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A look at Graves’ hyperthyroidism in pregnancy 妊娠期Graves甲亢的观察
Pub Date : 2018-05-11 DOI: 10.21037/AOT.2018.10.02
C. Nguyen, J. Mestman
Maternal, obstetrical, and neonatal complications are increased in women with poorly controlled thyroid disease during pregnancy. Establishing the correct diagnosis and effectively managing Graves’ hyperthyroidism (GH) remains challenging for physicians due to several reasons including, but not limited to changes in thyroid physiology during pregnancy, effect of pregnancy on laboratory testing, and teratogenicity associated with anti-thyroid drugs. This paper will review the diagnosis and management of GH in pregnancy and address: (I) preconception counseling; (II) alterations in thyroid physiology in pregnancy; (III) thyroid laboratory testing; (IV) etiologies of hyperthyroidism; (V) pregnancy-related complications; (VI) maternal management; (VII) neonatal management; (VIII) ATDs and the associated maternal and fetal complications; and (IX) post-partum management. Establishing the diagnosis of GH early, maintaining euthyroidism throughout the duration of pregnancy, and avoiding overtreatment of the fetus with antithyroid drugs (ATDs) is essential to reducing the risk of complications for the mother, fetus, and newborn. The successful care of these complex patients requires close collaboration between the endocrinologist, maternal-fetal-medicine specialist, obstetrician, neonatologist, and pediatric endocrinologist.
妊娠期甲状腺疾病控制不佳的妇女,其母体、产科和新生儿并发症增加。由于几个原因,包括但不限于妊娠期间甲状腺生理学的变化、妊娠对实验室检测的影响以及与抗甲状腺药物相关的致畸性,确定正确的诊断并有效管理Graves’s甲状腺功能亢进症(GH)对医生来说仍然具有挑战性。本文将综述妊娠期生长激素的诊断和治疗,并讨论:(I)孕前咨询;(II) 妊娠期甲状腺生理变化;(III) 甲状腺实验室检测;(IV) 甲状腺功能亢进的病因;(V) 妊娠相关并发症;(VI) 孕产妇管理;(VII) 新生儿管理;(VIII) ATDs和相关的母婴并发症;以及(IX)产后管理。早期诊断GH,在整个妊娠期间保持甲状腺功能正常,避免使用抗甲状腺药物(ATD)过度治疗胎儿,对于降低母亲、胎儿和新生儿并发症的风险至关重要。这些复杂患者的成功护理需要内分泌学家、母婴医学专家、产科医生、新生儿医生和儿科内分泌学家之间的密切合作。
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引用次数: 2
The evolution and progress of mechanism and prevention of recurrent laryngeal nerve injury 喉返神经损伤机制及预防的演变与进展
Pub Date : 2018-03-12 DOI: 10.21037/aot.2018.11.02
A. Konturek, M. Barczyński
Vocal fold paralysis is among the most severe complications in neck and chest surgery, being most commonly associated with thyroid and parathyroid procedures; nevertheless, it may also be an effect of cardiac or thoracic surgery. It should be remembered that the scale of the problem is much greater than it might be thought. The phenomenon most assuredly results from lack of true data to be provided by all the centers involved in surgical procedures performed in this region. The improvement of surgical techniques and the strife to limit injuries have become the symbol of progress in surgery, and quality of life after thyroid and parathyroid procedures—a sign of striving for the least number of complications. Side by side with development of new technologies there have emerged possibilities of monitoring the electrophysiological function of the nerves that help in identification of these life-important structures and allow for prognosticating their postoperative function. It should be emphasized that understanding anatomy, laws that govern neural conductivity and the ability to use new technologies have become the determinants of quality in thyroid and parathyroid surgery. The paper discusses the most important problems pertaining to injuries of the recurrent laryngeal nerves (RLNs), the mechanisms of injury infliction, intraoperative identification and prevention, as well as prognosticating the postoperative voice quality.
声带麻痹是颈部和胸部手术中最严重的并发症之一,最常与甲状腺和甲状旁腺手术有关;然而,这也可能是心脏或胸外科手术的结果。应该记住,这个问题的规模比人们想象的要大得多。这种现象很可能是由于该地区所有参与外科手术的中心缺乏提供的真实数据造成的。手术技术的进步和限制伤害的努力已经成为外科手术进步的标志,以及甲状腺和甲状旁腺手术后的生活质量——努力减少并发症的标志。随着新技术的发展,监测神经电生理功能的可能性已经出现,这有助于识别这些对生命至关重要的结构,并允许预测其术后功能。应该强调的是,对解剖学的理解、控制神经传导的规律和使用新技术的能力已经成为甲状腺和甲状旁腺手术质量的决定因素。本文就喉返神经损伤的主要问题、损伤机制、术中识别和预防以及术后语音质量的预测进行了讨论。
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引用次数: 3
Active surveillance for very low-risk papillary thyroid carcinoma: experience and perspectives from Japan 极低风险甲状腺乳头状癌的主动监测:来自日本的经验和观点
Pub Date : 2018-02-11 DOI: 10.21037/AOT.2018.10.04
I. Sugitani
Low-risk papillary thyroid carcinoma (PTC) has been treated using lobectomy in Japan. This represents a very different approach to that used in Western countries, where the majority of patients have been treated with total thyroidectomy followed by radioactive iodine (RAI). Given the excellent survival and lower risk of surgical complications, Western guidelines have recently adopted a limited surgical approach for low-risk PTC. The treatment paradigm has shifted from a one-size-fits-all approach to more individualized protocols under the concept of risk-adapted management and treatment policies in the East and West have become increasingly integrated. The incidence of thyroid cancer has continued increasing around the world, mainly thanks to the increased detection of small PTCs, and debate is now emerging regarding the potential for overdiagnosis and overtreatment of subclinical thyroid cancers. Countermeasures to the phenomenon have been explored. Guidelines have been establishing new standards for cancer screening and clinical diagnosis. Pathologists have proposed changing the diagnostic criteria and terminology for indolent thyroid tumors. Since the 1990s, two Japanese institutions have initiated prospective trials of active surveillance for asymptomatic papillary microcarcinoma (PMC). These trials verified that the vast majority of tumors did not progress during active surveillance and outcomes were unaffected by delaying surgery. The Japanese guidelines adopted active surveillance management for asymptomatic PMC in 2010. The 2015 American Thyroid Association (ATA) guidelines have accepted the policy as an alternative to immediate surgery in patients with very low-risk tumors. Further studies have revealed that PMC was less progressive in older patients than in younger patients. Strong calcification and poor vascularity were indicators of stable disease. Several clinical issues remain unsolved in terms of active surveillance options for very low-risk PTC. Studies on patient-reported outcomes are still lacking and more specific predictors for the progression of low-risk PTC at the time of diagnosis are in demand.
低风险甲状腺乳头状癌(PTC)已在日本使用肺叶切除术进行治疗。这代表了一种与西方国家截然不同的方法,在西方国家,大多数患者都接受了甲状腺全切除术,然后接受放射性碘(RAI)治疗。鉴于良好的生存率和较低的手术并发症风险,西方指南最近对低风险PTC采用了有限的手术方法。在风险适应管理的概念下,治疗模式已经从一刀切的方法转变为更个性化的方案,东方和西方的治疗政策也越来越一体化。癌症的发病率在世界各地持续增加,这主要归功于小PTC的检测增加,目前正在就亚临床甲状腺癌的过度诊断和过度治疗潜力展开辩论。已经探讨了应对这一现象的对策。指导方针一直在为癌症筛查和临床诊断制定新的标准。病理学家建议改变惰性甲状腺肿瘤的诊断标准和术语。自20世纪90年代以来,两个日本机构已经启动了无症状乳头状微癌(PMC)主动监测的前瞻性试验。这些试验证实,绝大多数肿瘤在积极监测期间没有进展,延迟手术也不会影响结果。2010年,日本指南对无症状PMC采取了积极的监测管理。2015年美国甲状腺协会(ATA)指南已接受该政策,将其作为极低风险肿瘤患者立即手术的替代方案。进一步的研究表明,老年患者的PMC进展不如年轻患者。强烈的钙化和较差的血管是疾病稳定的指标。就极低风险PTC的积极监测选择而言,几个临床问题仍未解决。对患者报告的结果的研究仍然缺乏,需要在诊断时对低风险PTC的进展进行更具体的预测。
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引用次数: 7
Central neck dissection via the transoral approach. 经口入路中央颈部清扫术。
Pub Date : 2017-01-01 Epub Date: 2017-10-31 DOI: 10.21037/aot.2017.10.02
Christopher R Razavi, Akeweh Fondong, Ralph P Tufano, Jonathon O Russell

There has been a strong impetus for the development of remote access approaches to the central neck. The primary motivation for this has been to alleviate the negative impact that some patients may perceive from a central neck scar. Numerous approaches have been described; however the only approach that provides midline access and equivalent visualization of the bilateral thyroid lobes and paratracheal basins is transoral neck surgery (TONS). TONS has been shown to be safe and effective in performing thyroidectomy, parathyroidectomy, and central neck dissection (CND) via both the endoscopic and robotic techniques. In contrast with other remote access techniques, it provides the surgeon with familiar views of the bilateral recurrent laryngeal nerves (RLN) at their insertion site in concert with equivalent access to both paratracheal basins, thus uniquely facilitating safe and comprehensive CND. Though feasible and safe, CND via TONS is not appropriate in all cases. CND via TONS should only be performed with concomitant transoral total thyroidectomy, either prophylactically if the surgeon routinely performs prophylactic CND, or therapeutically if there is newly found evidence of nodal metastasis in the central compartment at the time of surgery. We base these recommendations on both the recent American Head and Neck Society (AHNS) consensus statement for indications for transcervical CND and the baseline indications for TONS.

有一股强大的动力推动了对中央颈部的远程访问方法的发展。这样做的主要动机是为了减轻一些患者可能感受到的颈部中心疤痕的负面影响。已经描述了许多方法;然而,唯一能提供中线通路和双侧甲状腺叶和气管旁盆腔等效可视化的方法是经口颈部手术(TONS)。通过内窥镜和机器人技术,TONS已被证明在甲状腺切除术、甲状旁腺切除术和中央颈部清扫术(CND)中安全有效。与其他远程进入技术相比,它为外科医生提供了双侧喉返神经(RLN)插入部位的熟悉视图,同时也提供了对两个气管旁盆地的同等进入,从而独特地促进了安全和全面的CND。虽然可行和安全,但并非在所有情况下都适用通过ton进行CND。经TONS行CND只能同时行经口全甲状腺切除术,如果外科医生常规行预防性CND,则可采取预防性措施;如果手术时新发现中央腔室淋巴结转移,则可采取治疗性措施。我们的建议基于最近美国头颈学会(AHNS)关于经宫颈CND适应症的共识声明和TONS的基线适应症。
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引用次数: 35
Indications and contraindications to transoral thyroidectomy. 经口甲状腺切除术的适应症和禁忌症。
Pub Date : 2017-01-01 Epub Date: 2017-10-31 DOI: 10.21037/aot.2017.10.01
Christopher R Razavi, Jonathon O Russell

Patient motivation to avoid neck scarring has been a strong impetus in the development of remote access approaches to the thyroid, including transoral robotic or endoscopic thyroidectomy vestibular approach (TOR/ETVA). TOR/ETVA continues to become more prevalent given its early success in North America and the demonstration of its safety and efficacy in Asia. As more surgeons perform this procedure, it is important that specific and uniform indications and contraindications exist to prevent surgical complications due to poor patient selection. In this article, we review the existing English literature regarding TOR/ETVA and compile the inclusion and exclusion criteria of individual authors for both robotic and endoscopic techniques to date. We then resolve differences in the existing literature to provide recommended indications and contraindications to TOR/ETVA based on both our review and our own experience with TOR/ETVA to date. The following are our resultant recommended indications for TOR/ETVA: patient history of hypertrophic scarring or motivation to avoid a cervical neck incision with a maximal thyroid diameter ≤ 10 cm and dominant nodule ≤6 cm, with one of the following pathologic criteria; benign lesion, multinodular goiter, indeterminate nodule, or suspicious lesions/well-differentiated thyroid carcinomas ≤ 2 cm. Recommended contraindications to TOR/ETVA are as follows: history of head & neck surgery, history of head, neck, or upper mediastinal irradiation, inability to tolerate general anesthesia, evidence of clinical hyperthyroidism, preoperative recurrent laryngeal nerve palsy, lymph node metastasis, extrathyroidal extension including tracheal or esophageal invasion, oral abscesses, substernal thyroidal extension, or failure to meet inclusion criteria as above. Relative contraindications include smoking and other oral pathology, and surgeons should be aware that morbid obesity may make it difficult to raise skin flaps.

患者避免颈部瘢痕形成的动机一直是甲状腺远程入路发展的强大推动力,包括经口机器人或内窥镜甲状腺切除术前庭入路(TOR/ETVA)。鉴于TOR/ETVA在北美的早期成功以及其在亚洲的安全性和有效性的证明,它将继续变得更加普遍。随着越来越多的外科医生进行这种手术,重要的是要有具体和统一的适应症和禁忌症,以防止由于患者选择不当而导致的手术并发症。在本文中,我们回顾了现有的关于TOR/ETVA的英文文献,并编制了迄今为止机器人和内窥镜技术的个体作者的纳入和排除标准。然后,我们根据我们的综述和我们自己迄今为止使用TOR/ETVA的经验,解决现有文献中的差异,提供TOR/ETVA的推荐适应症和禁忌症。以下是我们推荐的TOR/ETVA适应症:患者有增生性瘢痕病史,或有避免颈部切口的动机,最大甲状腺直径≤10厘米,主要结节≤6厘米,符合以下病理标准之一;良性病变、多结节性甲状腺肿、不确定结节或可疑病变/≤2 cm的高分化甲状腺癌。TOR/ETVA的推荐禁忌症如下:有头颈部手术史,有头颈部或上纵隔照射史,不能耐受全麻,有临床甲状腺功能亢进的证据,术前喉返神经麻痹,淋巴结转移,甲状腺外展包括气管或食管侵犯,口腔脓肿,胸骨下甲状腺展,或不符合上述纳入标准。相关禁忌症包括吸烟和其他口腔病理,外科医生应该意识到病态肥胖可能会使皮瓣难以抬起。
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引用次数: 60
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Annals of thyroid
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