首页 > 最新文献

Biomedica最新文献

英文 中文
Pulmonary and central nervous system nocardiosis: Alcoholism as an immunocompromising factor 肺和中枢神经系统诺卡病:酒精中毒作为免疫损害因素
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-03-30 DOI: 10.7705/biomedica.6606
Adriana Isabel Márquez, Eduardo Mora, Andrés Felipe Bernal, Andrés Felipe Salazar, Diana Patricia Mora, Ledmar Jovanny Vargas

Nocardiosis is a disease with worldwide distribution. It is usually found in tropical areas and mainly affects immunocompromised patients, however, there are also cases where its infection has been reported in immunocompetent patients. This pathology is caused by bacteria known as Nocardia spp., which are gram-positive microorganisms and environmental saprophytes, and although exposure to Nocardia spp. is almost universal, only a small fraction of exposed people develops the disease.We present the case of a 47-year-old man, with no evidence of immunosuppression, from a rural area of Boyacá, who was admitted due to intense and intermittent headache accompanied by paresthesia and, finally, a decrease in consciousness. A brain magnetic resonance was performed and evidenced a fronto-temporo- occipital space-occupying lesion in the cortico-subcortical region with a compressive effect and displacement of the ventricular system cavities. It was suspected at first a neoplastic lesion or a brain abscess.The lesion was surgically resected, and its culture showed Nocardia africana/nova. In later studies a possible primary pulmonary focus was evidenced. Alcoholism was the only risk factor documented. The patient completed 6 weeks of hospital antibiotic treatment with favorable clinical and radiological evolution and was discharged with a 1-year plan of outpatient antibiotic therapy. Although Nocardia spp. mainly affects immunocompromised patients, evidence shows that this microorganism can also be a threat to individuals without traditional immunosuppression risk factors.

诺卡菌病是一种全球分布的疾病。它通常在热带地区发现,主要影响免疫功能低下的患者,然而,也有在免疫功能正常的患者中报告感染的病例。这种病理是由诺卡菌属细菌引起的,诺卡菌属细菌是革兰氏阳性微生物和环境腐生菌,尽管诺卡菌属细菌的暴露几乎是普遍存在的,但只有一小部分暴露者会患上这种疾病。我们报告一例47岁男性患者,无免疫抑制证据,来自boyac农村地区,因强烈和间歇性头痛伴有感觉异常,最后意识下降而入院。进行脑磁共振检查,发现皮质-皮质下区出现额-颞-枕占位性病变,伴有心室系统腔的压缩作用和移位。起初怀疑是肿瘤病变或脑脓肿。病变手术切除,其培养显示非洲诺卡菌/新星。在后来的研究中,证实了可能的原发性肺病灶。酗酒是唯一记录在案的危险因素。患者完成了6周的医院抗生素治疗,临床和放射学进展良好,出院时计划进行1年的门诊抗生素治疗。虽然诺卡菌主要影响免疫功能低下的患者,但有证据表明,这种微生物也可能对没有传统免疫抑制危险因素的个体构成威胁。
{"title":"Pulmonary and central nervous system nocardiosis: Alcoholism as an immunocompromising factor","authors":"Adriana Isabel Márquez,&nbsp;Eduardo Mora,&nbsp;Andrés Felipe Bernal,&nbsp;Andrés Felipe Salazar,&nbsp;Diana Patricia Mora,&nbsp;Ledmar Jovanny Vargas","doi":"10.7705/biomedica.6606","DOIUrl":"https://doi.org/10.7705/biomedica.6606","url":null,"abstract":"<p><p>Nocardiosis is a disease with worldwide distribution. It is usually found in tropical areas and mainly affects immunocompromised patients, however, there are also cases where its infection has been reported in immunocompetent patients. This pathology is caused by bacteria known as Nocardia spp., which are gram-positive microorganisms and environmental saprophytes, and although exposure to Nocardia spp. is almost universal, only a small fraction of exposed people develops the disease.\u0000We present the case of a 47-year-old man, with no evidence of immunosuppression, from a rural area of Boyacá, who was admitted due to intense and intermittent headache accompanied by paresthesia and, finally, a decrease in consciousness. A brain magnetic resonance was performed and evidenced a fronto-temporo- occipital space-occupying lesion in the cortico-subcortical region with a compressive effect and displacement of the ventricular system cavities. It was suspected at first a neoplastic lesion or a brain abscess.\u0000The lesion was surgically resected, and its culture showed Nocardia africana/nova. In later studies a possible primary pulmonary focus was evidenced. Alcoholism was the only risk factor documented. The patient completed 6 weeks of hospital antibiotic treatment with favorable clinical and radiological evolution and was discharged with a 1-year plan of outpatient antibiotic therapy. Although Nocardia spp. mainly affects immunocompromised patients, evidence shows that this microorganism can also be a threat to individuals without traditional immunosuppression risk factors.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"43 1","pages":"37-43"},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10157060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Participation of Healthy Volunteers in Clinical Trials – Motives, Barriers and Ethical Issues 健康志愿者参与临床试验的动机、障碍和伦理问题
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-869
Rajabzadeh Asghar, J. Saleem, Muhammad Ishaq
Recruitment of adequate number of healthy volunteers is vital for success of clinical trials but there is limited research on factors motivating the healthy volunteers to participate in clinical trials especially in developing countries. Pakistani researchers also faced the problems in enrollment of enough healthy volunteers during COVID-19 pandemic when a number of clinical trials began in Pakistan. Around 117 research proposals were processed by the National Bioethics Committee (NBC) of Pakistan in last two years. A major proportion of these clinical research studies target healthy populations as primary research subjects or as controls. Numerous studies have investigated factors such as motives, barriers, risks. benefits and ethical values affecting recruitment and participation of healthy volunteers in clinical trials. We have reviewed the literature to learn about factors that motivate or prevent the healthy persons to volunteer along with the pertaining ethical issues. Financial incentive is the principal motive for healthy volunteers to participate in clinical trials along with altruism, contribution to sciences, research and other people’s health, desire to take part in something important, learning more about science and medicine, access to healthcare & free medical checkup and prospects of one’s social network expansion whereas time inconvenience, confidentiality, possible side effects & route of administration of drug and fear of contacting the disease were identified as important barriers. Application of knowledge of these motives and barriers will help Pakistani researchers to enroll adequate number of healthy volunteer for their clinical trials.
招募足够数量的健康志愿者对临床试验的成功至关重要,但关于促使健康志愿者参加临床试验的因素的研究有限,特别是在发展中国家。在2019冠状病毒病大流行期间,巴基斯坦的研究人员也面临着招募足够健康志愿者的问题,当时巴基斯坦开始了一些临床试验。巴基斯坦国家生物伦理委员会(NBC)在过去两年中处理了大约117个研究提案。这些临床研究的主要目标是健康人群作为主要研究对象或对照。许多研究调查了动机、障碍、风险等因素。影响招募和参与临床试验的健康志愿者的利益和伦理价值。我们对相关文献进行了回顾,以了解激励或阻止健康人志愿服务的因素以及相关的伦理问题。经济激励是健康志愿者参与临床试验的主要动机,此外还有利他主义、对科学、研究和他人健康的贡献、参与重要活动的愿望、对科学和医学的更多了解、获得医疗保健和免费体检的机会以及扩大社交网络的前景,而时间不便、保密、可能的副作用和给药途径以及对接触疾病的恐惧被认为是重要的障碍。应用这些动机和障碍的知识将有助于巴基斯坦研究人员为他们的临床试验招募足够数量的健康志愿者。
{"title":"Participation of Healthy Volunteers in Clinical Trials – Motives, Barriers and Ethical Issues","authors":"Rajabzadeh Asghar, J. Saleem, Muhammad Ishaq","doi":"10.24911/biomedica/5-869","DOIUrl":"https://doi.org/10.24911/biomedica/5-869","url":null,"abstract":"Recruitment of adequate number of healthy volunteers is vital for success of clinical trials but there is limited research on factors motivating the healthy volunteers to participate in clinical trials especially in developing countries. Pakistani researchers also faced the problems in enrollment of enough healthy volunteers during COVID-19 pandemic when a number of clinical trials began in Pakistan. Around 117 research proposals were processed by the National Bioethics Committee (NBC) of Pakistan in last two years. A major proportion of these clinical research studies target healthy populations as primary research subjects or as controls. \u0000Numerous studies have investigated factors such as motives, barriers, risks. benefits and ethical values affecting recruitment and participation of healthy volunteers in clinical trials. We have reviewed the literature to learn about factors that motivate or prevent the healthy persons to volunteer along with the pertaining ethical issues. \u0000Financial incentive is the principal motive for healthy volunteers to participate in clinical trials along with altruism, contribution to sciences, research and other people’s health, desire to take part in something important, learning more about science and medicine, access to healthcare & free medical checkup and prospects of one’s social network expansion whereas time inconvenience, confidentiality, possible side effects & route of administration of drug and fear of contacting the disease were identified as important barriers. \u0000Application of knowledge of these motives and barriers will help Pakistani researchers to enroll adequate number of healthy volunteer for their clinical trials.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"13 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79931927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
De Quervain’s tenosynovitis and thumb pain in physiotherapists practicing manual therapy: prevalence and associated factors De Quervain的腱鞘炎和拇指疼痛的物理治疗师进行手工治疗:患病率和相关因素
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-846
T. Mazhar, Saba Riaz, Sumbal Riaz, A. Batool, Awishbah Khan, Sadia Khan
Background and Objective: Manual therapy is a treatment approach by physical therapists where different techniques are applied to patients with hands for rehabilitation purposes. The objective of the study was to find the frequency of De’Quervain tenosynovitis and thumb and wrist pain in physical therapists working in different rehabilitation centers in relation to age, body mass index (BMI), and working hours. Methods: A cross-sectional study was conducted on 135 physical therapists working in different settings in Lahore, Pakistan. Physiotherapists were enrolled by convenience sampling. Data were recorded on a questionnaire form. Finkelstein test was performed to check De Quervain’s tenosynovitis. A numeric pain rating scale was sued to measure pain. The data were tested for significance using statistical tests. Results: On the dominant hand, 99 (73.3%) physical therapists had no wrist pain, 104 (77%) had no thumb pain, 28 (20.7%) had mild wrist pain and 20 (14.8%) had mild thumb pain. Only 21 (15.6%) physiotherapists were tested positive for Finkelstein (De Quervain’s tenosynovitis). Finkelstein test reported 100% negative result on the non-dominant side. There is a negative correlation between thumb pain with the age (r = -0.005), BMI (r = -0.110) and working hours (r = -0.033) of the physical therapists. Conclusion: The study concluded that the prevalence of De Quervain’s tenosynovitis, thumb, and wrist pain was more on the dominant hand than on the non-dominant side. The majority of the physical therapists reported mild to no pain in the wrist and thumb. There is a negative correlation of thumb pain with age, BMI and working hours.  
背景和目的:手工疗法是一种由物理治疗师应用不同技术对手部患者进行康复的治疗方法。本研究的目的是发现在不同康复中心工作的物理治疗师患De 'Quervain腱鞘炎、拇指和手腕疼痛的频率与年龄、体重指数(BMI)和工作时间的关系。方法:对在巴基斯坦拉合尔不同环境工作的135名物理治疗师进行了横断面研究。采用方便抽样的方法纳入物理治疗师。数据以问卷形式记录。采用Finkelstein试验检查De Quervain氏腱鞘炎。使用数字疼痛评定量表来测量疼痛。采用统计学检验对数据进行显著性检验。结果:优势手无腕痛99人(73.3%),无拇指痛104人(77%),轻度腕痛28人(20.7%),轻度拇指痛20人(14.8%)。仅有21名(15.6%)物理治疗师Finkelstein (De Quervain’s腱鞘炎)检测呈阳性。芬克尔斯坦试验报告非显性侧100%阴性。拇指疼痛与物理治疗师的年龄(r = -0.005)、BMI (r = -0.110)、工作时间(r = -0.033)呈负相关。结论:本研究认为,De Quervain肌腱滑膜炎、拇指和腕关节疼痛的患病率在优势侧多于非优势侧。大多数物理治疗师报告手腕和拇指的疼痛轻微至无痛。拇指疼痛与年龄、BMI、工作时间呈负相关。
{"title":"De Quervain’s tenosynovitis and thumb pain in physiotherapists practicing manual therapy: prevalence and associated factors","authors":"T. Mazhar, Saba Riaz, Sumbal Riaz, A. Batool, Awishbah Khan, Sadia Khan","doi":"10.24911/biomedica/5-846","DOIUrl":"https://doi.org/10.24911/biomedica/5-846","url":null,"abstract":"Background and Objective: Manual therapy is a treatment approach by physical therapists where different techniques are applied to patients with hands for rehabilitation purposes. The objective of the study was to find the frequency of De’Quervain tenosynovitis and thumb and wrist pain in physical therapists working in different rehabilitation centers in relation to age, body mass index (BMI), and working hours. \u0000Methods: A cross-sectional study was conducted on 135 physical therapists working in different settings in Lahore, Pakistan. Physiotherapists were enrolled by convenience sampling. Data were recorded on a questionnaire form. Finkelstein test was performed to check De Quervain’s tenosynovitis. A numeric pain rating scale was sued to measure pain. The data were tested for significance using statistical tests. \u0000Results: On the dominant hand, 99 (73.3%) physical therapists had no wrist pain, 104 (77%) had no thumb pain, 28 (20.7%) had mild wrist pain and 20 (14.8%) had mild thumb pain. Only 21 (15.6%) physiotherapists were tested positive for Finkelstein (De Quervain’s tenosynovitis). Finkelstein test reported 100% negative result on the non-dominant side. There is a negative correlation between thumb pain with the age (r = -0.005), BMI (r = -0.110) and working hours (r = -0.033) of the physical therapists. \u0000Conclusion: The study concluded that the prevalence of De Quervain’s tenosynovitis, thumb, and wrist pain was more on the dominant hand than on the non-dominant side. The majority of the physical therapists reported mild to no pain in the wrist and thumb. There is a negative correlation of thumb pain with age, BMI and working hours. \u0000 ","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79778274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D levels have a potential role in predicting the disease severity in COVID-19 positive pediatric patients 维生素D水平在预测COVID-19阳性儿科患者疾病严重程度方面具有潜在作用
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-880
Margaret Hassan, Iffat Batool, Hasan Mujtaba, M. Javaid, Uzma Abid
Background and Objective: The contagious and invasive nature has made coronavirus disease-19 (COVID-19) a critical health issue for the community. The lower respiratory tract is the major site of inflammation seen in COVID-19-positive individuals. Vitamin D (Vit D) has been proposed to have a positive role in immunomodulation, hence, this study aimed to determine the association between Vit D levels and the severity of COVID-19 in infected pediatric patients presenting at a secondary healthcare hospital in Pakistan. Methods: This cross-sectional analytical study was conducted on 100 pediatric patients of the age range 1-18 years from March to December 2021. These patients were hospitalized and diagnosed with coronavirus disease with confirmed results on a real‐time reverse transcription-polymerase chain reaction. Blood samples of the patients were taken to monitor the baseline levels of markers of acute infection and Vit D levels. Patients with serum Vit D levels ≤ 20ng/ml were labeled with deficiency, those with levels 21-29ng/ml were presumed to have Vit D insufficiency whereas levels ≥30 ng/ml were considered normal. Results: There were 57 (57%) males and 43 (43%) female pediatric patients. The mean age of the patients was 10.46 ± 4.25 years (1-18 years). The deficient Vit D level group had a greater frequency of pyrexia, weakness, cough, anosmia, headache, myalgia, and diarrhea. The levels of Vit D and severity of the disease were significantly associated (p-value = 0.027). Conclusion: Pediatric patients with COVID-19 having optimum levels of Vit D were less likely to develop complications associated with the severity of the disease.
背景与目的:新型冠状病毒病(COVID-19)具有传染性和侵袭性,已成为社会面临的重大健康问题。下呼吸道是covid -19阳性个体的主要炎症部位。维生素D (Vit D)被认为在免疫调节中具有积极作用,因此,本研究旨在确定在巴基斯坦二级医疗医院就诊的感染儿科患者中维生素D水平与COVID-19严重程度之间的关系。方法:对2021年3月至12月100例1-18岁儿童患者进行横断面分析研究。这些患者住院并被诊断为冠状病毒病,实时逆转录聚合酶链反应结果证实。采集患者血液样本,监测急性感染标志物的基线水平和Vit D水平。血清Vit D水平≤20ng/ml的患者被标记为缺乏,21-29ng/ml的患者被认为是Vit D不足,而≥30ng /ml的患者被认为是正常的。结果:男57例(57%),女43例(43%)。患者平均年龄10.46±4.25岁(1 ~ 18岁)。维生素D缺乏组出现发热、虚弱、咳嗽、嗅觉丧失、头痛、肌痛和腹泻的频率更高。Vit D水平与疾病严重程度显著相关(p值= 0.027)。结论:具有最佳维生素D水平的COVID-19儿科患者发生与疾病严重程度相关的并发症的可能性较小。
{"title":"Vitamin D levels have a potential role in predicting the disease severity in COVID-19 positive pediatric patients","authors":"Margaret Hassan, Iffat Batool, Hasan Mujtaba, M. Javaid, Uzma Abid","doi":"10.24911/biomedica/5-880","DOIUrl":"https://doi.org/10.24911/biomedica/5-880","url":null,"abstract":"Background and Objective: The contagious and invasive nature has made coronavirus disease-19 (COVID-19) a critical health issue for the community. The lower respiratory tract is the major site of inflammation seen in COVID-19-positive individuals. Vitamin D (Vit D) has been proposed to have a positive role in immunomodulation, hence, this study aimed to determine the association between Vit D levels and the severity of COVID-19 in infected pediatric patients presenting at a secondary healthcare hospital in Pakistan. \u0000Methods: This cross-sectional analytical study was conducted on 100 pediatric patients of the age range 1-18 years from March to December 2021. These patients were hospitalized and diagnosed with coronavirus disease with confirmed results on a real‐time reverse transcription-polymerase chain reaction. Blood samples of the patients were taken to monitor the baseline levels of markers of acute infection and Vit D levels. Patients with serum Vit D levels ≤ 20ng/ml were labeled with deficiency, those with levels 21-29ng/ml were presumed to have Vit D insufficiency whereas levels ≥30 ng/ml were considered normal. \u0000Results: There were 57 (57%) males and 43 (43%) female pediatric patients. The mean age of the patients was 10.46 ± 4.25 years (1-18 years). The deficient Vit D level group had a greater frequency of pyrexia, weakness, cough, anosmia, headache, myalgia, and diarrhea. The levels of Vit D and severity of the disease were significantly associated (p-value = 0.027). \u0000Conclusion: Pediatric patients with COVID-19 having optimum levels of Vit D were less likely to develop complications associated with the severity of the disease.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"60 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73343000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pretreatment with Ajwa dates (Phoenix dactylifera Linn) prevents development of alloxan-induced diabetes in rats 用Ajwa枣(Phoenix dactylifera Linn)预处理可以防止大鼠四氧嘧啶诱导的糖尿病的发展
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-841
A. H. Siddiqui, S. Chiragh, M. Malik
ABSTRACT Background and Objective: A global increase in the prevalence of diabetes mellitus (DM) is associated with increased morbidity and mortality. Oxidative stress is a fundamental component in the pathogenesis of DM Ajwa dates are known to have a high antioxidant content, especially in their seeds. Hence this study was designed to determine the preventive effects of Ajwa date fruit on alloxan-induced diabetes in an experimental rat model. Methods: This experimental study was conducted at the Post Graduate Medical Institute, Lahore, Pakistan. A total of forty Sprague-Dawley rats were divided into five groups with eight animals in each. Rats in group A were normal control, whereas rats in group B were induced with intraperitoneal alloxan (160 mg/kg body weight) to develop diabetes. Groups C, D, and E rats were fed on a diet supplemented with Ajwa flesh, seed, and whole Ajwa respectively for 1 week. Blood and urine glucose levels were measured on days 0, 7 (pre-alloxan) and 11, 14, 19 (post-alloxan). Serum insulin, homeostatic model assessment (HOMA) for β-cell function (HOMA-β), and insulin resistance (HOMA[1]IR) were estimated terminally. Results: Diabetes was induced successfully in animals of all experimental groups except the normal control group. Rats of the Ajwa-seed group (D) showed relative resistance to diabetes induction with three non-diabetic rats on day 19. In group E, rats had lower blood sugar levels than rats in group C (p = 0.010). Serum insulin, HOMA-β and HOMA-IR, revealed partial beta cells restoration in the experimental animals of groups D and C. Insulin resistance was significantly higher, despite the highest insulin level (3.77 µIU/ml; p value <0.001) in group C. Conclusion: Ajwa date seed powder appears to provide relative protection against the development of diabetes in rats induced by alloxan.
背景与目的:全球糖尿病(DM)患病率的增加与发病率和死亡率的增加有关。氧化应激是糖尿病发病机制的一个基本组成部分,已知Ajwa枣具有高抗氧化剂含量,特别是在其种子中。因此,本研究旨在确定Ajwa枣对四氧嘧啶诱导的糖尿病大鼠模型的预防作用。方法:本实验研究在巴基斯坦拉合尔研究生医学研究所进行。40只Sprague-Dawley大鼠被分成5组,每组8只。A组为正常对照,B组为腹腔注射四氧嘧啶(160 mg/kg体重)诱导糖尿病。C、D、E组大鼠分别饲喂在饲粮中添加Ajwa肉、种子和全Ajwa的饲粮,饲喂1周。在第0、7天(四氧嘧啶治疗前)和第11、14、19天(四氧嘧啶治疗后)测量血和尿糖水平。最后评估血清胰岛素、稳态模型评估(HOMA) β-细胞功能(HOMA-β)和胰岛素抵抗(HOMA[1]IR)。结果:除正常对照组外,其余试验组均成功诱导糖尿病。第19天,水草籽组(D)与3只非糖尿病大鼠表现出相对的糖尿病诱导抗性。E组大鼠血糖水平低于C组(p = 0.010)。血清胰岛素、HOMA-β和HOMA- ir显示D组和c组实验动物部分β细胞恢复,尽管胰岛素水平最高(3.77 μ IU/ml;结论:Ajwa枣籽粉对四氧嘧啶诱导的大鼠糖尿病的发生具有一定的保护作用。
{"title":"Pretreatment with Ajwa dates (Phoenix dactylifera Linn) prevents development of alloxan-induced diabetes in rats","authors":"A. H. Siddiqui, S. Chiragh, M. Malik","doi":"10.24911/biomedica/5-841","DOIUrl":"https://doi.org/10.24911/biomedica/5-841","url":null,"abstract":"ABSTRACT \u0000Background and Objective: A global increase in the prevalence of diabetes mellitus (DM) is associated with increased morbidity and mortality. Oxidative stress is a fundamental component in the pathogenesis of DM Ajwa dates are known to have a high antioxidant content, especially in their seeds. Hence this study was designed to determine the preventive effects of Ajwa date fruit on alloxan-induced diabetes in an experimental rat model. \u0000Methods: This experimental study was conducted at the Post Graduate Medical Institute, Lahore, Pakistan. A total of forty Sprague-Dawley rats were divided into five groups with eight animals in each. Rats in group A were normal control, whereas rats in group B were induced with intraperitoneal alloxan (160 mg/kg body weight) to develop diabetes. Groups C, D, and E rats were fed on a diet supplemented with Ajwa flesh, seed, and whole Ajwa respectively for 1 week. Blood and urine glucose levels were measured on days 0, 7 (pre-alloxan) and 11, 14, 19 (post-alloxan). Serum insulin, homeostatic model assessment (HOMA) for β-cell function (HOMA-β), and insulin resistance (HOMA[1]IR) were estimated terminally. \u0000Results: Diabetes was induced successfully in animals of all experimental groups except the normal control group. Rats of the Ajwa-seed group (D) showed relative resistance to diabetes induction with three non-diabetic rats on day 19. In group E, rats had lower blood sugar levels than rats in group C (p = 0.010). Serum insulin, HOMA-β and HOMA-IR, revealed partial beta cells restoration in the experimental animals of groups D and C. Insulin resistance was significantly higher, despite the highest insulin level (3.77 µIU/ml; p value <0.001) in group C. \u0000Conclusion: Ajwa date seed powder appears to provide relative protection against the development of diabetes in rats induced by alloxan.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"22 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87023161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of single-stage reverse sural artery flap versus two-staged interpolated flap in distal lower limb injuries 单期腓肠动脉逆行皮瓣与两期内插皮瓣治疗下肢远端损伤的比较
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-802
Tauqeer Nazim, Sarfraz Ahmad, K. Hamid, Z. Bhatti, Muhammad Maaz Arif, S. Khalid, D. Mohsin
Background and Objective: Plastic surgeons face challenging conditions when dealing with soft tissue injuries or defects involving the lower part of the leg and the proximal part of the foot. The objective of the current study is to compare single-staged reverse sural artery flaps with two-staged interpolated flaps in distal lower limb injuries. Methods: It was a prospective study carried out at the Department of Plastic Surgery, Allama Iqbal Memorial Teaching Hospital, Sialkot, Pakistan, over 5 years from 2015 to 2020. Sixty-eight (n = 68) patients with distal lower limb soft-tissue defects were enrolled and randomly allotted a two-stage interpolated flap design (group A) or single-stage reverse sural artery flap design (group B). The measured outcomes included the frequency of flap-tip necrosis, epidermolysis, partial or total flap loss, and additional procedures needed for managing these complications. Results: Out of all the patients, 72% were of male gender and 28% were females with a mean age of 38.38 ± 10.76 years. In group A, there were 6% of the cases where tip necrosis was the only impediment as compared to 17% in group B. In patients of group A, epidermolysis was seen in 12% as compared to 35% in group B whereas only 6% of patients in group A required secondary procedures for flap tip necrosis as compared to group B (47%). Paired t-test was used to calculate the statistical significance of the outcome between the two groups (p-value of 0.0491). Conclusion: The two-staged interpolated flap procedure results in fewer complications as compared to a single-staged reverse sural artery flap procedure. However, the shorter hospital stay in single-staged flap design is satisfying for the patients who did not report any complications with this procedure.
背景与目的:整形外科医生在处理涉及小腿下部和足部近端软组织损伤或缺陷时面临着挑战。本研究的目的是比较单阶段腓肠动脉逆行皮瓣和两阶段内插皮瓣在下肢远端损伤中的应用。方法:前瞻性研究于2015 - 2020年在巴基斯坦锡亚尔科特Allama Iqbal纪念教学医院整形外科进行,为期5年。68例(n = 68)下肢远端软组织缺损患者被纳入研究,随机分配两期内插皮瓣设计(a组)或单期腓肠动脉逆行皮瓣设计(B组)。测量的结果包括皮瓣尖端坏死、表皮松解、部分或全部皮瓣丢失的频率,以及处理这些并发症所需的额外手术。结果:所有患者中男性占72%,女性占28%,平均年龄38.38±10.76岁。在A组中,6%的患者鼻尖坏死是唯一的障碍,而B组为17%。在A组患者中,表皮松解的发生率为12%,而B组为35%。与B组(47%)相比,A组中只有6%的患者需要对皮瓣鼻尖坏死进行二次手术。采用配对t检验计算两组结果的统计学显著性(p值为0.0491)。结论:两阶段内插皮瓣手术比单阶段腓肠动脉逆行皮瓣手术并发症少。然而,对于没有报告任何并发症的患者来说,单阶段皮瓣设计的住院时间较短是令人满意的。
{"title":"Comparison of single-stage reverse sural artery flap versus two-staged interpolated flap in distal lower limb injuries","authors":"Tauqeer Nazim, Sarfraz Ahmad, K. Hamid, Z. Bhatti, Muhammad Maaz Arif, S. Khalid, D. Mohsin","doi":"10.24911/biomedica/5-802","DOIUrl":"https://doi.org/10.24911/biomedica/5-802","url":null,"abstract":"Background and Objective: Plastic surgeons face challenging conditions when dealing with soft tissue injuries or defects involving the lower part of the leg and the proximal part of the foot. The objective of the current study is to compare single-staged reverse sural artery flaps with two-staged interpolated flaps in distal lower limb injuries. \u0000Methods: It was a prospective study carried out at the Department of Plastic Surgery, Allama Iqbal Memorial Teaching Hospital, Sialkot, Pakistan, over 5 years from 2015 to 2020. Sixty-eight (n = 68) patients with distal lower limb soft-tissue defects were enrolled and randomly allotted a two-stage interpolated flap design (group A) or single-stage reverse sural artery flap design (group B). The measured outcomes included the frequency of flap-tip necrosis, epidermolysis, partial or total flap loss, and additional procedures needed for managing these complications. \u0000Results: Out of all the patients, 72% were of male gender and 28% were females with a mean age of 38.38 ± 10.76 years. In group A, there were 6% of the cases where tip necrosis was the only impediment as compared to 17% in group B. In patients of group A, epidermolysis was seen in 12% as compared to 35% in group B whereas only 6% of patients in group A required secondary procedures for flap tip necrosis as compared to group B (47%). Paired t-test was used to calculate the statistical significance of the outcome between the two groups (p-value of 0.0491). \u0000Conclusion: The two-staged interpolated flap procedure results in fewer complications as compared to a single-staged reverse sural artery flap procedure. However, the shorter hospital stay in single-staged flap design is satisfying for the patients who did not report any complications with this procedure.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"31 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82167077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of TNF-α and DC-SIGN promoter polymorphisms in patients with dengue fever in Lahore city of Pakistan 巴基斯坦拉合尔市登革热患者TNF-α和DC-SIGN启动子多态性调查
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-835
Syed Rizvan Ali, Sumra Batool, S. Khaliq
Background and Objective: Dengue fever (DF) has been a major health concern globally. Pakistan is also combating this infection for the last decade. Cytokine genes play an important role in DF pathogenesis. This study aimed to analyze dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and tumor necrosis factor α (TNF-α) genes promoter polymorphisms in DF patients. Methods: A total of 140 (n = 140) dDF patients were recruited for study at the Department of Human Genetics and Molecular Biology of University of Health Sciences, Lahore, Pakistan over a period of 3 years. Simple DF was noted in 105 patients (75%) while 35 (25%) showed bleeding complications. All patients were found positive for dengue non-structural protein or dengue IgM. All patients were tested for two polymorphisms in TNF-α (-238G/A, and -308G/A) and one polymorphism in DC-SIGN (-336G/A) using restriction fragment length polymorphism technique. A single nucleotide polymorphism stats program was used for statistical analysis. Results: Susceptibility to develop dengue infection in the presence of -336G allele odds ratio (OR = 27.95, p = <0.0001) and GG genotype (OR = 183.77, p = <0.0001) was found to be significantly associated in this study. Presence of a combination of alleles -336G/-238A/-308A was noted in 59.4% of DF cases and 7.6% healthy controls, a difference with statistical significance (OR = 31.46, p = <0.0001). Moreover, prevalence of DF symptoms showed a trend higher in G-carriers versus non-G-carriers of DC-SIGN -336 polymorphism. Conclusion: This work suggests a potential association of DC-SIGN -336 polymorphism with susceptibility to develop symptomatic dengue illness. However, no potential association was found between TNF-α promoter polymorphisms and dengue infection in this study.
背景和目的:登革热(DF)一直是全球主要的健康问题。巴基斯坦在过去十年中也在与这种感染作斗争。细胞因子基因在DF发病中起重要作用。本研究旨在分析DF患者树突状细胞特异性细胞间粘附分子-3捕获非整合素(DC-SIGN)和肿瘤坏死因子α (TNF-α)基因启动子多态性。方法:在巴基斯坦拉合尔健康科学大学人类遗传学和分子生物学学系招募了140例(n = 140) dDF患者,为期3年。单纯DF 105例(75%),出血并发症35例(25%)。所有患者均呈登革热非结构蛋白或登革热IgM阳性。使用限制性片段长度多态性技术检测所有患者TNF-α (-238G/A和-308G/A)的两个多态性和DC-SIGN (-336G/A)的一个多态性。采用单核苷酸多态性统计程序进行统计分析。结果:本研究发现-336G等位基因优势比(OR = 27.95, p = <0.0001)和GG基因型(OR = 183.77, p = <0.0001)与登革热感染易感性显著相关。DF病例中-336G/-238A/-308A等位基因组合的存在率为59.4%,健康对照为7.6%,差异有统计学意义(OR = 31.46, p = <0.0001)。此外,DC-SIGN -336多态性的g -携带者与非g -携带者相比,DF症状的患病率有更高的趋势。结论:本研究提示DC-SIGN -336多态性与出现症状性登革热疾病的易感性可能存在关联。然而,在本研究中没有发现TNF-α启动子多态性与登革热感染之间的潜在关联。
{"title":"Investigation of TNF-α and DC-SIGN promoter polymorphisms in patients with dengue fever in Lahore city of Pakistan","authors":"Syed Rizvan Ali, Sumra Batool, S. Khaliq","doi":"10.24911/biomedica/5-835","DOIUrl":"https://doi.org/10.24911/biomedica/5-835","url":null,"abstract":"Background and Objective: Dengue fever (DF) has been a major health concern globally. Pakistan is also combating this infection for the last decade. Cytokine genes play an important role in DF pathogenesis. This study aimed to analyze dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and tumor necrosis factor α (TNF-α) genes promoter polymorphisms in DF patients. \u0000Methods: A total of 140 (n = 140) dDF patients were recruited for study at the Department of Human Genetics and Molecular Biology of University of Health Sciences, Lahore, Pakistan over a period of 3 years. Simple DF was noted in 105 patients (75%) while 35 (25%) showed bleeding complications. All patients were found positive for dengue non-structural protein or dengue IgM. All patients were tested for two polymorphisms in TNF-α (-238G/A, and -308G/A) and one polymorphism in DC-SIGN (-336G/A) using restriction fragment length polymorphism technique. A single nucleotide polymorphism stats program was used for statistical analysis. \u0000Results: Susceptibility to develop dengue infection in the presence of -336G allele odds ratio (OR = 27.95, p = <0.0001) and GG genotype (OR = 183.77, p = <0.0001) was found to be significantly associated in this study. Presence of a combination of alleles -336G/-238A/-308A was noted in 59.4% of DF cases and 7.6% healthy controls, a difference with statistical significance (OR = 31.46, p = <0.0001). Moreover, prevalence of DF symptoms showed a trend higher in G-carriers versus non-G-carriers of DC-SIGN -336 polymorphism. \u0000Conclusion: This work suggests a potential association of DC-SIGN -336 polymorphism with susceptibility to develop symptomatic dengue illness. However, no potential association was found between TNF-α promoter polymorphisms and dengue infection in this study.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"5 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88180115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of parental knowledge and attitude towards poliomyelitis and its immunization in Sialkot city: a mix method study 锡亚尔科特市父母对脊髓灰质炎及其免疫的知识和态度的决定因素:一项混合方法研究
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-683
Taskeen Zahra, Ayesha Parvez, Hamzah Ahmad, Hassiba Ifftikhar, F. Mushtaq, S. Ayub
Background and Objectives: Poliomyelitis still remains a significant public health concern in developing countries though it has been eradicated from most of the world. Illiteracy, cultural constraints, and skepticism of the general public regarding vaccination are considered major impediments to its successful eradication from developing countries. In this study, the authors aimed to evaluate parental knowledge and attitudes about poliomyelitis and its immunization in a local population as well as to elucidate the determinants and barriers relating to the immunization process. Methods: This mixed-method study was conducted on 350 consenting parents who accompanied their children under 5 years of age at the pediatric outdoors of a tertiary care hospital in Sialkot, Pakistan. Parents of only those children were included for the study who had failed to receive a polio dose during the last two supplementary immunization activities The parents were interviewed on a pre-tested, semi structured questionnaire. Statistical Package for the Social Sciences was used for statistical analysis considering p-value <0.05 as significant. Results: Among 350 parents, 91.7% lacked knowledge about polio vaccination and 82% reported a negative attitude towards the disease and its immunization. A total of 11.4% of subjects completely refused to get their child vaccinated. The socioeconomic status, religious myths, level of literacy, and occupation of the parents significantly influenced their level of knowledge and attitude toward the disease and its vaccination (p < 0.05). Conclusion: Poor knowledge and negative attitudes of parents towards poliomyelitis vaccination were observed. Fear of side effects and religious beliefs were identified as the most common barriers to immunization toward achieving polio eradication.
背景和目标:尽管脊髓灰质炎已在世界大部分地区根除,但它仍然是发展中国家一个重大的公共卫生问题。文盲、文化限制和公众对疫苗接种的怀疑被认为是在发展中国家成功根除该病的主要障碍。在这项研究中,作者旨在评估当地人群中父母对脊髓灰质炎及其免疫的知识和态度,并阐明与免疫过程有关的决定因素和障碍。方法:这项混合方法研究对350名父母进行了研究,这些父母陪同他们的5岁以下的孩子在巴基斯坦锡亚尔科特的一家三级护理医院的儿科户外进行。只有那些在最近两次补充免疫活动中未能接种脊髓灰质炎疫苗的儿童的父母才被纳入研究。父母们接受了一份预先测试的半结构化问卷调查。采用Statistical Package for the Social Sciences进行统计分析,p值<0.05为显著性。结果:在350名家长中,91.7%的家长对脊髓灰质炎疫苗接种缺乏了解,82%的家长对脊髓灰质炎及其免疫接种持否定态度。总共有11.4%的受试者完全拒绝让他们的孩子接种疫苗。父母的社会经济地位、宗教神话、文化水平和职业显著影响其对该病及其疫苗接种的知识水平和态度(p < 0.05)。结论:儿童家长对小儿麻痹症疫苗接种知识贫乏,态度消极。对副作用的恐惧和宗教信仰被确定为实现根除脊髓灰质炎的免疫接种的最常见障碍。
{"title":"Determinants of parental knowledge and attitude towards poliomyelitis and its immunization in Sialkot city: a mix method study","authors":"Taskeen Zahra, Ayesha Parvez, Hamzah Ahmad, Hassiba Ifftikhar, F. Mushtaq, S. Ayub","doi":"10.24911/biomedica/5-683","DOIUrl":"https://doi.org/10.24911/biomedica/5-683","url":null,"abstract":"Background and Objectives: Poliomyelitis still remains a significant public health concern in developing countries though it has been eradicated from most of the world. Illiteracy, cultural constraints, and skepticism of the general public regarding vaccination are considered major impediments to its successful eradication from developing countries. In this study, the authors aimed to evaluate parental knowledge and attitudes about poliomyelitis and its immunization in a local population as well as to elucidate the determinants and barriers relating to the immunization process. \u0000Methods: This mixed-method study was conducted on 350 consenting parents who accompanied their children under 5 years of age at the pediatric outdoors of a tertiary care hospital in Sialkot, Pakistan. Parents of only those children were included for the study who had failed to receive a polio dose during the last two supplementary immunization activities The parents were interviewed on a pre-tested, semi structured questionnaire. Statistical Package for the Social Sciences was used for statistical analysis considering p-value <0.05 as significant. \u0000Results: Among 350 parents, 91.7% lacked knowledge about polio vaccination and 82% reported a negative attitude towards the disease and its immunization. A total of 11.4% of subjects completely refused to get their child vaccinated. The socioeconomic status, religious myths, level of literacy, and occupation of the parents significantly influenced their level of knowledge and attitude toward the disease and its vaccination (p < 0.05). \u0000Conclusion: Poor knowledge and negative attitudes of parents towards poliomyelitis vaccination were observed. Fear of side effects and religious beliefs were identified as the most common barriers to immunization toward achieving polio eradication.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"8 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85236264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aplicaciones actuales de la ultrasonografía en anestesia 超声在麻醉中的应用
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-01-30 DOI: 10.5377/alerta.v6i1.15610
Luis Arévalo Gutiérrez
La ecografía es una herramienta segura, portátil, económica y de fácil acceso. Los médicos anestesiólogos pueden beneficiarse con esta herramienta diagnóstica rápida y precisa en su práctica habitual. Existen múltiples áreas potenciales donde la ecografía desempeña un papel importante, para la orientación de intervenciones a ciegas e invasivas, el diagnóstico de condiciones críticas y la evaluación de posibles variaciones anatómicas que pueden conducir a la modificación del plan anestésico. Esta revisión narrativa describe las principales aplicaciones de la ecografía en anestesia, las técnicas ecoguiadas y las tendencias actuales del manejo anestésico perioperatorio del paciente quirúrgico. Se realizó una búsqueda en las bases de datos PubMed y Cochrane, se incluyeron artículos originales, estudios aleatorizados y de revisión, en español y en inglés, publicados entre 2017-2021. El uso de ecografía ha entrado en el campo de la medicina del dolor, anestesia regional y del intervencionismo analgésico durante la última década, e incluso es el estándar de la práctica, por tanto, la capacitación y un adecuado aprendizaje en la ecografía deben ser parte del plan de estudios de cualquier programa de anestesiología.
超声波是一种安全、便携、经济、方便的工具。麻醉师可以在他们的日常实践中受益于这种快速和准确的诊断工具。在许多潜在的领域,超声在指导盲法和侵入性干预、诊断危重情况和评估可能导致麻醉计划修改的解剖变化方面发挥着重要作用。本综述描述了超声在麻醉中的主要应用,超声引导技术和手术患者围手术期麻醉管理的当前趋势。检索PubMed和Cochrane数据库,包括2017-2021年发表的西班牙语和英语的原始文章、随机和综述研究。使用doppler已进入疼痛医学领域,区域麻醉和镇痛干预的十年里,甚至是标准做法,因此培训和适当学习doppler必须麻醉学任何程序的研究计划的一部分。
{"title":"Aplicaciones actuales de la ultrasonografía en anestesia","authors":"Luis Arévalo Gutiérrez","doi":"10.5377/alerta.v6i1.15610","DOIUrl":"https://doi.org/10.5377/alerta.v6i1.15610","url":null,"abstract":"La ecografía es una herramienta segura, portátil, económica y de fácil acceso. Los médicos anestesiólogos pueden beneficiarse con esta herramienta diagnóstica rápida y precisa en su práctica habitual. Existen múltiples áreas potenciales donde la ecografía desempeña un papel importante, para la orientación de intervenciones a ciegas e invasivas, el diagnóstico de condiciones críticas y la evaluación de posibles variaciones anatómicas que pueden conducir a la modificación del plan anestésico. Esta revisión narrativa describe las principales aplicaciones de la ecografía en anestesia, las técnicas ecoguiadas y las tendencias actuales del manejo anestésico perioperatorio del paciente quirúrgico. Se realizó una búsqueda en las bases de datos PubMed y Cochrane, se incluyeron artículos originales, estudios aleatorizados y de revisión, en español y en inglés, publicados entre 2017-2021. El uso de ecografía ha entrado en el campo de la medicina del dolor, anestesia regional y del intervencionismo analgésico durante la última década, e incluso es el estándar de la práctica, por tanto, la capacitación y un adecuado aprendizaje en la ecografía deben ser parte del plan de estudios de cualquier programa de anestesiología.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"54 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81016196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seis años de allanar brechas para la indexación 用六年时间填补指数化缺口
IF 0.9 4区 医学 Q4 TROPICAL MEDICINE Pub Date : 2023-01-30 DOI: 10.5377/alerta.v6i1.15468
Xochitl Sandoval López
La revista Alerta del Instituto Nacional de Salud (INS) de la República de El Salvador, es más que en un medio digital para la divulgación del conocimiento científico en salud, en la actualidad es un proyecto de país, que promueve la investigación y la cultura de publicación. Con esta decimosegunda edición, que corresponde al volumen seis, número uno del 2023, inicia su sexto año de vida.Desde el año 2018, la revista dio sus primeros pasos y se prepararon condiciones para cumplir con las normas internacionales y buenas prácticas de publicación, mediante la elaboración de la norma técnica, el manual de procedimientos y el manual de estilo, documentos fundamentales para su publicación, que a la fecha se han actualizado varias veces, producto de su evolución y desarrollo.No menos importante es el interés y la colaboración de reconocidos investigadores nacionales e internacionales que fueron o siguen siendo parte del comité científico y comité editorial, que poco a poco se ha ido internacionalizando, en busca de ampliar su visión e impacto.
萨尔瓦多共和国国家卫生研究所(INS)的《Alerta》杂志不仅仅是传播卫生科学知识的数字媒体,它目前是一个促进研究和出版文化的国家项目。随着第十二版,对应于第六卷,2023年的第一卷,它开始了它生命的第六年。给杂志2018年以来的第一个步骤,制作了各种条件,发布符合国际标准和良好做法,通过制定技术标准、程序手册和风格,基本文件手册》出版,至今已多次更新、产品的演变和发展。同样重要的是,过去或现在是科学委员会和编辑委员会成员的国内和国际知名研究人员的兴趣和合作,这些研究人员逐渐国际化,寻求扩大其视野和影响。
{"title":"Seis años de allanar brechas para la indexación","authors":"Xochitl Sandoval López","doi":"10.5377/alerta.v6i1.15468","DOIUrl":"https://doi.org/10.5377/alerta.v6i1.15468","url":null,"abstract":"La revista Alerta del Instituto Nacional de Salud (INS) de la República de El Salvador, es más que en un medio digital para la divulgación del conocimiento científico en salud, en la actualidad es un proyecto de país, que promueve la investigación y la cultura de publicación. Con esta decimosegunda edición, que corresponde al volumen seis, número uno del 2023, inicia su sexto año de vida.Desde el año 2018, la revista dio sus primeros pasos y se prepararon condiciones para cumplir con las normas internacionales y buenas prácticas de publicación, mediante la elaboración de la norma técnica, el manual de procedimientos y el manual de estilo, documentos fundamentales para su publicación, que a la fecha se han actualizado varias veces, producto de su evolución y desarrollo.No menos importante es el interés y la colaboración de reconocidos investigadores nacionales e internacionales que fueron o siguen siendo parte del comité científico y comité editorial, que poco a poco se ha ido internacionalizando, en busca de ampliar su visión e impacto.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"8 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81192233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Biomedica
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1