Trends in diabetes and metabolism最新文献

{"title":"Heart changes in a fetus of a diabetic mother","authors":"Julia Simões Pabis, L. Schneider, Luisa F Stoll, Mona A. Simões","doi":"10.15761/TDM.1000108","DOIUrl":"https://doi.org/10.15761/TDM.1000108","url":null,"abstract":"","PeriodicalId":92596,"journal":{"name":"Trends in diabetes and metabolism","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84478235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized, double-blind, placebo-controlled study evaluating the effects of the GOLO weight management program with and without Release supplement on weight and metabolic parameters in subjects with obesity","authors":"Robert J Buynak","doi":"10.31525/ct1-nct03842501","DOIUrl":"https://doi.org/10.31525/ct1-nct03842501","url":null,"abstract":"","PeriodicalId":92596,"journal":{"name":"Trends in diabetes and metabolism","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76434454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency of hypothyroidism in Saudi community-based hospital: A retrospective single centre study","authors":"K. Aljabri, Ibrahim M Alnasser, Facharatz, S. Bokhari, Muneera Alshareef, Patan Murthuza Khan, Abdulla M Mallosho, H. M. Abuelsaoud, Mohammad M Jalal, Rania F Safwat, Rehab El Boraie, Nawaf K Aljabri, Bandari K Aljabri, Arwa Y Alsuraihi, Amjad I Hawsawi","doi":"10.15761/TDM.1000107","DOIUrl":"https://doi.org/10.15761/TDM.1000107","url":null,"abstract":"Background and objective: Thyroid gland is one of the important organs in human body and the burden of thyroid diseases in the general population is enormous specially in females. To estimate retrospectively the frequency of hypothyroidism in Saudi community-based hospital. Design: We analyzed retrospectively 3872 participants whom are between the age 12 to 105 years. All patients were from the population of the Primary health centre at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. All data were collected on the basis of a review of electronic medical data. Patients with TSH above the normal range of TSH for our laboratory reference (4.2 MIU/L, history of hypothyroidism and taking thyroid replacement therapy were included. Patient who are pregnant were excluded. Results: Out of the initial screening of 6023 subjects, 3872 subjects were included. There were 884 (22.8 %) male and 2988 (77.2 %) were female with mean age 44.1 ± 16.3. The mean and median TSH values were 4.4 ± 8.7 and 2.6 respectively. Among them we found 1125 (29.1%) cases with hypothyroidism. Among cases of hypothyroidism, there were 964 (85.7 %) cases were female and 161 (14.3 %) were male with male to female ratio of 1 to 6.0, p < 0.0001. Cases with hypothyroidism were nonsignificantly older than cases with no hypothyroidism, 44.9 ± 16.2 vs. 43.8 ± 16.4 respectively, p = 0.06. Hypothyroidism was more prevalent in the fifth decade (32%). Hypothyroidsm was significantly more prevalent in females between the second to the sixth decades as compared to males. Male was nonsignificantly more prevalent than females in the eighth and ninth decades. Conclusion: We conclude that despite the limitations of this hospital-based retrospective study, hypothyroidism is highly prevalent in cohort of Saudis. The majority of our patients with primary hypothyroidism were young and predominantly females. These two observations remain to be validated by population-based studies. In the absence of registry data, larger cooperative studies involving diverse population samples from multiple centers could help to provide further information on the true frequency nationally. *Correspondence to: Khalid S Aljabri, Department of Endocrinology, King Fahad Armed Forces Hospital, Jeddah, PO Box 9862, Jeddah 21159, Kingdom of Saudi Arabia, Tel: +96-623-233-33 ext. 59200, E-mail: khalidsaljabri@yahoo.com","PeriodicalId":92596,"journal":{"name":"Trends in diabetes and metabolism","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90052135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency is related to thyroid antibodies among type 2 diabetic mellitus patients","authors":"K. Aljabri, Ibrahim M Alnasser, S. Bokhari, Muneera Alshareef, Patan Murthuza Khan, Abdullah Mallisho, H. M. Abuelsaoud, Mohammad M Jalal, Rania F Safwat, Rehab El Boraie, Abdullah Alamri, Bushra A Baeshen, Waleed O Bawzeer, Mohammad A Melibari, Nawaf K Aljabri, Bandari K Aljabri, Turky A Alharthy","doi":"10.15761/TDM.1000111","DOIUrl":"https://doi.org/10.15761/TDM.1000111","url":null,"abstract":"","PeriodicalId":92596,"journal":{"name":"Trends in diabetes and metabolism","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87219302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery of platinum-group metals using a microbial fuel cell","authors":"Naixu Hu, Yufeng Cui, C. Choi","doi":"10.15761/tdm.1000115","DOIUrl":"https://doi.org/10.15761/tdm.1000115","url":null,"abstract":"The aim of this study is to develop a recovery system of platinum group metals (PGMs), such as palladium, platinum, and rhodium from wastewaters that contain [PdCl4], [PtCl6] or [RhCl6-n(H2O)6] ions. A built-in electromotive force from a microbial fuel cell (MFC) was utilized for recovering the PGMs from its cathode chamber under the biofilm-coated anode. After 40 hours of reaction, the obtained Pd, Pt and Rh recovery efficiencies from MFC cathodes with an initial concentration of 200 ppm were 99.2%, 99.5%, and 98.7%, respectively. The highest maximum power density of 7.03 W/m2 with a fill factor of 0.638 was achieved at 1000 ppm Pd2+ catholyte concentration under the experimental range. Using an initial catholyte concentration of 500 ppm for comparison, the maximum power density that was achieved was 4.22 W/m2 for [PdCl4], 5.04 W/m2 for [PtCl6], and 2.44 W/m2 for [RhCl6-n (H2O)6], respectively. Finally, the electrical energy generation rate was obtained from discharging curves and remaining concentration data in the order of Pd-MFC (39.2 Wh/kg) > Rh-MFC (35.1 Wh/kg) > Pt-MFC (17.2 Wh/kg). The metals recovered on the electrode surface were found to be pure based on the SEM micrographs and EDS analysis. *Correspondence to: platinum group metal recovery, built-in electromotive force, microbial fuel cell, biofilm-coated anode, electrical energy generation, wastewater treatment","PeriodicalId":92596,"journal":{"name":"Trends in diabetes and metabolism","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74701473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency in female Saudis with Type 2 diabetes mellitus","authors":"Khalid S Aljabri","doi":"10.15761/tdm.1000110","DOIUrl":"https://doi.org/10.15761/tdm.1000110","url":null,"abstract":"","PeriodicalId":92596,"journal":{"name":"Trends in diabetes and metabolism","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88949752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOXF2 differentially regulates expression of metabolic genes in non-cancerous and cancerous breast epithelial cells.","authors":"Pang-Kuo Lo","doi":"10.15761/TDM.1000103","DOIUrl":"https://doi.org/10.15761/TDM.1000103","url":null,"abstract":"<p><p>Forkhead box F2 (FOXF2) functions as a transcription factor and is critically involved in programming organogenesis and regulating epithelial-to-mesenchymal transition (EMT) and cell proliferation. We recently have revealed that FOXF2 can exert distinct functional effects on different molecular subtypes of breast cancer. We found that FOXF2 expression is epigenetically silenced in luminal breast cancers due to its tumor-suppressive role in DNA replication regulation. In contrast, FOXF2 is overexpressed in basal-like triple-negative breast cancers (TNBCs) due to its oncogenic role in promoting EMT. Although our and other studies have shown that FOXF2 dysregulation is critical for tumorigenesis of various tissue types, the role of FOXF2 in metabolic rewiring of cancer remains unknown. In this study, we analyzed our previous microarray data to understand the metabolic role of FOXF2 in non-cancerous and cancerous breast epithelial cells. Our studies showed that in non-cancerous breast epithelial cells FOXF2 can also play a dual role either in tumor suppression or in tumor promotion through regulating expression of tumor-suppressive and oncogenic metabolic genes. Furthermore, we found that FOXF2-regulated metabolic genes are not conserved between non-cancerous and cancerous breast epithelial cells and FOXF2 is involved in metabolic rewiring in breast cancer cells. This is the first report to explore the metabolic function of FOXF2 in breast cancer.</p>","PeriodicalId":92596,"journal":{"name":"Trends in diabetes and metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169805/pdf/nihms-988062.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36553650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}