International journal of cerebrovascular disease and stroke最新文献

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Histopathological Profile of Thrombi Differs Depending on Pathogenesis of Embolic Cerebral Infarction and Evidence of Intracardiac Thrombus 血栓的组织病理学特征取决于栓塞性脑梗死的发病机制和心内血栓的证据

International journal of cerebrovascular disease and stroke

Pub Date : 2023-04-28 DOI: 10.29011/2688-8734.100047

V. Meļņikova, K. Jurjāns, Katrīna Kupča, J. Vētra, Daira Lapse, A. Veiss, Jurijs Nazarovs, E. Miglāne, V. Meļņikova

Histopathological Profile of Thrombi Differs Depending on Pathogenesis of Embolic Cerebral Infarction and Evidence of Intracardiac Thrombus

血栓的组织病理学特征取决于栓塞性脑梗死的发病机制和心内血栓的证据

引用次数: 0

Delayed Activation of Sirt1 Induced Autophagy Signaling Promotes Astrogliosis, Infarct in Experimental Stroke 延迟激活Sirt1诱导的自噬信号促进实验性脑卒中的星形胶质细胞形成和梗死

International journal of cerebrovascular disease and stroke

Pub Date : 2023-04-27 DOI: 10.29011/2688-8734.100048

S. Teertam, Varalakshmi Manchana, P. Phanithi, P. Babu, Phanithi

Delayed Activation of Sirt1 Induced Autophagy Signaling Promotes

延迟激活Sirt1诱导自噬信号促进

引用次数: 0

AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum. 妊娠期输注AT1-AA会影响产后CBF的自我调节。

International journal of cerebrovascular disease and stroke

Pub Date : 2023-01-01 Epub Date: 2023-07-17 DOI: 10.29011/2688-8734.100154

Nathan Campbell, Luke Strong, Xing Fang, Jane J Border, Owen Herrock, Ty Turner, Evangeline Deer, Lorena Amaral, Ralf Dechend, Richard J Roman, Babbette LaMarca

Preeclampsia (PE), new-onset hypertension during pregnancy alongside organ dysfunction, is a leading cause of morbidity and mortality for the mother and fetus. PE women have activated B cells that produce agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA). AT1-AA impairs cerebral blood flow (CBF) autoregulation during pregnancy. Although AT1-AA often remains elevated up to 8 years postpartum, AT1-AA's effect on CBF autoregulation postpartum is unknown. This study examined whether elevated AT1-AA during pregnancy impairs CBF autoregulation postpartum and if this was augmented by infusion of AT1-AA postpartum. AT1-AA was infused into 12-week-old timed-pregnant Sprague Dawley rats beginning on gestational day 14. Uterine artery resistance index (UARI) was measured on gestational day 18 as a measure of endothelial dysfunction associated with PE. Dams were allowed to deliver. One group was given a second infusion of AT1-AA (50% perinatal dose mimicking levels observed in postpartum PE women) at 9 weeks postpartum. After postpartum week 10, mean arterial pressure (MAP) was measured in conscious rats and CBF autoregulation was measured by laser Doppler flowmetry. AT1-AA during pregnancy increased UARI (P<0.05). AT1-AA during pregnancy did not affect MAP postpartum but did impair CBF autoregulation postpartum. Infusion of AT1-AA postpartum significantly elevated blood pressure (P<0.01) but did not further impair CBF autoregulation. This study demonstrates that circulating AT1-AA during pregnancy causes impairment of CBF autoregulation well into the postpartum period indicating that elevated AT1-AA leads to long-term cerebrovascular consequences. Targeting AT1-AA may prevent cerebrovascular effects associated with PE during pregnancy and postpartum.

先兆子痫（PE）是妊娠期新发的高血压和器官功能障碍，是母亲和胎儿发病率和死亡率的主要原因。PE妇女具有活化的B细胞，其产生血管紧张素II 1型受体（AT1-AA）的激动性自身抗体。AT1-AA在妊娠期间损害脑血流量（CBF）的自动调节。尽管AT1-AA通常在产后8年内保持升高，但AT1-AA对产后CBF自动调节的影响尚不清楚。本研究检查了妊娠期AT1-AA升高是否会损害产后CBF的自动调节，以及产后输注AT1-AA是否会增强这种调节。AT1-AA从妊娠第14天开始输注到12周龄的定时妊娠的Sprague-Dawley大鼠中。在妊娠第18天测量子宫动脉阻力指数（UARI），作为与PE相关的内皮功能障碍的指标。允许母鼠分娩。其中一组在产后9周再次输注AT1-AA（50%围产期剂量模拟产后PE妇女的观察水平）。产后10周后，测量清醒大鼠的平均动脉压（MAP），并通过激光多普勒流量计测量CBF自动调节。妊娠期AT1-AA增加UARI（P

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引用次数: 0

Predictors of Fatal Outcome after Incident of Stroke among Patients from Three Hospitals in Kinshasa, Democratic Republic of the Congo 来自刚果民主共和国金沙萨三家医院的患者中风事件后致命结果的预测因素

International journal of cerebrovascular disease and stroke

Pub Date : 2022-10-26 DOI: 10.29011/2688-8734.000044

Limbole Bakilo, DS NkarnkwinKasanza, Atheno Simele, Panzi Kalunda, Mutombo Beya, Emmanuel Limbole Bakilo

Summary Objective: This study investigated the predictors of stroke fatal outcome after a one year follow-up. Methods: This was a historic cohort of 166 stroke patients from three hospitals in Kinshasa, capital of the Democratic Republic of Congo. Data were collected from patients as they were admitted. Vital outcome information was collected throughout the follow-up period. The Cox proportional hazard modeling was used to measure predictors. Results: The patients’ median age was 59 (IQR: 52-68) years. The majority of them were male (65.1%) and known hypertensive (79.5%). Around 31% patients died within the one year period of follow-up; the median duration between the occurrence of stroke and death was 37 (14-155.5) days. The Glasgow Coma Score and day 7 blood glucose showed a significant influence on vital outcome: an early disorder of consciousness (Glasgow score ˂13) multiplies by 2.5 the risk of death (HR: 2.46, 95% CI [1.3-4.6], p = 0.005) and the glycaemia level at day 7 greater than or equal to 180 mg / dl increases the risk of death by 2.4 times (HR: 2.4, 95% CI [1.03 -5.7], p = 0.04). Conclusion: Hyperglycemia in the acute phase of stroke and early consciousness disorder are predictors of fatal prognosis of stroke, easy to detect in routine clinical practice. They should therefore be used to identify patients with potentially poor prognosis in the short and in the long term for appropriate care.

目的:本研究对脑卒中致死性结局的预测因素进行了为期一年的随访。方法:这是来自刚果民主共和国首都金沙萨三家医院的166例中风患者的历史性队列研究。数据是在病人入院时收集的。在整个随访期间收集重要结果信息。采用Cox比例风险模型测量预测因子。结果:患者中位年龄59岁(IQR: 52 ~ 68岁)。其中男性居多(65.1%)，已知高血压(79.5%)。约31%的患者在1年随访期内死亡;卒中发生至死亡的中位持续时间为37(14-155.5)天。格拉斯哥昏迷评分和第7天血糖对生命结局有显著影响:早期意识障碍(格拉斯哥评分小于13)使死亡风险增加2.5倍(HR: 2.46, 95% CI [1.3-4.6]， p = 0.005)，第7天血糖水平大于或等于180 mg / dl使死亡风险增加2.4倍(HR: 2.4, 95% CI [1.03 -5.7]， p = 0.04)。结论:脑卒中急性期高血糖和早期意识障碍是脑卒中致死性预后的预测因素，在常规临床实践中易于发现。因此，它们应用于识别短期和长期预后可能较差的患者，以便进行适当的护理。

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引用次数: 0

Association Between Serum BDNF Level and Cognitive-Linguistic Outcomes in Aphasic Stroke 失语症脑卒中患者血清BDNF水平与认知语言预后的关系

International journal of cerebrovascular disease and stroke

Pub Date : 2022-01-12 DOI: 10.29011/2688-8734.000042

Lin Zhang, Yaping Huai, Mingzhu Xu, Xin Wang, Xun Luo, Xinjie Zeng, Qing-mei Wang

) Association Between Serum BDNF Level and Cognitive-Linguistic Outcomes in Aphasic Stroke. Int J Cerebrovasc Dis Stroke

失语症脑卒中患者血清BDNF水平与认知语言预后的关系。[J]脑血管病卒中

引用次数: 0

Dysphagia Incidence and Comorbidity in Hospitalized Acute Stroke Patients 住院急性脑卒中患者吞咽困难发生率及合并症

International journal of cerebrovascular disease and stroke

Pub Date : 2021-12-06 DOI: 10.29011/2688-8734.000041

Ruiying Ding

Introduction: There has been limited literature examined in a general population sample of the incidence of dysphagia in acute stroke patients, stroke patients with pneumonia and gastrostomy comorbidity, and the increased costs associated with the complications. Methods: The current study used Illinois Hospital Discharge data for in-patients admitted during September 2012 to June 2016 to investigate the incidence of dysphagia among patients who had a primary diagnosis of stroke. Sub-analysis of dysphagia incidence among stroke patients with co-morbidity pneumonia and gastrostomy was also performed. Results: The study found a 14.9% incidence of dysphagia in a population of hospitalized acute stroke patients. The rate of dysphagia was greater in the elderly and in blacks and Hispanics than whites. In stroke patients diagnosed with dysphagia, the incidence of pneumonia is 23.1% and the incidence of percutaneous endoscopic gastrostomy (PEG) is 62.1%. Stroke patients with dysphagia had doubled length of hospital stay than those without dysphagia. With the co-morbid conditions of dysphagia and pneumonia or PEG tube placement, the length of hospital stay tripled. Increased length of hospital stay is associated with significantly higher healthcare cost. Conclusions: These findings suggested the importance of early detection and treatment of dysphagia in stroke population. International Journal of Cerebrovascular Disease and Stroke Ding R. Int J Cerebrovasc Dis Stroke 4: 140. www.doi.org/10.29011/2688-8734.000041 www.gavinpublishers.com

在一般人群样本中，关于急性卒中患者、卒中患者合并肺炎和胃造口术的吞咽困难发生率以及与并发症相关的费用增加的文献研究有限。方法:本研究利用2012年9月至2016年6月期间伊利诺斯州医院住院患者的出院数据，调查初步诊断为脑卒中的患者中吞咽困难的发生率。对合并肺炎和胃造口术的脑卒中患者的吞咽困难发生率进行亚分析。结果:该研究发现住院急性脑卒中患者中有14.9%的吞咽困难发生率。老年人、黑人和西班牙裔的吞咽困难率高于白人。在诊断为吞咽困难的脑卒中患者中，肺炎的发生率为23.1%，经皮内镜胃造口术(PEG)的发生率为62.1%。有吞咽困难的中风患者住院时间是无吞咽困难患者的两倍。吞咽困难合并肺炎或置置PEG管时，住院时间增加了两倍。住院时间的延长与医疗费用的显著增加相关。结论:提示脑卒中患者早期发现和治疗吞咽困难的重要性。丁仁。中华脑血管病杂志(英文版)，第4卷第1期。www.doi.org/10.29011/2688 - 8734.000041 www.gavinpublishers.com

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引用次数: 0

Cerebral Autoregulation and Blood Flow Redistribution in the Precerebral Arteries in Patients with Carotid Artery Occlusion 颈动脉闭塞患者脑自动调节和脑前动脉血流再分布

International journal of cerebrovascular disease and stroke

Pub Date : 2021-01-01 DOI: 10.29011/2688-8734.000039

引用次数: 0

Inpatient Utility of Pro-BNP in COVID-19: A Single Center Experience 住院患者在COVID-19中使用亲bnp:单中心经验

International journal of cerebrovascular disease and stroke

Pub Date : 2021-01-01 DOI: 10.29011/2688-8734.000035

引用次数: 0

Imaging of the Intracranial Artery Dissection 颅内动脉夹层的影像学检查

International journal of cerebrovascular disease and stroke

Pub Date : 2021-01-01 DOI: 10.29011/2688-8734.000027

引用次数: 0

A Case of Caseous Calcification of the Mitral Annulus Leading to Rupture into Pericardium and Cerebral Infarction 二尖瓣环干酪样钙化致心包破裂脑梗死1例

International journal of cerebrovascular disease and stroke

Pub Date : 2021-01-01 DOI: 10.29011/2688-8734.000030

引用次数: 0

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