Pub Date : 2021-07-20DOI: 10.26420/austinjnephrolhypertens.2021.1094
Vicente R, Santos R, Amoedo M
This is the case of a 64-year-old man, on renal replacement therapy since 2008, due to autosomal dominant polycystic kidney disease. The patient was on peritoneal dialysis from 2008 to 2016, when he underwent renal transplantation. Transplant duration was less than a month due to acute vascular rejection. Since then, he is on hemodialysis. A few months after transplantation, it was incidentally identified confluent bilateral opacities, more prominent on the left lung in a routine X-ray (Figure 1). The patient had made a chest radiography in 2015 without any changes at that time. The CT scan showed parenchymatous densification areas, partially calcified, in both lungs (Figure 2). The patient also developed secondary hyperparathyroidism refractory to medical therapy but refused surgery. Nevertheless, the lesions had a slow progression until the present time.
{"title":"Metastatic Pulmonary Calcification in a Hemodialysis Patient after Renal Transplantation","authors":"Vicente R, Santos R, Amoedo M","doi":"10.26420/austinjnephrolhypertens.2021.1094","DOIUrl":"https://doi.org/10.26420/austinjnephrolhypertens.2021.1094","url":null,"abstract":"This is the case of a 64-year-old man, on renal replacement therapy since 2008, due to autosomal dominant polycystic kidney disease. The patient was on peritoneal dialysis from 2008 to 2016, when he underwent renal transplantation. Transplant duration was less than a month due to acute vascular rejection. Since then, he is on hemodialysis. A few months after transplantation, it was incidentally identified confluent bilateral opacities, more prominent on the left lung in a routine X-ray (Figure 1). The patient had made a chest radiography in 2015 without any changes at that time. The CT scan showed parenchymatous densification areas, partially calcified, in both lungs (Figure 2). The patient also developed secondary hyperparathyroidism refractory to medical therapy but refused surgery. Nevertheless, the lesions had a slow progression until the present time.","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44549513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-09DOI: 10.26420/austinjnephrolhypertens.2021.1093
X. Hul, Y. Jiangw, Y. Wangy, W. Chenj, Zhang Gx
Aims: To investigate the renal aquaporin-1 (AQP1) expression under chronic stress (induced by foot shock) condition and possible mechanisms involved in rats. Methods: The chronic stress model was established in male Sprague Dawley (SD) rats by foot shock for two weeks. Rats were randomly divided into control group, chronic stress group, renal denervation group, renal denervation plus chronic stress group, captopril (an angiotensin I converting enzyme inhibitor, ACEI) plus chronic stress group and tempol (a superoxide dismutase mimetic) plus chronic stress group. Body weight, food intake, water intake, blood pressure and heart rate were monitored. Real-time PCR was used to detect the mRNA level of AQP1 in the renal tissue. Immunohistochemistry stain was used to observe the expression and location of AQP1 in rat kidneys. Results: Chronic stress reduced body weight gain and food intake, while it significantly increased systolic blood pressure and renal expressions of mRNA and protein of AQP1 (P<0.05) as compared with control group. Renal denervation and tempol treatments did not affect stress-induced decreases of body weight gain and food intake. Renal denervation, captopril and tempol treatments decreased systolic blood pressure. Compared with the chronic stress group, mRNA and protein expression of AQP1 was decreased (P<0.05) in renal denervation plus chronic stress group, captopril plus chronic stress group and tempol plus chronic stress group. Conclusion: Chronic stress induces increase of the AQP1 expression in kidney, which is regulated by renal nerve system, renin-angiotensin system and oxidative stress.
{"title":"Role of Renin-Angiotensin System, Renal Nerve System, and Oxidative Stress in Chronic Stress-Induced Renal Expression of Aquaporin-1 in Rats","authors":"X. Hul, Y. Jiangw, Y. Wangy, W. Chenj, Zhang Gx","doi":"10.26420/austinjnephrolhypertens.2021.1093","DOIUrl":"https://doi.org/10.26420/austinjnephrolhypertens.2021.1093","url":null,"abstract":"Aims: To investigate the renal aquaporin-1 (AQP1) expression under chronic stress (induced by foot shock) condition and possible mechanisms involved in rats. Methods: The chronic stress model was established in male Sprague Dawley (SD) rats by foot shock for two weeks. Rats were randomly divided into control group, chronic stress group, renal denervation group, renal denervation plus chronic stress group, captopril (an angiotensin I converting enzyme inhibitor, ACEI) plus chronic stress group and tempol (a superoxide dismutase mimetic) plus chronic stress group. Body weight, food intake, water intake, blood pressure and heart rate were monitored. Real-time PCR was used to detect the mRNA level of AQP1 in the renal tissue. Immunohistochemistry stain was used to observe the expression and location of AQP1 in rat kidneys. Results: Chronic stress reduced body weight gain and food intake, while it significantly increased systolic blood pressure and renal expressions of mRNA and protein of AQP1 (P<0.05) as compared with control group. Renal denervation and tempol treatments did not affect stress-induced decreases of body weight gain and food intake. Renal denervation, captopril and tempol treatments decreased systolic blood pressure. Compared with the chronic stress group, mRNA and protein expression of AQP1 was decreased (P<0.05) in renal denervation plus chronic stress group, captopril plus chronic stress group and tempol plus chronic stress group. Conclusion: Chronic stress induces increase of the AQP1 expression in kidney, which is regulated by renal nerve system, renin-angiotensin system and oxidative stress.","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":"24 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41256291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-16DOI: 10.26420/austinjnephrolhypertens.2021.1091
Torres-Díaz Ja, Gonzalez-Gonzalez Jg, Zúñiga Ja, Olivo-Gutiérrez Mc, Garza-García Ca, Sánchez-Romo Sm, Villarreal-Martínez Jz, R. Rodríguez‐Gutiérrez
Introduction: The End Stage Renal Disease (ESRD) is one of the leading causes of mortality in Mexico. The quality of care these patients receive remains uncertain. Methods: This is a descriptive, single-center and cross-sectional cohort study. The KDOQI performance measures, hemoglobin level >11 g/dL, blood pressure <140/90 mmHg, serum albumin >4 g/dL and use of arteriovenous fistula of patients with ESRD on hemodialysis were analyzed in a period of a year. The association between mortality and the KDOQI objectives was evaluated with a logistic regression model. A linear regression model was also performed with the number of readmissions. Results: A total of 124 participants were included. Participants were categorized by the number of measures completed. Fourteen (11.3%) of the participants did not meet any of the goals, 51 (41.1%) met one, 43 (34.7%) met two, 11 (8.9%) met three, and 5 (4%) met the four clinical goals analyzed. A mortality of 11.2% was registered. In the logistic regression model, the number of goals met had an OR for mortality of 1.1 (95% CI 0.5-2.8). In the linear regression model, for the number of readmissions, a beta correlation with the number of KDOQI goals met was 0.246 (95% CI -0.872-1.365). Conclusion: The attainment of clinical goals and the mortality rate in our center is similar to that reported in the world literature. Our study did not find a significant association between compliance with clinical guidelines and mortality or the number of hospital admissions in CKD patients on hemodialysis.
{"title":"Quality of Care in Long-Term Hemodialysis Patients in Mexico","authors":"Torres-Díaz Ja, Gonzalez-Gonzalez Jg, Zúñiga Ja, Olivo-Gutiérrez Mc, Garza-García Ca, Sánchez-Romo Sm, Villarreal-Martínez Jz, R. Rodríguez‐Gutiérrez","doi":"10.26420/austinjnephrolhypertens.2021.1091","DOIUrl":"https://doi.org/10.26420/austinjnephrolhypertens.2021.1091","url":null,"abstract":"Introduction: The End Stage Renal Disease (ESRD) is one of the leading causes of mortality in Mexico. The quality of care these patients receive remains uncertain. Methods: This is a descriptive, single-center and cross-sectional cohort study. The KDOQI performance measures, hemoglobin level >11 g/dL, blood pressure <140/90 mmHg, serum albumin >4 g/dL and use of arteriovenous fistula of patients with ESRD on hemodialysis were analyzed in a period of a year. The association between mortality and the KDOQI objectives was evaluated with a logistic regression model. A linear regression model was also performed with the number of readmissions. Results: A total of 124 participants were included. Participants were categorized by the number of measures completed. Fourteen (11.3%) of the participants did not meet any of the goals, 51 (41.1%) met one, 43 (34.7%) met two, 11 (8.9%) met three, and 5 (4%) met the four clinical goals analyzed. A mortality of 11.2% was registered. In the logistic regression model, the number of goals met had an OR for mortality of 1.1 (95% CI 0.5-2.8). In the linear regression model, for the number of readmissions, a beta correlation with the number of KDOQI goals met was 0.246 (95% CI -0.872-1.365). Conclusion: The attainment of clinical goals and the mortality rate in our center is similar to that reported in the world literature. Our study did not find a significant association between compliance with clinical guidelines and mortality or the number of hospital admissions in CKD patients on hemodialysis.","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48083679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-04DOI: 10.26420/austinjnephrolhypertens.2021.1090
M. Mm, H. Sousa, M. Góis, F. Nolasco, Costa Ll., E. Soares
Introduction: Dysproteinemia-associated kidney diseases can have diverse clinical and histological presentation but not all patients with monoclonal gammopathy have Monoclonal Gammopathy of Renal Significance (MGRS) and some have other causes for kidney lesions. Therefore, kidney biopsy is essential to make this diagnosis. We made a retrospective study, which aimed to: 1. Identify dysproteinemiaassociated kidney lesions; 2. Establish clinicopathological correlations of patients with those lesions and 3. Identify kidney and patient survival predictors. Methods: A retrospective, observational chart review of kidney biopsies performed, between January 2015 and February 2020, in three Portuguese Hospitals, to a total of 39 patients, with kidney lesions associated with monoclonal gammopathy, was undertaken. Results: The three main dysproteinemic kidney diseases identified were cast nephropathy, AL amyloidosis and Monoclonal Immunoglobulin Deposition Disease (MIDD), with different features among them. Only three patients fulfilled the criteria to Monoclonal Gammopathy of Renal Significance (MGRS). In regard to treatment, we verified that most of our patients were treated with chemotherapy. Unfortunately, only four recovered, either partially or completely. The mean kidney survival since kidney biopsy was 29,23 months and the mean patient survival since diagnosis was 24,46 months. Some clinical and pathologic features correlated to lowerkidney survival: acute tubular necrosis, cast nephropathy, Thrombotic Microangiopathy (TMA), haemoglobin and estimated Glomerular Filtration Rate (eGFR). Previous Nephrology follow-up correlated with higher kidney survival. Only eGFR was associated with lowerpatient survival.
{"title":"Dysproteinemia-Associated Kidney Diseases: Clinicopathological Correlations","authors":"M. Mm, H. Sousa, M. Góis, F. Nolasco, Costa Ll., E. Soares","doi":"10.26420/austinjnephrolhypertens.2021.1090","DOIUrl":"https://doi.org/10.26420/austinjnephrolhypertens.2021.1090","url":null,"abstract":"Introduction: Dysproteinemia-associated kidney diseases can have diverse clinical and histological presentation but not all patients with monoclonal gammopathy have Monoclonal Gammopathy of Renal Significance (MGRS) and some have other causes for kidney lesions. Therefore, kidney biopsy is essential to make this diagnosis. We made a retrospective study, which aimed to: 1. Identify dysproteinemiaassociated kidney lesions; 2. Establish clinicopathological correlations of patients with those lesions and 3. Identify kidney and patient survival predictors. Methods: A retrospective, observational chart review of kidney biopsies performed, between January 2015 and February 2020, in three Portuguese Hospitals, to a total of 39 patients, with kidney lesions associated with monoclonal gammopathy, was undertaken. Results: The three main dysproteinemic kidney diseases identified were cast nephropathy, AL amyloidosis and Monoclonal Immunoglobulin Deposition Disease (MIDD), with different features among them. Only three patients fulfilled the criteria to Monoclonal Gammopathy of Renal Significance (MGRS). In regard to treatment, we verified that most of our patients were treated with chemotherapy. Unfortunately, only four recovered, either partially or completely. The mean kidney survival since kidney biopsy was 29,23 months and the mean patient survival since diagnosis was 24,46 months. Some clinical and pathologic features correlated to lowerkidney survival: acute tubular necrosis, cast nephropathy, Thrombotic Microangiopathy (TMA), haemoglobin and estimated Glomerular Filtration Rate (eGFR). Previous Nephrology follow-up correlated with higher kidney survival. Only eGFR was associated with lowerpatient survival.","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45801235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-06DOI: 10.26420/austinjnephrolhypertens.2019.1079
Chippa Mv
Kidney injury associated with bisphosphonates is well known in literature, though it is more common with intravenous bisphosphonates. Case reports about focal segmental glomerulosclerosis are reported with oral and intravenous bisphosphonates. We present a case of 87-year-old female with acute renal failure and volume overload found to have minimal change disease on biopsy while on Alendronate for a period of four months. She has failed oral prednisone treatment and is now dependent on hemodialysis. This is probably the first case report of minimal change disease with oral bisphosphonates.
{"title":"Alendronate Associated Minimal Change Disease","authors":"Chippa Mv","doi":"10.26420/austinjnephrolhypertens.2019.1079","DOIUrl":"https://doi.org/10.26420/austinjnephrolhypertens.2019.1079","url":null,"abstract":"Kidney injury associated with bisphosphonates is well known in literature, though it is more common with intravenous bisphosphonates. Case reports about focal segmental glomerulosclerosis are reported with oral and intravenous bisphosphonates. We present a case of 87-year-old female with acute renal failure and volume overload found to have minimal change disease on biopsy while on Alendronate for a period of four months. She has failed oral prednisone treatment and is now dependent on hemodialysis. This is probably the first case report of minimal change disease with oral bisphosphonates.","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42654078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-18DOI: 10.26420/AUSTINJNEPHROLHYPERTENS.2019.1078
E. Habas
Background: Hemodialysis (HD) is a renal replacement modality that widely used in End Stage Renal Disease (ESRD) therapy. HD complications occur during HD, post-HD session, and at long term. Aim of the Study: To assess frequency of common complications that occur during HD-session. Method and Patients: Study planned to assess the complications happened during HD-session for 335 patients. All patients had been informed about study aim. All patients included had not any evidence of HBV, HCV or HIV infection. Patient had their weight, blood pressure, pulse, Random Blood Sugar (RBS) and body temperature before they sat on HD-bed. Regular checkup of vital signs every 30 minutes. Any change of these parameters were recorded. Other parameters as hypoglycemic feature, hypotension, rigor, hotness and others were noted. Statistical Analysis: After data collection and arrangement in Excel sheet of Microsoft Office version 16, frequency and average of the parameters are calculated by IBM-SPSS version 25 (SPSS, Chicago, IL, USA) statistical package. Results: Three hundred thirty-five patients enrolled. They were 132 females and 203 male patients, aged 31- 56 years (48 ± 5.2), and weight range was 51-76 Kg (66 ± 3.4). There were 156 patients; 46 hypertensive, 62 diabetics, and 48 diabetics and hypertensive. The rest were not hypertensive or diabetic. Vomiting reported in (61.8%) of patients; during 1 st hour, vomiting occurred in (40.9%) of patients. During 2 nd and at 3 rd hour of HD-session, patients had vomiting almost the same number during this time of HD session. Epigastric mostly three sessions per week. They were 132 females and 203 male patients (Figure 1). Their age average 48 ± 5.2 (sem) with a range of 31 to 56 years. Weight average was 66 Kg ± 3.4 with a range of 51-76 Kg. one hundred and six patients either hypertensive, diabetic or both diabetic and hypertensive (46, 62, 48 patients) respectively, 170 patients were not hypertensive or diabetic. All patients had 3 hours’ HD session with mean of inter-dialytic weight increase of 2.3 ± 5.4 Kg. A case sheet for every patient for 6 sessions were prepared for the studied complications and given to duty doctor and technician to Conclusion: Vomiting is the commonest complication and low RBS. Hotness and hypotension were not also uncommon. Early start of HD, better control of dialysate temperature, strict infection control, and regular vital signs on short time basis and using glucose containing dialysate solutions are major issues to minimize these acute HD complications.
背景:血液透析(HD)是一种广泛应用于终末期肾病(ESRD)治疗的肾脏替代方式。HD并发症发生在HD期间、HD后以及长期。研究目的:评估hd治疗期间常见并发症的发生频率。方法与患者:本研究拟对335例患者进行hd治疗期间的并发症评估。所有患者都被告知研究目的。所有纳入的患者没有任何HBV、HCV或HIV感染的证据。患者坐床前测量体重、血压、脉搏、随机血糖(RBS)和体温。每30分钟定期检查一次生命体征。记录这些参数的任何变化。其他参数如低血糖、低血压、严密性、体温等进行记录。统计分析:数据在Microsoft Office version 16的Excel表格中收集整理后，使用IBM-SPSS version 25 (SPSS, Chicago, IL, USA)统计软件包计算参数的频率和平均值。结果:纳入了335例患者。其中女性132例，男性203例，年龄31 ~ 56岁(48±5.2)，体重51 ~ 76 Kg(66±3.4)。共有156例患者;46例高血压，62例糖尿病，48例糖尿病合并高血压。其余的没有高血压或糖尿病。61.8%的患者出现呕吐;第1小时出现呕吐(40.9%)。在HD阶段的第2小时和第3小时，患者呕吐次数几乎相同。上腹部每周大约三次。其中女性132例，男性203例(图1)，年龄31 ~ 56岁，平均48±5.2岁(sem)。体重平均为66 Kg±3.4，范围为51-76 Kg。高血压、糖尿病或糖尿病合并高血压者分别为46例、62例、48例，非高血压、非糖尿病者170例。所有患者透析时间均为3小时，透析间期体重平均增加2.3±5.4 Kg。针对所研究的并发症，为每位患者准备了6个疗程的病例表，并交给值班医生和技术人员。结论:呕吐是最常见的并发症，RBS较低。发热和低血压也不罕见。早期开始HD，更好地控制透析液温度，严格控制感染，短时间内规律生命体征，使用含葡萄糖的透析液是减少这些急性HD并发症的主要问题。
{"title":"Common Complications during Hemodialysis Session; Single Central Experience","authors":"E. Habas","doi":"10.26420/AUSTINJNEPHROLHYPERTENS.2019.1078","DOIUrl":"https://doi.org/10.26420/AUSTINJNEPHROLHYPERTENS.2019.1078","url":null,"abstract":"Background: Hemodialysis (HD) is a renal replacement modality that widely used in End Stage Renal Disease (ESRD) therapy. HD complications occur during HD, post-HD session, and at long term. Aim of the Study: To assess frequency of common complications that occur during HD-session. Method and Patients: Study planned to assess the complications happened during HD-session for 335 patients. All patients had been informed about study aim. All patients included had not any evidence of HBV, HCV or HIV infection. Patient had their weight, blood pressure, pulse, Random Blood Sugar (RBS) and body temperature before they sat on HD-bed. Regular checkup of vital signs every 30 minutes. Any change of these parameters were recorded. Other parameters as hypoglycemic feature, hypotension, rigor, hotness and others were noted. Statistical Analysis: After data collection and arrangement in Excel sheet of Microsoft Office version 16, frequency and average of the parameters are calculated by IBM-SPSS version 25 (SPSS, Chicago, IL, USA) statistical package. Results: Three hundred thirty-five patients enrolled. They were 132 females and 203 male patients, aged 31- 56 years (48 ± 5.2), and weight range was 51-76 Kg (66 ± 3.4). There were 156 patients; 46 hypertensive, 62 diabetics, and 48 diabetics and hypertensive. The rest were not hypertensive or diabetic. Vomiting reported in (61.8%) of patients; during 1 st hour, vomiting occurred in (40.9%) of patients. During 2 nd and at 3 rd hour of HD-session, patients had vomiting almost the same number during this time of HD session. Epigastric mostly three sessions per week. They were 132 females and 203 male patients (Figure 1). Their age average 48 ± 5.2 (sem) with a range of 31 to 56 years. Weight average was 66 Kg ± 3.4 with a range of 51-76 Kg. one hundred and six patients either hypertensive, diabetic or both diabetic and hypertensive (46, 62, 48 patients) respectively, 170 patients were not hypertensive or diabetic. All patients had 3 hours’ HD session with mean of inter-dialytic weight increase of 2.3 ± 5.4 Kg. A case sheet for every patient for 6 sessions were prepared for the studied complications and given to duty doctor and technician to Conclusion: Vomiting is the commonest complication and low RBS. Hotness and hypotension were not also uncommon. Early start of HD, better control of dialysate temperature, strict infection control, and regular vital signs on short time basis and using glucose containing dialysate solutions are major issues to minimize these acute HD complications.","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46851665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-30DOI: 10.26420/AUSTINJNEPHROLHYPERTENS.2018.1077
R. Uo
Objective: To describe clinical and radiological oral manifestations in children with chronic renal failure on dialysis therapy and the relationship with disease, period of dialysis, and history of secondary hyperparathyroidism. Methods: A comparative study of 2 independent groups, including thirty- three children with chronic renal failure on dialysis (between 7-16 years old) and 33 children without chronic renal failure and with similar characteristics was conducted. Intraoral examinations, including a smear of oral mucosa and digital panoramic maxillary radiographs, were performed. Results: Among children with chronic renal failure, 16 (48.5%) had xerostomia, 18 (54.5%) had uremic breath, 16 (48.5%) showed changes in oral mucosa, 24 (72.7%) had regular oral hygiene with a low rate of dental caries, 20 (60.6%) had enamel hypoplasia, 25 (75.8%) tested positive for Candida hyphae, 5 (15.2%) had changes in the shape of the mandibular cortex, and 14 (42.4%) had signs of osteopenia in the jaws. Conclusion: We found significant differences between the groups with and without chronic renal failure for xerostomia, uremic breath, changes in oral mucosa, enamel hypoplasia, dental caries, mandibular cortical shape, and signs of osteopenia. Moreover, we observed significant relationships between several aforementioned findings and the period of kidney disease, duration of dialysis, and presence of osteodystrophy.
{"title":"Clinical and Radiographic Oral Manifestations in Pediatric Patients with Chronic Renal Failure on Dialysis Therapy","authors":"R. Uo","doi":"10.26420/AUSTINJNEPHROLHYPERTENS.2018.1077","DOIUrl":"https://doi.org/10.26420/AUSTINJNEPHROLHYPERTENS.2018.1077","url":null,"abstract":"Objective: To describe clinical and radiological oral manifestations in children with chronic renal failure on dialysis therapy and the relationship with disease, period of dialysis, and history of secondary hyperparathyroidism. Methods: A comparative study of 2 independent groups, including thirty- three children with chronic renal failure on dialysis (between 7-16 years old) and 33 children without chronic renal failure and with similar characteristics was conducted. Intraoral examinations, including a smear of oral mucosa and digital panoramic maxillary radiographs, were performed. Results: Among children with chronic renal failure, 16 (48.5%) had xerostomia, 18 (54.5%) had uremic breath, 16 (48.5%) showed changes in oral mucosa, 24 (72.7%) had regular oral hygiene with a low rate of dental caries, 20 (60.6%) had enamel hypoplasia, 25 (75.8%) tested positive for Candida hyphae, 5 (15.2%) had changes in the shape of the mandibular cortex, and 14 (42.4%) had signs of osteopenia in the jaws. Conclusion: We found significant differences between the groups with and without chronic renal failure for xerostomia, uremic breath, changes in oral mucosa, enamel hypoplasia, dental caries, mandibular cortical shape, and signs of osteopenia. Moreover, we observed significant relationships between several aforementioned findings and the period of kidney disease, duration of dialysis, and presence of osteodystrophy.","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43565357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Nishimoto, Benjamin T Duhart, Robert B Canada, D. Shoop, Joanna Q Hudson
Methods: In this single-center, retrospective study, adult hospitalized patients with end-stage renal disease requiring HD during a 2-year evaluation period were divided into IDH and non-IDH cohorts based on the occurrence of IDH during HD. AHT and nitrate use within twelve hours prior to each HD session was compared. The association between the development of IDH and serum albumin, pre-HD blood pressure, serum sodium, and ultrafiltration rate during HD was also evaluated.
{"title":"Antihypertensive use and risk of intradialytic hypotension in hospitalized end-stage renal disease patients","authors":"A. Nishimoto, Benjamin T Duhart, Robert B Canada, D. Shoop, Joanna Q Hudson","doi":"10.33582/2637-9619/1007","DOIUrl":"https://doi.org/10.33582/2637-9619/1007","url":null,"abstract":"Methods: In this single-center, retrospective study, adult hospitalized patients with end-stage renal disease requiring HD during a 2-year evaluation period were divided into IDH and non-IDH cohorts based on the occurrence of IDH during HD. AHT and nitrate use within twelve hours prior to each HD session was compared. The association between the development of IDH and serum albumin, pre-HD blood pressure, serum sodium, and ultrafiltration rate during HD was also evaluated.","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86248199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The albuminuria is the early evidence of glomerular filtration membrane damaged and increased permeability. Slit diaphragm is a most important part of selective filtration in the glomerulus. CD2 Associated Protein (CD2AP) is one of slit diaphragm molecules, which is associated with proteinuria. Continuous proteinuria increases the risk of cardiovascular event rate and mortality. Hence, we reviewed the potential signaling pathway and the molecular mechanism of CD2AP associated with proteinuria in glomerular disease. Journal of Nephrology and Hypertension
{"title":"Potential signaling pathway and molecular mechanism of CD2AP associated with proteinuria in glomerular disease","authors":"Hongzhen Zhong, Hongyan Li, Zhiqing Zhong, Tianbiao Zhou","doi":"10.33582/2637-9619/1006","DOIUrl":"https://doi.org/10.33582/2637-9619/1006","url":null,"abstract":"The albuminuria is the early evidence of glomerular filtration membrane damaged and increased permeability. Slit diaphragm is a most important part of selective filtration in the glomerulus. CD2 Associated Protein (CD2AP) is one of slit diaphragm molecules, which is associated with proteinuria. Continuous proteinuria increases the risk of cardiovascular event rate and mortality. Hence, we reviewed the potential signaling pathway and the molecular mechanism of CD2AP associated with proteinuria in glomerular disease. Journal of Nephrology and Hypertension","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86548411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is well known that kidney α-intercalated cells can acidify the urine and acidified urine can inhibit bacterial growth and other urinary organisms. However, regulation of acid-base balance rather than a dedicated function in preventing urinary tract infection has been assigned to α-intercalated cells. A series of studies, culminated by the publication of a paper (J Clin Invest. 2014 Jul 1;124(7):2963-76) from Dr. Barasch's lab unearthed a novel mechanism by which α-intercalated cells function in the innate immune defense of urinary tract infection. This mechanism involves production and release of neutrophil gelatinase-associated lipocalin by α-intercalated cells to chelate the siderophore containing host iron to achieve bacteriostasis.
{"title":"Kidney α-Intercalated Cells, NGAL and Urinary Tract Infection.","authors":"Lihe Chen, Wenzheng Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is well known that kidney α-intercalated cells can acidify the urine and acidified urine can inhibit bacterial growth and other urinary organisms. However, regulation of acid-base balance rather than a dedicated function in preventing urinary tract infection has been assigned to α-intercalated cells. A series of studies, culminated by the publication of a paper (J Clin Invest. 2014 Jul 1;124(7):2963-76) from Dr. Barasch's lab unearthed a novel mechanism by which α-intercalated cells function in the innate immune defense of urinary tract infection. This mechanism involves production and release of neutrophil gelatinase-associated lipocalin by α-intercalated cells to chelate the siderophore containing host iron to achieve bacteriostasis.</p>","PeriodicalId":91451,"journal":{"name":"Austin journal of nephrology and hypertension","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924622/pdf/nihms787463.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34691902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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