vascular Endothelial Growth Factor (VEGF) in the pathogenesis of ascites in ovarian carcinomas. Finally we hypothesize a signaling axis between Ubc9 over expression, loss of Caveolin-1 and induction of VEGF in BRCA1 mutant HGSEOC cells. We suggest that Ubc9-mediated stimulation of VEGF as a novel mechanism underlying ovarian cancer aggressiveness and ascites formation. Agents that target Ubc9 and VEGF signaling may represent a novel therapeutic strategy to impede peritoneal growth and spread of HGSEOC.","PeriodicalId":91315,"journal":{"name":"Journal of gynecology research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76635074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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