{"title":"Inclusion in research: strategies to tackle implicit barriers for older people.","authors":"Emma Tenison","doi":"10.1136/bmj.s215","DOIUrl":"https://doi.org/10.1136/bmj.s215","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s215"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Matt Morgan: What mermaids can teach us about misinformation.","authors":"Matt Morgan","doi":"10.1136/bmj.s123","DOIUrl":"https://doi.org/10.1136/bmj.s123","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s123"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Towards the equal recognition of autism in girls and women.","authors":"Anne E Cary","doi":"10.1136/bmj.s120","DOIUrl":"https://doi.org/10.1136/bmj.s120","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s120"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To compare the diagnostic accuracy of minipad collected menstrual blood versus clinician collected cervical samples to test for human papillomavirus (HPV) in the detection of cervical intraepithelial neoplasia grade 2/3 or worse (CIN2+/CIN3+).
Design: Cross sectional population based study.
Setting: Four urban and three rural communities in Hubei Province, China.
Participants: 3068 women aged 20-54 years with regular menstrual cycles, enrolled between September 2021 and January 2025.
Interventions: HPV testing using minipad collected menstrual blood, clinician collected cervical samples, and ThinPrep cytology. Women who tested HPV positive by either collection method or by cytology (atypical squamous cells of undetermined significance or worse) were referred for colposcopy directed biopsy sampling.
Main outcome measure: Diagnostic accuracy for detecting CIN2+ and CIN3+.
Results: Among 3068 participants, minipad based HPV testing showed a sensitivity of 94.7% (95% confidence interval 80.9% to 99.1%) for CIN2+ detection, comparable to clinician based HPV testing (92.1%, 77.5% to 97.9%; P=1.00). Although minipad HPV testing showed a lower specificity than clinician HPV testing (89.1%, 88.0% to 90.2% v 90.0%, 88.9% to 91.1%; P=0.001), the negative predictive value matched that of clinician HPV testing (99.9%, 99.7% to 100.0% v 99.9%, 99.7% to 100.0%; P=1.00). Both collection methods had a similar positive predictive value (9.9%, 7.1% to 13.5% v 10.4%, 7.4% to 14.3%; P=0.82) and screening efficiency (10.1 v 9.6 referrals per CIN2+ detected; P=0.82).
Conclusions: Minipad collected menstrual blood showed comparable diagnostic accuracy to clinician collected cervical samples for HPV testing for detecting CIN2+ and CIN3+.
目的：比较迷你pad采集经血与临床采集宫颈标本检测人乳头瘤病毒（HPV）对宫颈上皮内瘤变2/3级及以上（CIN2+/CIN3+）的诊断准确性。设计：基于人群的横断面研究。地点：中国湖北省4个城市和3个农村社区。参与者：3068名年龄在20-54岁、月经周期正常的女性，于2021年9月至2025年1月登记。干预措施：使用迷你pad收集经血进行HPV检测，临床医生收集宫颈样本，并进行ThinPrep细胞学检查。通过收集方法或细胞学检测HPV阳性的妇女（不典型鳞状细胞的不确定意义或更糟）被转介进行阴道镜指导活检取样。主要观察指标：检测CIN2+和CIN3+的诊断准确性。结果：在3068名参与者中，基于迷你pad的HPV检测对CIN2+检测的敏感性为94.7%(95%置信区间为80.9%至99.1%)，与基于临床医生的HPV检测（92.1%，77.5%至97.9%；P=1.00）相当。虽然minipad HPV检测的特异性低于临床HPV检测（89.1%,88.0% ~ 90.2% v 90.0%, 88.9% ~ 91.1%； P=0.001），但阴性预测值与临床HPV检测相匹配（99.9%,99.7% ~ 100.0% v 99.9%, 99.7% ~ 100.0%； P=1.00）。两种收集方法具有相似的阳性预测值（9.9%,7.1% ~ 13.5% v 10.4%, 7.4% ~ 14.3%， P=0.82）和筛选效率（10.1 v 9.6转诊/ CIN2+检测，P=0.82）。结论：Minipad采集经血与临床采集宫颈HPV检测CIN2+、CIN3+的诊断准确率相当。试验注册：ClinicalTrials.gov NCT06082765。
{"title":"Testing menstrual blood for human papillomavirus during cervical cancer screening in China: cross sectional population based study.","authors":"Xun Tian, Chen Cao, Lejing Wang, Jingjing Zhang, Ye Chen, Rui Tian, Bo Zhou, Lili Sun, Caixia Zhang, Lijuan Gan, Yu Jin, Jiahui Liu, Ting Wang, Yanqing Shen, Sisi Huang, Ling Zhang, Shenhua Zhang, Ping Chen, Chunli Tong, Jiaqi Kang, Hongli Fan, Guocheng Zhou, Liming Xiang, Yu Wen, Ruiliu Gan, Yong Chen, Xiaolan Li, Li Zhai, Qinghua Zhang, Ding Ma, Zhiqiang Han, Zheng Hu","doi":"10.1136/bmj-2025-084831","DOIUrl":"10.1136/bmj-2025-084831","url":null,"abstract":"<p><strong>Objective: </strong>To compare the diagnostic accuracy of minipad collected menstrual blood versus clinician collected cervical samples to test for human papillomavirus (HPV) in the detection of cervical intraepithelial neoplasia grade 2/3 or worse (CIN2+/CIN3+).</p><p><strong>Design: </strong>Cross sectional population based study.</p><p><strong>Setting: </strong>Four urban and three rural communities in Hubei Province, China.</p><p><strong>Participants: </strong>3068 women aged 20-54 years with regular menstrual cycles, enrolled between September 2021 and January 2025.</p><p><strong>Interventions: </strong>HPV testing using minipad collected menstrual blood, clinician collected cervical samples, and ThinPrep cytology. Women who tested HPV positive by either collection method or by cytology (atypical squamous cells of undetermined significance or worse) were referred for colposcopy directed biopsy sampling.</p><p><strong>Main outcome measure: </strong>Diagnostic accuracy for detecting CIN2+ and CIN3+.</p><p><strong>Results: </strong>Among 3068 participants, minipad based HPV testing showed a sensitivity of 94.7% (95% confidence interval 80.9% to 99.1%) for CIN2+ detection, comparable to clinician based HPV testing (92.1%, 77.5% to 97.9%; P=1.00). Although minipad HPV testing showed a lower specificity than clinician HPV testing (89.1%, 88.0% to 90.2% <i>v</i> 90.0%, 88.9% to 91.1%; P=0.001), the negative predictive value matched that of clinician HPV testing (99.9%, 99.7% to 100.0% <i>v</i> 99.9%, 99.7% to 100.0%; P=1.00). Both collection methods had a similar positive predictive value (9.9%, 7.1% to 13.5% <i>v</i> 10.4%, 7.4% to 14.3%; P=0.82) and screening efficiency (10.1 <i>v</i> 9.6 referrals per CIN2+ detected; P=0.82).</p><p><strong>Conclusions: </strong>Minipad collected menstrual blood showed comparable diagnostic accuracy to clinician collected cervical samples for HPV testing for detecting CIN2+ and CIN3+.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT06082765.</p>","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"e084831"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Supermarket-style scanners can track medical devices safely and easily-so why are they not used across the NHS?","authors":"Terence Stephenson","doi":"10.1136/bmj.s235","DOIUrl":"https://doi.org/10.1136/bmj.s235","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s235"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scarlett McNally: Shared decision making requires striking the right balance.","authors":"Scarlett McNally","doi":"10.1136/bmj.s191","DOIUrl":"https://doi.org/10.1136/bmj.s191","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s191"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ediriweera Desapriya, Siyath Ariyaratne, Hasara Illuppella, Peter Tiu, Thamindu Widyaratne, Dinidu Akalanka Wijesinghe, Shaluka Manchanayake, Jay Herath
{"title":"Chatbots must be assessed for emotional harms.","authors":"Ediriweera Desapriya, Siyath Ariyaratne, Hasara Illuppella, Peter Tiu, Thamindu Widyaratne, Dinidu Akalanka Wijesinghe, Shaluka Manchanayake, Jay Herath","doi":"10.1136/bmj.s211","DOIUrl":"https://doi.org/10.1136/bmj.s211","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s211"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Most cancers are not caused by lifestyle but four in 10 could be prevented, WHO study finds.","authors":"Jacqui Wise","doi":"10.1136/bmj.s232","DOIUrl":"https://doi.org/10.1136/bmj.s232","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s232"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical training posts bill: Why are UK graduates being prioritised, and what are the concerns?","authors":"Jane Feinmann","doi":"10.1136/bmj.s234","DOIUrl":"https://doi.org/10.1136/bmj.s234","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s234"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exhibition puts female surgeons in the spotlight.","authors":"Alison Shepherd","doi":"10.1136/bmj.s210","DOIUrl":"https://doi.org/10.1136/bmj.s210","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s210"},"PeriodicalIF":42.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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