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Mineralocorticoid Receptor Antagonists for Recurrent Hypertensive Emergency due to Bilateral Renal Artery Stenosis 矿物质皮质激素受体拮抗剂治疗双侧肾动脉狭窄导致的复发性高血压急症
Pub Date : 2023-12-31 DOI: 10.23937/2474-3690/1510076
Hayes Michael, Sexton Donal J
Introduction: Bilateral renal artery stenosis (RAS) causing recurrent hypertensive emergency and pulmonary oedema is difficult to manage. Use of angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) is usually contraindicated. We present a systematic review of literature and a case vignette which highlights the useful properties of mineralocorticoid receptor antagonists (MRAs) in this scenario. Methods: Medline, EMBASE, and the Cochrane Central Register of Controlled Trials were searched. Online searches were also conducted. Eligible studies involved the use of MRAs in bilateral RAS. Our search included case reports, case series, case-controls, cohort studies, randomised controlled trials, and systematic reviews. Consensus guidelines on the management of bilateral RAS were also included. Results: 354 abstracts were screened. One case report was included for review. This reported successful use of eplerenone in bilateral RAS following unilateral renal artery stenting. Online search yielded one international guideline for inclusion. This did not mention the use of MRAs in bilateral RAS. Discussion and conclusion: There is no evidence or recommendations from controlled trials, cohort studies, or consensus guidelines to inform clinicians on the use of MRAs in bilateral RAS. One case report describes successful use of eplerenone for management of refractory hypertension secondary to bilateral RAS. We describe our experience of the successful addition of spironolactone to an anti-hypertensive regimen which prevented recurrence of hypertensive emergency and pulmonary oedema in a patient with multiple previous hospital admissions. We feel that MRAs offer an effective and relatively safe but underused option in this condition.
简介导致复发性高血压急症和肺水肿的双侧肾动脉狭窄(RAS)很难处理。通常禁用血管紧张素转换酶抑制剂(ACEi)和血管紧张素 II 受体阻滞剂(ARB)。我们对文献进行了系统回顾,并通过一则病例强调了矿物皮质激素受体拮抗剂(MRA)在这种情况下的有用特性。研究方法检索了 Medline、EMBASE 和 Cochrane Central Register of Controlled Trials。此外还进行了在线搜索。符合条件的研究涉及在双侧 RAS 中使用 MRA。我们的检索包括病例报告、系列病例、病例对照、队列研究、随机对照试验和系统综述。此外还包括有关双侧 RAS 管理的共识指南。结果:共筛选出 354 篇摘要。一份病例报告被纳入审查范围。该报告称在单侧肾动脉支架术后成功使用依普利酮治疗双侧 RAS。在线搜索得到一份国际指南供纳入。该指南并未提及在双侧 RAS 中使用 MRA。讨论与结论:目前还没有来自对照试验、队列研究或共识指南的证据或建议来指导临床医生在双侧 RAS 中使用 MRA。一份病例报告描述了成功使用依普利酮治疗继发于双侧 RAS 的难治性高血压。我们介绍了在抗高血压治疗方案中添加螺内酯的成功经验,该方案防止了一名曾多次入院的患者再次出现高血压急症和肺水肿。我们认为,在这种情况下,MRA 是一种有效且相对安全的选择,但却未得到充分利用。
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引用次数: 0
The Increasing Burden of Hypertension in Cameroon: Considerations for Prevention and Non-Pharmacological Interventions 喀麦隆日益沉重的高血压负担:预防和非药物干预的考虑因素
Pub Date : 2023-12-31 DOI: 10.23937/2474-3690/1510077
Ngeh Etienne Ngeh
Hypertension is an emerging health concern in Cameroon that is expected to cause a heavy health burden in the future. Prevention and management with non-pharmacological interventions are feasible and effective. This article highlights the benefits, and challenges of implementing non-pharmacological interventions in Cameroon and proposes strategies to improve the situation
高血压是喀麦隆新出现的健康问题,预计未来将造成沉重的健康负担。采用非药物干预措施进行预防和管理是可行且有效的。本文强调了在喀麦隆实施非药物干预措施的益处和挑战,并提出了改善这一状况的策略。
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引用次数: 0
Smoking May Not Have a Long Term Effect on Body Weight 吸烟可能对体重没有长期影响
Pub Date : 2023-06-30 DOI: 10.23937/2474-3690/1510074
Helvaci Mehmet Rami, Kaya Yasemin, Yalcin Atilla, Muftuoglu Orhan Ekrem, Abyad Abdulrazak, Pocock Lesley
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引用次数: 0
Beyond Pills: Exploring Effective Ways to Tackle Hypertension through Non-Pharmacological Means 超越药片:探索通过非药物手段治疗高血压的有效方法
Pub Date : 2023-06-30 DOI: 10.23937/2474-3690/1510075
Harrisingh Kamahl, Gursky Paul, Himed Khaled, Shoreibah Ahmed
Hypertension (HTN) is a systemic disease characterized by the force of pressure within the arterial vessels. HTN is a modifiable risk factor for multiple health outcomes, including cardiovascular disease and stroke, which have substantial impact on an individual's quality of life and the healthcare system as a whole. Accumulating evidence suggests lifestyle interventions can play an important role in the reduction of blood pressure and in some cases may obviate the need for pharmacotherapy. Interventions which show the most promise include dietary modification, weight loss
高血压(HTN)是一种系统性疾病,其特征是动脉血管内的压力。HTN是多种健康结果的一个可改变的风险因素,包括心血管疾病和中风,这些疾病对个人的生活质量和整个医疗系统都有重大影响。越来越多的证据表明,生活方式干预可以在降低血压方面发挥重要作用,在某些情况下可以消除药物治疗的必要性。最有希望的干预措施包括改变饮食、减肥
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引用次数: 0
Electronic Diary Monitoring for Hypertension Post Stroke 脑卒中后高血压的电子日记监测
Pub Date : 2023-06-30 DOI: 10.23937/2474-3690/1510073
Levine Minna, Buonanno Ferdinando, Calvanio Ronald, G. Richard, Jacobson Jared, MingMing Ning
Background: We tried to understand whether or not there is a long term effect of smoking on the body weight. Method: Consecutive daily smokers at least with a history of one pack-year and age and sex-matched non-smokers were studied. Results: The study included 247 smokers (173 males) and 167 non-smokers (112 males). The mean age of smokers was 46.2 years, and 70.0% of them were males. Plasma triglycerides (163.1 versus 151.3 mg/dL, p < 0.05), low density lipoproteins (LDL) (123.8 versus 117.5 mg/dL, p < 0.05), erythrocyte sedimentation rate (ESR) (10.6 versus 9.3 mm/h, p < 0.05), and C-reactive protein (CRP) (2.3 versus 2.0 mg/L, p < 0.05) were higher in the smokers. Whereas high density lipoproteins (HDL) (40.9 versus 44.0 mg/dL, p < 0.05) and fasting plasma glucose (FPG) (102.3 versus 111.6 mg/dL, p = 0.007) values and prevalence of diabetes mellitus (8.9% versus 14.3%, p < 0.05) were lower in the smokers. Interestingly, the body weight (76.1 versus 74.7 kg) and body mass index (BMI) (26.6 versus 26.5 kg/ m 2 ) were higher in the smokers, nonsignificantly ( p > 0.05 for both). Smokers had a mean history of 20.5 ± 15.0 (1-100) pack years. Conclusion: Smoking may cause a low-grade systemic inflammation on vascular endothelium terminating with an accelerated atherosclerosis-induced end-organ insufficiencies all over the body. Plasma triglycerides, LDL, ESR, and CRP may be positive whereas HDL and FPG negative acute phase reactants indicating such inflammatory effects in the body. Probably due to the low-grade nature of inflammation caused by smoking, the body weight and BMI were not suppressed in the smokers in long term.
背景:我们试图了解吸烟是否会对体重产生长期影响。方法:研究至少有一包烟病史的连续每日吸烟者,年龄和性别匹配的非吸烟者。结果:该研究包括247名吸烟者(173名男性)和167名非吸烟者(112名男性)。吸烟者的平均年龄为46.2岁,其中男性占70.0%。吸烟者的血浆甘油三酯(163.1对151.3 mg/dL,p<0.05)、低密度脂蛋白(123.8对117.5 mg/dL)、血沉(10.6对9.3 mm/h,p<0.05)和C反应蛋白(2.3对2.0 mg/L,p<0.05)较高。而高密度脂蛋白(HDL)(40.9对44.0 mg/dL,p<0.05)和空腹血糖(FPG)(102.3对111.6 mg/dL)值和糖尿病患病率(8.9%对14.3%,p<0.05)在吸烟者中较低。有趣的是,吸烟者的体重(76.1对74.7 kg)和体重指数(BMI)(26.6对26.5 kg/m2)较高,但无统计学意义(两者均p>0.05)。吸烟者的平均吸烟史为20.5±15.0(1-100)包年。结论:吸烟可能导致血管内皮的低度全身炎症,最终导致全身动脉粥样硬化诱导的末端器官不足。血浆甘油三酯、低密度脂蛋白、ESR和CRP可能呈阳性,而高密度脂蛋白和FPG呈阴性的急性期反应物表明体内存在这种炎症作用。可能是由于吸烟引起的炎症的低度性质,吸烟者的体重和BMI在长期内没有受到抑制。
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引用次数: 0
Isolated Systolic Hypertension in Young Patients 年轻患者的孤立性收缩性高血压
Pub Date : 2022-12-31 DOI: 10.23937/2474-3690/1510070
J. Minetto
Citation: Julian M (2022) Isolated Systolic Hypertension in Young Patients. J Hypertens Manag 8:070. doi.org/10.23937/2474-3690/1510070 Accepted: September 29, 2022: Published: October 01, 2022 Copyright: © 2022 Julian M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
引文:Julian M(2022)《年轻患者的孤立性收缩性高血压》。高血压管理杂志8:070。doi.org/10.23937/2474-3690/1110070接受时间:2022年9月29日:发布时间:2022月1日版权所有:©2022 Julian M.这是一篇根据知识共享署名许可证条款分发的开放获取文章,该许可证允许在任何媒体上不受限制地使用、分发和复制,前提是原作者和来源可信。
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引用次数: 0
Association of Blood Pressure, Anthropometric Indices and Blood Group among Hypertensive Patients at Health centers in Addis Ababa Ethiopia 埃塞俄比亚亚的斯亚贝巴保健中心高血压患者血压、人体测量指数和血型的关系
Pub Date : 2022-12-31 DOI: 10.23937/2474-3690/1510072
Oumer Fetiya, Tolossa Tesfaye, Aragaw Abebaye
Background: Uncontrolled BP is a major health problem both in developed and developing countries. Life style, behavioral or genetic factors are some of the risk factors for uncontrolled BP. There are many researches have done on the risk factors for hypertension. However, there is no research done on the association between blood pressure, anthropometric indices and blood group among hypertensive patients in health centers in Addis Ababa, Ethiopia. The aim of this study was therefore, to assess the association between blood pressure, anthropometric indices and blood group among hypertensive patients. Materials and methods: A facility-based quantitative cross-sectional study was carried out among 235 hypertensive patients in health centers in Addis Ababa, Ethiopia. Structured questionnaires, anthropometric measurements and laboratory analysis were used to collect the data. The data were analyzed by using SPSS version 25 software. The binary and multiple logistic regression analysis were used. Result: In more than half, 142 (60.4%) of the hypertensive patients, the blood pressure was not controlled. “O” blood type was found to be the most common blood group accounting for 100 (42.6%), followed by “A” 66(28%), “B” 58(24.7%) and “AB” (4.7%). Physical inactivity (AOR = 2.47, 95% CI (1.10, 5.52), P = 0.027), salt intake (AOR = 2.22, 95% CI (1.03, 4.8), P = 0.043), BMI (AOR = 7.79, 95% CI (3.54, 17.13), P = 0.000), high waist circumference (AOR = 3.18, 95% CI (1.19, 8.47), P = 0.021), High Hip (AOR = 5.1, 95% CI (1.2, 21.25), P = 0.025), and “O” blood group (AOR = 2.46, 95% CI (1.0, 5.62), P = 0.026) were significantly associated with uncontrolled blood pressure. Conclusion: More than half of the hypertensive patients’ BP was not controlled. Significant associations were found between BP and salt intake, physical inactivity, BMI, WC, HC and blood group. HC and WC indices should be used routinely as a monitoring method of uncontrolled blood pressure in addition to BMI.
背景:无论在发达国家还是发展中国家,不受控制的BP都是一个主要的健康问题。生活方式、行为或遗传因素是血压失控的一些危险因素。关于高血压的危险因素已经做了很多研究。然而,埃塞俄比亚亚的斯亚贝巴保健中心高血压患者的血压、人体测量指标和血型之间的关系尚无相关研究。因此,本研究的目的是评估高血压患者血压、人体测量指标和血型之间的关系。材料和方法:在埃塞俄比亚亚的斯亚贝巴的卫生中心对235名高血压患者进行了一项基于设施的定量横断面研究。采用结构化问卷调查、人体测量和实验室分析来收集数据。采用SPSS 25软件对数据进行分析。采用二元和多元logistic回归分析。结果:142例(60.4%)高血压患者血压未得到控制。O型血是最常见的血型,占100人(42.6%),其次是A型66人(28%),B型58人(24.7%),AB型占4.7%。缺乏身体活动(AOR = 2.47, 95% CI (1.10, 5.52), P = 0.027),盐的摄入量(优势比= 2.22,95% CI (1.03, 4.8), P = 0.043), BMI(优势比= 7.79,95% CI (3.54, 17.13), P = 0.000),高腰围(优势比= 3.18,95% CI (1.19, 8.47), P = 0.021),高臀部(优势比= 5.1,95% CI (1.2, 21.25), P = 0.025),和“O”血型(优势比= 2.46,95% CI (1.0, 5.62), P = 0.026)和控制血压显著相关。结论:半数以上高血压患者血压未得到控制。血压与盐摄入量、缺乏运动、BMI、WC、HC和血型之间存在显著相关性。除BMI外,HC和WC指标应作为血压不控制的常规监测方法。
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引用次数: 0
Assessment of an Ambulatory Blood Pressure Monitoring Protocol in an Academic Outpatient Clinic 学术门诊门诊动态血压监测方案评估
Pub Date : 2022-06-30 DOI: 10.23937/2474-3690/1510069
Zeng Yvette, C. Les, Sbar Evelyn, Lewis Beverly, Young Rodney B, MacLaughlin Eric
Purpose: To evaluate the initial implementation effectiveness of an ambulatory blood pressure monitoring (ABPM) protocol based on provider perception through survey and assesses its fidelity, adoption, and impact in an academic outpatient clinic. Methods: A prospective study was conducted. A protocol was created to implement an ABPM device for use in patients who qualified in the clinic. Providers and staff were educated on the workflow steps and the importance of utilizing ABPM to detect and manage hypertension (HTN). Surveys were distributed before implementation of the protocol and two months after the initial implementation date. The primary outcome was a change in the composite provider survey score. Results: Thirty-two pre-surveys and 13 post-surveys were collected. The majority of pre-survey and post-survey responses were completed by post-graduate year three resident physicians (28% vs. 36% respectively). Eightyfive percent and 92% of providers had zero to five years of experience for pre-survey and post-survey responses, respectively. Following the ABPM protocol implementation, the composite provider score increased from a pre-survey score of 25 to a post-survey score of 32 (p = 0.0024). Conclusion: Education is a critical component in creating a new service, and the support of all clinic providers and the staff was vital in a successful implementation. With proper dissemination and education, provider perception of ABPM was positive, and the tool’s interest grew.
目的:通过调查评估基于供方感知的动态血压监测(ABPM)方案的初步实施效果,并评估其在学术门诊的保真度、采用率和影响。方法:采用前瞻性研究。制定了一项协议,以实施ABPM设备,供临床合格的患者使用。对提供者和工作人员进行了工作流程步骤和利用ABPM检测和管理高血压(HTN)的重要性的教育。调查是在议定书实施前和最初实施日期后两个月分发的。主要结果是综合提供者调查得分的变化。结果:共收集前期调查32份,后期调查13份。大多数调查前和调查后的回答是由研究生三年级住院医师完成的(分别为28%和36%)。在调查前和调查后的回应中,分别有85%和92%的提供者有0到5年的经验。在ABPM协议实施之后,综合提供者得分从调查前的25分增加到调查后的32分(p = 0.0024)。结论:教育是创建新服务的关键组成部分,所有诊所提供者和工作人员的支持对成功实施至关重要。通过适当的宣传和教育,提供者对ABPM的看法是积极的,对该工具的兴趣也在增加。
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引用次数: 0
Caffeine Elevates Blood Pressure 咖啡因会升高血压
Pub Date : 2022-03-31 DOI: 10.23937/2474-3690/1510067
Ambrosini Maria Teresa
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引用次数: 0
Effects of a Four-Week Isometric Exercise Training on Blood Pressure of Hypertensive Stroke Survivors in a Tertiary Health Institution 在三级医疗机构进行为期四周的等长运动训练对高血压卒中幸存者血压的影响
Pub Date : 2022-03-13 DOI: 10.23937/2474-3690/1510066
Okwudili Obaseki Chigozie, Samuel Adodo M, Sunday Ede Stephen, Agbonlahor Elvis I
Background: Little is known about the potency of isometric exercise for blood pressure control among hypertensive stroke survivors (HSS). Meanwhile, the isometric exercise regimen stands to be a preferable intervention for at-risk subjects even at acute phases as it could be carried out at a resting position compared to aerobic and resistance exercise regimens. Objective: This study investigated the acute effect of isometric exercise training protocol on blood pressure of hypertensive stroke survivors in the University of Benin Teaching Hospital, Benin city. Methods: This study adopted the experimental research design. The sample size of 12-hypertensive stroke survivors from the neurology outpatient clinic of the University of Benin Teaching Hospital was randomly selected from amongst the hypertensive stroke survivors who met the inclusion criteria. The participants were further randomly allotted to the experimental and control groups. The instruments employed include several measuring and timing equipment. The trial proceeded for four weeks during which a combination of unilateral isometric handgrip and unilateral isometric quadriceps exercise training was administered on the experimental group in two sessions per week. Results: Findings revealed there was no significant difference in the effect of isometric exercise training on systolic blood pressure but there was a significant difference in diastolic blood pressure parameters taken from both the right and left sides of the brachial arteries. Conclusion: The acute responses of this study support the clinical significance of isometric exercise training as a time-efficient, valuable new therapeutic adjunct, and effective training modality to reduce blood pressure and thereby assist in regulating and preventing a recurrent stroke in hypertensive stroke survivors. To confirm this, an expanded study in terms of duration was suggested to investigate the adaptation of this study.
背景:在高血压卒中幸存者(HSS)中,关于等长运动对血压控制的效力知之甚少。与此同时,与有氧和阻力运动方案相比,等长运动方案可以在静止位置进行,因此即使在急性期,也可以成为高危受试者的首选干预措施。目的:研究在贝宁市贝宁大学教学医院进行的等长运动训练方案对高血压脑卒中幸存者血压的急性影响。方法:本研究采用实验研究设计。本研究从符合纳入标准的高血压脑卒中幸存者中随机抽取12例来自贝宁大学教学医院神经内科门诊的高血压脑卒中幸存者。参与者进一步被随机分配到实验组和对照组。所使用的仪器包括几个测量和定时设备。试验进行了四周,在此期间,实验组每周进行两次单侧等距握力和单侧等距股四头肌运动训练的组合。结果:研究结果显示,等长运动训练对收缩压的影响无显著性差异,但左、右肱动脉舒张压参数有显著性差异。结论:本研究的急性反应支持了等长运动训练作为一种高效、有价值的新型治疗辅助手段的临床意义,它是一种有效的训练方式,可以降低高血压卒中幸存者的血压,从而帮助调节和预防卒中复发。为了证实这一点,建议在持续时间方面进行扩展研究,以调查本研究的适应性。
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引用次数: 1
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Journal of hypertension and management
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