Pub Date : 2021-01-01DOI: 10.1016/b978-0-12-801238-3.11471-0
Zhilan Feng, John W. Glasser
{"title":"Infectious Disease Modeling","authors":"Zhilan Feng, John W. Glasser","doi":"10.1016/b978-0-12-801238-3.11471-0","DOIUrl":"https://doi.org/10.1016/b978-0-12-801238-3.11471-0","url":null,"abstract":"","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-12-801238-3.11471-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54161436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1016/b978-0-12-801238-3.11608-3
J. Wittmann
{"title":"Modeling Lymphocytes","authors":"J. Wittmann","doi":"10.1016/b978-0-12-801238-3.11608-3","DOIUrl":"https://doi.org/10.1016/b978-0-12-801238-3.11608-3","url":null,"abstract":"","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54161861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-28DOI: 10.1016/B978-0-12-801238-3.11708-8
D. Rozman
{"title":"Overview: Data Generation Techniques: From Omics to Personalized Approaches and Clinical Care","authors":"D. Rozman","doi":"10.1016/B978-0-12-801238-3.11708-8","DOIUrl":"https://doi.org/10.1016/B978-0-12-801238-3.11708-8","url":null,"abstract":"","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":"1 1","pages":"222 - 223"},"PeriodicalIF":0.0,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45555116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-28DOI: 10.1016/B978-0-12-801238-3.11640-X
Loan Vulliard, Jörg Menche
{"title":"Complex Networks in Health and Disease","authors":"Loan Vulliard, Jörg Menche","doi":"10.1016/B978-0-12-801238-3.11640-X","DOIUrl":"https://doi.org/10.1016/B978-0-12-801238-3.11640-X","url":null,"abstract":"","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":"1 1","pages":"26 - 33"},"PeriodicalIF":0.0,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-801238-3.11640-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46169669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-26eCollection Date: 2020-01-01DOI: 10.1089/sysm.2020.0001
Emma Kurnat-Thoma, Ancha Baranova, Pat Baird, Elia Brodsky, Atul J Butte, Amrita K Cheema, Feixiong Cheng, Shuchismita Dutta, Christina Grant, James Giordano, Anke H Maitland-van der Zee, Douglas B Fridsma, Robert Jarrin, Maricel G Kann, Jonathon Keeney, Joseph Loscalzo, Guru Madhavan, Bradley A Maron, Dennis K McBride, Maeve McKean, Seong K Mun, James C Palmer, Bakul Patel, Kapil Parakh, Anne R Pariser, Christian Pristipino, Timothy R D J Radstake, Harsha K Rajasimha, William B Rouse, Damjana Rozman, Alif Saleh, Harald H H W Schmidt, Nikolaus Schultz, Tavpritesh Sethi, Edwin K Silverman, Jessica Skopac, Igor Svab, Sylvia Trujillo, James E Valentine, Dinesh Verma, Bruce J West, Sona Vasudevan
The First International Conference in Systems and Network Medicine gathered together 200 global thought leaders, scientists, clinicians, academicians, industry and government experts, medical and graduate students, postdoctoral scholars and policymakers. Held at Georgetown University Conference Center in Washington D.C. on September 11-13, 2019, the event featured a day of pre-conference lectures and hands-on bioinformatic computational workshops followed by two days of deep and diverse scientific talks, panel discussions with eminent thought leaders, and scientific poster presentations. Topics ranged from: Systems and Network Medicine in Clinical Practice; the role of -omics technologies in Health Care; the role of Education and Ethics in Clinical Practice, Systems Thinking, and Rare Diseases; and the role of Artificial Intelligence in Medicine. The conference served as a unique nexus for interdisciplinary discovery and dialogue and fostered formation of new insights and possibilities for health care systems advances.
{"title":"Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine.","authors":"Emma Kurnat-Thoma, Ancha Baranova, Pat Baird, Elia Brodsky, Atul J Butte, Amrita K Cheema, Feixiong Cheng, Shuchismita Dutta, Christina Grant, James Giordano, Anke H Maitland-van der Zee, Douglas B Fridsma, Robert Jarrin, Maricel G Kann, Jonathon Keeney, Joseph Loscalzo, Guru Madhavan, Bradley A Maron, Dennis K McBride, Maeve McKean, Seong K Mun, James C Palmer, Bakul Patel, Kapil Parakh, Anne R Pariser, Christian Pristipino, Timothy R D J Radstake, Harsha K Rajasimha, William B Rouse, Damjana Rozman, Alif Saleh, Harald H H W Schmidt, Nikolaus Schultz, Tavpritesh Sethi, Edwin K Silverman, Jessica Skopac, Igor Svab, Sylvia Trujillo, James E Valentine, Dinesh Verma, Bruce J West, Sona Vasudevan","doi":"10.1089/sysm.2020.0001","DOIUrl":"https://doi.org/10.1089/sysm.2020.0001","url":null,"abstract":"<p><p>The <i>First International Conference in Systems and Network Medicine</i> gathered together 200 global thought leaders, scientists, clinicians, academicians, industry and government experts, medical and graduate students, postdoctoral scholars and policymakers. Held at Georgetown University Conference Center in Washington D.C. on September 11-13, 2019, the event featured a day of pre-conference lectures and hands-on bioinformatic computational workshops followed by two days of deep and diverse scientific talks, panel discussions with eminent thought leaders, and scientific poster presentations. Topics ranged from: Systems and Network Medicine in Clinical Practice; the role of -omics technologies in Health Care; the role of Education and Ethics in Clinical Practice, Systems Thinking, and Rare Diseases; and the role of Artificial Intelligence in Medicine. The conference served as a unique nexus for interdisciplinary discovery and dialogue and fostered formation of new insights and possibilities for health care systems advances.</p>","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":"3 1","pages":"22-35"},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sysm.2020.0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37783631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wienand A. Omta, R. V. Heesbeen, I. Shen, A. Feelders, Matthieu J. S. Brinkhuis, D. Egan, M. Spruit
Life science experiments that employ automated technologies, such as high-content screens, frequently produce large datasets that require substantial amounts of preprocessing before analysis can be...
使用自动化技术的生命科学实验，如高内容屏幕，经常产生大型数据集，在分析之前需要大量的预处理。。。
{"title":"PurifyR: An R Package for Highly Automated, Reproducible Variable Extraction and Standardization","authors":"Wienand A. Omta, R. V. Heesbeen, I. Shen, A. Feelders, Matthieu J. S. Brinkhuis, D. Egan, M. Spruit","doi":"10.1089/sysm.2019.0007","DOIUrl":"https://doi.org/10.1089/sysm.2019.0007","url":null,"abstract":"Life science experiments that employ automated technologies, such as high-content screens, frequently produce large datasets that require substantial amounts of preprocessing before analysis can be...","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sysm.2019.0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46371774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Precision medicine requires the accurate identification of genes and pathways that mechanistically define a disease phenotype. Modern omics may deliver this, but has until now yielded...
{"title":"De Novo and Supervised Endophenotyping Using Network-Guided Ensemble Learning","authors":"S. Larsen, Harald H. H. W. Schmidt, J. Baumbach","doi":"10.1089/sysm.2019.0008","DOIUrl":"https://doi.org/10.1089/sysm.2019.0008","url":null,"abstract":"Introduction: Precision medicine requires the accurate identification of genes and pathways that mechanistically define a disease phenotype. Modern omics may deliver this, but has until now yielded...","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sysm.2019.0008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41585318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1089/sysm.2019.29006.abstracts
{"title":"First International Conference in Systems and Network Medicine: Applications of Systems Science and Thinking to Biomedicine Georgetown University Medical Center Washington DC, USA September 11–13, 2019","authors":"","doi":"10.1089/sysm.2019.29006.abstracts","DOIUrl":"https://doi.org/10.1089/sysm.2019.29006.abstracts","url":null,"abstract":"","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sysm.2019.29006.abstracts","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46215653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fentaw Abegaz, F. V. Lishout, J. M. John, Kridsadakorn Chiachoompu, Archana Bhardwaj, Elena S. Gusareva, Zhi Wei, H. Hakonarson, K. Steen
Abstract Over the years, a more prominent role has been given to gene–gene interaction (epistasis) detection, in view of precision medicine and the hunt for novel drug targets and biomarkers for co...
{"title":"Epistasis Detection in Genome-Wide Screening for Complex Human Diseases in Structured Populations","authors":"Fentaw Abegaz, F. V. Lishout, J. M. John, Kridsadakorn Chiachoompu, Archana Bhardwaj, Elena S. Gusareva, Zhi Wei, H. Hakonarson, K. Steen","doi":"10.1089/sysm.2019.0003","DOIUrl":"https://doi.org/10.1089/sysm.2019.0003","url":null,"abstract":"Abstract Over the years, a more prominent role has been given to gene–gene interaction (epistasis) detection, in view of precision medicine and the hunt for novel drug targets and biomarkers for co...","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sysm.2019.0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42737840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. C. Felix Garza, J. Liebmann, M. Born, Paj Peter Hilbers, Nathan A. Riel
Abstract Background: Treatment of psoriasis with blue light reduces the symptoms of this skin condition. Despite the therapeutic effects of blue light, no clear guidelines have been established reg...
背景:用蓝光治疗牛皮癣可以减轻这种皮肤病的症状。尽管蓝光有治疗效果，但目前还没有明确的指导方针。
{"title":"In Silico Clinical Studies on the Efficacy of Blue Light for Treating Psoriasis in Virtual Patients","authors":"Z. C. Felix Garza, J. Liebmann, M. Born, Paj Peter Hilbers, Nathan A. Riel","doi":"10.1089/SYSM.2018.0007","DOIUrl":"https://doi.org/10.1089/SYSM.2018.0007","url":null,"abstract":"Abstract Background: Treatment of psoriasis with blue light reduces the symptoms of this skin condition. Despite the therapeutic effects of blue light, no clear guidelines have been established reg...","PeriodicalId":92727,"journal":{"name":"Systems medicine (New Rochelle, N.Y.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/SYSM.2018.0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42123537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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