{"title":"Ultraviolet radiation is not the major cause of melanoma mortality in the UK and sun exposure advice should be revised.","authors":"Richard B Weller, Jiayue Gu","doi":"10.1093/bjd/ljae426","DOIUrl":"10.1093/bjd/ljae426","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"548-550"},"PeriodicalIF":11.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fauve C A P van Veen, Vanya Rossel, Peter M Steijlen, Albine Moser, Karin Veldman, Michel van Geel, Julia M K Clabbers, Jolien van der Geugten, Antoni H Gostyński
{"title":"The perceived quality of life in adult patients with inherited ichthyosis: a qualitative interview study.","authors":"Fauve C A P van Veen, Vanya Rossel, Peter M Steijlen, Albine Moser, Karin Veldman, Michel van Geel, Julia M K Clabbers, Jolien van der Geugten, Antoni H Gostyński","doi":"10.1093/bjd/ljae436","DOIUrl":"10.1093/bjd/ljae436","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"553-555"},"PeriodicalIF":11.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intra-rater agreement of lesion counts in hidradenitis suppurativa.","authors":"Bria Midgette, Andrew Strunk, Amit Garg","doi":"10.1093/bjd/ljae379","DOIUrl":"10.1093/bjd/ljae379","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"535-537"},"PeriodicalIF":11.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nidia Planella-Fontanillas, Xavier Bosch-Amate, Alicia Jiménez Antón, Carlos Moreno-Vílchez, María Gamo Guerrero, María Del Mar Blanes Martínez, María Asunción Ballester Martínez, Patricia Bassas-Freixas, Juan Luis Castaño Fernández, Andrea Estébanez Corrales, Ricardo Suarez Fernández, Sergio Santos Alarcón, Ana Bauzá Alonso, Marina Torrent, Adrian Ballano Ruiz, Cristina Collantes Rodríguez, Agustín España, Eduardo Fonseca Capdevila, Inmaculada Gil Faure, Carlos Pelayo Hernández Fernández, Francisco Javier Melgosa Ramos, Jorge Spertino, Violeta Zaragoza Ninet, Lucia Armillas, Isabel Bielsa, Cristina Carrera, Mireia Esquius Rafat, Jon Fulgencio Barbarin, Javier Fernandez Vela, Miguel Lova Navarro, Clara Martín Callizo, Sara Martín-Sala, Rosa Ojeda, Maria Elisabet Parera Amer, Anna Sánchez Puigdollers, Ramon M Pujol, Sebastian Podlipnik, José Manuel Mascaró, Laia Curto-Barredo
Background: Bullous pemphigoid (BP) affects elderly individuals with multiple comorbidities, making conventional treatments unsuitable.
Objectives: Evaluate the effectiveness and safety of dupilumab in the treatment of BP.
Methods: A multicentre ambispective cohort study was conducted across 34 hospitals. Patients with BP treated with dupilumab were included. Most of the patients (97.1%) received an initial 600-mg dose followed by 300 mg every 2 weeks. The primary outcome was the proportion of patients achieving complete remission (CR) within 4 weeks, defined as an Investigator's Global Assessment score of 0 or 1. CR at weeks 16, 24 and 52, adverse events (AEs), reductions in Peak Pruritus Numerical Rating Scale (PP-NRS) and systemic glucocorticoid use were also assessed.
Results: The study included 103 patients with a median age of 77.3 years; 58.3% were male. CR was achieved by 53.4% within 4 weeks and 95.7% by week 52. The PP-NRS score reduced by 70.0% by week 4 and was completely controlled by week 24. Thirteen patients presented with AEs, most of which were mild. Systemic glucocorticoid use reduced by 82.1% by week 52. Shorter disease duration and exclusive cutaneous involvement predicted better response at 16 weeks. No differences in response rates to dupilumab were observed between drug-associated BP and idiopathic cases. No significant difference in response rates was observed between patients treated with dupilumab in monotherapy and those receiving dupilumab with concomitant treatments.
Conclusions: Dupilumab is effective, rapid and safe in managing BP, reducing the need for corticosteroids and other treatments. Early initiation and exclusive skin involvement predict better outcomes.
{"title":"Real-world evaluation of the effectiveness and safety of dupilumab in bullous pemphigoid: an ambispective multicentre case series.","authors":"Nidia Planella-Fontanillas, Xavier Bosch-Amate, Alicia Jiménez Antón, Carlos Moreno-Vílchez, María Gamo Guerrero, María Del Mar Blanes Martínez, María Asunción Ballester Martínez, Patricia Bassas-Freixas, Juan Luis Castaño Fernández, Andrea Estébanez Corrales, Ricardo Suarez Fernández, Sergio Santos Alarcón, Ana Bauzá Alonso, Marina Torrent, Adrian Ballano Ruiz, Cristina Collantes Rodríguez, Agustín España, Eduardo Fonseca Capdevila, Inmaculada Gil Faure, Carlos Pelayo Hernández Fernández, Francisco Javier Melgosa Ramos, Jorge Spertino, Violeta Zaragoza Ninet, Lucia Armillas, Isabel Bielsa, Cristina Carrera, Mireia Esquius Rafat, Jon Fulgencio Barbarin, Javier Fernandez Vela, Miguel Lova Navarro, Clara Martín Callizo, Sara Martín-Sala, Rosa Ojeda, Maria Elisabet Parera Amer, Anna Sánchez Puigdollers, Ramon M Pujol, Sebastian Podlipnik, José Manuel Mascaró, Laia Curto-Barredo","doi":"10.1093/bjd/ljae403","DOIUrl":"10.1093/bjd/ljae403","url":null,"abstract":"<p><strong>Background: </strong>Bullous pemphigoid (BP) affects elderly individuals with multiple comorbidities, making conventional treatments unsuitable.</p><p><strong>Objectives: </strong>Evaluate the effectiveness and safety of dupilumab in the treatment of BP.</p><p><strong>Methods: </strong>A multicentre ambispective cohort study was conducted across 34 hospitals. Patients with BP treated with dupilumab were included. Most of the patients (97.1%) received an initial 600-mg dose followed by 300 mg every 2 weeks. The primary outcome was the proportion of patients achieving complete remission (CR) within 4 weeks, defined as an Investigator's Global Assessment score of 0 or 1. CR at weeks 16, 24 and 52, adverse events (AEs), reductions in Peak Pruritus Numerical Rating Scale (PP-NRS) and systemic glucocorticoid use were also assessed.</p><p><strong>Results: </strong>The study included 103 patients with a median age of 77.3 years; 58.3% were male. CR was achieved by 53.4% within 4 weeks and 95.7% by week 52. The PP-NRS score reduced by 70.0% by week 4 and was completely controlled by week 24. Thirteen patients presented with AEs, most of which were mild. Systemic glucocorticoid use reduced by 82.1% by week 52. Shorter disease duration and exclusive cutaneous involvement predicted better response at 16 weeks. No differences in response rates to dupilumab were observed between drug-associated BP and idiopathic cases. No significant difference in response rates was observed between patients treated with dupilumab in monotherapy and those receiving dupilumab with concomitant treatments.</p><p><strong>Conclusions: </strong>Dupilumab is effective, rapid and safe in managing BP, reducing the need for corticosteroids and other treatments. Early initiation and exclusive skin involvement predict better outcomes.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"501-509"},"PeriodicalIF":11.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daan J W Rauwerdink, Yann Hoogland, Anne M R Schrader, Thomas P Potjer, Ellen Kapiteijn, Jos A van der Hage, Remco van Doorn
{"title":"Melanoma arising from pre-existing naevus in carriers of a germline CDKN2A pathogenic variant.","authors":"Daan J W Rauwerdink, Yann Hoogland, Anne M R Schrader, Thomas P Potjer, Ellen Kapiteijn, Jos A van der Hage, Remco van Doorn","doi":"10.1093/bjd/ljae417","DOIUrl":"10.1093/bjd/ljae417","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"546-548"},"PeriodicalIF":11.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qizhang Wang, Guanglin Niu, Zhuang Liu, Maria A Toma, Jennifer Geara, Xiaowei Bian, Letian Zhang, Minna Piipponen, Dongqing Li, Aoxue Wang, Pehr Sommar, Ning Xu Landén
Background: Skin wound healing involves a complex gene expression programme that remains largely undiscovered in humans. Circular RNAs (circRNAs) and microRNAs (miRNAs) are key players in this process.
Objectives: To understand the functions and potential interactions of circRNAs and miRNAs in human skin wound healing.
Methods: CircRNA, linear RNA and miRNA expression in human acute and chronic wounds were analysed with RNA sequencing and quantitative reverse transcription polymerase chain reaction. The roles of circASH1L(4,5) and miR-129-5p were studied in human primary keratinocytes (proliferation and migration assays, microarray analysis) and ex vivo wound models (histological analysis). The interaction between circASH1L(4,5) and miR-129-5p was examined using luciferase reporter and RNA pulldown assays.
Results: We identified circASH1L(4,5) and its interaction with miR-129-5p, both of which increased during human skin wound healing. Unlike typical miRNA sponging, circASH1L enhanced miR-129 stability and silencing activity by protecting it from target-directed degradation triggered by NR6A1 mRNA. Transforming growth factor-β signalling - crucial in wound healing - promoted circASH1L expression while suppressing NR6A1, thereby increasing the abundance of miR-129 at the post-transcriptional level. CircASH1L and miR-129 enhanced keratinocyte migration and proliferation, crucial processes for the re-epithelialization of human wounds.
Conclusions: Our study uncovered a novel role for circRNAs as protectors of miRNAs and highlights the importance of regulated miRNA degradation in skin wound healing.
{"title":"Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing.","authors":"Qizhang Wang, Guanglin Niu, Zhuang Liu, Maria A Toma, Jennifer Geara, Xiaowei Bian, Letian Zhang, Minna Piipponen, Dongqing Li, Aoxue Wang, Pehr Sommar, Ning Xu Landén","doi":"10.1093/bjd/ljae405","DOIUrl":"10.1093/bjd/ljae405","url":null,"abstract":"<p><strong>Background: </strong>Skin wound healing involves a complex gene expression programme that remains largely undiscovered in humans. Circular RNAs (circRNAs) and microRNAs (miRNAs) are key players in this process.</p><p><strong>Objectives: </strong>To understand the functions and potential interactions of circRNAs and miRNAs in human skin wound healing.</p><p><strong>Methods: </strong>CircRNA, linear RNA and miRNA expression in human acute and chronic wounds were analysed with RNA sequencing and quantitative reverse transcription polymerase chain reaction. The roles of circASH1L(4,5) and miR-129-5p were studied in human primary keratinocytes (proliferation and migration assays, microarray analysis) and ex vivo wound models (histological analysis). The interaction between circASH1L(4,5) and miR-129-5p was examined using luciferase reporter and RNA pulldown assays.</p><p><strong>Results: </strong>We identified circASH1L(4,5) and its interaction with miR-129-5p, both of which increased during human skin wound healing. Unlike typical miRNA sponging, circASH1L enhanced miR-129 stability and silencing activity by protecting it from target-directed degradation triggered by NR6A1 mRNA. Transforming growth factor-β signalling - crucial in wound healing - promoted circASH1L expression while suppressing NR6A1, thereby increasing the abundance of miR-129 at the post-transcriptional level. CircASH1L and miR-129 enhanced keratinocyte migration and proliferation, crucial processes for the re-epithelialization of human wounds.</p><p><strong>Conclusions: </strong>Our study uncovered a novel role for circRNAs as protectors of miRNAs and highlights the importance of regulated miRNA degradation in skin wound healing.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"468-480"},"PeriodicalIF":11.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junxian Wen, Yingrou Tan, Yong Yao Chun, Timothy T Y Tan, Hong Liang Tey
{"title":"Fibroblast-immune crosstalk under mechanical forces in keloids.","authors":"Junxian Wen, Yingrou Tan, Yong Yao Chun, Timothy T Y Tan, Hong Liang Tey","doi":"10.1093/bjd/ljae449","DOIUrl":"10.1093/bjd/ljae449","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"556"},"PeriodicalIF":11.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interactive effect of genetic and environmental risk factors on psoriasis: current evidence and future directives.","authors":"Nidhi Singh, Tamara Schikowski","doi":"10.1093/bjd/ljae450","DOIUrl":"10.1093/bjd/ljae450","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"374-375"},"PeriodicalIF":11.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aparna Potluru, Pick N Woo, Daryl Teo, Michael V McKiernan
{"title":"Basosquamous carcinoma: a survey study on current management in the UK.","authors":"Aparna Potluru, Pick N Woo, Daryl Teo, Michael V McKiernan","doi":"10.1093/bjd/ljae408","DOIUrl":"10.1093/bjd/ljae408","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"538-540"},"PeriodicalIF":11.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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