Pub Date : 2020-07-17DOI: 10.31080/ascb.2020.04.0243
S. Premi
{"title":"Carcinogenicity of “Photoprotective” Skin-Pigments","authors":"S. Premi","doi":"10.31080/ascb.2020.04.0243","DOIUrl":"https://doi.org/10.31080/ascb.2020.04.0243","url":null,"abstract":"","PeriodicalId":92470,"journal":{"name":"Acta scientific cancer biology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82936332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-29DOI: 10.31080/ascb.2020.04.0230
Andre da Silva Santos, Sandra Maria Matta, Henry Okigami
{"title":"Sulforaphane: Mechanisms of Epigenetic Reversion and its Anti-Carcinogenic Pathways as Potential Adjunctive Treatment in Cancer","authors":"Andre da Silva Santos, Sandra Maria Matta, Henry Okigami","doi":"10.31080/ascb.2020.04.0230","DOIUrl":"https://doi.org/10.31080/ascb.2020.04.0230","url":null,"abstract":"","PeriodicalId":92470,"journal":{"name":"Acta scientific cancer biology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89922837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-27DOI: 10.31080/ascb.2020.04.0229
D. Ramiah
{"title":"Getting the Most Value from Novel Healthcare Technologies","authors":"D. Ramiah","doi":"10.31080/ascb.2020.04.0229","DOIUrl":"https://doi.org/10.31080/ascb.2020.04.0229","url":null,"abstract":"","PeriodicalId":92470,"journal":{"name":"Acta scientific cancer biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88282688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-07DOI: 10.22541/au.158888252.25907382
Omar Chamdine, M. Abdulkader, W. Al-Issawi, Shaymaa Al-Umran, Youssef Housaawi, Mahmoud S. Taha
{"title":"Synchronous Primary Brain Tumors in the Pediatric Age Group. Report of Two Cases and Review of the Literature","authors":"Omar Chamdine, M. Abdulkader, W. Al-Issawi, Shaymaa Al-Umran, Youssef Housaawi, Mahmoud S. Taha","doi":"10.22541/au.158888252.25907382","DOIUrl":"https://doi.org/10.22541/au.158888252.25907382","url":null,"abstract":"","PeriodicalId":92470,"journal":{"name":"Acta scientific cancer biology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83811575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-01Epub Date: 2020-04-27DOI: 10.31080/ascb.2020.04.0223
Leslie C Costello, Renty B Franklin
Evidence is evolving that support the relationship that all carcinomas exhibit the following important relationships: The malignant cells exhibit a significant decreased zinc compared to the normal cells. The higher zinc levels that exist in the normal cells are cytotoxic in the malignant cells. The decrease in zinc is due to the down regulation of the ZIP-family zinc uptake transporter. These cells are as "ZIP-deficient/decreased zinc" malignancies. This provides a target for a chemotherapy that can restore the high zinc levels that will manifest cytotoxic effects in the malignant cells. In order to achieve this, a vehicle that facilitates the uptake and accumulation of zinc in the ZIP-deficient cells is required. The zinc ionophore, clioquinol, exhibits the properties that will provide these requirements. This is demonstrated by the treatment of a patient with 3% Clioquinol Cream, which successfully suppressed the progression of androgen-dependent prostate cancer. This treatment should also be efficacious for pancreatic cancer, liver cancer, breast cancer, thyroid cancer, kidney cancer, stomach cancer, gall bladder cancer, and lung cancer; which are carcinomas that exhibit decreased zinc. Thus, it is appropriate to describe that "Zinc is the wonder drug for the treatment of carcinomas".
{"title":"Zinc: The Wonder Drug for the Treatment of Carcinomas.","authors":"Leslie C Costello, Renty B Franklin","doi":"10.31080/ascb.2020.04.0223","DOIUrl":"https://doi.org/10.31080/ascb.2020.04.0223","url":null,"abstract":"<p><p>Evidence is evolving that support the relationship that all carcinomas exhibit the following important relationships: The malignant cells exhibit a significant decreased zinc compared to the normal cells. The higher zinc levels that exist in the normal cells are cytotoxic in the malignant cells. The decrease in zinc is due to the down regulation of the ZIP-family zinc uptake transporter. These cells are as \"ZIP-deficient/decreased zinc\" malignancies. This provides a target for a chemotherapy that can restore the high zinc levels that will manifest cytotoxic effects in the malignant cells. In order to achieve this, a vehicle that facilitates the uptake and accumulation of zinc in the ZIP-deficient cells is required. The zinc ionophore, clioquinol, exhibits the properties that will provide these requirements. This is demonstrated by the treatment of a patient with 3% Clioquinol Cream, which successfully suppressed the progression of androgen-dependent prostate cancer. This treatment should also be efficacious for pancreatic cancer, liver cancer, breast cancer, thyroid cancer, kidney cancer, stomach cancer, gall bladder cancer, and lung cancer; which are carcinomas that exhibit decreased zinc. Thus, it is appropriate to describe that \"Zinc is the wonder drug for the treatment of carcinomas\".</p>","PeriodicalId":92470,"journal":{"name":"Acta scientific cancer biology","volume":"4 5","pages":"33-39"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316362/pdf/nihms-1595423.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38087037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.31080/ascb.2020.04.in-vitro-study-of-pomegranate-seed-extract-on-gadd45a-gene-expression-in-mda-b
Mahmoud Mohamed Helmy
{"title":"In Vitro Study of Pomegranate Seed Extract on GADD45A Gene Expression in (MDA) Breast Cancer Cells","authors":"Mahmoud Mohamed Helmy","doi":"10.31080/ascb.2020.04.in-vitro-study-of-pomegranate-seed-extract-on-gadd45a-gene-expression-in-mda-b","DOIUrl":"https://doi.org/10.31080/ascb.2020.04.in-vitro-study-of-pomegranate-seed-extract-on-gadd45a-gene-expression-in-mda-b","url":null,"abstract":"","PeriodicalId":92470,"journal":{"name":"Acta scientific cancer biology","volume":"355 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76415617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-07DOI: 10.31080/ascb.2020.04.a-challenge-to-artificial-intelligence-find-molecular-structures-uniquely-and-
Karel Petrak D Phil
{"title":"A Challenge to Artificial Intelligence: Find Molecular Structures Uniquely and Functionally Connected to the Initiation and Progression of Diseases","authors":"Karel Petrak D Phil","doi":"10.31080/ascb.2020.04.a-challenge-to-artificial-intelligence-find-molecular-structures-uniquely-and-","DOIUrl":"https://doi.org/10.31080/ascb.2020.04.a-challenge-to-artificial-intelligence-find-molecular-structures-uniquely-and-","url":null,"abstract":"","PeriodicalId":92470,"journal":{"name":"Acta scientific cancer biology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85172708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-10DOI: 10.31080/ASCB.2020.04.GLIOBLASTOMA-APPLICATION-OF-GENE-THERAPY-DURING-A-QUARTER-OF-A-CENTURY-ANTI-GE
G. Quintero, Andrea L. Guzman, Diana M. Gómez, H. Kasprzak, P. Penagos, Heber Siachoque, A. Shevelev, A. Trojan, Alvaro Alvarez, J. Trojan.
{"title":"Glioblastoma - Application of Gene Therapy During A Quarter of A Century: Anti - Gene IGF-I Strategy","authors":"G. Quintero, Andrea L. Guzman, Diana M. Gómez, H. Kasprzak, P. Penagos, Heber Siachoque, A. Shevelev, A. Trojan, Alvaro Alvarez, J. Trojan.","doi":"10.31080/ASCB.2020.04.GLIOBLASTOMA-APPLICATION-OF-GENE-THERAPY-DURING-A-QUARTER-OF-A-CENTURY-ANTI-GE","DOIUrl":"https://doi.org/10.31080/ASCB.2020.04.GLIOBLASTOMA-APPLICATION-OF-GENE-THERAPY-DURING-A-QUARTER-OF-A-CENTURY-ANTI-GE","url":null,"abstract":"","PeriodicalId":92470,"journal":{"name":"Acta scientific cancer biology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81304120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-19DOI: 10.31080/ascb.2019.03.0185
H. Pandey, S. Nangia, Robin Khosa, Maneesh H. Singh, Divya Piyushi, Vikas Kashyap, Shuab Zaidi
{"title":"Primary Apocrine Carcinoma of the Axilla: A Case Report, Review of Literature and Treatment Recommendation","authors":"H. Pandey, S. Nangia, Robin Khosa, Maneesh H. Singh, Divya Piyushi, Vikas Kashyap, Shuab Zaidi","doi":"10.31080/ascb.2019.03.0185","DOIUrl":"https://doi.org/10.31080/ascb.2019.03.0185","url":null,"abstract":"","PeriodicalId":92470,"journal":{"name":"Acta scientific cancer biology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90318743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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