Pub Date : 2021-01-01DOI: 10.12974/2312-5411.2021.08.5
Ramnik Patel, R. Patel, Dhaval Govani, F. Anthony
{"title":"Successful Innovative Minimal Invasive Splenectomy in a Child with Combined Congenital Immunodeficiency and Acquired Pancytopenia Secondary to Hypersplenism","authors":"Ramnik Patel, R. Patel, Dhaval Govani, F. Anthony","doi":"10.12974/2312-5411.2021.08.5","DOIUrl":"https://doi.org/10.12974/2312-5411.2021.08.5","url":null,"abstract":"","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66337883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.12974/2312-5411.2021.08.6
Pamukçuoğlu Merve
{"title":"The Relationship between Conditioning Regimen with Viral and Fungal Infections in Allogeneic Hematopoietic Stem Cell Transplantation","authors":"Pamukçuoğlu Merve","doi":"10.12974/2312-5411.2021.08.6","DOIUrl":"https://doi.org/10.12974/2312-5411.2021.08.6","url":null,"abstract":"","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66337974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.12974/2312-5411.2020.07.5
N. A. Sheikh, S. Kosalge, T. R. Desai, A. Dewani, D. Mohale, A. Tripathi
{"title":"Evaluation of Beneficial Effects of Melilotus officinalis on Blood Profiles in iron Overloaded Sprague Dawley Rats","authors":"N. A. Sheikh, S. Kosalge, T. R. Desai, A. Dewani, D. Mohale, A. Tripathi","doi":"10.12974/2312-5411.2020.07.5","DOIUrl":"https://doi.org/10.12974/2312-5411.2020.07.5","url":null,"abstract":"","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43898731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-06DOI: 10.12974/2312-5411.2020.07.4
P. Malhotra, V. Malhotra, Y. Sanwariya, I. Pahuja, A. Chugh, Akshay
Background: There are limited number of studies providing information regarding the progression of acute hepatitis B virus (HBV) infection to chronic phase. Aim: To determine the percentage of patients of acute hepatitis B who progressed to chronic hepatitis B stage. Methods: It was a prospective study over a period of four years in which total 409 confirmed acute hepatitis B patients were enrolled but out of them only three hundred and four, (221 men and 83 women, 06–82 years old) were followed regularly for at least six months or more, thus data pertaining to them was analyzed. Results: Out of total of 304 acute hepatitis B patients, 279 patients resolved and became Hepatitis B surface antigen (HbsAg) and Hepatitis B virus DNA negative whereas 25 patients went into chronic phase. No differences were found between groups with respect to age and sex. However, Serum Bilirubin, Serum amino transaminases, HbeAg and HBV DNA Quantitative levels were significantly lower in patients who progressed to chronic hepatitis stage. Conclusions: Around 91.78% of acute hepatitis B patients resolved but 8.22% progressed to Chronic hepatitis B stage The twenty five patients who progressed to chronic infection had mild hepatitis on comparison to 279 patients who resolved, thus suggesting that patients with mild acute hepatitis B infection may have a higher risk of progressing to chronic infection.
{"title":"Acute Hepatitis B Progression to Chronicity - A Prospective Study at Tertiary Care Centre of Northeren India","authors":"P. Malhotra, V. Malhotra, Y. Sanwariya, I. Pahuja, A. Chugh, Akshay","doi":"10.12974/2312-5411.2020.07.4","DOIUrl":"https://doi.org/10.12974/2312-5411.2020.07.4","url":null,"abstract":"Background: There are limited number of studies providing information regarding the progression of acute hepatitis B virus (HBV) infection to chronic phase.\u0000Aim: To determine the percentage of patients of acute hepatitis B who progressed to chronic hepatitis B stage.\u0000Methods: It was a prospective study over a period of four years in which total 409 confirmed acute hepatitis B patients were enrolled but out of them only three hundred and four, (221 men and 83 women, 06–82 years old) were followed regularly for at least six months or more, thus data pertaining to them was analyzed.\u0000Results: Out of total of 304 acute hepatitis B patients, 279 patients resolved and became Hepatitis B surface antigen (HbsAg) and Hepatitis B virus DNA negative whereas 25 patients went into chronic phase. No differences were found between groups with respect to age and sex. However, Serum Bilirubin, Serum amino transaminases, HbeAg and HBV DNA Quantitative levels were significantly lower in patients who progressed to chronic hepatitis stage.\u0000Conclusions: Around 91.78% of acute hepatitis B patients resolved but 8.22% progressed to Chronic hepatitis B stage The twenty five patients who progressed to chronic infection had mild hepatitis on comparison to 279 patients who resolved, thus suggesting that patients with mild acute hepatitis B infection may have a higher risk of progressing to chronic infection. ","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49167247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-08DOI: 10.12974/2312-5411.2019.06.2
G. Cicero
Multiple myeloma is one of the most common hematologic malignancies. Bone marrow is typically involved and characterization of osseous lesions, in terms of number, size and localization, is necessary for disease staging and post-treatment assessment. Different imaging modalities can be performed in multiple myeloma evaluation, with a consequential number of information achievable. The aim of this work is to provide a general overview of multiple myeloma radiological findings detectable at X-ray, CT-scan and MRI, with relative advantages and drawbacks for each technique.
{"title":"Skeletal Involvement in Multiple Myeloma: The Radiological Point of View","authors":"G. Cicero","doi":"10.12974/2312-5411.2019.06.2","DOIUrl":"https://doi.org/10.12974/2312-5411.2019.06.2","url":null,"abstract":"Multiple myeloma is one of the most common hematologic malignancies.\u0000Bone marrow is typically involved and characterization of osseous lesions, in terms of number, size and localization, is necessary for disease staging and post-treatment assessment.\u0000Different imaging modalities can be performed in multiple myeloma evaluation, with a consequential number of information achievable.\u0000The aim of this work is to provide a general overview of multiple myeloma radiological findings detectable at X-ray, CT-scan and MRI, with relative advantages and drawbacks for each technique. ","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47858038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-08DOI: 10.12974/2312-5411.2019.06.1
K. Satué, A. Muñoz
Genetic diseases that affect blood cells and clotting factors in the horse are uncommon. Unfortunately, the prognosis is reserved, because the treatment in many cases is only symptomatic and when it fails, euthanasia of the patient is the only viable option. The detection of carriers is of pivotal importance in order to prevent the spread of these disorders in the equine population. This manuscript reviews the current state of knowledge of genetic diseases that affect red blood cells, leukocytes, platelets and clotting factors in the horse. The genetic diseases that affect equine red blood cells are defects in the activity of enzymes and cofactors involved in erythrocytes metabolism, such as glucose 6 phosphate dehydrogenase, flavin adenine dinucleotide, glutathione reductase and glutathione. Therefore, their deficiency triggers methemoglobinemia and hemolytic anemia. Genetic disorders affecting granulocytes are rare in horses, but a Pelget-Hüet anomaly has been reported. Primary immunodeficiencies described in horses and arising from defects in the immune system are severe combined immunodeficiency, X-linked agammaglobulinemia and Fell pony immunodeficiency syndrome. Because of the immunodeficiency, foals usually develop fatal infections during the first weeks or months of life, caused for opportunistic organisms. Prognosis of these animals is poor. The most common genetic defect of platelet is Glanzmann thrombasthenia, which results in prolonged bleeding time and hematoma formation. Spontaneous bleeding or impaired hemostasis after trauma or surgery are clinical findings in types 1 and 2 von Willebrand disease. Hemophilia A, resulting from a decreased activity of coagulation factor VIII has also been described in male horses of different breeds, being the most common genetic disorder affecting coagulation factor in the horse. Prekallikrein deficit, although described in some horses, is a rare genetic coagulation factor deficiency.
{"title":"Genetic Disorders Affecting Equine Blood Cells and Coagulation Factors: A-State-of-The-Art Review","authors":"K. Satué, A. Muñoz","doi":"10.12974/2312-5411.2019.06.1","DOIUrl":"https://doi.org/10.12974/2312-5411.2019.06.1","url":null,"abstract":"Genetic diseases that affect blood cells and clotting factors in the horse are uncommon. Unfortunately, the prognosis is reserved, because the treatment in many cases is only symptomatic and when it fails, euthanasia of the patient is the only viable option. The detection of carriers is of pivotal importance in order to prevent the spread of these disorders in the equine population. This manuscript reviews the current state of knowledge of genetic diseases that affect red blood cells, leukocytes, platelets and clotting factors in the horse.\u0000The genetic diseases that affect equine red blood cells are defects in the activity of enzymes and cofactors involved in erythrocytes metabolism, such as glucose 6 phosphate dehydrogenase, flavin adenine dinucleotide, glutathione reductase and glutathione. Therefore, their deficiency triggers methemoglobinemia and hemolytic anemia. Genetic disorders affecting granulocytes are rare in horses, but a Pelget-Hüet anomaly has been reported. Primary immunodeficiencies described in horses and arising from defects in the immune system are severe combined immunodeficiency, X-linked agammaglobulinemia and Fell pony immunodeficiency syndrome. Because of the immunodeficiency, foals usually develop fatal infections during the first weeks or months of life, caused for opportunistic organisms. Prognosis of these animals is poor. The most common genetic defect of platelet is Glanzmann thrombasthenia, which results in prolonged bleeding time and hematoma formation. Spontaneous bleeding or impaired hemostasis after trauma or surgery are clinical findings in types 1 and 2 von Willebrand disease. Hemophilia A, resulting from a decreased activity of coagulation factor VIII has also been described in male horses of different breeds, being the most common genetic disorder affecting coagulation factor in the horse. Prekallikrein deficit, although described in some horses, is a rare genetic coagulation factor deficiency. ","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45546798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-08DOI: 10.12974/2312-5411.2019.06.3
D. Diallo, Mohamed Ag Baraïka, A. Guindo, I. Kéita, R. Charrel, M. Coulibaly, M. Kanta, Assétou Traoré, Y. Sarro, B. A. Touré, O. Tessougué, P. Guindo, Y. Badiaga, A. K. Dembélé, Drissa Diabaté, D. Raoult
The burden of severe bacterial and malaria infections in children with SCD has been reduced through the use of prophylactic antibiotics and chemoprevention with Sulfadoxine-pyrimethamine. However, such therapies have the potential to promote bacterial and parasitic resistance. To our knowledge, no study has been conducted to determine whether systematic use of prophylactic antimicrobials in children with SCD has an impact on resistance patterns in sub-Saharan Africa. The aim of our study was to determine the incidence and the outcome of severe bacterial and P. falciparum infections in this context. 231 children with SCD and new onset fever associated with either acute pneumonia, urinary tract infection, cholecystitis, meningitis, acute osteomyelitis, or P. falciparum infections were entered into the study. The children in the cohort were an average age of 93 months (± 44 months) and were all followed in a referral center in Western Africa. The 231 children represented 36.67% of the patients regularly followed in the center during the study period and included 183 SS, 26 SC, 12 S?°thal, 10 S?+thal. There were 144 boys and 87 girls in the cohort. The incidence of severe bacterial and Plasmodium falciparum infections were lower than those reported in the general pediatric or sickle cell population in the absence of regular follow-up (ie 5.2, 1.4, 1.0 and, 4.1 per 1000 person/month for urinary tract infections, acute pneumonia, bacteremia and P. falciparum malaria respectively). We observed bacterial strains to be mainly in the Enterobacteria family with high levels of antibiotic resistance. No cases of Streptococcus pneumoniae bacteremia were found. Sulfadoxine-pyrimethamine resistance was observed at high levels. In light of these findings, prophylactic antibiotherapy and antimalarial chemoprevention guidelines in sickle-cell children should be revisited in the context of organized SCD care in sub-Saharan Africa.
{"title":"Severe Bacterial and Plasmodium Falciparum Infections in Febrile Children with Sickle Cell Disease Receiving Organized Specialty Care in a Referral Center in Sub-Saharan Africa: lessons for Clinical Practice","authors":"D. Diallo, Mohamed Ag Baraïka, A. Guindo, I. Kéita, R. Charrel, M. Coulibaly, M. Kanta, Assétou Traoré, Y. Sarro, B. A. Touré, O. Tessougué, P. Guindo, Y. Badiaga, A. K. Dembélé, Drissa Diabaté, D. Raoult","doi":"10.12974/2312-5411.2019.06.3","DOIUrl":"https://doi.org/10.12974/2312-5411.2019.06.3","url":null,"abstract":"The burden of severe bacterial and malaria infections in children with SCD has been reduced through the use of prophylactic antibiotics and chemoprevention with Sulfadoxine-pyrimethamine. However, such therapies have the potential to promote bacterial and parasitic resistance. To our knowledge, no study has been conducted to determine whether systematic use of prophylactic antimicrobials in children with SCD has an impact on resistance patterns in sub-Saharan Africa. The aim of our study was to determine the incidence and the outcome of severe bacterial and P. falciparum infections in this context. 231 children with SCD and new onset fever associated with either acute pneumonia, urinary tract infection, cholecystitis, meningitis, acute osteomyelitis, or P. falciparum infections were entered into the study. The children in the cohort were an average age of 93 months (± 44 months) and were all followed in a referral center in Western Africa. The 231 children represented 36.67% of the patients regularly followed in the center during the study period and included 183 SS, 26 SC, 12 S?°thal, 10 S?+thal. There were 144 boys and 87 girls in the cohort. The incidence of severe bacterial and Plasmodium falciparum infections were lower than those reported in the general pediatric or sickle cell population in the absence of regular follow-up (ie 5.2, 1.4, 1.0 and, 4.1 per 1000 person/month for urinary tract infections, acute pneumonia, bacteremia and P. falciparum malaria respectively). We observed bacterial strains to be mainly in the Enterobacteria family with high levels of antibiotic resistance. No cases of Streptococcus pneumoniae bacteremia were found. Sulfadoxine-pyrimethamine resistance was observed at high levels. In light of these findings, prophylactic antibiotherapy and antimalarial chemoprevention guidelines in sickle-cell children should be revisited in the context of organized SCD care in sub-Saharan Africa. ","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46019711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-23DOI: 10.12974/2312-5411.2018.05.1
G. Elpek
{"title":"Inflammatory Pseudotumor of the Spleen in a Patient with Idiopathic Thrombocytopenic Purpura","authors":"G. Elpek","doi":"10.12974/2312-5411.2018.05.1","DOIUrl":"https://doi.org/10.12974/2312-5411.2018.05.1","url":null,"abstract":"","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43906251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-27DOI: 10.12974/2312-5411.2017.04.5
V. Malhotra, P. Malhotra, Vandana Bhuriya, I. Pahuja, S. Nanda, M. Chauhan, N. Sangwan
Objectives: To investigate the Seroprevalence of hepatitis B surface antigen in pregnant women and managing chronic HBV infection in pregnant women for preventing mother to child transmission. Methods: Fifteen thousand pregnant women were evaluated using history, examination and test for serum HbsAg and who were found to be HbsAg positive underwent liver function tests, HbeAg and HBV DNA analysis by Polymerase Chain Reaction (PCR). Results: out of fifteen thousand (15000) women, 52 women tested positive for HbsAg. Of these, 8(15.38%) presented with acute hepatitis and 44(84.6%) were asymptomatic carriers. The highest HbsAg positivity was seen in age group of 20-25 years and maximum women were multiparous (67.23%). Assessment of risk factors revealed history of tattooing in 22 women (42.3%). Out of 52 women, 12 patients tested positive for HbeAg and their DNA tires were more than one Lakh copies/ml. Forty six women(88.4%) delivered vaginally and rest 6(11.5%) underwent cesarean section which was mainly done for obstetric indications. All the babies born received immunoglobulin and first dose of HBV vaccine within 12 hours of birth. Conclusion: Seroprevalence of HbsAg in antenatal women was found to be 0.34%.
{"title":"Hepatitis B Infection in Pregnancy-Experience at a Tertiary Care Centre of North India","authors":"V. Malhotra, P. Malhotra, Vandana Bhuriya, I. Pahuja, S. Nanda, M. Chauhan, N. Sangwan","doi":"10.12974/2312-5411.2017.04.5","DOIUrl":"https://doi.org/10.12974/2312-5411.2017.04.5","url":null,"abstract":"Objectives: To investigate the Seroprevalence of hepatitis B surface antigen in pregnant women and managing chronic HBV infection in pregnant women for preventing mother to child transmission.\u0000Methods: Fifteen thousand pregnant women were evaluated using history, examination and test for serum HbsAg and who were found to be HbsAg positive underwent liver function tests, HbeAg and HBV DNA analysis by Polymerase Chain Reaction (PCR).\u0000Results: out of fifteen thousand (15000) women, 52 women tested positive for HbsAg. Of these, 8(15.38%) presented with acute hepatitis and 44(84.6%) were asymptomatic carriers. The highest HbsAg positivity was seen in age group of 20-25 years and maximum women were multiparous (67.23%). Assessment of risk factors revealed history of tattooing in 22 women (42.3%). Out of 52 women, 12 patients tested positive for HbeAg and their DNA tires were more than one Lakh copies/ml. Forty six women(88.4%) delivered vaginally and rest 6(11.5%) underwent cesarean section which was mainly done for obstetric indications. All the babies born received immunoglobulin and first dose of HBV vaccine within 12 hours of birth.\u0000Conclusion: Seroprevalence of HbsAg in antenatal women was found to be 0.34%. ","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43373227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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