Pub Date : 2025-02-01Epub Date: 2025-03-17DOI: 10.1192/bjp.2024.240
Saad F Ghalib
{"title":"Delusions as 'wrong beliefs': a conceptual history: commentary, Ghalib.","authors":"Saad F Ghalib","doi":"10.1192/bjp.2024.240","DOIUrl":"https://doi.org/10.1192/bjp.2024.240","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":"226 2","pages":"117"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-03-17DOI: 10.1192/bjp.2024.210
Stella Barbanti Zancheta, Arthur Henrique de Alencar Quirino, Sarah Pereira Gomes, Guilherme Nobre Nogueira, Fabio Gomes de Matos E Souza, Luísa Weber Bisol
{"title":"Adverse childhood experiences and psychological functioning among women with schizophrenia or bipolar disorder: population-based study: commentary, Zancheta et al.","authors":"Stella Barbanti Zancheta, Arthur Henrique de Alencar Quirino, Sarah Pereira Gomes, Guilherme Nobre Nogueira, Fabio Gomes de Matos E Souza, Luísa Weber Bisol","doi":"10.1192/bjp.2024.210","DOIUrl":"https://doi.org/10.1192/bjp.2024.210","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":"226 2","pages":"114-115"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-03-17DOI: 10.1192/bjp.2024.218
Eugene G Breen
{"title":"Assisted dying for mental illness: commentary, Breen.","authors":"Eugene G Breen","doi":"10.1192/bjp.2024.218","DOIUrl":"https://doi.org/10.1192/bjp.2024.218","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":"226 2","pages":"116"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-01-30DOI: 10.1192/bjp.2024.158
Madhusudan Dalvi
{"title":"Alois Alzheimer and some of his lesser-known scientific contributions - Psychiatry in history.","authors":"Madhusudan Dalvi","doi":"10.1192/bjp.2024.158","DOIUrl":"https://doi.org/10.1192/bjp.2024.158","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":"226 1","pages":"60"},"PeriodicalIF":8.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oloyede and colleagues advocate for updating haematological monitoring requirements for clozapine, arguing that current protocols overestimate the risk of clozapine-induced agranulocytosis. Their research suggests that stringent monitoring may unnecessarily limit access to clozapine, a crucial treatment for resistant schizophrenia. The editorial supports calls for international consensus to carefully weigh the pros and cons of relaxing monitoring guidelines while ensuring comprehensive care for patients.
{"title":"Clozapine monitoring requirements: is it time for an update?","authors":"Emilio Fernandez-Egea, Robert A McCutcheon","doi":"10.1192/bjp.2024.150","DOIUrl":"10.1192/bjp.2024.150","url":null,"abstract":"<p><p>Oloyede and colleagues advocate for updating haematological monitoring requirements for clozapine, arguing that current protocols overestimate the risk of clozapine-induced agranulocytosis. Their research suggests that stringent monitoring may unnecessarily limit access to clozapine, a crucial treatment for resistant schizophrenia. The editorial supports calls for international consensus to carefully weigh the pros and cons of relaxing monitoring guidelines while ensuring comprehensive care for patients.</p>","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"1-3"},"PeriodicalIF":7.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yunqing Zhu, Yongbing Lan, Jun Lv, Dianjianyi Sun, Liming Li, Dai Zhang, Canqing Yu, Weihua Yue
Background: Observational studies have shown a controversial relationship between dietary fat intake and Alzheimer's disease, and the causal effects are unclear.
Aims: To assess the causal effects of total fat, saturated fat and polyunsaturated fat (PUF) intakes on the risk of Alzheimer's disease.
Method: A two-sample Mendelian randomisation analysis was performed using genome-wide association study summary statistics on different types of fat intake from UK Biobank (n = 51 413) and on late-onset Alzheimer's disease (LOAD; 4282 cases, n = 307 112) and all forms of Alzheimer's disease (6281 cases, n = 309 154) from the FinnGen consortium. In addition, a multivariable Mendelian randomisation (MVMR) analysis was conducted to estimate the effects independent of carbohydrate and protein intakes.
Results: Genetically predicted per standard deviation increase in the total fat and saturated fat intakes were associated with 44 and 38% higher risks of LOAD (total fat: odds ratio = 1.44, 95% CI 1.03-2.02; saturated fat: odds ratio = 1.38, 95% CI 1.002-1.90; P = 0.049). The associations remained significant in the MVMR analysis (total fat: odds ratio = 3.31, 95% CI 1.74-6.29; saturated fat: odds ratio = 2.04, 95% CI 1.16-3.59). Total fat and saturated fat intakes were associated with a higher risk of all forms of Alzheimer's disease in the MVMR analysis (total fat: odds ratio = 2.09, 95% CI 1.22-3.57; saturated fat: odds ratio = 1.60, 95% CI 1.01-2.52). The PUF intake was not associated with LOAD or all forms of Alzheimer's disease.
Conclusions: This study indicated that total dietary fat intake, especially saturated fat, contributed to the risk of Alzheimer's disease, and the effects were independent of other nutrients. These findings informed prevention strategies and management for Alzheimer's disease directly towards reducing dietary saturated fat intake.
背景：目的：评估总脂肪、饱和脂肪和多不饱和脂肪（PUF）摄入量对阿尔茨海默病风险的因果关系：方法：利用英国生物库（UK Biobank，n = 51 413）中关于不同类型脂肪摄入量的全基因组关联研究汇总统计数据，以及芬兰基因联盟（FinnGen consortium）中关于晚发性阿尔茨海默病（LOAD；4 282例，n = 307 112）和所有形式阿尔茨海默病（6 281例，n = 309 154）的全基因组关联研究汇总统计数据，进行了双样本孟德尔随机分析。此外，还进行了多变量孟德尔随机化（MVMR）分析，以估计与碳水化合物和蛋白质摄入量无关的影响：结果：根据基因预测，总脂肪和饱和脂肪摄入量每增加一个标准差，患 LOAD 的风险分别增加 44% 和 38%（总脂肪：几率比 = 1.44，95% CI 1.03-2.02；饱和脂肪：几率比 = 1.38，95% CI 1.002-1.90；P = 0.049）。在 MVMR 分析中，相关性仍然显著（总脂肪：几率比 = 3.31，95% CI 1.74-6.29；饱和脂肪：几率比 = 2.04，95% CI 1.16-3.59）。在 MVMR 分析中，总脂肪和饱和脂肪摄入量与罹患各种形式阿尔茨海默病的较高风险相关（总脂肪：几率比 = 2.09，95% CI 1.22-3.57；饱和脂肪：几率比 = 1.60，95% CI 1.01-2.52）。PUF摄入量与LOAD或所有形式的阿尔茨海默病无关：这项研究表明，膳食脂肪总摄入量，尤其是饱和脂肪的摄入量，会增加阿尔茨海默病的患病风险，而且其影响与其他营养素无关。这些发现为阿尔茨海默氏症的预防策略和管理提供了参考，可直接减少膳食中饱和脂肪的摄入量。
{"title":"Association between dietary fat intake and the risk of Alzheimer's disease: Mendelian randomisation study.","authors":"Yunqing Zhu, Yongbing Lan, Jun Lv, Dianjianyi Sun, Liming Li, Dai Zhang, Canqing Yu, Weihua Yue","doi":"10.1192/bjp.2024.163","DOIUrl":"10.1192/bjp.2024.163","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have shown a controversial relationship between dietary fat intake and Alzheimer's disease, and the causal effects are unclear.</p><p><strong>Aims: </strong>To assess the causal effects of total fat, saturated fat and polyunsaturated fat (PUF) intakes on the risk of Alzheimer's disease.</p><p><strong>Method: </strong>A two-sample Mendelian randomisation analysis was performed using genome-wide association study summary statistics on different types of fat intake from UK Biobank (<i>n</i> = 51 413) and on late-onset Alzheimer's disease (LOAD; 4282 cases, <i>n</i> = 307 112) and all forms of Alzheimer's disease (6281 cases, <i>n</i> = 309 154) from the FinnGen consortium. In addition, a multivariable Mendelian randomisation (MVMR) analysis was conducted to estimate the effects independent of carbohydrate and protein intakes.</p><p><strong>Results: </strong>Genetically predicted per standard deviation increase in the total fat and saturated fat intakes were associated with 44 and 38% higher risks of LOAD (total fat: odds ratio = 1.44, 95% CI 1.03-2.02; saturated fat: odds ratio = 1.38, 95% CI 1.002-1.90; <i>P</i> = 0.049). The associations remained significant in the MVMR analysis (total fat: odds ratio = 3.31, 95% CI 1.74-6.29; saturated fat: odds ratio = 2.04, 95% CI 1.16-3.59). Total fat and saturated fat intakes were associated with a higher risk of all forms of Alzheimer's disease in the MVMR analysis (total fat: odds ratio = 2.09, 95% CI 1.22-3.57; saturated fat: odds ratio = 1.60, 95% CI 1.01-2.52). The PUF intake was not associated with LOAD or all forms of Alzheimer's disease.</p><p><strong>Conclusions: </strong>This study indicated that total dietary fat intake, especially saturated fat, contributed to the risk of Alzheimer's disease, and the effects were independent of other nutrients. These findings informed prevention strategies and management for Alzheimer's disease directly towards reducing dietary saturated fat intake.</p>","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"24-30"},"PeriodicalIF":8.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-01-30DOI: 10.1192/bjp.2024.149
John H Ward, Brendan Sargent, Rob Bale, Johannes C Klein, Paul J Harrison, Belinda Lennox, Adam Al-Diwani, Adam E Handel
{"title":"Can liaison neurology add value to patient care within a mental health setting?","authors":"John H Ward, Brendan Sargent, Rob Bale, Johannes C Klein, Paul J Harrison, Belinda Lennox, Adam Al-Diwani, Adam E Handel","doi":"10.1192/bjp.2024.149","DOIUrl":"https://doi.org/10.1192/bjp.2024.149","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":"226 1","pages":"47-48"},"PeriodicalIF":8.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamaldeep Bhui, Aileen O'Brien, Rachel Upthegrove, Alexander C Tsai, Mustafa Soomro, Giles Newton-Howes, Matthew R Broome, Andrew Forrester, Patricia Casey, Anne M Doherty, William Lee, Kenneth R Kaufman
We argue that editorial independence, through robust practice of publication ethics and research integrity, promotes good science and prevents bad science. We elucidate the concept of research integrity, and then discuss the dimensions of editorial independence. Best practice guidelines exist, but compliance with these guidelines varies. Therefore, we make recommendations for protecting and strengthening editorial independence.
{"title":"Protecting and promoting editorial independence.","authors":"Kamaldeep Bhui, Aileen O'Brien, Rachel Upthegrove, Alexander C Tsai, Mustafa Soomro, Giles Newton-Howes, Matthew R Broome, Andrew Forrester, Patricia Casey, Anne M Doherty, William Lee, Kenneth R Kaufman","doi":"10.1192/bjp.2024.6","DOIUrl":"10.1192/bjp.2024.6","url":null,"abstract":"<p><p>We argue that editorial independence, through robust practice of publication ethics and research integrity, promotes good science and prevents bad science. We elucidate the concept of research integrity, and then discuss the dimensions of editorial independence. Best practice guidelines exist, but compliance with these guidelines varies. Therefore, we make recommendations for protecting and strengthening editorial independence.</p>","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"4-6"},"PeriodicalIF":7.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139734501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-23DOI: 10.1192/bjp.2024.192
João Martins-Correia
{"title":"The phenomenology within Cézanne's work: a reflection - Psychiatry in art.","authors":"João Martins-Correia","doi":"10.1192/bjp.2024.192","DOIUrl":"https://doi.org/10.1192/bjp.2024.192","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":"225 6","pages":"592"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dosage effects of psychodynamic and schema therapy in people with comorbid depression and personality disorder: four-arm pragmatic randomised controlled trial: commentary, Mulder.","authors":"Roger T Mulder","doi":"10.1192/bjp.2024.105","DOIUrl":"10.1192/bjp.2024.105","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"583-584"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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