Pub Date : 1968-06-01DOI: 10.1111/j.1476-5381.1968.tb00996.x
R W Foster
{"title":"A correlation between inhibition of the uptake of 3H from (+)-3H-noradrenaline and potentiation of the responses to (-)-noradrenaline in the guinea-pig isolated trachea.","authors":"R W Foster","doi":"10.1111/j.1476-5381.1968.tb00996.x","DOIUrl":"https://doi.org/10.1111/j.1476-5381.1968.tb00996.x","url":null,"abstract":"","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"33 2","pages":"357-67"},"PeriodicalIF":0.0,"publicationDate":"1968-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1476-5381.1968.tb00996.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16741152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1968-06-01DOI: 10.1111/j.1476-5381.1968.tb00984.x
J E Pearson, R L Williams
{"title":"Analysis of direct renal actions of alpha and beta adrenergic stimulation upon sodium excretion compared to acetylcholine.","authors":"J E Pearson, R L Williams","doi":"10.1111/j.1476-5381.1968.tb00984.x","DOIUrl":"https://doi.org/10.1111/j.1476-5381.1968.tb00984.x","url":null,"abstract":"","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"33 2","pages":"223-41"},"PeriodicalIF":0.0,"publicationDate":"1968-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1476-5381.1968.tb00984.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16741142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1968-06-01DOI: 10.1111/j.1476-5381.1968.tb00987.x
W Lippmann, M Wishnick
Agents have been found which cause marked lowering of the catecholamine and/or 5-hydroxytryptamine concentrations in tissues and some (for example, a-methyldihydroxyphenylalanine, guanethidine and reserpine) are useful in the treatment of hypertension (Hafkenschiel & Sellers, 1954; Richardson & Wyso, 1959; Hollander, 1961; Page, Hurley & Dustan, 1961; Gillespie, Oates, Crout & Sjoerdsma, 1962; Cannon, Whitlock, Morris, Angers & Laragh, 1962). Ethyl 3-acetamido-4H-pyrrolo[3,4-c]isoxazole-5(6H)-carboxylate (CL-62375) has been reported to decrease both the catecholamine and 5-hydroxytryptamine concentrations in tissues of the rat (Lippmann & Wishnick, 1967). After a single administration of CL-62375 there is an appreciable lowering of the catecholamine concentration in the heart and brain and a slight fall in brain 5-hydroxytryptamine. After repeated administration of CL-62375 the heart shows the largest decrease in the catecholamine concentration followed by the brain and the adrenals; the brain 5-hydroxytryptamine decreases appreciably. CL-62375 causes a lowering of blood pressure in the rat (Cummings & Welter, 1967, personal communication). Studies on the mechanism of the biogenic amine-depleting activity of CL-62375 were carried out and the results are presented in the present paper.
{"title":"Aspects of the biogenic amine-depleting activity of ethyl 3-acetamido-4H-pyrrolo-[3,4-c]isoxazole-5(6H)-carboxylate in the rat.","authors":"W Lippmann, M Wishnick","doi":"10.1111/j.1476-5381.1968.tb00987.x","DOIUrl":"https://doi.org/10.1111/j.1476-5381.1968.tb00987.x","url":null,"abstract":"Agents have been found which cause marked lowering of the catecholamine and/or 5-hydroxytryptamine concentrations in tissues and some (for example, a-methyldihydroxyphenylalanine, guanethidine and reserpine) are useful in the treatment of hypertension (Hafkenschiel & Sellers, 1954; Richardson & Wyso, 1959; Hollander, 1961; Page, Hurley & Dustan, 1961; Gillespie, Oates, Crout & Sjoerdsma, 1962; Cannon, Whitlock, Morris, Angers & Laragh, 1962). Ethyl 3-acetamido-4H-pyrrolo[3,4-c]isoxazole-5(6H)-carboxylate (CL-62375) has been reported to decrease both the catecholamine and 5-hydroxytryptamine concentrations in tissues of the rat (Lippmann & Wishnick, 1967). After a single administration of CL-62375 there is an appreciable lowering of the catecholamine concentration in the heart and brain and a slight fall in brain 5-hydroxytryptamine. After repeated administration of CL-62375 the heart shows the largest decrease in the catecholamine concentration followed by the brain and the adrenals; the brain 5-hydroxytryptamine decreases appreciably. CL-62375 causes a lowering of blood pressure in the rat (Cummings & Welter, 1967, personal communication). Studies on the mechanism of the biogenic amine-depleting activity of CL-62375 were carried out and the results are presented in the present paper.","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"33 2","pages":"257-65"},"PeriodicalIF":0.0,"publicationDate":"1968-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1476-5381.1968.tb00987.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16741144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1968-06-01DOI: 10.1111/j.1476-5381.1968.tb00994.x
R E Dyball
{"title":"The effects of drugs on the release of vasopressin.","authors":"R E Dyball","doi":"10.1111/j.1476-5381.1968.tb00994.x","DOIUrl":"https://doi.org/10.1111/j.1476-5381.1968.tb00994.x","url":null,"abstract":"","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"33 2","pages":"329-41"},"PeriodicalIF":0.0,"publicationDate":"1968-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1476-5381.1968.tb00994.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16741150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1968-06-01DOI: 10.1111/j.1476-5381.1968.tb00997.x
M M Bertels-Meeuws, R L Polak
{"title":"Influence of antimuscarinic substances on in vitro synthesis of acetylcholine by rat cerebral cortex.","authors":"M M Bertels-Meeuws, R L Polak","doi":"10.1111/j.1476-5381.1968.tb00997.x","DOIUrl":"https://doi.org/10.1111/j.1476-5381.1968.tb00997.x","url":null,"abstract":"","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"33 2","pages":"368-80"},"PeriodicalIF":0.0,"publicationDate":"1968-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1476-5381.1968.tb00997.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16741153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1968-06-01DOI: 10.1111/j.1476-5381.1968.tb00985.x
K Vidal-Beretervide
{"title":"Pharmacological actions of pseudoscopine and some of its derivatives.","authors":"K Vidal-Beretervide","doi":"10.1111/j.1476-5381.1968.tb00985.x","DOIUrl":"https://doi.org/10.1111/j.1476-5381.1968.tb00985.x","url":null,"abstract":"","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"33 2","pages":"242-4"},"PeriodicalIF":0.0,"publicationDate":"1968-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1476-5381.1968.tb00985.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15405206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1968-06-01DOI: 10.1111/j.1476-5381.1968.tb00988.x
H W Kosterlitz, A J Watt
{"title":"Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allylnoroxymorphone (naloxone).","authors":"H W Kosterlitz, A J Watt","doi":"10.1111/j.1476-5381.1968.tb00988.x","DOIUrl":"https://doi.org/10.1111/j.1476-5381.1968.tb00988.x","url":null,"abstract":"","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"33 2","pages":"266-76"},"PeriodicalIF":0.0,"publicationDate":"1968-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1476-5381.1968.tb00988.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16741145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1968-06-01DOI: 10.1111/j.1476-5381.1968.tb01000.x
D I Barron, A R Copley, D K Vallance
{"title":"Anti-inflammatory and related properties of 4-(p-biphenylyl)-3-hydroxybutyric acid.","authors":"D I Barron, A R Copley, D K Vallance","doi":"10.1111/j.1476-5381.1968.tb01000.x","DOIUrl":"https://doi.org/10.1111/j.1476-5381.1968.tb01000.x","url":null,"abstract":"","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"33 2","pages":"396-407"},"PeriodicalIF":0.0,"publicationDate":"1968-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1476-5381.1968.tb01000.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16741156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1968-05-01DOI: 10.1111/J.1476-5381.1968.TB00484.X
N. Ambache, Hilary C. Brummer
An easy and relatively rapid procedure for distinguishihg the ketonic prostaglandins E (PGEs) from the nonketonic prostaglandins F (PGFs) and other hydroxy-acid lipid spasmogens is presented. The method depends on the ability of certain hydrazine derivatives to combine specifically with keto groups. Girard's reagent T (trimethyl-ammonium-acetohydrazide chloride) was used for differentiation. PGFs were unaffected by the reagent, whereas the reagent affected E series prostaglandins by apparently inactivating them. In addition, apparent inactivation also occurred when the reagent was applied to a mixture of the PGEs and PGFs. After treatment of PGEs in aqueous solution with the reagent for 1 hour, at room temperature or 0 degrees centigrade, their extraction into ether on partition at pH 3-4 was reduced. Freezing to -15 degrees centigrade after the 1 hour treatment, and thawing before the ether partition, further reduced the recovery of PGEs. After reagent treatment in these different conditions, PGFs were recovered fully. The presence of a PGE-like ketonic component in the hydroxy-acid constituents of rabbit and cat irins was demonstrated, along with a lower proportion of the ketonic components in ether-purified rabbit cerebral hemisphere extract.
{"title":"A simple chemical procedure for distinguishing E from F prostaglandins, with application to tissue extracts.","authors":"N. Ambache, Hilary C. Brummer","doi":"10.1111/J.1476-5381.1968.TB00484.X","DOIUrl":"https://doi.org/10.1111/J.1476-5381.1968.TB00484.X","url":null,"abstract":"\u0000 An easy and relatively rapid procedure for distinguishihg the ketonic prostaglandins E (PGEs) from the nonketonic prostaglandins F (PGFs) and other hydroxy-acid lipid spasmogens is presented. The method depends on the ability of certain hydrazine derivatives to combine specifically with keto groups. Girard's reagent T (trimethyl-ammonium-acetohydrazide chloride) was used for differentiation. PGFs were unaffected by the reagent, whereas the reagent affected E series prostaglandins by apparently inactivating them. In addition, apparent inactivation also occurred when the reagent was applied to a mixture of the PGEs and PGFs. After treatment of PGEs in aqueous solution with the reagent for 1 hour, at room temperature or 0 degrees centigrade, their extraction into ether on partition at pH 3-4 was reduced. Freezing to -15 degrees centigrade after the 1 hour treatment, and thawing before the ether partition, further reduced the recovery of PGEs. After reagent treatment in these different conditions, PGFs were recovered fully. The presence of a PGE-like ketonic component in the hydroxy-acid constituents of rabbit and cat irins was demonstrated, along with a lower proportion of the ketonic components in ether-purified rabbit cerebral hemisphere extract.\u0000","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"26 1","pages":"162-70"},"PeriodicalIF":0.0,"publicationDate":"1968-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82257635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A simple chemical procedure for distinguishing E from F prostaglandins, with application to tissue extracts.","authors":"N Ambache, H C Brummer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9255,"journal":{"name":"British journal of pharmacology and chemotherapy","volume":"33 1","pages":"162-70"},"PeriodicalIF":0.0,"publicationDate":"1968-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16737279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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