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Character of somatic and psycho-emotional disorders in children with various types of juvenile arthritis 不同类型幼年关节炎患儿躯体和心理情绪障碍的特点
Pub Date : 2023-06-01 DOI: 10.17352/2455-2976.000197
O. Efimenko, MSh Ganieva, LR Khaidarova, U. Ganieva
Rheumatic diseases in children are a source of serious medical, social, and personal problems due to the prevalence, and severity of pain syndrome, progressive course with involvement of internal organs and disorders in the psycho-emotional sphere in the pathological process. The nature of somatic and psycho-emotional disorders was studied in 70 children aged 7 years - 16 years old with various types of Juvenile Rheumatoid Arthritis (JRA). The severe course of the disease, and as a result, disability, leads to emotional instability and social maladjustment of children. The predominance of articular forms with a primary lesion of the joints of the lower extremities and their deformation was remarkable. In children with a systemic variant of JRA, kidney damage was detected in the form of urinary syndrome and tubulointerstitial nephritis. Headache was the leading clinical manifestation of autonomic disorders caused by vascular disorders.
儿童风湿性疾病是严重的医疗、社会和个人问题的来源,由于疼痛综合征的普遍性和严重性,在病理过程中累及内脏器官和心理情绪领域的疾病的进行性过程。本文对70例7 ~ 16岁不同类型的幼年类风湿性关节炎(JRA)患儿的躯体和心理情绪障碍进行了研究。这种疾病的严重病程,以及由此导致的残疾,导致儿童情绪不稳定和社会适应不良。关节形式的优势与原发性病变的下肢关节和他们的变形是显著的。在JRA全身性变异的儿童中,肾脏损害以泌尿综合征和小管间质性肾炎的形式被检测到。头痛是血管病变引起的自主神经紊乱的主要临床表现。
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引用次数: 0
Nutritional aspects in the sportsman’s functional rehabilitation program 运动员功能康复计划的营养方面
Pub Date : 2023-05-31 DOI: 10.17352/2455-2976.000196
A. Fondi, A. D'Angelo, A. Bartoletti, G. Di Giacinto, P. Ripari
The adoption of a proper dietary regimen is of vital importance in the sports practice of athletes, as it is able to ensure an adequate turn-over of all those substances that are consumed with exercise. Our purpose was to demonstrate how adequate protein intake can favorably influence the post-injury rehabilitation phase. Our work is presented as a case-control study on a group of 16 competitive athletes recovering from sports injuries who were prescribed a balanced diet with, to 8 of them, oral supplementation with a pool of amino acids in optimal composition in the dose of 1g/kg/day. In the two groups, recovery time, muscle strength, and injured limb diameter were taken as variables. It was observed that the group treated with amino acid supplementation had statistically significant benefits compared with the group treated with diet prescription alone.
在运动员的运动实践中,采用适当的饮食方案是至关重要的,因为它能够确保在运动中消耗的所有物质的充分周转。我们的目的是证明充足的蛋白质摄入如何对损伤后康复阶段产生有利影响。我们的工作是一项病例对照研究,研究对象是一组16名从运动损伤中恢复的竞技运动员,他们被要求均衡饮食,其中8人口服补充最佳组成的氨基酸,剂量为1g/kg/天。两组均以恢复时间、肌力、伤肢直径为变量。观察到,与单独服用饮食处方的组相比,服用氨基酸补充剂的组有统计学上显著的益处。
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引用次数: 0
Myocardial fibrosis in aortic stenosis: comparison between clinical data, laboratory, echocardiography, and cardiac magnetic resonance 主动脉狭窄的心肌纤维化:临床数据、实验室、超声心动图和心脏磁共振的比较
Pub Date : 2023-05-16 DOI: 10.29328/journal.jccm.1001153
Tosto Giuseppe, Passaniti Giulia, Gibiino Fortunata Alessandra, Deste Wanda, Indelicato Antonino, Torrisi Tito, Bottaro Giuseppe, Cannizzaro Maria Teresa, Tamburino Corrado
Introduction: Patients with aortic stenosis often develop hypertrophy and fibrosis, regardless of symptoms. Cardiac Magnetic Resonance (CMR) represents the gold standard for the evaluation of fibrosis despite numerous limitations: cost, availability, atrial fibrillation, claustrophobia, kidney failure or inability to apnea. Purpose: The aim is to validate the role of echocardiographic parameters, such as Global Longitudinal Strain (GLS), as early markers of fibrosis. Clinical and laboratory data, particularly B-type Natriuretic Peptide (BNP), were also analyzed. Material and methods: In our study we recruited 33 patients with severe aortic stenosis, correlating echocardiographic values of GLS with the qualitative analysis of Late Gadolinium Enhancement (LGE) and the quantitative analysis of T1 mapping of CMR. Results: 70% of patients with an alteration of GLS had LGE+. Univariate logistic regression shows that the factors associated with the presence of LGE on CMR are hypertension (p = 0.043), GLS (p = 0.032), and elevated BNP values (p = 0.021); for GLS, Odds Ratio (OR) is 5 so the chance of finding fibrosis on CMR increases 5 times in presence of an altered GLS. The multivariate analysis confirms the association with impaired GLS values (p = 0.033) and hypertension (p = 0.025), but not with elevated Pro-BNP values. Conclusion: In patients with severe aortic stenosis, the association between GLS, LGE, and T1 mapping can help identify earlier those patients with structural changes caused by the disease, who could benefit from early intervention. It remains to be established how the presence of these alterations has a role in determining the intervention time and the outcome of these patients.
导言:主动脉瓣狭窄患者常发生肥大和纤维化,无论症状如何。心脏磁共振(CMR)代表了评估纤维化的金标准,尽管存在许多限制:成本、可用性、心房颤动、幽闭恐怖症、肾衰竭或无法呼吸暂停。目的:目的是验证超声心动图参数的作用,如全局纵向应变(GLS),作为纤维化的早期标志物。临床和实验室数据,特别是b型利钠肽(BNP),也进行了分析。材料与方法:本研究招募33例重度主动脉瓣狭窄患者,将GLS超声心动图值与晚期钆增强(LGE)定性分析和CMR T1作图定量分析相关联。结果:GLS改变患者中LGE+占70%。单因素logistic回归分析显示,与LGE对CMR的影响相关的因素有高血压(p = 0.043)、GLS (p = 0.032)和BNP升高(p = 0.021);对于GLS,比值比(OR)为5,因此在GLS改变的情况下,CMR发现纤维化的机会增加了5倍。多变量分析证实与GLS值受损(p = 0.033)和高血压(p = 0.025)相关,但与Pro-BNP值升高无关。结论:在严重主动脉瓣狭窄患者中,GLS、LGE和T1图谱的相关性可以帮助早期识别疾病引起的结构改变患者,这些患者可以从早期干预中获益。这些改变的存在如何在决定这些患者的干预时间和结果方面发挥作用仍有待确定。
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引用次数: 0
Security and performance of remote patient monitoring for chronic heart failure with Satelia® Cardio: First results from real-world use 使用Satelia®Cardio远程监测慢性心力衰竭患者的安全性和性能:来自现实世界使用的第一个结果
Pub Date : 2023-05-15 DOI: 10.29328/journal.jccm.1001152
J. Patrick, Picard F, Girerd N, Lemieux H, Barritault F, Seronde Mf, Labarre Jp, Pages N, Bedel C, Betito L, Nisse-Durgeat S, Diebold B
Background: Since 2019, remote patient monitoring (RPM) for patients with chronic heart failure (CHF) has been supported by the European Society of Cardiology. However, real-world data on the use of such solutions has been limited and not primarily based on patient-reported outcomes. The aim of this study was to describe the Satelia® Cardio solution in France within the French ETAPES funding program and assess the security and performance of its clinical algorithm. Methods: A retrospective observational study was conducted on CHF patients monitored by RPM through Satelia® Cardio. From September 1, 2018, to June 30, 2020, patients were included if they had completed over six months of follow-up. The risk of a possible CHF decompensation was categorized by the system in three levels: green, orange and red. The algorithm security and performance were assessed through the negative predictive value (NPV) of the prediction of hospitalization of a patient within seven days. Results: In total, 331 patients were included in this study with 36,682 patient self-administered questionnaires answered. Patients were mostly males (70.4%) and had a mean age of 68.1 years. The mean left ventricular ejection fraction (LVEF) was 35.4% (± 12.3) and 73.3% of patients had a LVEF ≤ 40%. The questionnaire response rate was 90.9%. A green status was generated for 95.3% of answers. There were 4.5% (n = 1,499) orange alerts and 0.2% (n = 74) red alerts. Overall, 92.1% of patients had at least one CHF related hospitalization and 31.7% (n = 105) of these cases were non-scheduled. The NPV at seven days was 99.43%. Conclusion: Satelia® Cardio is a feasible, relevant and reliable solution to safely monitor the cohorts of patients with CHF, reassuring cardiologists about patient stability.
背景:自2019年以来,慢性心力衰竭(CHF)患者的远程患者监测(RPM)得到了欧洲心脏病学会的支持。然而,关于使用此类解决方案的实际数据有限,而且主要不是基于患者报告的结果。本研究的目的是在法国ETAPES资助项目中描述法国的Satelia®Cardio解决方案,并评估其临床算法的安全性和性能。方法:对通过Satelia®Cardio进行RPM监测的CHF患者进行回顾性观察研究。从2018年9月1日至2020年6月30日,如果患者完成了6个月以上的随访,则纳入患者。瑞士法郎可能失偿的风险被系统分为三个级别:绿色、橙色和红色。通过预测患者7天内住院的负预测值(NPV)来评估算法的安全性和性能。结果:本研究共纳入331例患者,共回复36682份患者自填问卷。患者以男性居多(70.4%),平均年龄68.1岁。平均左室射血分数(LVEF)为35.4%(±12.3),73.3%的患者LVEF≤40%。问卷回复率为90.9%。95.3%的回答为绿色状态。有4.5% (n = 1499)的橙色警报和0.2% (n = 74)的红色警报。总体而言,92.1%的患者至少有一次与CHF相关的住院治疗,其中31.7% (n = 105)的患者未安排住院治疗。7天NPV为99.43%。结论:Satelia®Cardio是一种可行、相关和可靠的解决方案,可安全监测CHF患者队列,使心脏病专家对患者的稳定性放心。
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引用次数: 0
Restoration of sinus rhythm in a late presentation of inferior STEMI complicated by complete heart block with percutaneous coronary intervention 经皮冠状动脉介入治疗晚期下段STEMI合并完全心脏传导阻滞的窦性心律恢复
Pub Date : 2023-04-01 DOI: 10.17352/2455-2976.000195
F. Omar, Chaabo Omar, Khoury Maurice, Ghazzal Ziyad
An 87-year-old female patient presented with a two-day history of the chest and epigastric pain associated with generalized fatigue. She was diagnosed with late presentation inferior ST-elevation myocardial infarction complicated by complete heart block. Given her late presentation, she was not taken to the catheterization laboratory immediately. She was admitted to the cardiac care unit. Transthoracic echocardiography showed an ejection fraction of 55% - 60% with wall motion abnormalities involving the posterior and inferior walls. A coronary angiogram the next day showed a total occlusion of the proximal segment of the RCA. Despite the uncertain benefit, taking into account the complete heart block, the artery was re-canalized with stent placement. She remained in complete heart block with stable hemodynamics. The heart team took the decision with the family to delay the insertion of a permanent pacemaker to maximize the chance of spontaneous recovery. Indeed, three days after coronary revascularization, her rhythm evolved into atrial fibrillation and two days later reverted to sinus rhythm with first-degree AV block and LAFB. She remained in normal sinus rhythm and first-degree AV block at her six months follow-up clinic visit. Data regarding the role of percutaneous intervention in patients presenting with late inferior STEMI and complete heart block is lacking. Our case illustrates the possible therapeutic role of late intervention in restoring sinus rhythm and avoiding the insertion of a permanent pacemaker.
一位87岁的女性患者,有两天的胸痛和上腹部疼痛史,并伴有全身疲劳。她被诊断为晚期下位st段抬高型心肌梗死并完全性心脏传导阻滞。由于她的报告迟了,她没有立即被带到导尿实验室。她被送进了心脏科。经胸超声心动图显示射血分数为55% - 60%,壁运动异常累及后壁和下壁。第二天的冠状动脉造影显示RCA近段完全闭塞。尽管益处不确定,但考虑到完全的心脏传导阻滞,动脉通过支架置入术重新通管。她仍处于完全心脏传导阻滞,血流动力学稳定。心脏小组与家人一起决定推迟植入永久起搏器,以最大限度地提高自发恢复的机会。的确,冠状动脉血运重建术后3天,她的心律演变为心房颤动,2天后恢复为窦性心律,伴有一级房室传导阻滞和LAFB。在6个月的随访中,她保持正常的窦性心律和一级房室传导阻滞。关于经皮介入治疗在晚期下壁STEMI和完全性心脏传导阻滞患者中的作用的数据缺乏。我们的病例说明了晚期干预在恢复窦性心律和避免植入永久性起搏器方面可能发挥的治疗作用。
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引用次数: 0
A rare case of foreign body in coronary sinus. A novel endovascular method for retrieval 冠状窦内异物一例。一种新的血管内检索方法
Pub Date : 2023-03-29 DOI: 10.29328/journal.jccm.1001151
Maturi Bhanu, Sharma Ashwini, Runkana Ashok, Rajasekaran Rhoshini, K. Varshitha, Parajuli Tilachan
Central venous catheter fracture and migration are rare complications in patients receiving long-term infusions or chemotherapy. We present a rare case of a chest port catheter fracture that migrated into the coronary sinus. This case is likely the fourth report of a port catheter fracture with migration to the coronary sinus. Because of the difficult-to-retrieve location, multiple attempts were unsuccessful with traditional techniques using a loop snare. Finally, the fractured portion was disengaged from the coronary sinus using a navigational electrophysiology catheter guided by intracardiac echocardiography; the dislodged end was snared and eventually removed by the femoral route. This case of a chest port catheter fracture is unique because of the unusual migration to the coronary sinus and the use of a navigational electrophysiology catheter as a novel retrieval technique.
中心静脉导管断裂和移位是长期输注或化疗患者的罕见并发症。我们报告一例罕见的胸廓导管断裂并移位到冠状动脉窦内。本病例可能是第四个报告的端口导管断裂并迁移到冠状动脉窦。由于难以回收的位置,使用环形陷阱的传统技术多次尝试都失败了。最后,在心内超声心动图引导下使用导航性电生理导管将骨折部分与冠状窦脱离;移位的末端被套住并最终通过股径路取出。本例胸口导管骨折是独特的,因为不寻常的移动到冠状窦和使用导航电生理导管作为一种新的检索技术。
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引用次数: 0
A proposal of risk indicators for pathological development from hemodynamic simulation: application to aortic dissection 血流动力学模拟病理发展危险指标的提出:在主动脉夹层中的应用
Pub Date : 2023-03-28 DOI: 10.29328/journal.jccm.1001150
Cardiovascular diseases are the leading cause of mortality in the industrialized world. Among these diseases, aortic dissection affects the aorta wall and is a surgical emergency with a low survival rate. This pathology occurs when an injury leads to a localized tear of the innermost layer of the aorta. It allows blood to flow between the layers of the aortic wall, forcing the layers apart and creating a false lumen. Endovascular treatment seeks to obliterate the entrances to the false lumen with a covered stent. There are very few studies on the postoperative demonstration of blood flow phenomena in the aortic dissection endovascular treatment. It is crucial to study the hemodynamics of blood in the aorta after an intervention because the new geometrical configuration of the aorta with a stent leads to modifications in blood flow. For the surgeons, the procedure can only be performed empirically, using MRI-4D images to view the postoperative flow of the patient’s blood in the aorta with the stent. This paper aims to present a numerical tool developed from the open-source software FOAM- Extend®, allowing for multiphysics numerical simulations. Using MRI data, a bio-faithful model of the patient-specific case was built. Numerical simulations were performed to predict preoperative and postoperative (endovascular treatment) hemodynamics. The modifications of the flow in the aorta were analyzed focusing on the postoperative perfusions. The results were compared with the corresponding MRI data and have a good qualitative agreement. Biomarkers are calculated to localize possible zones of post-operative pathological developments and recommendations may be suggested to the surgeons.
心血管疾病是工业化世界死亡的主要原因。在这些疾病中,主动脉夹层影响主动脉壁,是一种存活率较低的外科急诊。当损伤导致主动脉最内层局部撕裂时,就会发生这种病理。它允许血液在主动脉壁的各层之间流动,迫使各层分离并形成假管腔。血管内治疗试图用有盖支架堵住假管腔的入口。关于主动脉夹层血管内治疗术后血流现象的研究很少。研究干预后主动脉中血液的血液动力学至关重要,因为带有支架的主动脉的新几何结构会导致血流的改变。对于外科医生来说,该手术只能凭经验进行,使用MRI-4D图像来观察患者在带支架的主动脉中的术后血流。本文旨在介绍一种由开源软件FOAM-Extend®开发的数值工具,该工具可用于多物理数值模拟。利用MRI数据,建立了患者特定病例的生物忠实模型。进行数值模拟以预测术前和术后(血管内治疗)的血液动力学。分析了主动脉血流的变化,重点是术后灌注。将结果与相应的MRI数据进行比较,并具有良好的定性一致性。计算生物标记物以定位术后病理发展的可能区域,并可向外科医生提出建议。
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引用次数: 0
Soliton phenomena in the process of the functioning of the heart 心脏功能过程中的孤子现象
Pub Date : 2023-03-14 DOI: 10.29328/journal.jccm.1001149
Adamski Adam
The biochemical model explains the intricate mechanisms of psychobiological life. He still cannot explain what the transition from inanimate to living matter is all about. Where is the threshold and what is its essence, what role do biochemical processes play in the coherence of the soma with consciousness and its impact on the soma and vice versa? A similar problem is with other mental processes, their nature does not fit into the biochemical model of life and is inexplicable on the basis of biochemical interactions, again it is much easier to describe it in the light of quantum processes - including wave physics. It is similar to the functioning of the heart or other organs, where only the biochemical processes of the cell are considered, ignoring the bioelectronic processes. Man is not only a purely biological construct but also contains the basis of biochemical, bioelectronic, information, and cybernetic processes that are responsible for shaping the psychobiological processes of man. Contemporary biosystems in science are considered at the level of corpuscular structures, ignoring energy and information structures. By shifting the cognitive emphasis towards energy and information structures, the organism can be perceived as a quantum generator of information: electromagnetic, soliton, acoustic, spin and bioplasma. This bioelectronic construction creates homo electronics with his electronic personality.
生物化学模型解释了心理生物生命的复杂机制。他仍然无法解释从无生命物质到有生命物质的转变是怎么回事。阈值在哪里,它的本质是什么,生物化学过程在躯体与意识的一致性中起着什么作用,它对躯体的影响,反之亦然?其他心理过程也存在类似的问题,它们的性质不符合生命的生物化学模型,并且基于生物化学相互作用是无法解释的,同样,从量子过程(包括波动物理学)的角度来描述它要容易得多。它类似于心脏或其他器官的功能,只考虑细胞的生化过程,而忽略了生物电子过程。人不仅是一个纯粹的生物结构,还包含着生物化学、生物电子、信息和控制论过程的基础,这些过程负责塑造人的心理生物学过程。现代科学中的生物系统被认为是在小体结构的层面上,忽略了能量和信息结构。通过将认知重点转向能量和信息结构,生物体可以被视为信息的量子生成器:电磁、孤立子、声学、自旋和生物等离子体。这种生物电子结构创造了具有电子个性的人类电子。
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引用次数: 0
Left ventricular assessment in patients with significant mitral incompetence: a multi-modality imaging study 二尖瓣功能不全患者的左心室评估:一项多模式成像研究
Pub Date : 2023-03-09 DOI: 10.29328/journal.jccm.1001148
Elgammal Reham Mostafa, Elsaiedy Mona Adel, Alamrosy Mahmoud Zki, Elsetiha Mohamed Elsaied, Almasry Magdy Mohamed
Background: Detection of the deleterious effect of MR on LV is crucial in guiding the surgical decision. Aim of the study: Comprehensive assessment of LV with significant primary MR using (2D, 3D echo and CMR). Methods: 40 patients with significant MR have been recruited in a prospective study. Patients underwent 2D and 3D echo and CMR studies. LV volumes, function and GLS were calculated. Results: End diastolic and systolic volumes were significantly larger when measured by CMR (all p < 0.001). EDV measures were strongly correlated with CMR and 3D echocardiography. Conclusion: It’s important to identify early deleterious LV changes.
背景:检测MR对左心室的有害影响对于指导手术决策至关重要。研究目的:应用(2D、3D回波和CMR)对具有显著原发性MR的左心室进行综合评估。方法:在一项前瞻性研究中招募了40名具有显著MR的患者。患者接受了2D和3D回声和CMR研究。计算左心室容积、功能和GLS。结果:CMR测量的舒张末期和收缩末期容积明显更大(均p<0.001)。EDV测量与CMR和3D超声心动图密切相关。结论:早期发现有害的左心室变化非常重要。
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引用次数: 0
A patient with subacute bacterial endocarditis and positive PR3-ANCA: A case report and literature review 亚急性细菌性心内膜炎伴PR3-ANCA阳性1例并文献复习
Pub Date : 2023-03-07 DOI: 10.17352/2455-2976.000194
Vodanović Ana, V. Ivana, Pocedić Jelena Stanka, Karačić Antonela, Škaro Dijana Borić, Perković Dijana
Patients with Subacute Bacterial Endocarditis (SBE) may present with multisystem disorders mimicking autoimmune diseases, such as An Antineutrophil Cytoplasmic Antibody (ANCA) - Associated Vasculitis (AAV). In this report, we present a 72-year-old female patient with streptococcal SBE who developed multiple inflammatory abnormalities, including ANCA positivity, which was complicated by the occurrence of leukocytoclastic vasculitis, glomerulonephritis, acute myocardial infarction, heart failure and subarachnoid hemorrhage. The patient had previously known mitral valve regurgitation. Repeated transthoracic echocardiography showed a floating lesion in the area of the mitral valve corresponding to chronic vegetation and confirmed the suspicion of SBE. Antibiotic treatment resulted in the decline of inflammatory parameters and complete recovery of renal function. Conservative treatment of acute myocardial infarction and neurorehabilitation were successful. Repeated ANCA tests were negative. Previously reported cases showed that ANCA-positive SBE can involve multiple organs. Distinguishing between AAV and SBE can sometimes be very difficult because of their clinical and serological similarities. Such a wide clinical presentation requires intensive monitoring of these patients. In conclusion, if systemic vasculitis is suspected, it is necessary to exclude diseases that mimic vasculitis, such as SBE.
亚急性细菌性心内膜炎(SBE)患者可能出现类似自身免疫性疾病的多系统疾病,如抗中性粒细胞细胞质抗体(ANCA)相关血管炎(AAV)。我们报告了一位72岁的女性链球菌性SBE患者,她出现了多种炎症异常,包括ANCA阳性,并并发白细胞分裂性血管炎、肾小球肾炎、急性心肌梗死、心力衰竭和蛛网膜下腔出血。患者先前已知二尖瓣返流。反复经胸超声心动图显示二尖瓣区域有浮性病变,与慢性植被相对应,证实了SBE的怀疑。抗生素治疗使炎症指标下降,肾功能完全恢复。急性心肌梗死保守治疗及神经康复均取得成功。反复的ANCA试验均为阴性。先前报道的病例显示,anca阳性SBE可累及多个器官。区分AAV和SBE有时非常困难,因为它们的临床和血清学相似。如此广泛的临床表现需要对这些患者进行密切监测。总之,如果怀疑是全身性血管炎,有必要排除类似血管炎的疾病,如SBE。
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引用次数: 0
期刊
Journal of cardiology and cardiovascular medicine
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