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Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma. DBF4在透明细胞肾细胞癌中的临床意义及促癌功能。
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-16 DOI: 10.1186/s12894-025-01694-x
Liuyan Chen, Lvying Wu, Minying Tang, Yuanhang Cheng, Kuanyin Wang, Jianan Zhang, Wenyi Deng, Lingfeng Zhu, Jin Chen

Background: Clear cell renal cell carcinoma (ccRCC) is the most common malignant urological tumor, and regrettably, and is insensitive to chemotherapy and radiotherapy, resulting in poor patient outcomes. DBF4 plays a critical role in DNA replication and participates in various biological functions, making it an attractive target for cancer treatment. However, its significance in ccRCC has not yet been explored.

Methods: We utilized external datasets and bioinformatics analyses to investigate the significance of DBF4 in ccRCC. We analysed its expression patterns, prognostic and diagnostic value, and potential mechanisms. We subsequently validated our findings through an immunohistochemistry (IHC) assay of ccRCC clinical samples. We further investigated the impact of DBF4 on the progression of ccRCC cells. Various assays, including assessments of cell proliferation, apoptosis, the cell cycle, cell migration and invasion, and colony formation, and xenograft tumor models were subsequently performed following to the knockdown of DBF4 expression via shRNA.

Results: Bioinformatics analyses revealed that DBF4 is significantly overexpressed in ccRCC tissues compared with adjacent normal tissues. This overexpression was confirmed by IHC analysis of 75 pairs of clinical ccRCC tumor and adjacent tissues. Kaplan-Meier analysis revealed that high DBF4 expression was associated with a significantly lower five-year overall survival rate. Moreover, DBF4 expression was identified as an independent risk factor in multivariate Cox regression analysis. GO and KEGG pathway enrichment analyses revealed a substantial enrichment of terms associated with cell division, whereas gene set enrichment analysis (GSEA) revealed correlations between increased DBF4 expression and the activation of cell cycle-related pathways. Subsequent in vitro and in vivo experiments demonstrated that DBF4 knockdown in ccRCC cells not only suppressed proliferation and migration in vitro but also significantly inhibited tumor growth in xenograft mice by arresting the cell cycle at the G1/G0 phase, which was mediated by the inhibition of MCM2 phosphorylation and cyclin D1 and CDK4 expression.

Conclusion: The current study revealed that DBF4 overexpression is a significant factor associated with malignant features and poor prognosis in patients with ccRCC. Therefore, it was proposed that DBF4 could serve as a novel potential prognostic biomarker and molecular target for ccRCC.

Clinical trial number: Not applicable.

背景:透明细胞肾细胞癌(ccRCC)是泌尿系统最常见的恶性肿瘤,对化疗和放疗不敏感,导致患者预后较差。DBF4在DNA复制中起着关键作用,参与多种生物学功能,使其成为癌症治疗的一个有吸引力的靶点。然而,其在ccRCC中的意义尚未得到探讨。方法:利用外部数据集和生物信息学分析,探讨DBF4在ccRCC中的意义。我们分析了其表达模式、预后和诊断价值以及潜在的机制。随后,我们通过ccRCC临床样本的免疫组织化学(IHC)分析验证了我们的发现。我们进一步研究了DBF4对ccRCC细胞进展的影响。在通过shRNA敲低DBF4表达后,随后进行各种实验,包括评估细胞增殖、凋亡、细胞周期、细胞迁移和侵袭、集落形成,以及异种移植肿瘤模型。结果:生物信息学分析显示,与邻近正常组织相比,DBF4在ccRCC组织中明显过表达。通过对75对临床ccRCC肿瘤及其邻近组织的免疫组化分析证实了这种过表达。Kaplan-Meier分析显示,DBF4高表达与5年总生存率显著降低相关。多因素Cox回归分析发现DBF4表达为独立危险因素。GO和KEGG通路富集分析显示,与细胞分裂相关的术语大量富集,而基因集富集分析(GSEA)显示,DBF4表达增加与细胞周期相关通路的激活之间存在相关性。随后的体外和体内实验表明,DBF4敲低ccRCC细胞不仅能抑制体外增殖和迁移,还能通过抑制MCM2磷酸化和cyclin D1和CDK4表达,将细胞周期阻滞在G1/G0期,从而显著抑制异种移植物小鼠的肿瘤生长。结论:本研究显示DBF4过表达是ccRCC患者恶性特征及预后不良的重要因素。因此,DBF4可作为ccRCC新的潜在预后生物标志物和分子靶点。临床试验号:不适用。
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引用次数: 0
The "prostate-pelvic syndrome" theory used in patients with type-III prostatitis and its correlation with prostate volume. iii型前列腺炎患者的“前列腺-盆腔综合征”理论及其与前列腺体积的相关性
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-16 DOI: 10.1186/s12894-025-01689-8
Xiao-Ma Zhang, Wei-Yi Li, Zong-Yao Hao, Lei Zhou, Cheng Yang, He-Xi Du, Chao-Zhao Liang

Background: Type-III prostatitis is the most common prostate disease in adult males below 40 years old. The actual operation of its diagnosis process is cumbersome. Recently, a group of top Chinese urologists have proposed the theory of "prostate-pelvic syndrome (PPS)" and suggested using it to replace the traditional term for type-III prostatitis. However, the practical application effectiveness of PPS theory in clinical practice is still unclear.

Objective: The aims of this study were to verify the clinical outcome of PPS theory in diagnosing the adult patients with type-III prostatitis below 40 years old and analyze the related factors for the main symptoms of PPS in adult males below 40 years old, providing references for the prevention and treatment of PPS in young adult males.

Methods: The clinical medical records of 548 adult outpatients with type-III prostatitis under 40 years old between August 2018 and May 2023 were retrospectively analyzed. The patients were diagnosed retrospectively again by using PPS diagnostic criteria in this retrospective cohort study. Subsequently, the age, disease duration, prostate volume (PV), PV ≥ 20 mL detection rate and other related indicators among different symptom groups were analyzed by univariate analysis. The correlation between different symptoms of PPS patients and PV as well as disease duration was analyzed by correlation analysis. Additionally, the related factors for different main symptoms of PPS patients were analyzed by multivariate analysis.

Results: Of the 548 patients, 229 patients had lower urinary tract symptoms, 159 patients had pelvic pain symptoms, and 160 patients had lower urinary tract and pelvic pain symptoms, respectively corresponding to those with voiding symptoms (VS), pain symptoms (PS), and voiding + pain symptoms (VS + PS) defined according to the concept of PPS. There were significant differences in PV and disease duration among the three main symptoms groups of PPS. PV in the VS group was larger than that in the PS group. Spearman correlation analysis showed that VS was positively correlated with PV and disease duration, while four secondary symptoms (including sexual dysfunction, psychosocial symptoms, reproductive dysfunction and other symptoms) were not related to PV. The proportion of VS patients in the PV ≥ 20 mL group was higher than that in the PV < 20 mL group. Multivariate logistic analysis showed that PV and disease duration were independent related factors for VS in adult PPS patients below 40 years old.

Conclusions: Type-III prostatitis in Chinese adult males below 40 years old can be diagnosed and treated with PPS. PV and disease duration were independent related factors for VS in Chinese adult PPS patients below 40 years old. The risk of VS in PPS patients with PV ≥ 20 mL was 5.348 times as long as that in PPS patients with PV < 20 mL.

背景:iii型前列腺炎是40岁以下成年男性最常见的前列腺疾病。其实际操作诊断过程繁琐。最近,一群顶尖的中国泌尿科医生提出了“前列腺盆腔综合征(PPS)”理论,并建议用它来取代传统的iii型前列腺炎术语。然而,PPS理论在临床实践中的实际应用效果尚不清楚。目的:验证PPS理论在诊断40岁以下成年iii型前列腺炎患者中的临床效果,分析40岁以下成年男性PPS主要症状的相关因素,为青年男性PPS的防治提供参考。方法:回顾性分析2018年8月~ 2023年5月548例40岁以下成人门诊iii型前列腺炎患者的临床病历。本回顾性队列研究采用PPS诊断标准对患者进行回顾性诊断。随后对不同症状组患者的年龄、病程、前列腺体积(PV)、PV≥20ml检出率等相关指标进行单因素分析。通过相关分析分析PPS患者不同症状与PV及病程的相关性。并通过多因素分析分析PPS患者不同主要症状的相关因素。结果:548例患者中,229例患者有下尿路症状,159例患者有盆腔疼痛症状,160例患者有下尿路和盆腔疼痛症状,分别对应于根据PPS概念定义的排尿症状(VS)、疼痛症状(PS)和排尿+疼痛症状(VS + PS)。三个主要症状组的PV和病程均有显著性差异。VS组PV大于PS组。Spearman相关分析显示VS与PV、病程呈正相关,而4个继发症状(性功能障碍、心理社会症状、生殖功能障碍等症状)与PV无相关性。PV≥20 mL组VS患者比例高于PV组。结论:中国40岁以下成年男性iii型前列腺炎可以用PPS诊断和治疗。PV和病程是40岁以下中国成年PPS患者VS的独立相关因素。PV≥20 mL的PPS患者发生VS的风险是PV患者的5.348倍
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引用次数: 0
Asthma-associated prostate enlargement and bladder smooth muscle hypercontractility: unveiling a potential link to LUTS. 哮喘相关的前列腺增大和膀胱平滑肌过度收缩:揭示与LUTS的潜在联系。
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-15 DOI: 10.1186/s12894-024-01686-3
Peibin Cen, Ming Chen, Xin Qiu, Wenbin Guo, Hongyu Lan, Xingyu Zhou, Ming Lei, Guohua Zeng, Qingfeng Yu

Background: In male patients, benign prostate hyperplasia (BPH) and overactive bladder (OAB) secondary to BPH are the primary causes of Lower Urinary Tract Symptoms (LUTS). Recent clinical studies have reported an increased risk of LUTS, particularly severe LUTS conditions, in male asthmatic patients. However, the potential link and mechanism remain unclear. In this study, we investigated the structural and molecular characteristics of the prostate, and the structural and functional characteristics of the bladder in an asthma rat model.

Methods: An asthma model was induced in rats through the intraperitoneal injection of ovalbumin. Prostate and bladder tissue structure was examined with Hematoxylin and Eosin (H&E) and Masson's trichrome (MT) staining, respectively. Prostatic smooth muscle contraction-related and synthesis-related protein levels were assessed using western blotting. Detrusor contractions were examined in an organ bath.

Results: Prostate epithelial thickness was significantly increased in asthmatic rats, accompanied by changes in molecular markers, including increased expression of desmin and tropomyosin and decreased expression of vimentin in the prostate tissue. The bladder wall structure and bladder weight were similar in both the asthma and control groups. Acetylcholine induced concentration-dependent bladder smooth muscle contractions, which were significantly enhanced in strips from asthmatic rats, however, acetyl-β-methylcholine and carbachol induced concentration-dependent bladder smooth muscle contractions were similar in both groups.

Conclusions: Our findings suggest a potential association between asthma and LUTS, with asthma possibly contributing to organ-specific changes, including prostate enlargement and increased smooth muscle contraction in the prostate and bladder. These results provide evidence for a biological connection between asthma and LUTS, laying a promising foundation for exploring new therapeutic strategies to manage LUTS in patients with asthma.

背景:在男性患者中,良性前列腺增生(BPH)和继发于BPH的膀胱过动症(OAB)是引起下尿路症状(LUTS)的主要原因。最近的临床研究报告了男性哮喘患者发生LUTS的风险增加,特别是严重的LUTS情况。然而,潜在的联系和机制尚不清楚。在这项研究中,我们研究了哮喘大鼠模型前列腺的结构和分子特征,以及膀胱的结构和功能特征。方法:采用卵清蛋白腹腔注射法建立大鼠哮喘模型。分别用苏木精和伊红(H&E)染色和马松三色(MT)染色检查前列腺和膀胱组织结构。western blotting检测前列腺平滑肌收缩相关蛋白和合成相关蛋白水平。在器官浴中检查逼尿肌收缩。结果:哮喘大鼠前列腺上皮厚度明显增加,前列腺组织中desmin、tropomyosin表达升高,vimentin表达降低,伴有分子标记物的改变。哮喘组和对照组的膀胱壁结构和膀胱重量相似。乙酰胆碱诱导的浓度依赖性膀胱平滑肌收缩在哮喘大鼠的条带中显著增强,而乙酰β-甲基胆碱和甲胆碱诱导的浓度依赖性膀胱平滑肌收缩在两组中相似。结论:我们的研究结果提示哮喘与LUTS之间存在潜在关联,哮喘可能导致器官特异性改变,包括前列腺增大和前列腺和膀胱平滑肌收缩增加。这些结果为哮喘与LUTS之间的生物学联系提供了证据,为探索治疗哮喘患者LUTS的新治疗策略奠定了良好的基础。
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引用次数: 0
Congenital urethral diverticulum with a large stone in a 16-year-old male: a case report. 先天性尿道憩室伴大结石1例16岁男性。
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-15 DOI: 10.1186/s12894-025-01692-z
Hazem Arab, Yousef Alsaffaf, Ahmed Aldolly, Mohammad Shehadeh

Background: Urethral diverticulum is a sac-like dilation that extends from the urethral lumen and is connected to it. It can either be congenital or acquired, with the latter being more common. The development of calculi is rare in such patients. Management is tailored based on the patient's symptoms and findings from investigations.

Case presentation: A 16-year-old African male presented with recurrent urinary tract infections and a burning sensation during urination. He was diagnosed with a congenital Urethral diverticulum in the bulbar urethral containing a large stone based on the findings of echography and retrograde urethrogram. He underwent urethral diverticulectomy and stone removal, and was discharged without any complications.

Conclusion: This case illustrated the uncommon presentation of congenital Urethral diverticulum with a large calculus. The cause of congenital urethral diverticula is unknown, with multiple theories proposed. The reason behind the development of such a large stone is most likely due to insufficient medical services and delayed diagnosis in the patient's environment.

背景:尿道憩室是一种囊状扩张,从尿道腔延伸并与之相连。它可以是先天性的,也可以是后天的,后者更为常见。在这类患者中,结石的发展是罕见的。管理是根据患者的症状和调查结果量身定制的。病例介绍:一名16岁的非洲男性表现为反复尿路感染和排尿时烧灼感。他被诊断为先天性尿道憩室在球尿道包含一个大的结石基于超声检查和逆行尿道造影的结果。患者行尿道憩室切除术及取石术,无并发症出院。结论:本病例为先天性尿道憩室伴大结石的罕见表现。先天性尿道憩室病因不明,目前提出多种理论。发展成如此大的结石的原因很可能是由于患者所处的环境中医疗服务不足和诊断延误。
{"title":"Congenital urethral diverticulum with a large stone in a 16-year-old male: a case report.","authors":"Hazem Arab, Yousef Alsaffaf, Ahmed Aldolly, Mohammad Shehadeh","doi":"10.1186/s12894-025-01692-z","DOIUrl":"10.1186/s12894-025-01692-z","url":null,"abstract":"<p><strong>Background: </strong>Urethral diverticulum is a sac-like dilation that extends from the urethral lumen and is connected to it. It can either be congenital or acquired, with the latter being more common. The development of calculi is rare in such patients. Management is tailored based on the patient's symptoms and findings from investigations.</p><p><strong>Case presentation: </strong>A 16-year-old African male presented with recurrent urinary tract infections and a burning sensation during urination. He was diagnosed with a congenital Urethral diverticulum in the bulbar urethral containing a large stone based on the findings of echography and retrograde urethrogram. He underwent urethral diverticulectomy and stone removal, and was discharged without any complications.</p><p><strong>Conclusion: </strong>This case illustrated the uncommon presentation of congenital Urethral diverticulum with a large calculus. The cause of congenital urethral diverticula is unknown, with multiple theories proposed. The reason behind the development of such a large stone is most likely due to insufficient medical services and delayed diagnosis in the patient's environment.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"6"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the characteristics of detrusor after contraction in females with pure urodynamic stress incontinence. 探讨女性单纯尿动力应激性尿失禁后逼尿肌收缩的特点。
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-13 DOI: 10.1186/s12894-025-01691-0
Xiao Zeng, Hong Shen, Deyi Luo, Tao Jin

Purpose: This study aims to evaluate detrusor after contraction (DAC) characteristics in females with pure urodynamic stress incontinence (USI).

Methods: We examined the urodynamics database from our urodynamic study center. Urodynamic data from pure USI cases with and without DAC were compared. DAC was categorized based on morphological features, and urodynamic parameters in different subgroups were analyzed.

Results: A total of 61 female pure USI patients met all the study requirements. Among them, there were 27 cases of pure USI with DAC and 34 cases of pure USI without DAC. The incidence of pure USI with DAC in the overall female sample was 2.5%.Significant differences were observed in Qmax between pure USI with DAC and pure USI without DAC (20.1 ± 7.2 vs. 13.0 ± 6.8, p = 0.00), as well as in Pdetqmax (24.3 ± 15.1 vs. 16.3 ± 9.8, p = 0.02). Comparing parameters among the three subtypes of DAC revealed statistical differences in uroflow time: Type 1 DAC vs. Type 2 DAC vs. Type 3 DAC [21(20,22.5) vs. 22(16,27) vs. 30(26.8,30.8), p = 0.02], and in the maximum DAC contraction amplitude [64(46.5,107) vs. 39(25.5,48) vs. 45.5(24,74.8), p = 0.03]. Additionally, DAC was categorized into three subgroups: Type 1, Type 2, and Type 3.

Conclusions: This study offers an initial exploration of morphological and mathematical aspects of DAC in urodynamics involving females with pure USI. The findings also suggest DAC may serve as a potential new indictor of bladder function in females with pure USI.

Trial registration: Not applicable.

目的:本研究旨在评估女性纯尿动力应激性尿失禁(USI)的逼尿肌收缩后(DAC)特征。方法:我们检查尿动力学研究中心的尿动力学数据库。比较单纯USI患者伴与不伴DAC的尿动力学数据。根据形态学特征对DAC进行分类,分析不同亚组的尿动力学参数。结果:61例女性单纯USI患者符合全部研究要求。其中单纯USI合并DAC 27例,单纯USI不合并DAC 34例。在整个女性样本中,纯USI伴DAC的发生率为2.5%。加DAC的纯USI与不加DAC的纯USI的Qmax(20.1±7.2比13.0±6.8,p = 0.00)和Pdetqmax(24.3±15.1比16.3±9.8,p = 0.02)差异有统计学意义。三种DAC亚型的参数比较显示尿流时间的统计学差异:1型DAC与2型DAC与3型DAC[21(20,22.5)、22(16,27)、30(26.8,30.8),p = 0.02],以及最大DAC收缩幅度[64(46.5,107)、39(25.5,48)、45.5(24,74.8),p = 0.03]。此外,DAC分为三个亚组:1型,2型和3型。结论:本研究对纯USI女性患者尿动力学中DAC的形态学和数学方面进行了初步探索。研究结果还表明,DAC可能作为纯USI女性膀胱功能的潜在新指标。试验注册:不适用。
{"title":"Exploring the characteristics of detrusor after contraction in females with pure urodynamic stress incontinence.","authors":"Xiao Zeng, Hong Shen, Deyi Luo, Tao Jin","doi":"10.1186/s12894-025-01691-0","DOIUrl":"10.1186/s12894-025-01691-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate detrusor after contraction (DAC) characteristics in females with pure urodynamic stress incontinence (USI).</p><p><strong>Methods: </strong>We examined the urodynamics database from our urodynamic study center. Urodynamic data from pure USI cases with and without DAC were compared. DAC was categorized based on morphological features, and urodynamic parameters in different subgroups were analyzed.</p><p><strong>Results: </strong>A total of 61 female pure USI patients met all the study requirements. Among them, there were 27 cases of pure USI with DAC and 34 cases of pure USI without DAC. The incidence of pure USI with DAC in the overall female sample was 2.5%.Significant differences were observed in Q<sub>max</sub> between pure USI with DAC and pure USI without DAC (20.1 ± 7.2 vs. 13.0 ± 6.8, p = 0.00), as well as in Pdet<sub>qmax</sub> (24.3 ± 15.1 vs. 16.3 ± 9.8, p = 0.02). Comparing parameters among the three subtypes of DAC revealed statistical differences in uroflow time: Type 1 DAC vs. Type 2 DAC vs. Type 3 DAC [21(20,22.5) vs. 22(16,27) vs. 30(26.8,30.8), p = 0.02], and in the maximum DAC contraction amplitude [64(46.5,107) vs. 39(25.5,48) vs. 45.5(24,74.8), p = 0.03]. Additionally, DAC was categorized into three subgroups: Type 1, Type 2, and Type 3.</p><p><strong>Conclusions: </strong>This study offers an initial exploration of morphological and mathematical aspects of DAC in urodynamics involving females with pure USI. The findings also suggest DAC may serve as a potential new indictor of bladder function in females with pure USI.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"5"},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bladder mucosal smoothness predicts early recovery of urinary continence after laparoscopic radical prostatectomy. 膀胱粘膜平滑度预测腹腔镜根治性前列腺切除术后尿失禁的早期恢复。
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-10 DOI: 10.1186/s12894-024-01682-7
Le Yu, Ye Yan, Hongling Chu, Shaohui Deng, Jianfei Ye, Guoliang Wang, Yi Huang, Fan Zhang, Shudong Zhang

Background: To propose the bladder mucosal smoothness (BMS) grade and validate a predictive model including MRI parameters preoperatively that can evaluate the early recovery of urinary continence (UC) after laparoscopic radical prostatectomy (LRP).

Methods: A retrospective analysis was conducted on 203 patients (83 patients experienced UI at the three-month follow-up) who underwent LRP in our medical center and were diagnosed with prostate cancer (PCa) from June 2016 to March 2020. Patients' clinicopathological data were collected. Prostate volume (PV), membranous urethra length (MUL), intravesical prostatic protrusion length (IPPL), and BMS grade were measured by MRI. The total sample was randomly divided into a training set (n = 142) and a validation set (n = 61). A model was developed to predict the risk of urinary incontinence (UI) at three months after LRP.

Results: Age group, clinical T stage group, BMS grade group, PV group, IPPL group, and MUL group differed significantly between patients in the UI group and the UC group (all P values < 0.05). Multivariate analysis identified 3 MRI-related predictors selected for the prediction model: BMS grade (1 odds ratio [OR] 0.17, 95% CI 0.11-0.66; P value = 0.024) (2 + 3 OR 0.17, 95% CI 0.04-0.66; P value = 0.011), IPPL (> 5 mm OR 0.17, 95% CI 0.1-0.64; P = 0.004), and MUL (≥ 14 mm OR 6.41, 95% CI 2.72-15.09; P value < 0.001). The model achieved a highest area under the curve of 0.900 in the training set and the validation set. The sensitivity and specificity of the prediction model were 0.800 and 0.816.

Conclusion: Our study confirmed that patients with lower BMS grade are associated with early recovery of urinary continence after LRP. A prediction model was developed and validated to evaluate the early recovery of urinary continence after LRP.

Clinical trial number: Not applicable.

背景:提出膀胱粘膜平滑度(BMS)等级,并验证包括术前MRI参数在内的预测模型,以评估腹腔镜根治性前列腺切除术(LRP)后尿失禁(UC)的早期恢复。方法:回顾性分析2016年6月至2020年3月在我中心行LRP并诊断为前列腺癌(PCa)的203例患者(其中83例随访3个月出现尿潴留)。收集患者的临床病理资料。MRI检测前列腺体积(PV)、膜性尿道长度(MUL)、膀胱内前列腺突出长度(IPPL)及BMS分级。总样本随机分为训练集(n = 142)和验证集(n = 61)。建立了一个模型来预测LRP术后3个月尿失禁(UI)的风险。结果:UI组和UC组患者的年龄组、临床T分期组、BMS分级组、PV组、IPPL组和MUL组差异有统计学意义(P值均为5 mm OR 0.17, 95% CI 0.1-0.64;P = 0.004), MUL(≥14 mm OR 6.41, 95% CI 2.72-15.09;结论:我们的研究证实BMS分级较低的患者与LRP术后尿失禁的早期恢复相关。我们建立并验证了一个预测模型来评估LRP术后尿失禁的早期恢复情况。临床试验号:不适用。
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引用次数: 0
Relationship between albumin-globulin ratio and prostate-specific antigen: a cross-sectional study based on NHANES 2003-2010. 白蛋白-球蛋白比率与前列腺特异性抗原的关系:基于NHANES 2003-2010的横断面研究。
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-07 DOI: 10.1186/s12894-024-01687-2
Simeng Gao, Shaojie Li, Baofang Wu, Jiayin Wang, Sijuan Ding, Zhaohui Tang

Purpose: The albumin-globulin ratio (AGR) influences the development of prostate cancer; however, the relationship between AGR and prostate-specific antigen (PSA) has not been reported.

Methods: This cross-sectional investigation used comprehensive AGR versus PSA data from men with 40 years of age and older, who participated in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2010, spanning 4 investigation cycles, as only these cycles contained complete PSA data. To evaluate the nonlinear relationship between the ARG and PSA level, a regression utilizing smoothed curve fitting (penalized spline approach) and a generalized additive model (GAM) were employed. A two-segment linear regression model was used to conduct threshold effect evaluations. Lastly, subgroup analyses were carried out along with interaction tests.

Results: This study included 5,376 subjects, whose total serum PSA (mean ± standard deviation) was 1.83 ± 3.34, and its level decreased roughly with increasing quartiles of AGR. In the fully-adjusted model, AGR was negatively correlated with the likelihood of PSA, and this relationship persisted across subgroups (trend > 0.05). The PSA was characterized by an "L"-shaped curve with an inflection point. On the left side of the inflection point (K = 1.32), there was a negative relationship between AGR and PSA.

Conclusion: In the United States, among men over 40 years of age without prostate diseases, AGR demonstrated a nonlinear relationship with PSA, negatively correlating when AGR was below 1.32.

Clinical trial number: Not applicable.

目的:白蛋白-球蛋白比值(AGR)影响前列腺癌的发生发展;然而,AGR与前列腺特异性抗原(PSA)之间的关系尚未见报道。方法:本横断面调查采用2003年至2010年参加国家健康与营养调查(NHANES)的40岁及以上男性的综合AGR和PSA数据,跨越4个调查周期,因为只有这些周期包含完整的PSA数据。为了评估ARG和PSA水平之间的非线性关系,采用平滑曲线拟合(惩罚样条方法)和广义加性模型(GAM)进行回归。采用两段线性回归模型进行阈值效应评价。最后,进行亚组分析和交互试验。结果:本研究共纳入5376例受试者,血清总PSA(均值±标准差)为1.83±3.34,随着AGR四分位数的增加,PSA水平大致下降。在完全调整模型中,AGR与PSA的可能性呈负相关,并且这种关系在亚组中持续存在(趋势> 0.05)。PSA呈“L”型曲线,有一个拐点。在拐点左侧(K = 1.32), AGR与PSA呈负相关。结论:在美国40岁以上无前列腺疾病的男性中,AGR与PSA呈非线性关系,当AGR低于1.32时呈负相关。临床试验号:不适用。
{"title":"Relationship between albumin-globulin ratio and prostate-specific antigen: a cross-sectional study based on NHANES 2003-2010.","authors":"Simeng Gao, Shaojie Li, Baofang Wu, Jiayin Wang, Sijuan Ding, Zhaohui Tang","doi":"10.1186/s12894-024-01687-2","DOIUrl":"https://doi.org/10.1186/s12894-024-01687-2","url":null,"abstract":"<p><strong>Purpose: </strong>The albumin-globulin ratio (AGR) influences the development of prostate cancer; however, the relationship between AGR and prostate-specific antigen (PSA) has not been reported.</p><p><strong>Methods: </strong>This cross-sectional investigation used comprehensive AGR versus PSA data from men with 40 years of age and older, who participated in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2010, spanning 4 investigation cycles, as only these cycles contained complete PSA data. To evaluate the nonlinear relationship between the ARG and PSA level, a regression utilizing smoothed curve fitting (penalized spline approach) and a generalized additive model (GAM) were employed. A two-segment linear regression model was used to conduct threshold effect evaluations. Lastly, subgroup analyses were carried out along with interaction tests.</p><p><strong>Results: </strong>This study included 5,376 subjects, whose total serum PSA (mean ± standard deviation) was 1.83 ± 3.34, and its level decreased roughly with increasing quartiles of AGR. In the fully-adjusted model, AGR was negatively correlated with the likelihood of PSA, and this relationship persisted across subgroups (trend > 0.05). The PSA was characterized by an \"L\"-shaped curve with an inflection point. On the left side of the inflection point (K = 1.32), there was a negative relationship between AGR and PSA.</p><p><strong>Conclusion: </strong>In the United States, among men over 40 years of age without prostate diseases, AGR demonstrated a nonlinear relationship with PSA, negatively correlating when AGR was below 1.32.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"3"},"PeriodicalIF":1.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ratio of COL2A1:COL1A1 in dartos tissue patients with hypospadias. 尿道下裂患者尿道组织中COL2A1:COL1A1的比值。
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-04 DOI: 10.1186/s12894-024-01688-1
Prahara Yuri, Hotman Christinus, Zico Yusuf Alfarizi, Medina Ndoye

Background: The inelasticity of dartos tissue and the regulation of collagen expression are significant factors in the pathophysiology of chordee associated with hypospadias. While the COL2A1:COL1A1 ratio is recognised as a measure of cell differentiation, there is yet to be a study specifically examining this ratio in hypospadias. The aim of this study was to determine the COL2A1:COL1A1 ratio.

Methods: We collected 55 samples of dartos tissue, comprising 35 from patients with hypospadias procured from urethroplasty procedures and 20 from patients with phimosis collected during circumcision without any lichen cases at our institution. The gene expression levels of COL1A1 and COL2A1 in the dartos tissue were analyzed using reverse-transcriptase polymerase chain reaction (qPCR).

Results: Based on the type of penile abnormality, the expression levels of COL1A1 and COL2A1 measured by qPCR were downregulated in hypospadias, with value of 0.83 (0.38-2.53) and 0.43 (0.10-5.66), respectively, compared to phimosis, which had levels of 1.85 (1.24-4.61) and 0.94 (0.26-2.47) (p < 0.001). The expression levels of COL1A1 and COL2A1 were also significantly downregulated among mild, moderate, severe penile curvature, and control groups (p < 0.001 and p = 0.02). However, the COL2A1:COL1A1 ratio did not show statistically significant differences based on penile abnormalities and curvature (p > 0.05).

Conclusion: The expression levels of COL1A1 and COL2A1 are significantly downregulated in patients with hypospadias and ventral curvature when compared to those in the phimosis group. However, the COL2A1:COL1A1 ratio was not significant.

背景:裂孔组织的不弹性和胶原蛋白表达的调控是尿道下裂相关脊索病病理生理的重要因素。虽然COL2A1:COL1A1比值被认为是衡量细胞分化的指标,但目前还没有一项研究专门研究尿道下裂的这一比值。本研究的目的是确定COL2A1:COL1A1比值。方法:我们收集了55份尿道组织样本,其中35份来自尿道成形术中获得的尿道下裂患者,20份来自本院包皮环切术中收集的无地衣病例的包茎患者。采用逆转录聚合酶链式反应(qPCR)分析COL1A1和COL2A1基因在dartos组织中的表达水平。结果:根据阴茎异常类型,qPCR检测的COL1A1和COL2A1在尿道下裂中表达水平下调,分别为0.83(0.38-2.53)和0.43(0.10-5.66),而包茎的表达水平分别为1.85(1.24-4.61)和0.94(0.26-2.47),差异有统计学意义(p 0.05)。结论:与包茎组相比,尿道下裂和腹弯曲组COL1A1和COL2A1的表达水平明显下调。COL2A1:COL1A1比值不显著。
{"title":"The ratio of COL2A1:COL1A1 in dartos tissue patients with hypospadias.","authors":"Prahara Yuri, Hotman Christinus, Zico Yusuf Alfarizi, Medina Ndoye","doi":"10.1186/s12894-024-01688-1","DOIUrl":"https://doi.org/10.1186/s12894-024-01688-1","url":null,"abstract":"<p><strong>Background: </strong>The inelasticity of dartos tissue and the regulation of collagen expression are significant factors in the pathophysiology of chordee associated with hypospadias. While the COL2A1:COL1A1 ratio is recognised as a measure of cell differentiation, there is yet to be a study specifically examining this ratio in hypospadias. The aim of this study was to determine the COL2A1:COL1A1 ratio.</p><p><strong>Methods: </strong>We collected 55 samples of dartos tissue, comprising 35 from patients with hypospadias procured from urethroplasty procedures and 20 from patients with phimosis collected during circumcision without any lichen cases at our institution. The gene expression levels of COL1A1 and COL2A1 in the dartos tissue were analyzed using reverse-transcriptase polymerase chain reaction (qPCR).</p><p><strong>Results: </strong>Based on the type of penile abnormality, the expression levels of COL1A1 and COL2A1 measured by qPCR were downregulated in hypospadias, with value of 0.83 (0.38-2.53) and 0.43 (0.10-5.66), respectively, compared to phimosis, which had levels of 1.85 (1.24-4.61) and 0.94 (0.26-2.47) (p < 0.001). The expression levels of COL1A1 and COL2A1 were also significantly downregulated among mild, moderate, severe penile curvature, and control groups (p < 0.001 and p = 0.02). However, the COL2A1:COL1A1 ratio did not show statistically significant differences based on penile abnormalities and curvature (p > 0.05).</p><p><strong>Conclusion: </strong>The expression levels of COL1A1 and COL2A1 are significantly downregulated in patients with hypospadias and ventral curvature when compared to those in the phimosis group. However, the COL2A1:COL1A1 ratio was not significant.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"2"},"PeriodicalIF":1.7,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous nephroscopy versus flexible ureteroscopy in the treatment of calyceal diverticulum calculi: a meta-analysis. 经皮肾镜与柔性输尿管镜治疗肾盏憩室结石:荟萃分析。
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-02 DOI: 10.1186/s12894-024-01655-w
Conglei Hu, Rui Ma, Yongxiang Shao, Zilong Liang, Meng Cheng, Haofeng Pang, Liping Yao, Fei Liu

Background: There is still controversy about the best minimally invasive surgical method for the treatment of calyceal diverticulum calculi. We conducted meta-analysis to evaluate the effectiveness and safety of PCNL and FURL in the treatment of calyceal diverticulum calculi.

Methods: We searched Pubmed, Cochrane Library, Web of Science, Embase, Clinical trial platform, CNKI, VIP until April 2024. We utilized the Newcastle-Ottawa Scale (NOS, 0 to 9 stars) to assess the quality of the included literature.

Results: Totally 15 high-quality studies with 755 patients were included in the meta-analysis. Meta-analysis showed that FURL group was better than PCNL group in blood loss [SMD = 1.713, 95%CI:(0.858, 2.568), Z = 3.928, P = 0.000] and hospital stay [SMD = 2.611, 95%CI: (1.726, 3.496), Z = 5.784, P = 0.000], there was no significant difference in operating time [SMD = 0.079, 95%CI:(-0.43, 0.589), Z = 0.306, P = 0.760], complication rate [OR = 1.793,95%CI: (0.952,2.602), Z = 1.586, P = 0.113], stone-free rate [OR = 1.339, 95%CI: (0.576, 3.112), Z = 0.678, P = 0.497] and symptom-free rate [OR = 3.826,95%CI: (0.561,10.238), Z = 0.966, P = 0.334] as well.

Conclusion: Whether FURL is indeed superior to PCNL in safety, whether FURL's efficacy is really close to PCNL, and whether FURL can surpass PCNL as the first choice for the treatment of renal diverticulum stones in the future need to be further verified by multi-center, large-sample and high-quality studies.

背景:关于治疗肾盏憩室结石的最佳微创手术方法仍存在争议。我们对 PCNL 和 FURL 治疗肾盏憩室结石的有效性和安全性进行了荟萃分析:我们检索了 Pubmed、Cochrane Library、Web of Science、Embase、临床试验平台、CNKI、VIP,直至 2024 年 4 月。我们采用纽卡斯尔-渥太华量表(Newcastle-Ottawa Scale,0 到 9 星级)来评估纳入文献的质量:结果:荟萃分析共纳入 15 项高质量研究,755 名患者。荟萃分析显示,FURL组在失血量[SMD = 1.713,95%CI:(0.858, 2.568),Z = 3.928,P = 0.000]和住院时间[SMD = 2.611,95%CI:(1.726, 3.496),Z = 5.784,P = 0.000]方面优于PCNL组,在手术时间[SMD = 0.079,95%CI:(-0.43, 0.589), Z = 0.306, P = 0.760]、并发症发生率[OR = 1.793,95%CI: (0.952,2.602), Z = 1.586, P = 0.113]、无结石率[OR = 1.339, 95%CI: (0.576, 3.112), Z = 0.678, P = 0.497]以及无症状率[OR = 3.826,95%CI: (0.561,10.238), Z = 0.966, P = 0.334]:结论:FURL的安全性是否真的优于PCNL,FURL的疗效是否真的接近PCNL,FURL是否能超越PCNL成为未来治疗肾憩室结石的首选,这些都需要多中心、大样本、高质量的研究来进一步验证。
{"title":"Percutaneous nephroscopy versus flexible ureteroscopy in the treatment of calyceal diverticulum calculi: a meta-analysis.","authors":"Conglei Hu, Rui Ma, Yongxiang Shao, Zilong Liang, Meng Cheng, Haofeng Pang, Liping Yao, Fei Liu","doi":"10.1186/s12894-024-01655-w","DOIUrl":"10.1186/s12894-024-01655-w","url":null,"abstract":"<p><strong>Background: </strong>There is still controversy about the best minimally invasive surgical method for the treatment of calyceal diverticulum calculi. We conducted meta-analysis to evaluate the effectiveness and safety of PCNL and FURL in the treatment of calyceal diverticulum calculi.</p><p><strong>Methods: </strong>We searched Pubmed, Cochrane Library, Web of Science, Embase, Clinical trial platform, CNKI, VIP until April 2024. We utilized the Newcastle-Ottawa Scale (NOS, 0 to 9 stars) to assess the quality of the included literature.</p><p><strong>Results: </strong>Totally 15 high-quality studies with 755 patients were included in the meta-analysis. Meta-analysis showed that FURL group was better than PCNL group in blood loss [SMD = 1.713, 95%CI:(0.858, 2.568), Z = 3.928, P = 0.000] and hospital stay [SMD = 2.611, 95%CI: (1.726, 3.496), Z = 5.784, P = 0.000], there was no significant difference in operating time [SMD = 0.079, 95%CI:(-0.43, 0.589), Z = 0.306, P = 0.760], complication rate [OR = 1.793,95%CI: (0.952,2.602), Z = 1.586, P = 0.113], stone-free rate [OR = 1.339, 95%CI: (0.576, 3.112), Z = 0.678, P = 0.497] and symptom-free rate [OR = 3.826,95%CI: (0.561,10.238), Z = 0.966, P = 0.334] as well.</p><p><strong>Conclusion: </strong>Whether FURL is indeed superior to PCNL in safety, whether FURL's efficacy is really close to PCNL, and whether FURL can surpass PCNL as the first choice for the treatment of renal diverticulum stones in the future need to be further verified by multi-center, large-sample and high-quality studies.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"1"},"PeriodicalIF":1.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Programmed cell death 1 inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic urothelial carcinoma: a single-center experience. 程序性细胞死亡1抑制剂单独或联合化疗治疗局部晚期或转移性尿路上皮癌:单中心研究
IF 1.7 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-12-31 DOI: 10.1186/s12894-024-01674-7
Xing Huang, Chupeng Sun, Peng Zhang, Lei Wang

Background: Immune checkpoint inhibitors (ICIs) alone or in combination with standard chemotherapy for advanced urothelial carcinoma (UC) have been tested as first-line treatment in clinical trials. This study aimed to evaluate the clinical outcomes of programmed cell death 1 (PD-1) inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic UC in a real world clinical care setting, and sought to identify prognostic factors for overall survival (OS).

Methods: A retrospective, real-world study involving 35 locally advanced or metastatic UC patients treated with PD-1 inhibitor alone or in combination with chemotherapy was conducted. Kaplan-Meier curves were used to assess progression-free survival (PFS) and OS. A Cox regression analysis was conducted to explore the association of baseline variables with OS.

Results: In our cohort of 35 patients, 7 patients were treated with PD-1 inhibitor alone and 28 with PD-1 inhibitor plus platinum-based chemotherapy. The median OS was 16.0 months (95% CI: 11.9-20.1), and median PFS was 12.0 months (95% CI: 8.6-15.4) for all patients. PD-1 inhibitor combined with chemotherapy was associated with better PFS than PD-1 inhibitor monotherapy (HR: 0.19, p = 0.018). Treatment-related adverse events (AEs) of any grade occurred in 5 (71.4%) patients who received PD-1 inhibitor and 24 (85.7%) patients who received PD-1 inhibitor plus chemotherapy. Eastern Cooperative Oncology Group (ECOG) performance status (PS) and neutrophil-lymphocyte ratio (NLR) were identified as prognostic factors.

Conclusion: This study suggested that patients with locally advanced or metastatic UC could benefit from PD-1 inhibitor alone or combined with chemotherapy in daily clinical practice. ECOG PS and NLR can be used for prognostication of survival.

背景:免疫检查点抑制剂(ICIs)单独或联合标准化疗治疗晚期尿路上皮癌(UC)已经在临床试验中作为一线治疗方法进行了测试。本研究旨在评估程序性细胞死亡1 (PD-1)抑制剂单独或联合化疗治疗局部晚期或转移性UC患者的临床结果,并试图确定总生存期(OS)的预后因素。方法:对35例局部晚期或转移性UC患者进行回顾性研究,这些患者单独或联合使用PD-1抑制剂进行化疗。Kaplan-Meier曲线用于评估无进展生存期(PFS)和OS。采用Cox回归分析探讨基线变量与OS的关系。结果:在我们的35例患者队列中,7例患者单独接受PD-1抑制剂治疗,28例患者接受PD-1抑制剂加铂类化疗。所有患者的中位OS为16.0个月(95% CI: 11.9-20.1),中位PFS为12.0个月(95% CI: 8.6-15.4)。PD-1抑制剂联合化疗的PFS优于PD-1抑制剂单药治疗(HR: 0.19, p = 0.018)。在接受PD-1抑制剂的5例(71.4%)患者和接受PD-1抑制剂加化疗的24例(85.7%)患者中发生了任何级别的治疗相关不良事件(ae)。确定东部肿瘤合作组(ECOG)表现状态(PS)和中性粒细胞淋巴细胞比率(NLR)为预后因素。结论:本研究提示局部晚期或转移性UC患者可在日常临床实践中受益于PD-1抑制剂或联合化疗。ECOG、PS和NLR可用于预后。
{"title":"Programmed cell death 1 inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic urothelial carcinoma: a single-center experience.","authors":"Xing Huang, Chupeng Sun, Peng Zhang, Lei Wang","doi":"10.1186/s12894-024-01674-7","DOIUrl":"10.1186/s12894-024-01674-7","url":null,"abstract":"<p><strong>Background: </strong>Immune checkpoint inhibitors (ICIs) alone or in combination with standard chemotherapy for advanced urothelial carcinoma (UC) have been tested as first-line treatment in clinical trials. This study aimed to evaluate the clinical outcomes of programmed cell death 1 (PD-1) inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic UC in a real world clinical care setting, and sought to identify prognostic factors for overall survival (OS).</p><p><strong>Methods: </strong>A retrospective, real-world study involving 35 locally advanced or metastatic UC patients treated with PD-1 inhibitor alone or in combination with chemotherapy was conducted. Kaplan-Meier curves were used to assess progression-free survival (PFS) and OS. A Cox regression analysis was conducted to explore the association of baseline variables with OS.</p><p><strong>Results: </strong>In our cohort of 35 patients, 7 patients were treated with PD-1 inhibitor alone and 28 with PD-1 inhibitor plus platinum-based chemotherapy. The median OS was 16.0 months (95% CI: 11.9-20.1), and median PFS was 12.0 months (95% CI: 8.6-15.4) for all patients. PD-1 inhibitor combined with chemotherapy was associated with better PFS than PD-1 inhibitor monotherapy (HR: 0.19, p = 0.018). Treatment-related adverse events (AEs) of any grade occurred in 5 (71.4%) patients who received PD-1 inhibitor and 24 (85.7%) patients who received PD-1 inhibitor plus chemotherapy. Eastern Cooperative Oncology Group (ECOG) performance status (PS) and neutrophil-lymphocyte ratio (NLR) were identified as prognostic factors.</p><p><strong>Conclusion: </strong>This study suggested that patients with locally advanced or metastatic UC could benefit from PD-1 inhibitor alone or combined with chemotherapy in daily clinical practice. ECOG PS and NLR can be used for prognostication of survival.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"289"},"PeriodicalIF":1.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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