Pub Date : 2022-03-02DOI: 10.1097/GRH.0000000000000056
Idris.M. Idris, S. Menghisteab
Objectives: Cesarean section delivery is at increasing rate worldwide. The present study was designed to explore the cesarean section delivery rate, and its common indications along with their socio-demographic determinants in Dekemhare Hospital, Southern region of Eritrea. Methods and Materials: A retrospective study was utilized to retrieve data of all women who delivered in Dekemhare Hospital during 2019. Using a structured questionnaire, all information required was recorded using data files such as birth (vaginal and cesarean) files, pregnancy registration file, and neonatal data. All women who delivered by cesarean section, their indications were collected reviewing registration records of the operating theater where the procedure was conducted. To describe the results, both descriptive and analytical analysis were conducted using SPSS version 25. χ2 test and multivariate logistic regression analysis were done to identify determinants of cesarean section. A significance level of 0.05 was used as a cut point of statistical significance. Main Findings: The rate of cesarean section delivery was 10.1%. The top 6 indications of cesarean section were: malposition (26.3%), prolonged and obstructed labor (21.2%), mal-presentation (14.4%), previous/repeat cesarean section (10.2%), amniotic fluid disorders (9.3%), and fetal distress (5.9%). Mothers who were nulliparous [odds ratio (OR): 9.2; 95% confidence interval (CI): 1.8–14.3; P-value: 0.007], referral from other health facility (OR: 7.8, 95% CI: 3.7–16.5, P-value <0.0001), and who had delivered stillbirths (OR: 8.2; 95% CI: 1.7–38.9; P-value: 0.008) were more likely to deliver through cesarean section. Conclusion: The rate of cesarean section in Dekemhare hospital is fairly optimal (10.1%). Prolonged and obstructed labor, mal-presentation and malposition were the most common indications. Nulliparous and referral mothers had higher risk of cesarean section. Decision-making for cesarean section should outweigh the benefits and risks of the intervention within the context of women’s entire reproductive life-cycle.
{"title":"Cesarean section delivery rates, determinants, and indications: a retrospective study in Dekemhare Hospital","authors":"Idris.M. Idris, S. Menghisteab","doi":"10.1097/GRH.0000000000000056","DOIUrl":"https://doi.org/10.1097/GRH.0000000000000056","url":null,"abstract":"Objectives: Cesarean section delivery is at increasing rate worldwide. The present study was designed to explore the cesarean section delivery rate, and its common indications along with their socio-demographic determinants in Dekemhare Hospital, Southern region of Eritrea. Methods and Materials: A retrospective study was utilized to retrieve data of all women who delivered in Dekemhare Hospital during 2019. Using a structured questionnaire, all information required was recorded using data files such as birth (vaginal and cesarean) files, pregnancy registration file, and neonatal data. All women who delivered by cesarean section, their indications were collected reviewing registration records of the operating theater where the procedure was conducted. To describe the results, both descriptive and analytical analysis were conducted using SPSS version 25. χ2 test and multivariate logistic regression analysis were done to identify determinants of cesarean section. A significance level of 0.05 was used as a cut point of statistical significance. Main Findings: The rate of cesarean section delivery was 10.1%. The top 6 indications of cesarean section were: malposition (26.3%), prolonged and obstructed labor (21.2%), mal-presentation (14.4%), previous/repeat cesarean section (10.2%), amniotic fluid disorders (9.3%), and fetal distress (5.9%). Mothers who were nulliparous [odds ratio (OR): 9.2; 95% confidence interval (CI): 1.8–14.3; P-value: 0.007], referral from other health facility (OR: 7.8, 95% CI: 3.7–16.5, P-value <0.0001), and who had delivered stillbirths (OR: 8.2; 95% CI: 1.7–38.9; P-value: 0.008) were more likely to deliver through cesarean section. Conclusion: The rate of cesarean section in Dekemhare hospital is fairly optimal (10.1%). Prolonged and obstructed labor, mal-presentation and malposition were the most common indications. Nulliparous and referral mothers had higher risk of cesarean section. Decision-making for cesarean section should outweigh the benefits and risks of the intervention within the context of women’s entire reproductive life-cycle.","PeriodicalId":92638,"journal":{"name":"Global reproductive health","volume":"114 1-2","pages":"e56 - e56"},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41299572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1097/grh.0000000000000061
J. Kekäläinen
{"title":"Infertility: a pathologic condition or selection against genetic incompatibility?","authors":"J. Kekäläinen","doi":"10.1097/grh.0000000000000061","DOIUrl":"https://doi.org/10.1097/grh.0000000000000061","url":null,"abstract":"","PeriodicalId":92638,"journal":{"name":"Global reproductive health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61697456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-29DOI: 10.1097/GRH.0000000000000054
Idris.M. Idris, Drar A. Amr
Objective: The authors tried to identify women’s level of awareness about menopausal symptoms and the measures they take to relieve the menopausal symptoms in selected areas of Asmara, Eritrea. Methodology: A cross-sectional study design was utilized from November 1 to 21, 2018. Data about menopausal symptoms and the relieving measures taken were collected using a pretested questionnaire from 180 selected women from Asmara College of Health Sciences and Public Transportation of Zoba Maekel. Bivariate and multivariate logistic regression was used to identify associations of demographic variables with level of awareness using SPSS (Version 22.0). Results: More than half of the study participants (56%) were between the age group of 40 and 45 and the mean age at which menopause had started was 45 years. About 52% of them reached menopause out of whom more than half (56%) were not aware of menopausal symptoms. The main menopausal symptoms mentioned were absence of periods (34.4%), followed by irritability (32.8%) and hot flashes (27.8%). About seven-tenth of the participants (68.3%) did not take any action to relive the menopausal symptoms. Women with higher level of education [adjusted odds ratio (95% confidence interval): 2.12 (1.07, 3.96)], who were from a nuclear family [adjusted odds ratio (95% confidence interval): 1.65 (0.76, 3.23)] were having a significantly better level of awareness about menopause and its symptoms. Conclusion: Majority of the women were not aware of the menopausal symptoms and the measures that should be taken. Appropriate actions to increase women’s awareness level regarding menopause should be incorporated as a critical aspect in promoting women’s health.
{"title":"Women’s awareness about menopausal symptoms and its management: a cross-sectional study in 2 selected settings of Asmara, Eritrea","authors":"Idris.M. Idris, Drar A. Amr","doi":"10.1097/GRH.0000000000000054","DOIUrl":"https://doi.org/10.1097/GRH.0000000000000054","url":null,"abstract":"Objective: The authors tried to identify women’s level of awareness about menopausal symptoms and the measures they take to relieve the menopausal symptoms in selected areas of Asmara, Eritrea. Methodology: A cross-sectional study design was utilized from November 1 to 21, 2018. Data about menopausal symptoms and the relieving measures taken were collected using a pretested questionnaire from 180 selected women from Asmara College of Health Sciences and Public Transportation of Zoba Maekel. Bivariate and multivariate logistic regression was used to identify associations of demographic variables with level of awareness using SPSS (Version 22.0). Results: More than half of the study participants (56%) were between the age group of 40 and 45 and the mean age at which menopause had started was 45 years. About 52% of them reached menopause out of whom more than half (56%) were not aware of menopausal symptoms. The main menopausal symptoms mentioned were absence of periods (34.4%), followed by irritability (32.8%) and hot flashes (27.8%). About seven-tenth of the participants (68.3%) did not take any action to relive the menopausal symptoms. Women with higher level of education [adjusted odds ratio (95% confidence interval): 2.12 (1.07, 3.96)], who were from a nuclear family [adjusted odds ratio (95% confidence interval): 1.65 (0.76, 3.23)] were having a significantly better level of awareness about menopause and its symptoms. Conclusion: Majority of the women were not aware of the menopausal symptoms and the measures that should be taken. Appropriate actions to increase women’s awareness level regarding menopause should be incorporated as a critical aspect in promoting women’s health.","PeriodicalId":92638,"journal":{"name":"Global reproductive health","volume":"6 1","pages":"e54 - e54"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46318303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.1097/GRH.0000000000000055
Idris.M. Idris, Samuel J. Wolday, D. N. Hassan, Luwam R. Tekle, Luna Yemane, Saron Ahferom, Million Andemariam
Background: Providing preferred methods of contraceptive for human immunodeficiency virus (HIV)-positive women and avoiding unintended pregnancy is one of the primary means of preventing mother to child transmission of HIV. This study assessed the prevalence of contraceptive use and method preference among HIV-positive women in Halibet Referral Hospital, Asmara, Eritrea. Patients and methods: A descriptive and analytical cross-sectional study was conducted among HIV-positive women in Halibet Referral Hospital, Asmara. Data were collected by interviewing HIV-positive women using a pretested and structured questionnaire. A binary logistic regression model was used to identify factors associated with contraceptive use, and odd ratio with 95% confidence interval was calculated to measure the strength of association. Results: A total of 196 women living with HIV were interviewed. The mean age of the study participants was 39.1 years (SD±6 y). The prevalence of current contraceptive use was 16.8%. The preferred and most commonly used contraceptive methods were male condom (45.5%) and injectable (36.4%). Younger age [adjusted odds ratio: 1.6 (1.1, 7.8), P=0.04], Married [adjusted odds ratio: 2.1 (1.4, 7.7), P=0.001], having more than 4 child [1.5 (1.1, 9.3), P=0.03], contraception counselling [1.8 (1.1, 5.4), P=0.02] were the only factors influencing contraception use. Conclusion: Utilization of contraceptives among the participants was low (16.8%). Being young, married, regularly counselled about contraceptives, and having more than 4 children were factors facilitating contraceptive use. Policy makers should design counselling programs to increase utilization of contraceptives among HIV positive women.
{"title":"Contraception use among HIV-positive women attending ART clinic: a cross-sectional study in Halibet Referral Hospital","authors":"Idris.M. Idris, Samuel J. Wolday, D. N. Hassan, Luwam R. Tekle, Luna Yemane, Saron Ahferom, Million Andemariam","doi":"10.1097/GRH.0000000000000055","DOIUrl":"https://doi.org/10.1097/GRH.0000000000000055","url":null,"abstract":"Background: Providing preferred methods of contraceptive for human immunodeficiency virus (HIV)-positive women and avoiding unintended pregnancy is one of the primary means of preventing mother to child transmission of HIV. This study assessed the prevalence of contraceptive use and method preference among HIV-positive women in Halibet Referral Hospital, Asmara, Eritrea. Patients and methods: A descriptive and analytical cross-sectional study was conducted among HIV-positive women in Halibet Referral Hospital, Asmara. Data were collected by interviewing HIV-positive women using a pretested and structured questionnaire. A binary logistic regression model was used to identify factors associated with contraceptive use, and odd ratio with 95% confidence interval was calculated to measure the strength of association. Results: A total of 196 women living with HIV were interviewed. The mean age of the study participants was 39.1 years (SD±6 y). The prevalence of current contraceptive use was 16.8%. The preferred and most commonly used contraceptive methods were male condom (45.5%) and injectable (36.4%). Younger age [adjusted odds ratio: 1.6 (1.1, 7.8), P=0.04], Married [adjusted odds ratio: 2.1 (1.4, 7.7), P=0.001], having more than 4 child [1.5 (1.1, 9.3), P=0.03], contraception counselling [1.8 (1.1, 5.4), P=0.02] were the only factors influencing contraception use. Conclusion: Utilization of contraceptives among the participants was low (16.8%). Being young, married, regularly counselled about contraceptives, and having more than 4 children were factors facilitating contraceptive use. Policy makers should design counselling programs to increase utilization of contraceptives among HIV positive women.","PeriodicalId":92638,"journal":{"name":"Global reproductive health","volume":"6 1","pages":"e55 - e55"},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41827525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-06DOI: 10.1097/GRH.0000000000000051
Idris.M. Idris, Samuel J. Wolday, Feven Habteselassie, Luwam Ghebremichael, Makda Andemariam, Rahwa Azmera, Frezghi H. Ghebrewoldi
Supplemental Digital Content is available in the text. Objective: Several factors appeared to influence the onset of menarche. The current study was aimed to determine the mean age of menarche and the factors influencing its onset among female high school students in Asmara. Methods: A cross-sectional study was conducted from January to February 2017 among secondary school female students of Asmara city. A 2 stage stratified sampling design was adopted to select the number of schools and students for the study. A structured and pretested questionnaire was used to collect the data through interview. Data analysis was done using SPSS version 22. Descriptive results were summarized using frequencies and percentages in tables and graphs. Moreover, bivariate and multivariate logistic regression analysis was done to find out the association of earlier onset of menarche and the predictor variables. Results: A total of 300 female students participated in the study. The mean age of the participants was 16.1 years (SD=1.3) with majority of them (57.3%) between the ages of 16 and 18 years. The mean age at menarche was 13.8 years (SD=1.2). About 39% of the participants have the onset of their menarche earlier (before 14 y). An earlier onset of menarche was observed among younger age (above 16) respondents {adjusted odds ratio [AOR] [95% confidence interval (CI)]: 1.8 (0.96, 4.88), P-value: 0.02}, having higher body mass index [AOR (95% CI): 3.8 (1.92, 7.85), P-value: 0.001] and from richer family. Lack of engaging in any kind of physical activity [AOR (95% CI): 2.56 (1.13, 5.27), P-value: 0.012] and more sleeping hours [AOR (95% CI): 2.2 (0.36, 4.18), P-value: 0.04] were also factors influencing earlier onset of menarche. Conclusion: The mean age at menarche was relatively low. Factors related to higher body mass index, physical inactivity, more sleeping hours, good socioeconomic status, and younger age were associated with earlier onset of menarche. Initiatives on awareness creation are required to increase lifestyle modifications at individual level.
{"title":"Factors associated with early age at menarche among female secondary school students in Asmara: a cross-sectional study","authors":"Idris.M. Idris, Samuel J. Wolday, Feven Habteselassie, Luwam Ghebremichael, Makda Andemariam, Rahwa Azmera, Frezghi H. Ghebrewoldi","doi":"10.1097/GRH.0000000000000051","DOIUrl":"https://doi.org/10.1097/GRH.0000000000000051","url":null,"abstract":"Supplemental Digital Content is available in the text. Objective: Several factors appeared to influence the onset of menarche. The current study was aimed to determine the mean age of menarche and the factors influencing its onset among female high school students in Asmara. Methods: A cross-sectional study was conducted from January to February 2017 among secondary school female students of Asmara city. A 2 stage stratified sampling design was adopted to select the number of schools and students for the study. A structured and pretested questionnaire was used to collect the data through interview. Data analysis was done using SPSS version 22. Descriptive results were summarized using frequencies and percentages in tables and graphs. Moreover, bivariate and multivariate logistic regression analysis was done to find out the association of earlier onset of menarche and the predictor variables. Results: A total of 300 female students participated in the study. The mean age of the participants was 16.1 years (SD=1.3) with majority of them (57.3%) between the ages of 16 and 18 years. The mean age at menarche was 13.8 years (SD=1.2). About 39% of the participants have the onset of their menarche earlier (before 14 y). An earlier onset of menarche was observed among younger age (above 16) respondents {adjusted odds ratio [AOR] [95% confidence interval (CI)]: 1.8 (0.96, 4.88), P-value: 0.02}, having higher body mass index [AOR (95% CI): 3.8 (1.92, 7.85), P-value: 0.001] and from richer family. Lack of engaging in any kind of physical activity [AOR (95% CI): 2.56 (1.13, 5.27), P-value: 0.012] and more sleeping hours [AOR (95% CI): 2.2 (0.36, 4.18), P-value: 0.04] were also factors influencing earlier onset of menarche. Conclusion: The mean age at menarche was relatively low. Factors related to higher body mass index, physical inactivity, more sleeping hours, good socioeconomic status, and younger age were associated with earlier onset of menarche. Initiatives on awareness creation are required to increase lifestyle modifications at individual level.","PeriodicalId":92638,"journal":{"name":"Global reproductive health","volume":"6 1","pages":"e51 - e51"},"PeriodicalIF":0.0,"publicationDate":"2021-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48440972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1097/grh.0000000000000053
S. Ory, Anna Veiga, M. Horton, L. Gianaroli
{"title":"Joint IFFS/ESHRE statement on COVID-19 vaccination for pregnant women and those considering pregnancy","authors":"S. Ory, Anna Veiga, M. Horton, L. Gianaroli","doi":"10.1097/grh.0000000000000053","DOIUrl":"https://doi.org/10.1097/grh.0000000000000053","url":null,"abstract":"","PeriodicalId":92638,"journal":{"name":"Global reproductive health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61697393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.1097/GRH.0000000000000048
Zinie Abita, Zeru Shikur
Background: Avoidable mortality and morbidity remains formidable challenge in many developing countries like Ethiopia. Pregnancy-related complications cannot be reliably predicted and it is necessary to design strategies to overcome problems when they arise. Lack of advance planning for use of a skilled birth attendant for normal births, and particularly inadequate preparation for rapid action in the events of obstetric complications, are well documented factors contributing to delay in receiving skilled obstetric care. Birth preparedness has been globally endorsed as an essential component of safe motherhood programs to reduce delays for care, so as to reduce maternal and neonatal mortality rate. Methods: A cross-sectional community based study was conducted to examine knowledge and practice of birth preparedness and complication readiness among women who gave birth in the last 12 months in Mizan-Aman town by using pretested structured questionnaires. The sampling technique was that of systematic sampling and the sample size was 239. Results: Data were obtained from 239 mothers, yielding 98% a response rate. Out of total respondents more than half (53.5%) of respondents said that they knew the term “birth preparedness.” More specifically, 44.7%, 50.8%, 31.8% of the respondents were knowledgeable about possible danger signs during pregnancy, during delivery, and postpartum period, respectively. Concerning complication readiness, 50% stated that they were prepared for birth and its complications. Conclusion and Recommendation: Knowledge and practices of birth preparedness and complication readiness is not comprehensive according to the result of this study. Many respondents did not know about birth preparedness and had no plans for emergencies. Therefore, community education about preparations for birth and its complications and empowerment of women through expansion of educational opportunities are recommended for improving birth preparedness and the effects of pregnancy-related complications.
{"title":"Assessment of knowledge and practice on birth preparedness and complication readiness among women who gave birth in the last 12 months in southwest, Ethiopia 2016","authors":"Zinie Abita, Zeru Shikur","doi":"10.1097/GRH.0000000000000048","DOIUrl":"https://doi.org/10.1097/GRH.0000000000000048","url":null,"abstract":"Background: Avoidable mortality and morbidity remains formidable challenge in many developing countries like Ethiopia. Pregnancy-related complications cannot be reliably predicted and it is necessary to design strategies to overcome problems when they arise. Lack of advance planning for use of a skilled birth attendant for normal births, and particularly inadequate preparation for rapid action in the events of obstetric complications, are well documented factors contributing to delay in receiving skilled obstetric care. Birth preparedness has been globally endorsed as an essential component of safe motherhood programs to reduce delays for care, so as to reduce maternal and neonatal mortality rate. Methods: A cross-sectional community based study was conducted to examine knowledge and practice of birth preparedness and complication readiness among women who gave birth in the last 12 months in Mizan-Aman town by using pretested structured questionnaires. The sampling technique was that of systematic sampling and the sample size was 239. Results: Data were obtained from 239 mothers, yielding 98% a response rate. Out of total respondents more than half (53.5%) of respondents said that they knew the term “birth preparedness.” More specifically, 44.7%, 50.8%, 31.8% of the respondents were knowledgeable about possible danger signs during pregnancy, during delivery, and postpartum period, respectively. Concerning complication readiness, 50% stated that they were prepared for birth and its complications. Conclusion and Recommendation: Knowledge and practices of birth preparedness and complication readiness is not comprehensive according to the result of this study. Many respondents did not know about birth preparedness and had no plans for emergencies. Therefore, community education about preparations for birth and its complications and empowerment of women through expansion of educational opportunities are recommended for improving birth preparedness and the effects of pregnancy-related complications.","PeriodicalId":92638,"journal":{"name":"Global reproductive health","volume":"5 1","pages":"e48 - e48"},"PeriodicalIF":0.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45544002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.1097/GRH.0000000000000039
S. Rechitsky, J. Simpson, A. Kuliev
Preimplantation genetic testing (PGT) for aneuploidy is an established indication to increase the pregnancy rate while still transferring a single embryo. Trophectoderm biopsy in experienced hands is safe with no association with birth defects. Accuracy is high using next-generation sequencing and clinical utility proven; predictive value of achieving pregnancy when transferring a euploid embryo is 10-fold greater than when transferring an aneuploid embryo. In our unit next-generation sequencing results show 8% of embryos having numerical mosaicis and 14% having segmental mosaicism. Mosaicism is defined as 20%–80% aneuploid DNA, compared with <20% in a sample considered nonmosaic euploid. Transfer of a mosaic (20%–80% aneuploid DNA) embryo may be appropriate if there are no euploid embryos in the cohort of a given cycle. Guidelines exist for prioritization of mosaic embryos for transfer.
{"title":"Frequency and clinical management of numerical and segmental mosaicism in embryo biopsies obtained for preimplantation genetic testing (PGT)","authors":"S. Rechitsky, J. Simpson, A. Kuliev","doi":"10.1097/GRH.0000000000000039","DOIUrl":"https://doi.org/10.1097/GRH.0000000000000039","url":null,"abstract":"Preimplantation genetic testing (PGT) for aneuploidy is an established indication to increase the pregnancy rate while still transferring a single embryo. Trophectoderm biopsy in experienced hands is safe with no association with birth defects. Accuracy is high using next-generation sequencing and clinical utility proven; predictive value of achieving pregnancy when transferring a euploid embryo is 10-fold greater than when transferring an aneuploid embryo. In our unit next-generation sequencing results show 8% of embryos having numerical mosaicis and 14% having segmental mosaicism. Mosaicism is defined as 20%–80% aneuploid DNA, compared with <20% in a sample considered nonmosaic euploid. Transfer of a mosaic (20%–80% aneuploid DNA) embryo may be appropriate if there are no euploid embryos in the cohort of a given cycle. Guidelines exist for prioritization of mosaic embryos for transfer.","PeriodicalId":92638,"journal":{"name":"Global reproductive health","volume":"5 1","pages":"e39 - e39"},"PeriodicalIF":0.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45853684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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