Pub Date : 2019-01-01DOI: 10.21767/2471-982x-c1-005
L. Ecochard
{"title":"Strategic and operational considerations in designing and executing multicenter pain trials","authors":"L. Ecochard","doi":"10.21767/2471-982x-c1-005","DOIUrl":"https://doi.org/10.21767/2471-982x-c1-005","url":null,"abstract":"","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.36648/2471-982X.5.1.25
Graciela María Frías Carrazana, Y. Bazán, Y. O. Sánchez, Secundino González Pardo, Bernardo Blanco-Zamora, R. Martínez
An epidemiological, observational, analytical and retrospective study of cases and controls was conducted with women undergoing elective cesarean section under spinal anesthesia at the Carlos Manuel de Cespedes Hospital in Bayamo, Granma province, from February 2013 to December 2015; with the objective of identifying the risk factors hypothetically related to the appearance of postpuncture dural headache in obstetric patients undergoing elective cesarean section. All the patients who gave their consent to participate, their data collection form was prepared for the study that collected the variables of the study. In addition, with each hypothetically influencing factor, the estimate of the benefit frame (OR) and its 95% confidence intervals (95% CI) and the hypothesis test of Chi to Square were performed. The age less than 25 years, the history of previous headache, the diameter of the needle of 20 and 22G, the greater number of puncture attempts and the position of the seated patient are the risk factors related to the appearance of post-puncture headache dural, but not the body mass index higher than 30 in obstetric patients undergoing elective cesarean section.
2013年2月至2015年12月，在格拉玛省巴亚莫Carlos Manuel de Cespedes医院对脊髓麻醉下择期剖宫产的妇女进行了流行病学、观察性、分析性和回顾性研究;目的是确定与选择性剖宫产的产科患者穿刺后硬膜头痛出现的假设相关的危险因素。所有同意参与的患者，他们的数据收集表是为研究准备的，收集了研究的变量。此外，对每个假设的影响因素，进行效益框架(OR)及其95%置信区间(95% CI)的估计和卡方检验的假设检验。择期剖宫产患者穿刺后硬脑膜头痛发生的危险因素为年龄小于25岁、既往头痛史、针径为20和22G、穿刺次数较多、坐位等，而体重指数大于30的产科患者与穿刺后硬脑膜头痛的发生无关。
{"title":"Factors that influence the appearance of dural post-puncture headache in patients undergoing elective cesarean section.","authors":"Graciela María Frías Carrazana, Y. Bazán, Y. O. Sánchez, Secundino González Pardo, Bernardo Blanco-Zamora, R. Martínez","doi":"10.36648/2471-982X.5.1.25","DOIUrl":"https://doi.org/10.36648/2471-982X.5.1.25","url":null,"abstract":"An epidemiological, observational, analytical and retrospective study of cases and controls was conducted with women undergoing elective cesarean section under spinal anesthesia at the Carlos Manuel de Cespedes Hospital in Bayamo, Granma province, from February 2013 to December 2015; with the objective of identifying the risk factors hypothetically related to the appearance of postpuncture dural headache in obstetric patients undergoing elective cesarean section. All the patients who gave their consent to participate, their data collection form was prepared for the study that collected the variables of the study. In addition, with each hypothetically influencing factor, the estimate of the benefit frame (OR) and its 95% confidence intervals (95% CI) and the hypothesis test of Chi to Square were performed. The age less than 25 years, the history of previous headache, the diameter of the needle of 20 and 22G, the greater number of puncture attempts and the position of the seated patient are the risk factors related to the appearance of post-puncture headache dural, but not the body mass index higher than 30 in obstetric patients undergoing elective cesarean section.","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.36648/2471-982X.5.1.25","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69705374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01Epub Date: 2016-08-02DOI: 10.21767/2471-982X.100012
T Maguire, M Davis, I Marrero-Berrios, C Zhu, C Gaughan, J Weinberg, D Manchikalapati, J SchianodiCola, H Kamath, R Schloss, J Yarmush
While general anesthetics control pain via consciousness regulation, local anesthetics (LAs) act by decreasing sensation in the localized area of administration by blocking nerve transmission to pain centers. Perioperative intra-articular administration of LAs is a commonly employed practice in orthopedic procedures to minimize patient surgical and post-surgical pain and discomfort. LAs are also co-administered with cellular mesenchymal stromal cell (MSC) therapies for a variety of tissue regenerative and inflammatory applications including osteoarthritis (OA) treatment; however, LAs can affect MSC viability and function. Therefore, finding an improved method to co-administer LAs with cells has become critically important. We have developed a sustained release LA delivery model that could enable the co-administration of LAs and MSCs. Encapsulation of liposomes within an alginate matrix leads to sustained release of bupivacaine as compared to bupivacaine-containing liposomes alone. Furthermore, drug release is maintained for a minimum of 4 days and the alginate-liposome capsules mitigated the adverse effects of bupivacaine on MSC viability.
{"title":"Control Release Anesthetics to Enable an Integrated Anesthetic-mesenchymal Stromal Cell Therapeutic.","authors":"T Maguire, M Davis, I Marrero-Berrios, C Zhu, C Gaughan, J Weinberg, D Manchikalapati, J SchianodiCola, H Kamath, R Schloss, J Yarmush","doi":"10.21767/2471-982X.100012","DOIUrl":"10.21767/2471-982X.100012","url":null,"abstract":"<p><p>While general anesthetics control pain via consciousness regulation, local anesthetics (LAs) act by decreasing sensation in the localized area of administration by blocking nerve transmission to pain centers. Perioperative intra-articular administration of LAs is a commonly employed practice in orthopedic procedures to minimize patient surgical and post-surgical pain and discomfort. LAs are also co-administered with cellular mesenchymal stromal cell (MSC) therapies for a variety of tissue regenerative and inflammatory applications including osteoarthritis (OA) treatment; however, LAs can affect MSC viability and function. Therefore, finding an improved method to co-administer LAs with cells has become critically important. We have developed a sustained release LA delivery model that could enable the co-administration of LAs and MSCs. Encapsulation of liposomes within an alginate matrix leads to sustained release of bupivacaine as compared to bupivacaine-containing liposomes alone. Furthermore, drug release is maintained for a minimum of 4 days and the alginate-liposome capsules mitigated the adverse effects of bupivacaine on MSC viability.</p>","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2471-982X.100012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36992213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Jwa, Seunghoon Kim, Hawon Jeon, Gi Yeon Park, Jung Ju Choi, Chul-Kyu Park
Background: Tannin is a naturally occurring plant polyphenol. Its main characteristic is that it displays anti-oxidant, anti-inflammatory, anti-viral, and anti-proliferative biological activities. However, the mechanism by which tannin impacts itch remains unknown. In the present study, through behavioral analysis and calcium imaging, we examined the mechanism by which tannin reduces histaminergic itch and non-histaminergic itch. Methods: First, we confirmed that tannin inhibited itch in the scratching test with histamine, compound 48/80, and SLIGRL-NH2 treatment. Second, we confirmed that tannin inhibited capsaicin- and AITC-induced calcium responses in primary-cultured DRG neurons. Third, tannin blocked the capsaicin- and AITC-induced calcium responses in TRPV1- and TRPA1-expressing HEK293 cells, respectively. Results: These results reveal that tannin reduced histamine-dependent or independent itching by activating inhibitory signals of TRPV1 and TRPA1. Conclusions: Thus, our findings suggest that tannin may be a promising drug for the treatment of histamine or non-histamine-dependent itch. fetal bovine serum (FBS; Gibco-BRL, USA) and 1% penicillin – streptomycin (Sigma, USA). Transfection was performed with Lipofectamine 2000 (Invitrogen) at 70-80% confluency, and transfected cells were cultured in the culture medium for 48 hours before calcium imaging analysis. TRPV1 plasmid vector or TRPA1 transfected HEK293 cells were provided by Seok bae Oh from Seoul University. variety of blockers and transgenic mice. Our results demonstrated that tannin alleviates histaminergic itch and non-histaminergic itch via inhibitory signaling of TRPV1 and TRPA1.
{"title":"Tannin Inhibits Histamine and SLIGRL-NH2-Induced Itch via\u0000\u0000TRPV1 and TRPA1 Signaling Pathway","authors":"H. Jwa, Seunghoon Kim, Hawon Jeon, Gi Yeon Park, Jung Ju Choi, Chul-Kyu Park","doi":"10.56718/ijp.20-002","DOIUrl":"https://doi.org/10.56718/ijp.20-002","url":null,"abstract":"Background: Tannin is a naturally occurring plant polyphenol. Its main characteristic is that it displays anti-oxidant, anti-inflammatory, anti-viral, and anti-proliferative biological activities. However, the mechanism by which tannin impacts itch remains unknown. In the present study, through behavioral analysis and calcium imaging, we examined the mechanism by which tannin reduces histaminergic itch and non-histaminergic itch. Methods: First, we confirmed that tannin inhibited itch in the scratching test with histamine, compound 48/80, and SLIGRL-NH2 treatment. Second, we confirmed that tannin inhibited capsaicin- and AITC-induced calcium responses in primary-cultured DRG neurons. Third, tannin blocked the capsaicin- and AITC-induced calcium responses in TRPV1- and TRPA1-expressing HEK293 cells, respectively. Results: These results reveal that tannin reduced histamine-dependent or independent itching by activating inhibitory signals of TRPV1 and TRPA1. Conclusions: Thus, our findings suggest that tannin may be a promising drug for the treatment of histamine or non-histamine-dependent itch. fetal bovine serum (FBS; Gibco-BRL, USA) and 1% penicillin – streptomycin (Sigma, USA). Transfection was performed with Lipofectamine 2000 (Invitrogen) at 70-80% confluency, and transfected cells were cultured in the culture medium for 48 hours before calcium imaging analysis. TRPV1 plasmid vector or TRPA1 transfected HEK293 cells were provided by Seok bae Oh from Seoul University. variety of blockers and transgenic mice. Our results demonstrated that tannin alleviates histaminergic itch and non-histaminergic itch via inhibitory signaling of TRPV1 and TRPA1.","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84731986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kun Kim, Y. Lee, Kyu Hyun Park, Jihoon Hwang, Si Gweon Nam, Sungchul Park, Young Uk Park, Jae Woo Lee, Noah Kim, J. Choi
{"title":"Corrigendum: Amputation for the Treatment of Complex Regional Pain Syndrome","authors":"Kun Kim, Y. Lee, Kyu Hyun Park, Jihoon Hwang, Si Gweon Nam, Sungchul Park, Young Uk Park, Jae Woo Lee, Noah Kim, J. Choi","doi":"10.56718/ijp.11-1_c","DOIUrl":"https://doi.org/10.56718/ijp.11-1_c","url":null,"abstract":"","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"376 4-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72457501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Won, S. Yoon, Junhyug Jeong, Bousung Lee, Kwang-Nam Lee, Dong-Sung Kim, Jaedo Lee, Rakmin Choi, Jaeyoung Yang
Various complications after Percutaneous epidural neuroplasty (PEN), such as mechanical catheter failure, bleeding, infection, and neurological damage, were reported. A 79 years-old male suffered from spondylodiscitis and paraspinal muscle infection without epidural space involvement after lumbar PEN. The postprocedural infection was difficult to diagnose, because the patient didn’t have common signs and symptoms of infections such as fever, malaise, redness or swelling and hot sense around wound. After 7 weeks of antibiotics treatment, the hospital discharge decision was made, because his lab values and vital sign were almost normal. Most of all, he was symptom free. Early detection of post procedural infection followed by the early administration of antibiotics should be the most important therapeutic strategy for better prognosis. pain unresponsive to other conservative treatments and elevated inflammatory markers . Obtaining bacterial blood cultures and baseline ESR and CRP are required in all patients with suspected spondylodiscitis. Plain radiographs of the spine are not recommended method for the early diagnosis of spondylodiscitis. Erosion of the base and upper plates or increasingly destructive kyphosis can manifest after days or weeks [7]. MRI remains the gold standard for the radiological diagnosis with 92% sensitivity and 96% specificity. MRI findings include decreased signal intensity from disc and adjacent vertebral bodies on T1-weighted images, increased signal intensity on T2-weighted images and loss of endplate definition on T1 weighting. MRI is also useful to measure the spatial extent of the infection or abscess formation. MRI findings of abscess include the presence of a region of high T2 signal, with low T1 signal and without enhancement (usually surrounded by a rim of enhancement)
{"title":"Acute Aggravation of Post Procedural Spondylodiscitis and Paraspinal Abscess without Epidural Space Involvement after Lumbar Percutaneous Epidural Neuroplasty (PEN)","authors":"J. Won, S. Yoon, Junhyug Jeong, Bousung Lee, Kwang-Nam Lee, Dong-Sung Kim, Jaedo Lee, Rakmin Choi, Jaeyoung Yang","doi":"10.56718/ijp.19-005","DOIUrl":"https://doi.org/10.56718/ijp.19-005","url":null,"abstract":"Various complications after Percutaneous epidural neuroplasty (PEN), such as mechanical catheter failure, bleeding, infection, and neurological damage, were reported. A 79 years-old male suffered from spondylodiscitis and paraspinal muscle infection without epidural space involvement after lumbar PEN. The postprocedural infection was difficult to diagnose, because the patient didn’t have common signs and symptoms of infections such as fever, malaise, redness or swelling and hot sense around wound. After 7 weeks of antibiotics treatment, the hospital discharge decision was made, because his lab values and vital sign were almost normal. Most of all, he was symptom free. Early detection of post procedural infection followed by the early administration of antibiotics should be the most important therapeutic strategy for better prognosis. pain unresponsive to other conservative treatments and elevated inflammatory markers . Obtaining bacterial blood cultures and baseline ESR and CRP are required in all patients with suspected spondylodiscitis. Plain radiographs of the spine are not recommended method for the early diagnosis of spondylodiscitis. Erosion of the base and upper plates or increasingly destructive kyphosis can manifest after days or weeks [7]. MRI remains the gold standard for the radiological diagnosis with 92% sensitivity and 96% specificity. MRI findings include decreased signal intensity from disc and adjacent vertebral bodies on T1-weighted images, increased signal intensity on T2-weighted images and loss of endplate definition on T1 weighting. MRI is also useful to measure the spatial extent of the infection or abscess formation. MRI findings of abscess include the presence of a region of high T2 signal, with low T1 signal and without enhancement (usually surrounded by a rim of enhancement)","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77002886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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