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International journal of keratoconus and ectatic corneal diseases最新文献

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Corneal Cross-Linking at the Slit Lamp 裂隙灯下角膜交联
Pub Date : 2021-11-21 DOI: 10.1007/978-3-030-84506-3_8
E. A. Torres-Netto, M. Hosny, F. Hafezi
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引用次数: 0
Femtosecond-Laser Assisted Deep Anterior Lamellar Keratoplasty (F-DALK) 飞秒激光辅助深前板层角膜移植术(F-DALK)
Pub Date : 2021-11-21 DOI: 10.1007/978-3-030-84506-3_13
G. Schmidinger, T. Seiler, Ruth Donner
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引用次数: 0
SLAK: Stromal Lanticule Addition Keratoplasty 间质角质层添加角膜移植术
Pub Date : 2021-11-21 DOI: 10.1007/978-3-030-84506-3_14
L. Mastropasqua, M. Nubile, M. Lanzini
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引用次数: 0
A Case of True Superior Keratoconus Confirmed Using Multiple Imaging Modalities 一例经多种成像方式证实的真上角砾岩
Pub Date : 2021-02-22 DOI: 10.5005/JP-JOURNALS-10025-1180
O. Özalp, E. Atalay, N. Yıldırım
To report an unusual case of a newly diagnosed bilateral superior keratoconus in an elderly patient.We report a case of bilateral superior keratoconus in a 64-year-old woman who was diagnosed after having presented with hydrops in one eye.Uncorrected visual acuity was counting fingers from 3 and 1 meter for the right and left eyes, respectively. A superiorly located deep stromal scar and chronic corneal edema consistent with a diagnosis of corneal hydrops were noted for the left eye. Although the cornea was clear, there was superior corneal protrusion in the right eye. Pentacam and Orbscan demonstrated overlapping focal corneal thinning, increased back elevation, and steepening in the superior cornea. Anterior segment optical coherence tomography (AS-OCT) showed stromal and epithelial thinning in the superior cornea and significant compensatory epithelial thickening in the opposing quadrant. In light of these findings, a diagnosis of superior keratoconus was established.Superior keratoconus is a rare condition. Meticulous evaluation of corneal tomography and epithelial thickness profile is crucial for localizing the superior cone in keratoconus.This is the first case report demonstrating epithelial thickness profile in a superior keratoconus case.Özalp O, Atalay E, Yıldırım N. A Case of True Superior Keratoconus Confirmed Using Multiple Imaging Modalities. Int J Kerat Ect Cor Dis 2019;8(2):43–45.
报告一例新诊断为双侧上圆锥角膜的老年患者。我们报告一个病例的双侧上圆锥角膜在64岁的妇女谁是诊断后,提出了一个眼睛积液。未矫正视力为右眼和左眼分别从3米和1米数手指。左眼可见位置优越的深间质瘢痕和慢性角膜水肿,符合角膜积液的诊断。右眼角膜虽清晰,但有角膜上突。Pentacam和Orbscan显示重叠局灶性角膜变薄,后抬高增加,上角膜变陡。前段光学相干断层扫描(AS-OCT)显示上角膜间质和上皮变薄,对象限代偿性上皮明显增厚。根据这些发现,诊断为上圆锥角膜。上圆锥角膜是一种罕见的疾病。仔细评估角膜断层扫描和上皮厚度分布对圆锥角膜上锥的定位至关重要。这是第一例报告显示上圆锥角膜的上皮厚度。Özalp O, Atalay E, Yıldırım N. 1例真性上圆锥角膜的多重影像学检查。中华医学杂志,2019;8(2):43-45。
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引用次数: 0
Mini Asymmetric Radial Keratotomy and Corneal Cross-linking for the Treatment and the Optical Rehabilitation of Keratoconus 迷你非对称径向角膜切开术及角膜交联治疗圆锥角膜及视力康复
Pub Date : 2021-02-22 DOI: 10.5005/JP-JOURNALS-10025-1181
M. Abbondanza, G. Abbondanza, V. D. Felice
To present and discuss the outcomes of the mini asymmetric radial keratotomy (MARK) and corneal cross-linking (CXL) combined intervention, also known as the “Rome protocol”, for patients with progressive stage I, II, and III keratoconus (KC) and contact lens intolerance (CLI).Retrospective, observational study.The postoperative outcomes of 48 eyes (35 patients) were selected and retrospectively analyzed, with an average follow-up of 3.8 years. To assess the efficacy of the MARK plus CXL combined protocol, mean keratometry, mean pachymetry, and best spectacle-corrected visual acuity were evaluated.Mean keratometry improved in 90% of cases (from 48.3 D to 45 D), mean pachymetry improved in 83% of cases (from 439 to 460 μm), and best spectacle-corrected visual acuity improved in all cases (from +0.4 to +0.15 logMAR).The MARK plus CXL intervention effectively halted the KC progression and improved the visual acuity, which suggests that this combined procedure should be taken into account when considering refractive procedures combined with corneal cross-linking (CXL plus), if the relevant inclusion criteria can be satisfied.Abbondanza M, Abbondanza G, De Felice V. Mini Asymmetric Radial Keratotomy and Corneal Cross-linking for the Treatment and the Optical Rehabilitation of Keratoconus. Int J Kerat Ect Cor Dis 2019;8(2):35–39.
介绍和讨论迷你不对称放射性角膜切开术(MARK)和角膜交联(CXL)联合干预(也称为“罗马方案”)治疗进行性I、II、III期圆锥角膜(KC)和隐形眼镜不耐受(CLI)患者的结果。回顾性观察性研究。回顾性分析48只眼(35例)的术后结果,平均随访3.8年。为了评估MARK + CXL联合方案的疗效,我们评估了平均角膜度数、平均角膜度数和最佳眼镜矫正视力。90%的病例平均角膜度数改善(从48.3 D到45 D), 83%的病例平均角膜度数改善(从439 μm到460 μm),所有病例的最佳眼镜矫正视力改善(从+0.4到+0.15 logMAR)。MARK + CXL干预有效地阻止了KC的进展并改善了视力,这表明如果能满足相关的纳入标准,在考虑屈光手术联合角膜交联(CXL +)时应考虑这种联合手术。陈建军,陈建军,陈建军,等。非对称桡骨角膜切开术与角膜交联治疗圆锥角膜的疗效及视力恢复。中华医学杂志,2019;8(2):35-39。
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引用次数: 0
Pregnancy-associated New-onset Progressive Keratoconus with Horizontally Aligned Vogt's Striae in a 36-year-old Female 36岁女性妊娠相关新发进行性圆锥角膜伴水平排列Vogt条纹
Pub Date : 2021-02-22 DOI: 10.5005/JP-JOURNALS-10025-1183
J. McKelvie, D. A. Scott, G. A. Wilson
Ab s t r Ac t Aim: The aim of the study is to report a case of pregnancy-associated progressive keratoconus with atypical horizontally aligned Vogt’s striae. Background: Hormonal changes during pregnancy have been proposed as a risk factor for progressive keratoconus. There have been only a few cases of progressive keratoconus diagnosed with progression after pregnancy, without either an existing disease or an attributable cause. Case description: A 36-year-old New Zealand European woman presented with progressive myopic astigmatism following her first pregnancy. Stigmata of keratoconus were present on clinical examination and included horizontally aligned Vogt’s striae. Tomography measurements confirmed the diagnosis with characteristic inferior corneal steepening and ectasia bilaterally. The patient was advised to abstain from eye rubbing, commenced topical olopatadine, and underwent corneal collagen cross-linking following delivery to prevent further keratoconus progression. Conclusion: Pregnancy-associated progressive keratoconus in a 36-year-old woman was documented after the pregnancy. Clinical significance: Atypical presentation features that include horizontally aligned Vogt’s striae, advanced age at diagnosis, and rapid pregnancy-associated progression in a previously stable patient.
Ab s t r Ac t目的:本研究的目的是报告一例妊娠相关进行性圆锥角膜伴非典型水平排列的Vogt纹。背景:妊娠期间的激素变化被认为是进行性圆锥角膜的危险因素。只有少数进展性圆锥角膜在怀孕后被诊断为进展,没有现有疾病或可归因的原因。病例描述:一名36岁的新西兰欧洲妇女在第一次怀孕后出现进行性近视散光。临床检查发现圆锥角膜的污斑,包括水平排列的Vogt纹。体层摄影测量证实诊断为特征性下角膜变陡和双侧扩张。建议患者停止揉眼,开始外用奥洛帕坦,并在分娩后进行角膜胶原交联,以防止圆锥角膜的进一步发展。结论:一名36岁女性在妊娠后出现妊娠相关进行性圆锥角膜。临床意义:不典型的表现特征,包括水平排列的Vogt纹、诊断时的高龄以及先前稳定患者的妊娠相关快速进展。
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引用次数: 1
Therapeutic Analysis in Patients with Keratoconus 角质炎患者的治疗分析
Pub Date : 2021-02-22 DOI: 10.5005/JP-JOURNALS-10025-1184
P. Rodrigues, N. Carvalho, Thaiane F Guerra, Cristiane F Moutinho, Françuilner S dos Santos, R. Miyashiro, Rosangela A Simoncelli, B. Moscovici
This study aimed at assessing the therapeutic decisions made by an individual keratoconus specialist in the last 10 years, to treat patients with keratoconus.We studied a case series and the descriptive analysis of individual cases treated by a single keratoconus specialist. Medical records of 636 patients totaling 1271 eyes were evaluated based on the therapeutic procedure used.For the treatment of keratoconus, the specialist chose expectant (only spectacles) in 22.3% of the cases, contact lenses in 39.3%, implantation of intrastromal corneal ring segments (ICRS) in 27.7%, cross-linking in 0.9%, and penetrating keratoplasty in 8.5% of the cases.The keratoconus specialist preferred noninvasive therapeutic options to improve vision quality, such as spectacles and contact lenses.Show the therapeutic preferences of a keratoconus specialist in order to compare with the daily practice.Carvalho N, Guerra TF, Moutinho CF, et al. Therapeutic Analysis in Patients with Keratoconus. Int J Kerat Ect Cor Dis 2019;8(2):40–42.
本研究旨在评估圆锥角膜专科医生在过去10年中对圆锥角膜患者的治疗决策。我们研究了由一位圆锥角膜专科医生治疗的病例系列和个体病例的描述性分析。根据所采用的治疗方法,对636例患者共计1271只眼的医疗记录进行了评估。对于圆锥角膜的治疗,专科医生选择期待(仅戴眼镜)的占22.3%,隐形眼镜占39.3%,角膜间环段植入术占27.7%,交联术占0.9%,穿透性角膜移植术占8.5%。圆锥角膜专家更倾向于非侵入性治疗方案,如眼镜和隐形眼镜,以提高视力质量。显示圆锥角膜专科医生的治疗偏好,以便与日常实践进行比较。Carvalho N, Guerra TF, Moutinho CF,等。圆锥角膜的治疗分析。中华医学杂志,2019;8(2):40-42。
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引用次数: 1
Regression of Corneal Vascularization Occurring after Corneal Suturing in a Case of Acute Hydrops Managed with a Combination Therapy of Argon Laser Photocoagulation and Intrastromal Ranibizumab Injection: A Case Report 氩激光光凝联合基质内注射雷尼单抗治疗急性积液术后角膜血管化消退1例
Pub Date : 2021-02-22 DOI: 10.5005/JP-JOURNALS-10025-1182
Abraham Kurian, Iodine Reghunadhan, Manoj Soman, Mohammed Shahbaaz, Unnikrishnan Nair
To report a case of acute hydrops with a large stromal cleft, in a case of keratoconus, managed with compression sutures and perfluoropropane (C3F8) descemetopexy and subsequent management of corneal vascularization in that eye with combination therapy of laser and anti-vascular endothelial growth factor (anti-VEGF).Acute hydrops in keratoconus occurs following a tear or rupture in the Descemet's membrane (DM), resulting in aqueous percolating into the stroma. The presence of large stromal clefts in acute hydrops has been described as a known risk factor for delayed resolution and persistent edema, which in turn can incite inflammation and vascularization and thereby adversely affect the chances of graft survival later. We describe such a case managed effectively with a combination of different treatment modalities.A 12-year-old boy with keratoconus presented with acute hydrops in his left eye. The acute hydrops was managed with compression sutures along with C3F8 descemetopexy. Subsequent development of persistent deep corneal vascularization and recurrence of inflammation after the resolution of hydrops was managed with a combination of argon laser photocoagulation and intrastromal anti-VEGF injections, resulting in complete regression of the deep vascularization and resolution of inflammation.In our case, a combination of management modalities to address severe acute hydrops and its subsequent complications resulted in complete regression of the superficial and deep vessels, thus heralding an optimal outcome for a future corneal graft.There are no definite guidelines for the management of acute hydrops in keratoconus. A customized and judicious combination of various treatment modalities described in the literature for acute hydrops and its sequelae can result in an accepted outcome, which can pave the way for an optimum result with elective treatments like keratoplasty later on.Kurian A, Reghunadhan I, Soman M, et al. Regression of Corneal Vascularization Occurring after Corneal Suturing in a Case of Acute Hydrops Managed with a Combination Therapy of Argon Laser Photocoagulation and Intrastromal Ranibizumab Injection: A Case Report. Int J Kerat Ect Cor Dis 2019;8(2):46–49.
报告一例伴有大基质裂隙的急性积液,圆锥角膜患者,采用加压缝合和全氟丙烷(C3F8)血管固定术治疗,随后采用激光和抗血管内皮生长因子(抗vegf)联合治疗该眼的角膜血管化。急性圆锥角膜积液发生在角膜下层膜(DM)撕裂或破裂后,导致水渗透到基质中。急性水肿中存在的大基质裂隙被认为是延迟消退和持续水肿的已知危险因素,这反过来又会引发炎症和血管形成,从而对移植物以后的存活机会产生不利影响。我们描述这样一个案例有效地管理与不同的治疗方式的组合。摘要一名十二岁男童患有圆锥角膜,以左眼急性积液表现。急性积液采用加压缝合联合C3F8椎体固定术治疗。在积液消退后,持续角膜深部血管形成和炎症复发的情况下,采用氩激光光凝联合角膜内抗vegf注射治疗,使角膜深部血管形成完全消退,炎症消退。在我们的病例中,治疗严重急性积液及其后续并发症的综合治疗方式导致浅层和深层血管完全消退,从而预示着未来角膜移植的最佳结果。对于圆锥角膜急性积液的处理尚无明确的指导方针。文献中描述的针对急性水肿及其后遗症的各种治疗方式的定制和明智的组合可以产生可接受的结果,这可以为以后选择治疗(如角膜移植术)的最佳结果铺平道路。李建军,李建军,李建军,等。氩激光光凝联合基质内注射雷尼单抗治疗急性积液术后角膜血管化消退1例中华医学杂志,2019;8(2):46-49。
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引用次数: 0
Comparison of Rigid Gas-permeable Contact Lenses with Soft Hydrogel Contact Lens in Keratoconus and their Impact on Quality of Life 硬质透气性隐形眼镜与软性水凝胶隐形眼镜治疗圆锥角膜的比较及其对生活质量的影响
Pub Date : 2019-06-01 DOI: 10.5005/jp-journals-10025-1178
J. Ram, S. Yangzes, Amit Gupta, A. Thakur
Ab s t r Ac t Purpose: To compare the efficacy of rigid gas-permeable (RGP) lens and soft hydrogel lens in patients with keratoconus and to assess their impact on quality of life (QoL). Setting: Tertiary care referral center. Materials and methods: A randomized, comparative, clinical interventional trial was conducted in patients with keratoconus. From July 2014 to June 2017, patients were enrolled for this study and were fitted with RGP contact lens (CL) (RoseK© Menicon Limited) or silicone hydrogel lens (Kerasoft© International Limited). The two groups were compared in terms of best spectacle corrected visual acuity (BSCVA), best CL corrected visual acuity (BCLCVA), corneal topography, Schirmer’s test, and contrast sensitivity. Quality of life was assessed by asking the patients to fill a self-reported questionnaire. Results: Forty eyes were enrolled and randomized to the Rose-K and Kerasoft groups. The two groups were comparable with respect to the mean patient age, sex, and mean K values. A statistically significant improvement was observed in BCLCVA in both groups at 6 months (p < 0.01). The Kerasoft group had a better comfort score at 6 months’ follow-up compared to Rose K (p < 0.05). In terms of contrast sensitivity, Rose K group fared better than Kerasoft group (p = 0.001). Conclusion: Both Kerasoft and Rose K groups showed improvement in visual acuity. Kerasoft lens users had better comfort and also required less number of trials before final fit. Rose K lens provided a better contrast sensitivity. We conclude that Kerasoft lens can be considered as a good alternative for optical correction of corneal astigmatism in patients with keratoconus, not tolerating RGP lenses.
目的:比较硬质透气性晶状体(RGP)与软性水凝胶晶状体在圆锥角膜患者中的应用效果,并评价其对生活质量(QoL)的影响。环境:三级保健转诊中心。材料与方法:对圆锥角膜患者进行随机、比较、临床介入试验。2014年7月至2017年6月,患者被纳入本研究,并配戴RGP隐形眼镜(CL) (RoseK©Menicon Limited)或硅酮水凝胶隐形眼镜(Kerasoft©International Limited)。比较两组患者最佳眼镜矫正视力(BSCVA)、最佳CL矫正视力(BCLCVA)、角膜地形图、Schirmer试验、对比敏感度。通过要求患者填写一份自我报告的问卷来评估生活质量。结果:40只眼被纳入,随机分为Rose-K组和Kerasoft组。两组患者的平均年龄、性别和平均K值具有可比性。两组患者在6个月时BCLCVA均有显著改善(p < 0.01)。随访6个月时,Kerasoft组患者舒适度评分高于Rose K组(p < 0.05)。对比敏感度方面,Rose K组优于Kerasoft组(p = 0.001)。结论:Kerasoft组和Rose K组视力均有明显改善。Kerasoft镜片用户有更好的舒适度,并且在最终匹配之前需要较少的试验次数。玫瑰K镜头提供了更好的对比灵敏度。我们的结论是,Kerasoft晶状体可以被认为是对不耐受RGP晶状体的圆锥角膜患者角膜散光进行光学矫正的良好选择。
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引用次数: 0
Clinical Evaluation of a New Approach for IOL Power Calculation in Keratoconus 一种新型人工晶状体屈光力计算方法的临床评价
Pub Date : 2019-06-01 DOI: 10.5005/jp-journals-10025-1177
D. P. Llorens, Esteban Caravaca-Arens, Vicente J. Camps, R. Fikry, Verónica Mateo, Fady E. Labib, M. T. Caballero
Purpose: To obtain an expression of the adjusted IOL power (PIOLadj) in keratoconus eyes associated with minimal errors in IOL power calculation. Materials and methods: This retrospective study included a total of 25 eyes of 25 patients with ages ranging from 20 years to 76 years. The following IOLs were implanted: Acrysof IQ Toric, Acrysof SA60AT in 9 eyes, Sensar in 3 eyes, Tecnis 1 in 4 eyes, and Tecnis Toric in 2 eyes. The PIOLadj is based on Gauss equations, using adjusted keratometric index (nkadj) specific to keratoconus eyes. From this nkadj, an adjusted keratometric corneal power is calculated (Pkadj). The PIOLadj calculation was performed after estimating the effective lens position (ELP) using a mathematical expression obtained by multiple regression analysis (named ELPadj). Comparison between the PIOLadj and the real intraocular power implanted in each patient (PIOLreal) was carried out. Results: No significant differences between PIOLreal and PIOLadj were found. However, differences could be clinically relevant up to of 2.54 D as PIOLreal increases. But, in the range of PIOLreal between 0 and 20 D, differences were lower than 1.5 D, being most of them below 1 D. Conclusion: A new formula of IOL power calculation (PIOLadj) based on the use of an adjusted keratometric power (Pkadj) that considers a variable keratometric index due to the influence of the posterior corneal surface (nkadj) and adjusted effective lens position (ELPadj) is useful for estimating IOL power in low-to-moderate keratoconus, with more limitation in the most advanced keratoconus.
目的:探讨圆锥角膜人工晶状体度数计算误差最小时人工晶状体调节度数(PIOLadj)的表达。材料与方法:本回顾性研究共纳入25例患者25眼,年龄从20岁到76岁不等。人工晶体植入:Acrysof IQ Toric 9眼,Acrysof SA60AT 3眼,Tecnis 1 4眼,Tecnis Toric 2眼。PIOLadj是基于高斯方程,使用特定于圆锥角膜的调整角膜测量指数(nkadj)。从这个nkadj,计算出一个调整后的角膜度数(Pkadj)。利用多元回归分析得到的数学表达式(ELPadj)估算出有效透镜位置(ELP)后,进行PIOLadj的计算。将每位患者的PIOLadj与实际植入的人工眼力(PIOLreal)进行比较。结果:PIOLreal与PIOLadj无显著性差异。然而,随着PIOLreal的增加,临床相关差异可达2.54 D。但在PIOLreal 0 ~ 20d范围内,差异均小于1.5 D,大部分小于1 D。一种新的人工晶状体度数计算公式(PIOLadj)是基于考虑角膜后表面(nkadj)和晶状体有效位置(ELPadj)影响的可变角膜度数(Pkadj),该公式可用于估计中低度圆锥角膜的人工晶状体度数,但在最先进的圆锥角膜中有更多的局限性。
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引用次数: 1
期刊
International journal of keratoconus and ectatic corneal diseases
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